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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3alpha-hydroxy-5beta-pregnan-20-one
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Accession:CHEBI:1712 term browser browse the term
Definition:The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.
Synonyms:related_synonym: (3alpha,5beta)-3-hydroxypregnan-20-one;   3alpha-Hydroxy-5beta-pregnane-20-one;   Formula=C21H34O2;   InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1;   InChIKey=AURFZBICLPNKBZ-YZRLXODZSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])(C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2;   eltanolona;   eltanolone;   eltanolonum;   pregnan-3alpha-ol-20-one;   pregnanolone
 xref: Beilstein:3211364;   CAS:128-20-1;   Drug_Central:997;   KEGG:C05480;   LIPID_MAPS_instance:LMST02030175
 xref_mesh: MESH:D011280
 xref: PMID:10958114;   PMID:15358441;   PMID:15935549;   PMID:23949204;   PMID:25620274;   Reaxys:3211364;   Wikipedia:Pregnanolone


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3alpha-hydroxy-5beta-pregnan-20-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 affects metabolic processing ISO AKR1C4 protein affects the metabolism of Pregnanolone CTD PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases reduction
affects metabolic processing
ISO AKR1C2 protein results in increased reduction of Pregnanolone
AKR1C2 protein affects the metabolism of Pregnanolone
CTD PMID:11995921 PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of Pregnanolone CTD PMID:25463305 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Crh corticotropin releasing hormone affects expression
multiple interactions
EXP Pregnanolone affects the expression of CRH mRNA
Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein]
CTD PMID:7816204 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases hydroxylation ISO CYP17A1 protein results in increased hydroxylation of Pregnanolone analog CTD PMID:14522586 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Egr2 early growth response 2 increases expression EXP Pregnanolone results in increased expression of EGR2 mRNA; Pregnanolone results in increased expression of EGR2 protein CTD PMID:17478888 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression
multiple interactions
EXP
ISO
Pregnanolone deficiency results in increased expression of GABRA4 mRNA; Pregnanolone deficiency results in increased expression of GABRA4 protein
Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]
CTD PMID:9651210 PMID:29038840 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases response to substance
multiple interactions
ISO GABRA6 protein results in increased susceptibility to Pregnanolone
Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
CTD PMID:9281599 PMID:29038840 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]; Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta decreases expression
multiple interactions
EXP
ISO
Pregnanolone results in decreased expression of GABRD protein
Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]
CTD PMID:16914187 PMID:29038840 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Pregnanolone CTD PMID:9039914 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP Pregnanolone results in decreased expression of GSK3B protein CTD PMID:17443805 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [Pregnanolone co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Il1b interleukin 1 beta decreases response to substance ISO Pregnanolone results in decreased susceptibility to IL1B protein CTD PMID:19458216 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mag myelin-associated glycoprotein increases expression EXP Pregnanolone results in increased expression of MAG mRNA CTD PMID:16787508 NCBI chr 1:89,345,325...89,360,905
Ensembl chr 1:89,345,429...89,360,733
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Pregnanolone results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:16581232 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapt microtubule-associated protein tau increases phosphorylation
decreases expression
EXP Pregnanolone results in increased phosphorylation of MAPT protein
Pregnanolone results in decreased expression of MAPT protein
CTD PMID:17443805 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mpz myelin protein zero increases expression EXP Pregnanolone results in increased expression of MPZ mRNA CTD PMID:16787508 NCBI chr13:89,524,204...89,530,070
Ensembl chr13:89,524,329...89,530,068
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO Pregnanolone metabolite inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Pregnanolone metabolite results in increased activity of NR1H4 protein
CTD PMID:22961653 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Pregnanolone analog inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Pregnanolone inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Penk proenkephalin increases expression EXP Pregnanolone results in increased expression of PENK mRNA CTD PMID:19458216 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression EXP Pregnanolone results in increased expression of PMP22 mRNA CTD PMID:16787508 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Pregnanolone results in decreased expression of PRKCA protein CTD PMID:16581232 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP Pregnanolone results in increased localization of and results in increased activity of SLC1A1 protein CTD PMID:21688266 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases chemical synthesis ISO SRD5A1 protein results in increased chemical synthesis of Pregnanolone CTD PMID:25463305 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link

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  CHEBI ontology 19771
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              central nervous system depressant 16026
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                  3alpha-hydroxy-5beta-pregnan-20-one 30
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  CHEBI ontology 19771
    subatomic particle 19770
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                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxo steroid 9722
                                          20-oxo steroid 7279
                                            3-hydroxypregnan-20-one 30
                                              3-hydroxy-5beta-pregnan-20-one 30
                                                3alpha-hydroxy-5beta-pregnan-20-one 30
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