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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphoramide
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Accession:CHEBI:17102 term browser browse the term
Definition:A compound in which one or more of the OH groups of phosphoric acid have been replaced with an amino or substituted amino group. The term is commonly confined to the phosphoric triamides, P(=O)(NR2)3, since replacement of one or two OH groups produces phosphoramidic acids: P(=O)(OH)(NR2)2 , P(=O)(OH)2(NR2).
Synonyms:related_synonym: phosphamide;   phosphamides;   phosphoramides
 alt_id: CHEBI:14827;   CHEBI:26076;   CHEBI:8162


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4-hydroperoxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase increases expression EXP perfosfamide results in increased expression of ABL1 mRNA CTD PMID:19429390 NCBI chr 2:31,688,244...31,807,093
Ensembl chr 2:31,688,376...31,804,227
JBrowse link
G Actb actin, beta decreases expression EXP perfosfamide results in decreased expression of ACTB mRNA CTD PMID:19429390 NCBI chr 5:142,903,115...142,907,976
Ensembl chr 5:142,903,115...142,906,754
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) decreases response to substance ISO AGT protein results in decreased susceptibility to perfosfamide CTD PMID:11034089 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions
increases response to substance
ISO Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; perfosfamide results in increased expression of and results in increased localization of AIFM1 protein
AIFM1 results in increased susceptibility to perfosfamide
CTD PMID:18034189 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) affects response to substance ISO AKR1B10 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 decreases response to substance ISO ALDH1A1 protein results in decreased susceptibility to perfosfamide CTD PMID:8662658 PMID:16614850 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 decreases response to substance ISO ALDH1A2 protein results in decreased susceptibility to perfosfamide CTD PMID:22079344 NCBI chr 9:71,215,789...71,296,243
Ensembl chr 9:71,215,789...71,296,243
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 affects response to substance ISO ALDH1B1 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial decreases response to substance ISO ALDH2 protein results in decreased susceptibility to perfosfamide CTD PMID:22079344 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 decreases response to substance ISO ALDH3A1 protein results in decreased susceptibility to perfosfamide CTD PMID:16614850 NCBI chr11:61,208,510...61,218,418
Ensembl chr11:61,207,537...61,218,421
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 decreases expression ISO perfosfamide results in decreased expression of APEX1 mRNA CTD PMID:11754170 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Bax BCL2-associated X protein multiple interactions
affects folding
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; perfosfamide results in increased expression of and results in increased localization of BAX
perfosfamide results in increased expression of BAX protein
CTD PMID:16488414 PMID:18034189 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression EXP perfosfamide results in increased expression of BBC3 mRNA CTD PMID:17068108 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bmpr1b bone morphogenetic protein receptor, type 1B decreases expression EXP perfosfamide results in decreased expression of BMPR1B mRNA CTD PMID:19429390 NCBI chr 3:141,837,135...142,169,585
Ensembl chr 3:141,837,136...142,169,425
JBrowse link
G C1d C1D nuclear receptor co-repressor increases expression EXP perfosfamide results in increased expression of C1D mRNA CTD PMID:19429390 NCBI chr11:17,257,547...17,269,176
Ensembl chr11:17,257,579...17,269,176
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
perfosfamide results in increased activity of CASP3
perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein]
CTD PMID:16488414 PMID:17434952 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 increases activity EXP perfosfamide results in increased activity of CASP9 protein CTD PMID:16488414 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO
EXP
perfosfamide results in increased expression of CDKN1A
perfosfamide results in increased expression of CDKN1A mRNA; perfosfamide results in increased expression of CDKN1A protein
CTD PMID:17068108 PMID:18034189 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cxcl9 chemokine (C-X-C motif) ligand 9 decreases expression EXP perfosfamide results in decreased expression of CXCL9 mRNA CTD PMID:19429390 NCBI chr 5:92,321,331...92,328,079
Ensembl chr 5:92,321,347...92,328,079
JBrowse link
G E2f1 E2F transcription factor 1 increases expression EXP perfosfamide results in increased expression of E2F1 mRNA CTD PMID:19429390 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G Egr1 early growth response 1 decreases expression EXP perfosfamide results in decreased expression of EGR1 mRNA CTD PMID:19429390 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Endog endonuclease G increases response to substance
multiple interactions
ISO ENDOG results in increased susceptibility to perfosfamide
Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]; perfosfamide results in increased expression of and results in increased localization of ENDOG protein
CTD PMID:18034189 NCBI chr 2:30,171,408...30,174,069
Ensembl chr 2:30,171,493...30,174,069
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression EXP perfosfamide results in increased expression of EPAS1 protein CTD PMID:23251655 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Epha6 Eph receptor A6 decreases expression EXP perfosfamide results in decreased expression of EPHA6 mRNA CTD PMID:19429390 NCBI chr16:59,641,433...60,610,911
Ensembl chr16:59,653,483...60,605,531
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression EXP perfosfamide results in decreased expression of EYA1 mRNA CTD PMID:19429390 NCBI chr 1:14,168,953...14,311,035
Ensembl chr 1:14,168,954...14,310,235
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO perfosfamide results in increased expression of FASLG mRNA; perfosfamide results in increased expression of FASLG protein CTD PMID:14760101 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Foxf1 forkhead box F1 affects expression EXP perfosfamide affects the expression of FOXF1 mRNA CTD PMID:19429390 NCBI chr 8:121,084,386...121,088,154
Ensembl chr 8:121,084,386...121,088,144
JBrowse link
G Gjc1 gap junction protein, gamma 1 increases expression EXP perfosfamide results in increased expression of GJC1 mRNA CTD PMID:19429390 NCBI chr11:102,799,477...102,819,686
Ensembl chr11:102,799,579...102,819,700
JBrowse link
G Gli2 GLI-Kruppel family member GLI2 decreases expression EXP perfosfamide results in decreased expression of GLI2 mRNA CTD PMID:19429390 NCBI chr 1:118,834,061...119,054,405
Ensembl chr 1:118,834,132...119,053,619
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression EXP perfosfamide results in increased expression of HES1 mRNA CTD PMID:19429390 NCBI chr16:30,065,357...30,067,796
Ensembl chr16:30,064,384...30,067,796
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression EXP perfosfamide results in increased expression of HIF1A mRNA; perfosfamide results in increased expression of HIF1A protein CTD PMID:19429390 PMID:23251655 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hoxa11 homeobox A11 decreases expression EXP perfosfamide results in decreased expression of HOXA11 mRNA CTD PMID:19429390 NCBI chr 6:52,242,105...52,245,810
Ensembl chr 6:52,242,106...52,245,810
JBrowse link
G Hoxa13 homeobox A13 increases expression EXP perfosfamide results in increased expression of HOXA13 mRNA CTD PMID:19429390 NCBI chr 6:52,258,853...52,260,880
Ensembl chr 6:52,257,694...52,260,880
JBrowse link
G Hoxd10 homeobox D10 increases expression EXP perfosfamide results in increased expression of HOXD10 mRNA CTD PMID:19429390 NCBI chr 2:74,684,273...74,695,106
Ensembl chr 2:74,691,924...74,695,105
JBrowse link
G Hras Harvey rat sarcoma virus oncogene decreases expression EXP perfosfamide results in decreased expression of HRAS mRNA CTD PMID:19429390 NCBI chr 7:141,189,934...141,194,019
Ensembl chr 7:141,189,105...141,194,005
JBrowse link
G Kl klotho decreases expression EXP perfosfamide results in decreased expression of KL mRNA CTD PMID:19429390 NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
JBrowse link
G Lig3 ligase III, DNA, ATP-dependent decreases expression ISO perfosfamide results in decreased expression of LIG3 mRNA CTD PMID:11754170 NCBI chr11:82,781,109...82,804,274
Ensembl chr11:82,781,108...82,804,274
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO perfosfamide results in increased expression of MDM2 CTD PMID:18034189 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO perfosfamide results in decreased expression of MGMT mRNA CTD PMID:11754170 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO perfosfamide results in decreased expression of MLH1 mRNA CTD PMID:11754170 NCBI chr 9:111,228,228...111,271,786
Ensembl chr 9:111,228,228...111,271,791
JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases expression ISO perfosfamide results in decreased expression of MPG mRNA CTD PMID:11754170 NCBI chr11:32,226,505...32,232,702
Ensembl chr11:32,226,505...32,232,700
JBrowse link
G Mre11a MRE11A homolog A, double strand break repair nuclease decreases expression ISO perfosfamide results in decreased expression of MRE11A mRNA CTD PMID:11754170 NCBI chr 9:14,784,654...14,837,125
Ensembl chr 9:14,784,654...14,837,123
JBrowse link
G Myo1b myosin IB increases expression EXP perfosfamide results in increased expression of MYO1B mRNA CTD PMID:19429390 NCBI chr 1:51,749,758...51,916,063
Ensembl chr 1:51,749,765...51,916,071
JBrowse link
G Myog myogenin increases expression EXP perfosfamide results in increased expression of MYOG mRNA CTD PMID:19429390 NCBI chr 1:134,290,004...134,292,548
Ensembl chr 1:134,289,989...134,292,548
JBrowse link
G Ndn necdin, MAGE family member increases expression EXP perfosfamide results in increased expression of NDN mRNA CTD PMID:19429390 NCBI chr 7:62,348,277...62,349,928
Ensembl chr 7:62,346,569...62,350,262
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases expression EXP perfosfamide results in decreased expression of ODC1 mRNA CTD PMID:19429390 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505
JBrowse link
G Pea15a phosphoprotein enriched in astrocytes 15A decreases expression EXP perfosfamide results in decreased expression of PEA15 mRNA CTD PMID:19429390 NCBI chr 1:172,196,728...172,206,804
Ensembl chr 1:172,196,728...172,206,804
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP perfosfamide results in increased expression of PMAIP1 mRNA CTD PMID:17068108 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component decreases expression ISO perfosfamide results in decreased expression of PMS1 mRNA CTD PMID:11754170 NCBI chr 1:53,189,187...53,297,031
Ensembl chr 1:53,189,187...53,297,018
JBrowse link
G Pms2 PMS1 homolog2, mismatch repair system component decreases expression ISO perfosfamide results in decreased expression of PMS2 mRNA CTD PMID:11754170 NCBI chr 5:143,909,901...143,972,745
Ensembl chr 5:143,909,964...143,933,968
JBrowse link
G Polb polymerase (DNA directed), beta decreases expression ISO perfosfamide results in decreased expression of POLB mRNA CTD PMID:11754170 NCBI chr 8:22,628,119...22,653,464
Ensembl chr 8:22,628,126...22,653,435
JBrowse link
G Pold1 polymerase (DNA directed), delta 1, catalytic subunit decreases expression EXP perfosfamide results in decreased expression of POLD1 mRNA CTD PMID:19429390 NCBI chr 7:44,532,744...44,548,815
Ensembl chr 7:44,532,746...44,548,849
JBrowse link
G Rad21 RAD21 cohesin complex component decreases expression EXP perfosfamide results in decreased expression of RAD21 mRNA CTD PMID:19429390 NCBI chr15:51,962,604...51,993,538
Ensembl chr15:51,962,240...51,991,747
JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO perfosfamide results in decreased expression of RAD50 mRNA CTD PMID:11754170 NCBI chr11:53,649,519...53,707,319
Ensembl chr11:53,649,519...53,707,319
JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO perfosfamide results in decreased expression of RAD51 mRNA CTD PMID:11754170 NCBI chr 2:119,112,814...119,136,073
Ensembl chr 2:119,112,793...119,147,445
JBrowse link
G Sdf4 stromal cell derived factor 4 decreases expression EXP perfosfamide results in decreased expression of SDF4 mRNA CTD PMID:19429390 NCBI chr 4:155,992,843...156,013,610
Ensembl chr 4:155,992,872...156,013,610
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases expression EXP perfosfamide results in decreased expression of SFRP2 mRNA CTD PMID:19429390 NCBI chr 3:83,765,750...83,774,314
Ensembl chr 3:83,766,321...83,774,316
JBrowse link
G Slc30a4 solute carrier family 30 (zinc transporter), member 4 decreases expression EXP perfosfamide results in decreased expression of SLC30A4 mRNA CTD PMID:19429390 NCBI chr 2:122,681,233...122,702,663
Ensembl chr 2:122,681,233...122,702,663
JBrowse link
G Smad1 SMAD family member 1 decreases expression EXP perfosfamide results in decreased expression of SMAD1 mRNA CTD PMID:19429390 NCBI chr 8:79,338,395...79,399,428
Ensembl chr 8:79,338,395...79,399,518
JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) affects response to substance ISO TAP1 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr17:34,187,556...34,197,225
Ensembl chr17:34,187,553...34,197,225
JBrowse link
G Tcf12 transcription factor 12 increases expression EXP perfosfamide results in increased expression of TCF12 mRNA CTD PMID:19429390 NCBI chr 9:71,844,252...72,111,893
Ensembl chr 9:71,842,688...72,111,871
JBrowse link
G Terc telomerase RNA component decreases expression EXP perfosfamide results in decreased expression of TERC mRNA CTD PMID:24571982 NCBI chr 3:96,414,437...96,414,833
Ensembl chr 3:96,414,437...96,414,859
Ensembl chr 3:96,414,437...96,414,859
JBrowse link
G Tert telomerase reverse transcriptase decreases expression EXP perfosfamide results in decreased expression of TERT mRNA CTD PMID:24571982 NCBI chr13:73,626,911...73,649,843
Ensembl chr13:73,626,911...73,649,843
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein] CTD PMID:16488414 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trim27 tripartite motif-containing 27 decreases expression EXP perfosfamide results in decreased expression of TRIM27 mRNA CTD PMID:19429390 NCBI chr13:21,179,450...21,194,723
Ensembl chr13:21,179,445...21,194,724
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [perfosfamide results in increased expression of TP53]
perfosfamide results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein
CTD PMID:17068108 PMID:18034189 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ttf1 transcription termination factor, RNA polymerase I decreases expression EXP perfosfamide results in decreased expression of TTF1 mRNA CTD PMID:19429390 NCBI chr 2:29,060,199...29,087,656
Ensembl chr 2:29,060,262...29,087,656
JBrowse link
G Ubb ubiquitin B decreases expression EXP perfosfamide results in decreased expression of UBB mRNA CTD PMID:19429390 NCBI chr11:62,551,171...62,553,213
Ensembl chr11:62,551,171...62,553,213
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP perfosfamide results in increased expression of VEGFA mRNA CTD PMID:19429390 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Vim vimentin decreases expression EXP perfosfamide results in decreased expression of VIM mRNA CTD PMID:19429390 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Wnt11 wingless-type MMTV integration site family, member 11 increases expression EXP perfosfamide results in increased expression of WNT11 mRNA CTD PMID:19429390 NCBI chr 7:98,835,084...98,854,747
Ensembl chr 7:98,835,112...98,855,195
JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 decreases expression ISO perfosfamide results in decreased expression of XRCC1 mRNA CTD PMID:11754170 NCBI chr 7:24,546,699...24,573,438
Ensembl chr 7:24,546,289...24,573,440
JBrowse link
G Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 decreases expression ISO perfosfamide results in decreased expression of XRCC5 mRNA CTD PMID:11754170 NCBI chr 1:72,307,417...72,394,953
Ensembl chr 1:72,307,427...72,394,952
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide decreases expression EXP perfosfamide results in decreased expression of YWHAZ mRNA CTD PMID:19429390 NCBI chr15:36,770,261...36,802,984
Ensembl chr15:36,770,770...36,796,929
JBrowse link
4-hydroxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA CTD PMID:25833159 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions ISO [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA CTD PMID:25833159 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA CTD PMID:25833159 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions ISO [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases chemical synthesis ISO CYP2C9 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases chemical synthesis ISO CYP2C9 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Il1r1 interleukin 1 receptor, type I multiple interactions ISO [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA CTD PMID:25833159 NCBI chr 1:40,222,480...40,316,201
Ensembl chr 1:40,225,080...40,317,257
JBrowse link
G Il2rg interleukin 2 receptor, gamma chain multiple interactions ISO [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA CTD PMID:25833159 NCBI chr  X:101,264,385...101,268,255
Ensembl chr  X:101,264,378...101,268,255
JBrowse link
G Klk15 kallikrein related-peptidase 15 multiple interactions ISO [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA CTD PMID:25833159 NCBI chr 7:43,929,405...43,940,035
Ensembl chr 7:43,933,740...43,939,639
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA CTD PMID:25833159 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
acephate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP
ISO
methamidophos inhibits the reaction [acephate results in decreased activity of ACHE protein] CTD PMID:9074804 PMID:11048668 PMID:12039681 PMID:22778074 PMID:23000449 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Alad aminolevulinate, delta-, dehydratase decreases activity ISO acephate results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions ISO acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 4:137,741,731...137,796,384
Ensembl chr 4:137,741,733...137,796,384
JBrowse link
G Bche butyrylcholinesterase decreases expression ISO acephate results in decreased expression of BCHE protein CTD PMID:31326399 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO [acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein
acephate results in decreased activity of CAT protein
CTD PMID:10874619 PMID:22034174 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Crh corticotropin releasing hormone increases expression
increases secretion
multiple interactions
ISO acephate results in increased expression of CRH mRNA
acephate results in increased secretion of CRH protein
acephate promotes the reaction [FOS protein binds to CRH promoter]; Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]; Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]
CTD PMID:12039681 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [acephate co-treated with vinclozolin] affects the expression of CYP1A1 protein; [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions EXP [acephate co-treated with vinclozolin] affects the expression of CYP2B1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B1 protein CTD PMID:17686559 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions EXP [acephate co-treated with vinclozolin] affects the expression of CYP2B2 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B2 protein CTD PMID:17686559 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [acephate co-treated with vinclozolin] affects the expression of CYP2E1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO acephate promotes the reaction [FOS protein binds to CRH promoter] CTD PMID:12039681 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G G6pc glucose-6-phosphatase, catalytic multiple interactions
increases activity
ISO diphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC1 protein] CTD PMID:22778074 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble decreases expression ISO acephate results in decreased expression of GPT protein CTD PMID:33217513 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr 8:76,898,083...77,245,012
Ensembl chr 8:76,899,442...77,245,012
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
ISO diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein] CTD PMID:19118596 PMID:22778074 NCBI chr 8:109,986,078...109,999,804
Ensembl chr 8:109,990,437...109,999,803
JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
decreases expression
increases expression
ISO [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; ABCB1 protein affects the susceptibility to [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil]; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; NR1I2 protein promotes the reaction [Cyclophosphamide results in increased expression of ABCB1 protein]
Cyclophosphamide results in decreased expression of ABCB1 mRNA; Cyclophosphamide results in decreased expression of ABCB1A mRNA
CTD PMID:12576456 PMID:20041327 PMID:20623750 PMID:30563925 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
decreases response to substance
ISO ABCC1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
ABCC1 protein results in decreased susceptibility to Cyclophosphamide
CTD PMID:11778547 PMID:12576456 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO ABCG2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:12576456 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Abhd3 abhydrolase domain containing 3 increases expression ISO Cyclophosphamide results in increased expression of ABHD3 mRNA CTD PMID:21527772 NCBI chr18:10,644,411...10,706,783
Ensembl chr18:10,642,092...10,706,771
JBrowse link
G Abi2 abl interactor 2 decreases expression ISO Cyclophosphamide results in decreased expression of ABI2 mRNA CTD PMID:27466211 NCBI chr 1:60,405,768...60,481,945
Ensembl chr 1:60,409,619...60,481,158
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 decreases expression ISO Cyclophosphamide results in decreased expression of ACE mRNA CTD PMID:27281708 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 decreases expression ISO Cyclophosphamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression ISO Cyclophosphamide results in increased expression of ACKR3 mRNA CTD PMID:20032115 NCBI chr 1:90,203,980...90,215,724
Ensembl chr 1:90,203,980...90,216,751
JBrowse link
G Acod1 aconitate decarboxylase 1 increases expression EXP Cyclophosphamide results in increased expression of ACOD1 mRNA CTD PMID:15331540 NCBI chr14:103,047,012...103,056,573
Ensembl chr14:103,046,977...103,056,573
JBrowse link
G Actb actin, beta decreases expression
affects expression
ISO Cyclophosphamide results in decreased expression of ACTB mRNA
Cyclophosphamide affects the expression of ACTB mRNA
CTD PMID:10859244 PMID:12167460 NCBI chr 5:142,903,115...142,907,976
Ensembl chr 5:142,903,115...142,906,754
JBrowse link
G Adam20 a disintegrin and metallopeptidase domain 20 decreases expression ISO Cyclophosphamide results in decreased expression of ADAM24 mRNA CTD PMID:27281708 NCBI chr 8:40,793,273...40,797,342
Ensembl chr 8:40,793,273...40,797,303
JBrowse link
G Adam24 a disintegrin and metallopeptidase domain 24 (testase 1) decreases expression ISO Cyclophosphamide results in decreased expression of ADAM24 mRNA CTD PMID:27281708 NCBI chr 8:40,675,077...40,682,199
Ensembl chr 8:40,675,077...40,682,199
JBrowse link
G Adamts9 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 increases expression ISO Cyclophosphamide results in increased expression of ADAMTS9 mRNA CTD PMID:27281708 NCBI chr 6:92,772,699...92,944,450
Ensembl chr 6:92,772,699...92,943,492
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 affects expression
increases expression
ISO Cyclophosphamide affects the expression of ADCYAP1 mRNA
Cyclophosphamide results in increased expression of ADCYAP1 protein
CTD PMID:9776515 PMID:10754506 PMID:18563302 NCBI chr17:93,198,245...93,206,541
Ensembl chr17:93,199,017...93,206,537
JBrowse link
G Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 affects expression ISO Cyclophosphamide affects the expression of ADCYAP1R1 mRNA CTD PMID:18563302 NCBI chr 6:55,451,501...55,501,455
Ensembl chr 6:55,451,978...55,501,451
JBrowse link
G Adm adrenomedullin affects response to substance ISO ADM protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 7:110,627,657...110,629,820
Ensembl chr 7:110,627,661...110,629,820
JBrowse link
G Afp alpha fetoprotein affects expression EXP Cyclophosphamide affects the expression of AFP protein CTD PMID:6177358 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Agl amylo-1,6-glucosidase, 4-alpha-glucanotransferase affects response to substance ISO AGL protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 3:116,739,999...116,808,166
Ensembl chr 3:116,739,999...116,808,166
JBrowse link
G Akap8 A kinase (PRKA) anchor protein 8 increases expression ISO Cyclophosphamide results in increased expression of AKAP8 mRNA CTD PMID:27281708 NCBI chr17:32,303,672...32,321,238
Ensembl chr17:32,303,672...32,321,238
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases expression
ISO Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of AKT1 protein] CTD PMID:19996110 PMID:25446862 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions ISO [Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein CTD PMID:19162187 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression EXP Cyclophosphamide results in increased expression of ALCAM mRNA CTD PMID:21041162 NCBI chr16:52,248,996...52,453,081
Ensembl chr16:52,248,996...52,454,074
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects response to substance
increases expression
decreases response to substance
ISO ALDH1A1 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of ALDH1A1 mRNA
ALDH1A1 protein results in decreased susceptibility to Cyclophosphamide
CTD PMID:12513786 PMID:17403535 PMID:18854779 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial increases expression ISO Cyclophosphamide results in increased expression of ALDH2 mRNA CTD PMID:17403535 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Cyclophosphamide CTD PMID:18854779 NCBI chr11:61,208,510...61,218,418
Ensembl chr11:61,207,537...61,218,421
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein decreases expression ISO Cyclophosphamide results in decreased expression of ALOX5AP mRNA CTD PMID:17403535 NCBI chr 5:149,265,004...149,288,153
Ensembl chr 5:149,264,767...149,288,153
JBrowse link
G Alyref Aly/REF export factor decreases expression EXP Cyclophosphamide results in decreased expression of ALYREF mRNA CTD PMID:21041162 NCBI chr11:120,594,504...120,598,399
Ensembl chr11:120,592,121...120,598,365
JBrowse link
G Amfr autocrine motility factor receptor multiple interactions ISO AMFR mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:93,971,588...94,012,640
Ensembl chr 8:93,971,588...94,012,842
JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO Cyclophosphamide results in increased expression of ANGPT1 mRNA CTD PMID:17403535 NCBI chr15:42,424,667...42,676,977
Ensembl chr15:42,424,723...42,676,977
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of APAF1 mRNA CTD PMID:29445054 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases expression ISO Cyclophosphamide results in increased expression of APEX1 mRNA CTD PMID:11599041 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Apob apolipoprotein B decreases expression ISO Cyclophosphamide results in decreased expression of APOB mRNA CTD PMID:18246545 NCBI chr12:7,977,629...8,016,839
Ensembl chr12:7,977,648...8,016,835
JBrowse link
G Apoe apolipoprotein E decreases expression
increases expression
EXP Cyclophosphamide results in decreased expression of APOE mRNA
Cyclophosphamide results in increased expression of APOE mRNA
CTD PMID:15331540 PMID:21041162 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Arg1 arginase, liver increases expression
decreases expression
affects expression
EXP
ISO
Cyclophosphamide results in increased expression of ARG1 mRNA
Cyclophosphamide results in decreased expression of ARG1 mRNA
Cyclophosphamide affects the expression of ARG1 mRNA
CTD PMID:18246545 PMID:21068404 NCBI chr10:24,915,207...24,927,470
Ensembl chr10:24,915,221...24,927,484
JBrowse link
G Arhgdib Rho, GDP dissociation inhibitor (GDI) beta increases expression ISO Cyclophosphamide results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr 6:136,923,655...136,941,899
Ensembl chr 6:136,923,655...136,941,899
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor (GEF) 26 increases expression ISO Cyclophosphamide results in increased expression of ARHGEF26 mRNA CTD PMID:20849824 NCBI chr 3:62,338,777...62,462,221
Ensembl chr 3:62,338,344...62,462,221
JBrowse link
G Asns asparagine synthetase decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ASNS mRNA CTD PMID:24356939 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atf2 activating transcription factor 2 increases expression ISO Cyclophosphamide results in increased expression of ATF2 mRNA CTD PMID:11599041 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Cyclophosphamide results in decreased expression of ATF5 mRNA CTD PMID:17403535 NCBI chr 7:44,812,256...44,816,658
Ensembl chr 7:44,812,256...44,816,658
JBrowse link
G Atg3 autophagy related 3 decreases expression ISO Cyclophosphamide results in decreased expression of ATG3 mRNA CTD PMID:20849824 NCBI chr16:45,158,829...45,188,538
Ensembl chr16:45,158,785...45,188,538
JBrowse link
G Atg5 autophagy related 5 multiple interactions
decreases expression
EXP Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein] CTD PMID:32151603 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G Atg7 autophagy related 7 multiple interactions
decreases expression
EXP Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein] CTD PMID:32151603 NCBI chr 6:114,643,127...114,860,604
Ensembl chr 6:114,643,097...114,860,614
JBrowse link
G Aurkb aurora kinase B increases expression ISO Cyclophosphamide results in increased expression of AURKB mRNA CTD PMID:11599041 NCBI chr11:69,045,624...69,051,664
Ensembl chr11:69,045,647...69,051,664
JBrowse link
G Axl AXL receptor tyrosine kinase increases expression ISO Cyclophosphamide results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr 7:25,756,500...25,788,924
Ensembl chr 7:25,757,273...25,788,705
JBrowse link
G B3galnt2 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 increases expression ISO Cyclophosphamide results in increased expression of B3GALNT2 mRNA CTD PMID:21527772 NCBI chr13:13,954,474...13,999,103
Ensembl chr13:13,954,469...13,999,103
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
ISO
EXP
Cyclophosphamide results in increased expression of BAD mRNA
Cyclophosphamide results in increased expression of BAD protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of BAD protein]
CTD PMID:11599041 PMID:29753871 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bag1 BCL2-associated athanogene 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BAG1 mRNA CTD PMID:16322899 NCBI chr 4:40,936,398...40,948,294
Ensembl chr 4:40,936,398...40,948,294
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO
EXP
Cyclophosphamide results in increased expression of BAX mRNA; Cyclophosphamide results in increased expression of BAX protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]
Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]
CTD PMID:25446862 PMID:29753871 PMID:30506662 PMID:32197949 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions
increases expression
ISO sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA] CTD PMID:32197949 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 (human) multiple interactions ISO BBS4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:59,321,966...59,353,508
Ensembl chr 9:59,321,990...59,353,508
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO [Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein
Cyclophosphamide results in decreased activity of BCHE protein
CTD PMID:4672170 PMID:4959505 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
increases expression
ISO
EXP
[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BCL2 mRNA; [Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP9 protein]
Cyclophosphamide results in decreased expression of BCL2 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]
Cyclophosphamide results in decreased expression of BCL2 mRNA; Cyclophosphamide results in decreased expression of BCL2 protein
Cyclophosphamide results in increased expression of BCL2 mRNA
CTD PMID:11723234 PMID:14503796 PMID:15582267 PMID:16322899 PMID:21182165 PMID:25446862 PMID:29753871 PMID:30506662 PMID:32197949 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 increases expression ISO Cyclophosphamide results in increased expression of BCL2L1 mRNA CTD PMID:11599041 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) multiple interactions
increases expression
ISO sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA] CTD PMID:32197949 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Bcl2l2 BCL2-like 2 increases expression EXP Cyclophosphamide results in increased expression of BCL2L2 mRNA CTD PMID:21041162 NCBI chr14:54,883,366...54,890,858
Ensembl chr14:54,892,500...54,898,169
Ensembl chr14:54,892,500...54,898,169
JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 decreases expression EXP
ISO
Cyclophosphamide results in decreased expression of BCL6 mRNA
Cyclophosphamide metabolite results in decreased expression of BCL6 mRNA
CTD PMID:21041162 PMID:24356939 NCBI chr16:23,965,050...23,988,866
Ensembl chr16:23,965,052...23,988,852
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase, type 1 affects response to substance ISO BDH1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr16:31,422,297...31,458,901
Ensembl chr16:31,422,280...31,458,901
JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 increases expression ISO Cyclophosphamide results in increased expression of BDKRB1 mRNA CTD PMID:10498854 PMID:15576455 NCBI chr12:105,604,091...105,605,511
Ensembl chr12:105,603,085...105,605,428
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 affects expression ISO Cyclophosphamide affects the expression of BDKRB2 mRNA CTD PMID:15576455 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Bdnf brain derived neurotrophic factor increases expression ISO Cyclophosphamide results in increased expression of BDNF mRNA CTD PMID:10683293 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
decreases expression
ISO
EXP
BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]
CTD PMID:16896004 PMID:32151603 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bik BCL2-interacting killer decreases expression ISO Cyclophosphamide results in decreased expression of BIK mRNA CTD PMID:17403535 NCBI chr15:83,526,790...83,544,635
Ensembl chr15:83,526,862...83,544,634
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of BIRC3 mRNA CTD PMID:24356939 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Blvrb biliverdin reductase B (flavin reductase (NADPH)) decreases expression ISO Cyclophosphamide results in decreased expression of BLVRB protein CTD PMID:9006340 NCBI chr 7:27,447,978...27,465,981
Ensembl chr 7:27,447,978...27,466,144
JBrowse link
G Bpi bactericidal permeablility increasing protein decreases expression ISO Cyclophosphamide results in decreased expression of BPI mRNA CTD PMID:17403535 NCBI chr 2:158,258,063...158,284,533
Ensembl chr 2:158,258,094...158,284,531
JBrowse link
G Brpf1 bromodomain and PHD finger containing, 1 increases expression ISO Cyclophosphamide results in increased expression of BRPF1 mRNA CTD PMID:27281708 NCBI chr 6:113,306,863...113,324,862
Ensembl chr 6:113,307,137...113,324,860
JBrowse link
G Bscl2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) increases expression EXP Cyclophosphamide results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr19:8,837,467...8,848,683
Ensembl chr19:8,837,467...8,848,683
JBrowse link
G Bsg basigin decreases expression EXP Cyclophosphamide results in decreased expression of BSG mRNA CTD PMID:15331540 NCBI chr10:79,704,358...79,711,979
Ensembl chr10:79,704,491...79,711,969
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression EXP Cyclophosphamide results in decreased expression of BTG1 mRNA CTD PMID:21041162 NCBI chr10:96,617,001...96,622,813
Ensembl chr10:96,617,006...96,622,809
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Cyclophosphamide results in increased expression of BTG2 mRNA CTD PMID:29445054 NCBI chr 1:134,074,865...134,079,155
Ensembl chr 1:134,075,170...134,079,120
JBrowse link
G Btg3 BTG anti-proliferation factor 3 multiple interactions ISO BTG3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr16:78,359,860...78,377,181
Ensembl chr16:78,332,637...78,377,192
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BUB3 mRNA CTD PMID:16322899 NCBI chr 7:131,560,367...131,571,895
Ensembl chr 7:131,560,222...131,571,895
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide increases expression EXP Cyclophosphamide results in increased expression of C1QA mRNA CTD PMID:21041162 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G C3 complement component 3 increases expression EXP Cyclophosphamide results in increased expression of C3 mRNA CTD PMID:21041162 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G Cabp1 calcium binding protein 1 decreases expression ISO Cyclophosphamide results in decreased expression of CABP1 mRNA CTD PMID:11906922 NCBI chr 5:115,168,691...115,194,381
Ensembl chr 5:115,168,689...115,194,381
JBrowse link
G Cabp2 calcium binding protein 2 decreases expression ISO Cyclophosphamide results in decreased expression of CABP2 mRNA CTD PMID:11906922 NCBI chr19:4,081,469...4,087,340
Ensembl chr19:4,081,578...4,087,340
JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit increases expression
multiple interactions
EXP Cyclophosphamide results in increased expression of CACNA1H protein
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein
CTD PMID:29129814 NCBI chr17:25,374,285...25,436,334
Ensembl chr17:25,374,285...25,433,783
JBrowse link
G Calr calreticulin increases expression
decreases expression
ISO Cyclophosphamide results in increased expression of CALR mRNA
Cyclophosphamide results in decreased expression of CALR mRNA
CTD PMID:11599041 PMID:11906922 PMID:18246545 NCBI chr 8:84,842,088...84,846,931
Ensembl chr 8:84,841,850...84,846,934
JBrowse link
G Canx calnexin decreases expression ISO Cyclophosphamide results in decreased expression of CANX mRNA CTD PMID:11906922 NCBI chr11:50,293,957...50,325,673
Ensembl chr11:50,293,961...50,325,673
JBrowse link
G Capn2 calpain 2 increases expression EXP Cyclophosphamide results in increased expression of CAPN2 mRNA CTD PMID:21041162 NCBI chr 1:182,467,253...182,517,610
Ensembl chr 1:182,467,260...182,517,608
JBrowse link
G Car12 carbonic anhydrase 12 multiple interactions ISO CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:66,712,296...66,766,845
Ensembl chr 9:66,713,686...66,766,845
JBrowse link
G Car2 carbonic anhydrase 2 decreases expression
increases expression
ISO
EXP
Cyclophosphamide results in decreased expression of CA2 mRNA
Cyclophosphamide results in increased expression of CAR2 mRNA
CTD PMID:15331540 PMID:17403535 NCBI chr 3:14,886,269...14,900,770
Ensembl chr 3:14,886,273...14,900,770
JBrowse link
G Car7 carbonic anhydrase 7 decreases expression ISO Cyclophosphamide results in decreased expression of CAR7 mRNA CTD PMID:27281708 NCBI chr 8:104,534,694...104,550,347
Ensembl chr 8:104,534,689...104,550,343
JBrowse link
G Cars cysteinyl-tRNA synthetase decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CARS1 mRNA CTD PMID:24356939 NCBI chr 7:143,557,230...143,600,090
Ensembl chr 7:143,557,230...143,600,090
JBrowse link
G Casp1 caspase 1 decreases expression
increases expression
ISO
EXP
Cyclophosphamide results in decreased expression of CASP1 mRNA
Cyclophosphamide results in increased expression of CASP1 mRNA
CTD PMID:17403535 PMID:21041162 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
decreases response to substance
ISO
EXP
[Bortezomib co-treated with oblimersen co-treated with Cyclophosphamide] results in increased activity of CASP3 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP3 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]
Cyclophosphamide results in increased expression of CASP3 protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]
Cyclophosphamide results in increased expression of CASP3 mRNA
CASP3 protein alternative form results in decreased susceptibility to Cyclophosphamide
CTD PMID:11723234 PMID:14503796 PMID:16675587 PMID:17020986 PMID:17898787 PMID:30506662 PMID:32197949 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase increases cleavage
multiple interactions
ISO Cyclophosphamide results in increased cleavage of CASP4 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein]
CTD PMID:32197949 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp8 caspase 8 multiple interactions
increases response to substance
ISO [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Cyclophosphamide metabolite; Cyclophosphamide metabolite results in increased expression of and results in increased cleavage of CASP8 protein; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP8 protein
CASP8 protein results in increased susceptibility to Cyclophosphamide metabolite
CTD PMID:17898787 PMID:22010212 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO
EXP
BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP9 protein]; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP9 protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP9 protein]
CTD PMID:11723234 PMID:17898787 PMID:30506662 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase decreases expression
decreases activity
affects activity
multiple interactions
ISO
EXP
Cyclophosphamide results in decreased expression of CAT protein
Cyclophosphamide results in decreased activity of CAT protein
Cyclophosphamide results in decreased expression of CAT mRNA; Cyclophosphamide results in decreased expression of CAT protein
Cyclophosphamide affects the activity of CAT protein
Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]; cinnamic acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Eicosapentaenoic Acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CAT mRNA]
mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]
CTD PMID:16076520 PMID:19107871 PMID:20052769 PMID:20957680 PMID:21772021 PMID:22285266 PMID:23542512 PMID:23695977 PMID:25753322 PMID:27633142 PMID:29753871 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccin calicin increases expression ISO Cyclophosphamide results in increased expression of CCIN protein CTD PMID:17475930 NCBI chr 4:43,983,504...43,985,533
Ensembl chr 4:43,983,483...43,985,423
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression
decreases expression
EXP
ISO
Cyclophosphamide results in increased expression of CCL2 mRNA
Cyclophosphamide results in decreased expression of CCL2 protein
CTD PMID:18848347 PMID:21068404 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl25 chemokine (C-C motif) ligand 25 decreases expression EXP Cyclophosphamide results in decreased expression of CCL25 mRNA CTD PMID:21041162 NCBI chr 8:4,325,205...4,360,020
Ensembl chr 8:4,325,210...4,360,020
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 decreases expression EXP Cyclophosphamide results in decreased expression of CCL3 protein CTD PMID:21880982 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl7 chemokine (C-C motif) ligand 7 increases expression EXP Cyclophosphamide results in increased expression of CCL7 mRNA CTD PMID:15331540 PMID:21041162 NCBI chr11:82,045,712...82,047,525
Ensembl chr11:82,045,712...82,047,525
JBrowse link
G Ccl8 chemokine (C-C motif) ligand 8 increases expression EXP Cyclophosphamide results in increased expression of CCL8 mRNA CTD PMID:21041162 NCBI chr11:82,115,185...82,116,799
Ensembl chr11:82,115,185...82,116,799
JBrowse link
G Ccl9 chemokine (C-C motif) ligand 9 increases expression EXP Cyclophosphamide results in increased expression of CCL9 mRNA CTD PMID:21041162 NCBI chr11:83,572,917...83,578,636
Ensembl chr11:83,572,919...83,578,636
JBrowse link
G Ccna2 cyclin A2 decreases expression EXP Cyclophosphamide results in decreased expression of CCNA2 mRNA CTD PMID:21041162 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnd2 cyclin D2 increases expression EXP Cyclophosphamide results in increased expression of CCND2 mRNA CTD PMID:21041162 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193
JBrowse link
G Ccnd3 cyclin D3 decreases expression EXP Cyclophosphamide results in decreased expression of CCND3 mRNA CTD PMID:21041162 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 increases expression EXP Cyclophosphamide results in increased expression of CCR5 mRNA CTD PMID:15331540 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Ccr8 chemokine (C-C motif) receptor 8 decreases expression ISO Cyclophosphamide results in decreased expression of CCR8 mRNA CTD PMID:17403535 NCBI chr 9:120,092,133...120,094,906
Ensembl chr 9:120,092,114...120,094,906
JBrowse link
G Ccr9 chemokine (C-C motif) receptor 9 decreases expression EXP Cyclophosphamide results in decreased expression of CCR9 mRNA CTD PMID:21041162 NCBI chr 9:123,767,211...123,783,457
Ensembl chr 9:123,678,439...123,784,330
JBrowse link
G Cct3 chaperonin containing Tcp1, subunit 3 (gamma) decreases expression ISO Cyclophosphamide results in decreased expression of CCT3 mRNA CTD PMID:11906922 NCBI chr 3:88,297,135...88,321,766
Ensembl chr 3:88,297,116...88,321,767
JBrowse link
G Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) decreases expression ISO Cyclophosphamide results in decreased expression of CCT5 mRNA CTD PMID:11906922 NCBI chr15:31,590,800...31,601,846
Ensembl chr15:31,590,800...31,601,804
JBrowse link
G Cct7 chaperonin containing Tcp1, subunit 7 (eta) decreases expression ISO Cyclophosphamide results in decreased expression of CCT7 mRNA CTD PMID:11906922 NCBI chr 6:85,451,505...85,468,477
Ensembl chr 6:85,451,514...85,468,475
JBrowse link
G Cd14 CD14 antigen increases expression EXP Cyclophosphamide results in increased expression of CD14 mRNA CTD PMID:15331540 PMID:21041162 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cd151 CD151 antigen increases expression EXP Cyclophosphamide results in increased expression of CD151 mRNA CTD PMID:21041162 NCBI chr 7:141,467,362...141,471,481
Ensembl chr 7:141,467,392...141,471,473
JBrowse link
G Cd2 CD2 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD2 mRNA CTD PMID:21041162 NCBI chr 3:101,275,908...101,287,939
Ensembl chr 3:101,275,899...101,287,939
JBrowse link
G Cd27 CD27 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD27 mRNA CTD PMID:21041162 NCBI chr 6:125,232,620...125,237,136
Ensembl chr 6:125,232,622...125,237,010
JBrowse link
G Cd28 CD28 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD28 mRNA CTD PMID:21041162 NCBI chr 1:60,746,388...60,773,359
Ensembl chr 1:60,716,800...60,773,359
JBrowse link
G Cd38 CD38 antigen increases expression EXP Cyclophosphamide results in increased expression of CD38 mRNA CTD PMID:21041162 NCBI chr 5:43,868,809...43,912,374
Ensembl chr 5:43,868,553...43,912,375
JBrowse link
G Cd3d CD3 antigen, delta polypeptide decreases expression EXP Cyclophosphamide results in decreased expression of CD3D mRNA CTD PMID:21041162 NCBI chr 9:44,981,769...44,987,052
Ensembl chr 9:44,981,786...44,987,339
JBrowse link
G Cd3e CD3 antigen, epsilon polypeptide decreases expression EXP Cyclophosphamide results in decreased expression of CD3E mRNA CTD PMID:21041162 NCBI chr 9:44,998,735...45,009,663
Ensembl chr 9:44,998,740...45,009,627
JBrowse link
G Cd3g CD3 antigen, gamma polypeptide decreases expression EXP Cyclophosphamide results in decreased expression of CD3G mRNA CTD PMID:21041162 NCBI chr 9:44,969,572...44,980,431
Ensembl chr 9:44,969,572...44,980,431
JBrowse link
G Cd4 CD4 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD4 mRNA CTD PMID:21041162 NCBI chr 6:124,864,693...124,888,247
Ensembl chr 6:124,864,692...124,888,221
JBrowse link
G Cd40 CD40 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD40 mRNA CTD PMID:21041162 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd5 CD5 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD5 mRNA CTD PMID:21041162 NCBI chr19:10,718,107...10,739,026
Ensembl chr19:10,717,116...10,739,002
JBrowse link
G Cd6 CD6 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD6 mRNA CTD PMID:21041162 NCBI chr19:10,789,339...10,830,062
Ensembl chr19:10,789,341...10,830,058
JBrowse link
G Cd69 CD69 antigen decreases expression EXP
ISO
Cyclophosphamide results in decreased expression of CD69 mRNA
Cyclophosphamide metabolite results in decreased expression of CD69 mRNA
CTD PMID:21041162 PMID:24356939 NCBI chr 6:129,267,324...129,275,375
Ensembl chr 6:129,267,325...129,275,436
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) decreases expression EXP Cyclophosphamide results in decreased expression of CD74 mRNA CTD PMID:15331540 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Cd79b CD79B antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD79B mRNA CTD PMID:15331540 NCBI chr11:106,311,341...106,314,562
Ensembl chr11:106,311,341...106,314,762
JBrowse link
G Cd83 CD83 antigen decreases expression EXP Cyclophosphamide results in decreased expression of CD83 mRNA CTD PMID:15331540 NCBI chr13:43,785,112...43,803,133
Ensembl chr13:43,784,775...43,803,132
JBrowse link
G Cd84 CD84 antigen increases expression ISO Cyclophosphamide metabolite results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr 1:171,839,697...171,890,718
Ensembl chr 1:171,839,697...171,890,718
JBrowse link
G Cd8a CD8 antigen, alpha chain decreases expression EXP Cyclophosphamide results in decreased expression of CD8A mRNA CTD PMID:21041162 NCBI chr 6:71,373,427...71,379,171
Ensembl chr 6:71,373,427...71,379,173
JBrowse link
G Cd8b1 CD8 antigen, beta chain 1 decreases expression EXP Cyclophosphamide results in decreased expression of CD8B1 mRNA CTD PMID:21041162 NCBI chr 6:71,322,788...71,337,492
Ensembl chr 6:71,322,788...71,337,494
JBrowse link
G Cdc20 cell division cycle 20 increases expression ISO Cyclophosphamide results in increased expression of CDC20 mRNA CTD PMID:11599041 NCBI chr 4:118,432,901...118,437,343
Ensembl chr 4:118,432,901...118,437,352
JBrowse link
G Cdh1 cadherin 1 affects expression ISO Cyclophosphamide affects the expression of CDH1 mRNA CTD PMID:10859244 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 affects expression ISO Cyclophosphamide affects the expression of CDH2 mRNA CTD PMID:10859244 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdh3 cadherin 3 affects expression ISO Cyclophosphamide affects the expression of CDH3 mRNA CTD PMID:10859244 NCBI chr 8:106,510,852...106,556,911
Ensembl chr 8:106,510,891...106,557,297
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression EXP Cyclophosphamide results in decreased expression of CDK2 mRNA CTD PMID:21041162 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO
EXP
Cyclophosphamide results in increased expression of CDKN1A mRNA CTD PMID:15331540 PMID:21527772 PMID:29445054 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CDKN1B mRNA CTD PMID:16322899 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) increases expression EXP Cyclophosphamide results in increased expression of CDKN1C mRNA CTD PMID:21041162 NCBI chr 7:143,458,339...143,461,059
Ensembl chr 7:143,458,339...143,461,050
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression EXP Cyclophosphamide results in decreased expression of CDKN2D mRNA CTD PMID:21041162 NCBI chr 9:21,288,459...21,291,421
Ensembl chr 9:21,288,410...21,291,407
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CEBPB mRNA CTD PMID:24356939 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Cel carboxyl ester lipase increases expression ISO Cyclophosphamide results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 2:28,555,819...28,563,403
Ensembl chr 2:28,555,795...28,563,403
JBrowse link
G Cfb complement factor B increases expression EXP Cyclophosphamide results in increased expression of CFB mRNA CTD PMID:21041162 NCBI chr17:34,856,374...34,862,514
Ensembl chr17:34,856,374...34,862,518
JBrowse link
G Cfi complement component factor i affects response to substance ISO CFI protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 3:129,836,727...129,875,332
Ensembl chr 3:129,835,884...129,875,332
JBrowse link
G Chac1 ChaC, cation transport regulator 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CHAC1 mRNA; Cyclophosphamide results in decreased expression of CHAC1 mRNA CTD PMID:23824090 PMID:24356939 NCBI chr 2:119,351,242...119,354,326
Ensembl chr 2:119,351,229...119,354,381
JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 increases expression ISO Cyclophosphamide results in increased expression of CHAMP1 mRNA CTD PMID:27281708 NCBI chr 8:13,869,641...13,881,639
Ensembl chr 8:13,869,641...13,881,639
JBrowse link
G Chd5 chromodomain helicase DNA binding protein 5 decreases expression ISO Cyclophosphamide results in decreased expression of CHD5 mRNA CTD PMID:27281708 NCBI chr 4:152,338,646...152,390,194
Ensembl chr 4:152,338,651...152,390,194
JBrowse link
G Chga chromogranin A decreases expression EXP Cyclophosphamide results in decreased expression of CHGA mRNA CTD PMID:15331540 NCBI chr12:102,554,941...102,565,027
Ensembl chr12:102,554,969...102,565,028
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 increases expression ISO Cyclophosphamide results in increased expression of CHRM5 protein CTD PMID:16125470 NCBI chr 2:112,478,733...112,536,361
Ensembl chr 2:112,479,171...112,480,769
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 affects expression
decreases expression
ISO Cyclophosphamide affects the expression of CITED2 mRNA
Cyclophosphamide results in decreased expression of CITED2 mRNA
CTD PMID:18246545 NCBI chr10:17,723,228...17,725,674
Ensembl chr10:17,723,218...17,725,674
JBrowse link
G Cldn1 claudin 1 multiple interactions
decreases expression
EXP Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr16:26,356,645...26,371,839
Ensembl chr16:26,356,642...26,371,841
JBrowse link
G Cldn4 claudin 4 multiple interactions
decreases expression
ISO Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein] CTD PMID:25451569 NCBI chr 5:134,945,123...134,946,934
Ensembl chr 5:134,945,119...134,946,934
JBrowse link
G Clic4 chloride intracellular channel 4 (mitochondrial) increases expression EXP Cyclophosphamide results in increased expression of CLIC4 mRNA CTD PMID:15331540 NCBI chr 4:135,213,969...135,272,760
Ensembl chr 4:135,213,969...135,272,814
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO Cyclophosphamide results in decreased expression of CLIP1 mRNA CTD PMID:27281708 NCBI chr 5:123,577,794...123,684,606
Ensembl chr 5:123,577,795...123,684,618
JBrowse link
G Coch cochlin affects response to substance ISO COCH protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr12:51,593,283...51,606,619
Ensembl chr12:51,593,341...51,605,771
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Cyclophosphamide results in increased expression of COMT mRNA CTD PMID:21041162 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression ISO Cyclophosphamide results in decreased expression of COX7A2 mRNA CTD PMID:17403535 NCBI chr 9:79,755,241...79,771,422
Ensembl chr 9:79,755,361...79,759,878
JBrowse link
G Crabp2 cellular retinoic acid binding protein II increases expression ISO Cyclophosphamide results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 3:87,948,693...87,953,372
Ensembl chr 3:87,948,666...87,953,376
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Cyclophosphamide results in increased expression of CREB1 protein modified form CTD PMID:18299998 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crem cAMP responsive element modulator decreases expression
multiple interactions
ISO Cyclophosphamide results in decreased expression of CREM mRNA; Cyclophosphamide results in decreased expression of CREM protein
Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM mRNA]; Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM protein]
CTD PMID:17624719 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Crh corticotropin releasing hormone increases expression ISO
EXP
Cyclophosphamide results in increased expression of CRH mRNA; Cyclophosphamide results in increased expression of CRH protein CTD PMID:15276878 PMID:16614059 PMID:17335920 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression ISO Cyclophosphamide results in increased expression of CRHR2 protein CTD PMID:16614059 NCBI chr 6:55,090,048...55,133,016
Ensembl chr 6:55,090,049...55,133,016
JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) multiple interactions EXP [Cyclophosphamide co-treated with Sizofiran] results in increased expression of CSF1 mRNA CTD PMID:10052129 NCBI chr 3:107,741,048...107,760,469
Ensembl chr 3:107,741,048...107,760,469
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) affects activity
increases expression
ISO CSF2 protein affects the activity of Cyclophosphamide
Cyclophosphamide results in increased expression of CSF2 protein
CTD PMID:8349185 PMID:18848347 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Csk c-src tyrosine kinase decreases expression EXP Cyclophosphamide results in decreased expression of CSK mRNA CTD PMID:21041162 NCBI chr 9:57,626,646...57,653,631
Ensembl chr 9:57,626,646...57,653,631
JBrowse link
G Cst7 cystatin F (leukocystatin) decreases expression ISO Cyclophosphamide results in decreased expression of CST7 mRNA CTD PMID:17403535 NCBI chr 2:150,570,415...150,578,944
Ensembl chr 2:150,570,415...150,578,944
JBrowse link
G Csta2 cystatin A family member 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CSTA mRNA CTD PMID:24356939 NCBI chr16:36,221,562...36,257,447
Ensembl chr16:36,221,468...36,257,444
JBrowse link
G Cth cystathionase (cystathionine gamma-lyase) increases expression EXP Cyclophosphamide results in increased expression of CTH protein CTD PMID:29129814 NCBI chr 3:157,894,248...157,925,081
Ensembl chr 3:157,894,248...157,925,077
JBrowse link
G Ctnnbip1 catenin beta interacting protein 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CTNNBIP1 mRNA CTD PMID:16322899 NCBI chr 4:149,518,241...149,566,437
Ensembl chr 4:149,518,236...149,566,437
JBrowse link
G Ctnnd2 catenin (cadherin associated protein), delta 2 multiple interactions ISO CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr15:30,172,534...31,029,344
Ensembl chr15:30,172,593...31,029,341
JBrowse link
G Ctsd cathepsin D multiple interactions
increases activity
EXP
ISO
[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNA
Cyclophosphamide results in increased activity of CTSD protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]
CTD PMID:18433785 PMID:25451569 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Ctsh cathepsin H increases expression ISO Cyclophosphamide results in increased expression of CTSH mRNA CTD PMID:17403535 NCBI chr 9:90,054,267...90,076,095
Ensembl chr 9:90,054,152...90,076,089
JBrowse link
G Ctsl cathepsin L increases expression
multiple interactions
decreases expression
ISO
EXP
Cyclophosphamide results in increased expression of CTSL mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in decreased expression of CTSL mRNA]
CTD PMID:17403535 PMID:30760223 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Cx3cl1 chemokine (C-X3-C motif) ligand 1 increases expression ISO Cyclophosphamide results in increased expression of CX3CL1 protein CTD PMID:16651033 NCBI chr 8:94,772,180...94,782,427
Ensembl chr 8:94,772,009...94,782,427
JBrowse link
G Cx3cr1 chemokine (C-X3-C motif) receptor 1 increases expression ISO Cyclophosphamide results in increased expression of CX3CR1 protein CTD PMID:16651033 NCBI chr 9:120,048,683...120,068,296
Ensembl chr 9:119,901,616...120,069,879
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 increases expression ISO Cyclophosphamide results in increased expression of CXCL1 protein CTD PMID:18848347 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 affects expression
increases expression
increases response to substance
EXP Cyclophosphamide affects the expression of CXCL10 mRNA
Cyclophosphamide results in increased expression of CXCL10 protein
CXCL10 protein results in increased susceptibility to Cyclophosphamide
CTD PMID:18957084 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl11 chemokine (C-X-C motif) ligand 11 increases expression EXP Cyclophosphamide results in increased expression of CXCL11 protein CTD PMID:18957084 NCBI chr 5:92,359,544...92,363,296
Ensembl chr 5:92,359,544...92,365,485
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 affects expression
increases expression
EXP
ISO
Cyclophosphamide affects the expression of CXCL12 mRNA
Cyclophosphamide results in increased expression of CXCL12 mRNA; Cyclophosphamide results in increased expression of CXCL12 protein
CTD PMID:12624490 PMID:16337237 PMID:19066630 PMID:20032115 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression ISO
EXP
Cyclophosphamide results in increased expression of CXCL8 mRNA
Cyclophosphamide results in increased expression of CXCL5 mRNA
CTD PMID:15331540 PMID:29594315 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 increases expression
affects expression
multiple interactions
EXP Cyclophosphamide results in increased expression of CXCL1 mRNA; Cyclophosphamide results in increased expression of CXCL1 protein
Cyclophosphamide affects the expression of CXCL3 mRNA
VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of CXCL1 protein]
CTD PMID:15331540 PMID:18483878 PMID:18957084 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cxcl9 chemokine (C-X-C motif) ligand 9 affects expression
decreases expression
increases expression
EXP Cyclophosphamide affects the expression of CXCL9 mRNA
Cyclophosphamide results in decreased expression of CXCL9 protein
Cyclophosphamide results in increased expression of CXCL9 mRNA; Cyclophosphamide results in increased expression of CXCL9 protein
CTD PMID:15331540 PMID:18957084 PMID:21041162 PMID:21880982 NCBI chr 5:92,321,331...92,328,079
Ensembl chr 5:92,321,347...92,328,079
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 multiple interactions
increases expression
decreases expression
affects localization
ISO
EXP
Cyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein]
Cyclophosphamide results in increased expression of CXCR4 mRNA; Cyclophosphamide results in increased expression of CXCR4 protein
Cyclophosphamide results in decreased expression of CXCR4 mRNA
Cyclophosphamide affects the localization of CXCR4 protein
CTD PMID:19066630 PMID:20032115 PMID:21041162 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Cxcr6 chemokine (C-X-C motif) receptor 6 increases expression EXP Cyclophosphamide results in increased expression of CXCR6 mRNA CTD PMID:21041162 NCBI chr 9:123,806,477...123,811,754
Ensembl chr 9:123,806,475...123,811,760
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP Cyclophosphamide results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP Cyclophosphamide results in decreased activity of CYP1A2 protein CTD PMID:18420780 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Cyclophosphamide results in decreased expression of CYP1B1 mRNA CTD PMID:12167460 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity EXP Cyclophosphamide results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases metabolic processing
increases expression
increases response to substance
increases hydroxylation
affects hydroxylation
affects metabolic processing
increases activity
ISO
EXP
Cyclophosphamide results in increased expression of and results in increased activity of CYP2B1 protein; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Cyclophosphamide]
CYP2B6 protein results in increased metabolism of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP2B10 mRNA
CYP2B6 protein results in increased susceptibility to Cyclophosphamide; CYP2B6 results in increased susceptibility to Cyclophosphamide
CYP2B6 protein results in increased hydroxylation of Cyclophosphamide
CYP2B6 intron polymorphism affects the hydroxylation of Cyclophosphamide; CYP2B6 promoter polymorphism affects the hydroxylation of Cyclophosphamide
[Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CYP2B6 mRNA; Cyclophosphamide results in decreased expression of and results in decreased activity of CYP2B6 protein; CYP2B6 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide; CYP2B6 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide; POR promotes the reaction [CYP2B6 results in increased susceptibility to Cyclophosphamide]; POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to Cyclophosphamide]
CYP2B1 protein results in increased susceptibility to Cyclophosphamide; CYP2B1 results in increased susceptibility to Cyclophosphamide
CYP2B1 protein affects the metabolism of Cyclophosphamide
CYP2B1 results in increased activity of Cyclophosphamide
CYP2B1 protein mutant form results in increased hydroxylation of Cyclophosphamide; CYP2B1 protein results in increased hydroxylation of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP2B1 mRNA; Cyclophosphamide results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of Cyclophosphamide; CYP2B1 results in increased metabolism of Cyclophosphamide
CTD PMID:2272335 PMID:7834628 PMID:8640822 PMID:9592392 PMID:9766669 PMID:10415877 PMID:10919648 PMID:11221871 PMID:11389073 PMID:11933215 PMID:12498089 PMID:12872138 PMID:15102956 PMID:15248218 PMID:15635577 PMID:15769884 PMID:16019949 PMID:16183265 PMID:16322899 PMID:17041008 PMID:17502835 PMID:17634551 PMID:18212249 PMID:18633247 PMID:19103281 PMID:20566340 PMID:24819615 PMID:25860621 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Cyclophosphamide results in increased expression of CYP2B2 mRNA; Cyclophosphamide results in increased expression of CYP2B2 protein CTD PMID:16019949 PMID:17634551 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 increases activity ISO CYP2B6 protein results in increased activity of Cyclophosphamide CTD PMID:11723234 NCBI chr 7:26,173,350...26,210,661
Ensembl chr 7:26,173,411...26,210,661
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases expression
increases activity
EXP
ISO
Cyclophosphamide results in increased expression of CYP2C29 mRNA
CYP2C8 results in increased activity of Cyclophosphamide
CTD PMID:9241661 PMID:24819615 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases metabolic processing
increases response to substance
increases hydroxylation
increases metabolic processing
increases activity
multiple interactions
ISO CYP2C19 gene polymorphism results in decreased metabolism of Cyclophosphamide
CYP2C19 protein results in increased susceptibility to Cyclophosphamide
CYP2C19 protein results in increased hydroxylation of Cyclophosphamide
CYP2C6V1 results in increased metabolism of Cyclophosphamide
CYP2C19 results in increased activity of Cyclophosphamide
CYP2C19 protein results in increased metabolism of Cyclophosphamide
[CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide; [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of Acrolein; CYP2C19 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide
CTD PMID:9241661 PMID:15248218 PMID:16116487 PMID:20566340 PMID:30500380 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene increases metabolic processing
increases expression
ISO CYP2C11 results in increased metabolism of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP2C11 mRNA
CTD PMID:16019949 PMID:20566340 NCBI chr19:38,976,662...39,003,627
Ensembl chr19:38,976,647...39,003,289
JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 increases activity
multiple interactions
increases response to substance
ISO CYP2C18 results in increased activity of Cyclophosphamide
POR promotes the reaction [CYP2C18 results in increased susceptibility to Cyclophosphamide]
CTD PMID:9241661 PMID:9766669 NCBI chr19:39,006,940...39,042,690
Ensembl chr19:39,007,019...39,042,693
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
increases activity
multiple interactions
increases response to substance
ISO CYP2C9 protein results in increased metabolism of Cyclophosphamide
CYP2C9 results in increased activity of Cyclophosphamide
[GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased susceptibility to Cyclophosphamide]
CTD PMID:9241661 PMID:10991840 PMID:11377097 PMID:24819615 PMID:28744217 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases metabolic processing
decreases activity
increases activity
multiple interactions
increases response to substance
ISO
EXP
CYP2C9 protein results in increased metabolism of Cyclophosphamide
Cyclophosphamide results in decreased activity of CYP2C9 protein
CYP2C9 results in increased activity of Cyclophosphamide
[GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased susceptibility to Cyclophosphamide]
CTD PMID:9241661 PMID:10991840 PMID:11377097 PMID:18420780 PMID:24819615 PMID:28744217 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Cyclophosphamide CTD PMID:11377097 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 results in increased metabolism of Cyclophosphamide CTD PMID:20566340 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects response to substance
increases expression
affects metabolic processing
multiple interactions
ISO
EXP
CYP3A5 gene polymorphism affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of CYP3A13 mRNA
CYP3A5 protein affects the metabolism of Cyclophosphamide
CYP3A5 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]
CTD PMID:16087946 PMID:24819615 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 decreases activity EXP Cyclophosphamide results in decreased activity of CYP3A4 protein CTD PMID:18420780 NCBI chr 5:145,773,983...145,805,891
Ensembl chr 5:145,773,983...145,805,874
JBrowse link
G Dcn decorin multiple interactions EXP DCN protein inhibits the reaction [TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa]] CTD PMID:9509296 NCBI chr10:97,479,500...97,518,163
Ensembl chr10:97,479,609...97,518,143
JBrowse link
G Ddb1 damage specific DNA binding protein 1 increases expression ISO Cyclophosphamide results in increased expression of DDB1 mRNA CTD PMID:11056294 NCBI chr19:10,605,568...10,629,828
Ensembl chr19:10,605,327...10,629,819
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression
multiple interactions
increases expression
decreases expression
ISO Cyclophosphamide affects the expression of DDIT3 mRNA
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein]
Cyclophosphamide results in increased expression of DDIT3 mRNA; Cyclophosphamide results in increased expression of DDIT3 protein
Cyclophosphamide metabolite results in decreased expression of DDIT3 mRNA
CTD PMID:18246545 PMID:24356939 PMID:32197949 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Deaf1 DEAF1, transcription factor decreases expression ISO Cyclophosphamide results in decreased expression of DEAF1 mRNA CTD PMID:27281708 NCBI chr 7:141,297,176...141,338,869
Ensembl chr 7:141,297,180...141,327,690
JBrowse link
G Dlc1 deleted in liver cancer 1 increases expression ISO Cyclophosphamide results in increased expression of DLC1 mRNA CTD PMID:17403535 NCBI chr 8:36,567,739...36,953,184
Ensembl chr 8:36,567,751...36,953,143
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression
increases expression
ISO Cyclophosphamide affects the expression of DNAJB1 mRNA
Cyclophosphamide metabolite results in increased expression of DNAJB1 mRNA
CTD PMID:18246545 PMID:24356939 NCBI chr 8:83,608,175...83,612,653
Ensembl chr 8:83,608,193...83,612,653
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Cyclophosphamide metabolite results in increased expression of DNAJB4 mRNA CTD PMID:24356939 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO Cyclophosphamide results in increased expression of DNAJB6 protein CTD PMID:17475930 NCBI chr 5:29,735,898...29,786,478
Ensembl chr 5:29,735,688...29,818,134
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions
increases expression
decreases methylation
ISO Cyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]
Cyclophosphamide results in increased expression of DNMT1 protein
Cyclophosphamide results in decreased methylation of DNMT1 protein
CTD PMID:22007908 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dntt deoxynucleotidyltransferase, terminal decreases expression EXP Cyclophosphamide results in decreased expression of DNTT mRNA CTD PMID:21041162 NCBI chr19:41,029,275...41,059,525
Ensembl chr19:41,029,275...41,059,525
JBrowse link
G Dpf3 D4, zinc and double PHD fingers, family 3 decreases expression ISO Cyclophosphamide results in decreased expression of DPF3 mRNA CTD PMID:27281708 NCBI chr12:83,213,751...83,487,736
Ensembl chr12:83,213,745...83,487,716
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Cyclophosphamide results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr 7:139,085,981...139,101,795
Ensembl chr 7:139,086,001...139,102,704
JBrowse link
G Drd1 dopamine receptor D1 affects binding EXP Cyclophosphamide binds to DRD1 protein CTD PMID:11180191 NCBI chr13:54,051,183...54,055,658
Ensembl chr13:54,051,183...54,055,705
JBrowse link
G Drd2 dopamine receptor D2 affects binding EXP Cyclophosphamide binds to DRD2 protein CTD PMID:11180191 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Dusp10 dual specificity phosphatase 10 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of DUSP10 mRNA CTD PMID:24356939 NCBI chr 1:184,034,381...184,075,636
Ensembl chr 1:184,013,302...184,075,636
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression EXP Cyclophosphamide results in decreased expression of DUSP2 mRNA CTD PMID:21041162 NCBI chr 2:127,336,159...127,338,377
Ensembl chr 2:127,336,159...127,338,376
JBrowse link
G Dzip1 DAZ interacting protein 1 increases expression ISO Cyclophosphamide results in increased expression of DZIP1 mRNA CTD PMID:17403535 NCBI chr14:118,875,517...118,925,537
Ensembl chr14:118,875,520...118,925,460
JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO E2F3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr13:29,906,575...29,986,064
Ensembl chr13:29,906,575...29,986,063
JBrowse link
G Ear6 eosinophil-associated, ribonuclease A family, member 6 decreases expression ISO Cyclophosphamide results in decreased expression of RNASE2 mRNA CTD PMID:17403535 NCBI chr14:51,853,768...51,854,643
Ensembl chr14:51,853,699...51,854,643
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO Cyclophosphamide results in increased expression of EDA2R mRNA CTD PMID:21527772 NCBI chr  X:97,333,837...97,377,234
Ensembl chr  X:97,333,840...97,377,216
JBrowse link
G Edn1 endothelin 1 increases expression ISO Cyclophosphamide results in increased expression of EDN1 protein CTD PMID:17562616 PMID:18548196 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Cyclophosphamide results in increased expression of EDNRB mRNA CTD PMID:20849824 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Cyclophosphamide results in decreased expression of EEF2 mRNA CTD PMID:18246545 NCBI chr10:81,176,631...81,182,509
Ensembl chr10:81,176,631...81,182,498
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with Fluorouracil] CTD PMID:15981280 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
decreases expression
ISO
EXP
Cyclophosphamide results in increased expression of EGR1 mRNA
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein
Cyclophosphamide results in increased expression of EGR1 protein
Cyclophosphamide results in decreased expression of EGR1 mRNA
CTD PMID:7498375 PMID:9776515 PMID:21041162 PMID:21527772 PMID:29129814 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Egr2 early growth response 2 decreases expression EXP Cyclophosphamide results in decreased expression of EGR2 mRNA CTD PMID:21041162 NCBI chr10:67,534,469...67,542,188
Ensembl chr10:67,535,475...67,542,188
JBrowse link
G Egr4 early growth response 4 decreases expression ISO Cyclophosphamide results in decreased expression of EGR4 mRNA CTD PMID:27281708 NCBI chr 6:85,511,121...85,513,589
Ensembl chr 6:85,511,121...85,513,589
JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of EIF1AX mRNA CTD PMID:16322899 NCBI chr  X:159,372,178...159,389,621
Ensembl chr  X:159,372,178...159,389,928
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32197949 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of EIF4EBP1 mRNA CTD PMID:16322899 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Elovl2 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 affects response to substance ISO ELOVL2 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr13:41,182,382...41,220,403
Ensembl chr13:41,182,381...41,220,405
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Cyclophosphamide results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr 6:135,362,550...135,383,173
Ensembl chr 6:135,362,545...135,383,173
JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Cyclophosphamide results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr 7:45,918,023...45,921,426
Ensembl chr 7:45,918,023...45,921,404
JBrowse link
G Epb41l2 erythrocyte membrane protein band 4.1 like 2 decreases expression ISO Cyclophosphamide results in decreased expression of EPB41L2 mRNA CTD PMID:17403535 NCBI chr10:25,359,782...25,523,519
Ensembl chr10:25,359,798...25,523,519
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal affects expression
increases expression
ISO Cyclophosphamide affects the expression of EPHX1 mRNA
Cyclophosphamide results in increased expression of EPHX1 mRNA
CTD PMID:18246545 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Epo erythropoietin multiple interactions
increases response to substance
decreases expression
ISO angelicae sinensis extract inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]; Astragali compound inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]
EPO protein results in increased susceptibility to Cyclophosphamide
CTD PMID:11245434 PMID:19627214 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 increases expression ISO Cyclophosphamide results in increased expression of ERAP1 mRNA CTD PMID:27281708 NCBI chr13:74,639,573...74,693,205
Ensembl chr13:74,639,568...74,693,201
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 affects the susceptibility to [Doxorubicin co-treated with Cyclophosphamide co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with pirarubicin co-treated with Fluorouracil]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin] CTD PMID:9816327 PMID:15834928 PMID:15940066 PMID:16446318 PMID:16682728 PMID:17010609 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 1:68,031,884...69,108,576
Ensembl chr 1:68,032,186...69,108,059
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 affects expression ISO Cyclophosphamide affects the expression of ERCC1 mRNA CTD PMID:11906922 NCBI chr 7:19,344,067...19,356,524
Ensembl chr 7:19,344,778...19,356,524
JBrowse link
G Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 affects expression
increases expression
multiple interactions
ISO
EXP
Cyclophosphamide affects the expression of ERCC2 mRNA
Cyclophosphamide results in increased expression of ERCC2 mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in increased expression of ERCC2 mRNA]
CTD PMID:11906922 PMID:30760223 NCBI chr 7:19,382,017...19,395,694
Ensembl chr 7:19,382,010...19,395,694
JBrowse link
G Erg ETS transcription factor increases expression ISO Cyclophosphamide results in increased expression of ERG mRNA CTD PMID:17403535 NCBI chr16:95,359,169...95,586,600
Ensembl chr16:95,359,169...95,586,593
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 increases phosphorylation
multiple interactions
ISO Cyclophosphamide results in increased phosphorylation of ERN1 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein]
CTD PMID:32197949 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR1 mRNA CTD PMID:16322899 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR2 mRNA CTD PMID:16322899 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression
increases expression
ISO Cyclophosphamide results in decreased expression of ESRRA mRNA
Cyclophosphamide results in increased expression of ESRRA mRNA
CTD PMID:27281708 NCBI chr19:6,910,977...6,922,048
Ensembl chr19:6,910,977...6,921,813
Ensembl chr19:6,910,977...6,921,813
JBrowse link
G Evi2a ecotropic viral integration site 2a decreases expression ISO Cyclophosphamide metabolite results in decreased expression of EVI2A mRNA CTD PMID:24356939 NCBI chr11:79,526,560...79,530,609
Ensembl chr11:79,526,560...79,530,609
JBrowse link
G F2rl1 coagulation factor II (thrombin) receptor-like 1 increases expression ISO Cyclophosphamide results in increased expression of F2RL1 protein CTD PMID:15643279 NCBI chr13:95,511,718...95,525,240
Ensembl chr13:95,511,732...95,525,227
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression ISO Cyclophosphamide results in increased expression of F2RL2 protein CTD PMID:15643279 NCBI chr13:95,696,920...95,702,768
Ensembl chr13:95,696,853...95,702,739
JBrowse link
G F2rl3 coagulation factor II (thrombin) receptor-like 3 increases expression ISO Cyclophosphamide results in increased expression of F2RL3 protein CTD PMID:15643279 NCBI chr 8:72,761,659...72,763,898
Ensembl chr 8:72,761,880...72,763,874
JBrowse link
G F3 coagulation factor III decreases expression ISO Cyclophosphamide results in decreased expression of F3 mRNA CTD PMID:17403535 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Fam107b family with sequence similarity 107, member B decreases expression ISO Cyclophosphamide metabolite results in decreased expression of FAM107B mRNA CTD PMID:24356939 NCBI chr 2:3,704,812...3,782,142
Ensembl chr 2:3,570,488...3,782,142
JBrowse link
G Fam234b family with sequence similarity 234, member B multiple interactions ISO FAM234B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 6:135,196,880...135,236,242
Ensembl chr 6:135,197,977...135,244,955
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
decreases expression
increases expression
ISO
EXP
[Cyclophosphamide co-treated with cacalol] results in decreased expression of FAS protein; [Cyclophosphamide co-treated with NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt] results in increased expression of FAS
Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of FAS mRNA]
Cyclophosphamide metabolite results in decreased expression of FAS mRNA
Cyclophosphamide results in increased expression of FAS mRNA; Cyclophosphamide results in increased expression of FAS protein
CTD PMID:10393266 PMID:16166447 PMID:20665104 PMID:24356939 PMID:25446862 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions ISO [Cyclophosphamide co-treated with NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt] results in increased expression of FASLG CTD PMID:16166447 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fau Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived) increases expression ISO Cyclophosphamide results in increased expression of FAU mRNA CTD PMID:11599041 NCBI chr19:6,057,947...6,059,524
Ensembl chr19:6,057,844...6,059,524
JBrowse link
G Fbxo40 F-box protein 40 increases expression ISO Cyclophosphamide results in increased expression of FBXO40 mRNA CTD PMID:27281708 NCBI chr16:36,963,461...36,990,530
Ensembl chr16:36,963,460...36,990,467
JBrowse link
G Fbxw7 F-box and WD-40 domain protein 7 increases expression ISO Cyclophosphamide results in increased expression of FBXW7 mRNA CTD PMID:29445054 NCBI chr 3:84,814,990...84,979,198
Ensembl chr 3:84,815,268...84,979,198
JBrowse link
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide increases expression EXP Cyclophosphamide results in increased expression of FCER1G mRNA CTD PMID:21041162 NCBI chr 1:171,229,572...171,234,349
Ensembl chr 1:171,229,572...171,234,365
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III increases expression EXP Cyclophosphamide results in increased expression of FCGR3 mRNA CTD PMID:21041162 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Fcgrt Fc fragment of IgG receptor and transporter increases expression EXP Cyclophosphamide results in increased expression of FCGRT mRNA CTD PMID:21041162 NCBI chr 7:45,092,993...45,103,822
Ensembl chr 7:45,092,990...45,103,851
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression ISO Cyclophosphamide results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:56,731,209...56,793,346
Ensembl chr  X:56,731,787...56,793,346
JBrowse link
G Fkbp1b FK506 binding protein 1b affects response to substance ISO FKBP1B protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr12:4,833,176...4,841,573
Ensembl chr12:4,833,174...4,841,591
JBrowse link
G Fkbpl FK506 binding protein-like increases expression ISO Cyclophosphamide results in increased expression of FKBPL mRNA CTD PMID:14503796 NCBI chr17:34,644,814...34,646,817
Ensembl chr17:34,644,764...34,646,324
JBrowse link
G Flnc filamin C, gamma increases expression ISO Cyclophosphamide results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 6:29,433,153...29,461,889
Ensembl chr 6:29,433,256...29,461,883
JBrowse link
G Flt3l FMS-like tyrosine kinase 3 ligand affects expression EXP Cyclophosphamide affects the expression of FLT3L mRNA CTD PMID:12624490 NCBI chr 7:45,131,183...45,136,490
Ensembl chr 7:45,129,788...45,136,432
JBrowse link
G Fndc3b fibronectin type III domain containing 3B affects response to substance ISO FNDC3B protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 3:27,416,135...27,711,307
Ensembl chr 3:27,416,162...27,711,307
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
EXP
ISO
Capsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS mRNA]
Cyclophosphamide results in increased expression of FOS protein
alfuzosin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; Capsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]
CTD PMID:7498375 PMID:8801120 PMID:8808730 PMID:9776515 PMID:10749792 PMID:15099680 PMID:15217452 PMID:17240043 PMID:18093676 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Foxp3 forkhead box P3 decreases expression
multiple interactions
EXP Cyclophosphamide results in decreased expression of FOXP3 mRNA; Cyclophosphamide results in decreased expression of FOXP3 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]
CTD PMID:15591121 PMID:32151603 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Foxp4 forkhead box P4 decreases expression ISO Cyclophosphamide results in decreased expression of FOXP4 mRNA CTD PMID:27281708 NCBI chr17:47,867,133...47,924,632
Ensembl chr17:47,867,133...47,924,645
JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression EXP Cyclophosphamide results in increased expression of FPR2 mRNA CTD PMID:15331540 NCBI chr17:17,887,824...17,893,952
Ensembl chr17:17,887,824...17,893,952
JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression ISO Cyclophosphamide results in increased expression of FSCN1 mRNA CTD PMID:17403535 NCBI chr 5:142,960,355...142,973,189
Ensembl chr 5:142,960,343...142,973,185
JBrowse link
G Fshb follicle stimulating hormone beta increases expression
multiple interactions
decreases secretion
ISO Cyclophosphamide results in increased expression of FSHB protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]
CTD PMID:6788612 PMID:25446862 PMID:32197949 NCBI chr 2:107,055,986...107,059,651
Ensembl chr 2:107,056,140...107,059,656
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions
decreases expression
EXP coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr17:88,984,952...89,200,675
Ensembl chr17:88,984,952...89,200,675
JBrowse link
G Fyn Fyn proto-oncogene increases expression ISO Cyclophosphamide results in increased expression of FYN mRNA CTD PMID:17403535 NCBI chr10:39,369,743...39,565,381
Ensembl chr10:39,368,855...39,565,381
JBrowse link
G G3bp1 GTPase activating protein (SH3 domain) binding protein 1 decreases expression EXP Cyclophosphamide results in decreased expression of G3BP1 mRNA CTD PMID:21041162 NCBI chr11:55,469,657...55,500,888
Ensembl chr11:55,469,685...55,504,838
JBrowse link
G G6pc2 glucose-6-phosphatase, catalytic, 2 decreases expression EXP Cyclophosphamide results in decreased expression of G6PC2 mRNA CTD PMID:15331540 NCBI chr 2:69,211,073...69,227,993
Ensembl chr 2:69,211,073...69,227,841
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression
affects expression
ISO Cyclophosphamide results in increased expression of GADD45A mRNA
Cyclophosphamide affects the expression of GADD45A mRNA
CTD PMID:18246545 PMID:29445054 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gal galanin and GMAP prepropeptide affects expression
increases expression
ISO
EXP
Cyclophosphamide affects the expression of GAL mRNA; Cyclophosphamide affects the expression of GAL protein
Cyclophosphamide results in increased expression of GAL mRNA
CTD PMID:16491427 PMID:17335920 PMID:18563302 NCBI chr19:3,409,915...3,414,544
Ensembl chr19:3,409,915...3,414,544
JBrowse link
G Galc galactosylceramidase affects response to substance ISO GALC protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr12:98,202,287...98,259,459
Ensembl chr12:98,202,294...98,259,459
JBrowse link
G Gamt guanidinoacetate methyltransferase multiple interactions ISO GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:80,258,151...80,261,025
Ensembl chr10:80,258,151...80,261,012
JBrowse link
G Gap43 growth associated protein 43 increases expression ISO Cyclophosphamide results in increased expression of GAP43 protein CTD PMID:9486479 PMID:10536274 NCBI chr16:42,248,552...42,340,651
Ensembl chr16:42,248,442...42,340,651
JBrowse link
G Gas2 growth arrest specific 2 increases expression ISO Cyclophosphamide results in increased expression of GAS2 protein CTD PMID:17475930 NCBI chr 7:51,861,791...51,995,005
Ensembl chr 7:51,862,015...51,994,975
JBrowse link
G Gata3 GATA binding protein 3 decreases expression
multiple interactions
EXP Cyclophosphamide results in decreased expression of GATA3 mRNA; Cyclophosphamide results in decreased expression of GATA3 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein]
CTD PMID:21041162 PMID:32151603 NCBI chr 2:9,857,078...9,887,953
Ensembl chr 2:9,857,078...9,890,034
JBrowse link
G Gbp2b guanylate binding protein 2b increases expression EXP Cyclophosphamide results in increased expression of GBP1 mRNA CTD PMID:21621594 NCBI chr 3:142,594,816...142,619,179
Ensembl chr 3:142,594,847...142,619,179
JBrowse link
G Gbp3 guanylate binding protein 3 increases expression EXP Cyclophosphamide results in increased expression of GBP3 mRNA CTD PMID:15331540 NCBI chr 3:142,560,016...142,573,213
Ensembl chr 3:142,560,026...142,573,209
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression
EXP Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]
Cyclophosphamide results in decreased expression of GCLC mRNA; Cyclophosphamide results in decreased expression of GCLC protein
CTD PMID:27633142 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gdnf glial cell line derived neurotrophic factor increases expression ISO Cyclophosphamide results in increased expression of GDNF mRNA CTD PMID:10683293 NCBI chr15:7,810,048...7,837,580
Ensembl chr15:7,810,846...7,837,575
JBrowse link
G Gem GTP binding protein (gene overexpressed in skeletal muscle) increases expression EXP Cyclophosphamide results in increased expression of GEM mRNA CTD PMID:21041162 NCBI chr 4:11,704,447...11,714,993
Ensembl chr 4:11,704,457...11,714,752
JBrowse link
G Gfi1 growth factor independent 1 transcription repressor decreases expression EXP Cyclophosphamide results in decreased expression of GFI1 mRNA CTD PMID:21041162 NCBI chr 5:107,716,655...107,725,805
Ensembl chr 5:107,716,657...107,726,036
JBrowse link
G Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 multiple interactions ISO GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr19:58,235,581...58,455,946
Ensembl chr19:58,235,604...58,455,909
JBrowse link
G Gimap4 GTPase, IMAP family member 4 decreases expression ISO Cyclophosphamide results in decreased expression of GIMAP4 mRNA CTD PMID:27466211 NCBI chr 6:48,684,578...48,692,062
Ensembl chr 6:48,684,549...48,692,060
JBrowse link
G Gja1 gap junction protein, alpha 1 affects expression ISO Cyclophosphamide affects the expression of GJA1 mRNA CTD PMID:10859244 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Cyclophosphamide results in decreased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:101,376,376...101,385,629
Ensembl chr  X:101,376,378...101,385,629
JBrowse link
G Glis1 GLIS family zinc finger 1 decreases expression ISO Cyclophosphamide results in decreased expression of GLIS1 mRNA CTD PMID:27281708 NCBI chr 4:107,426,636...107,635,061
Ensembl chr 4:107,434,591...107,635,061
JBrowse link
G Glod4 glyoxalase domain containing 4 decreases expression ISO Cyclophosphamide results in decreased expression of GLOD4 mRNA CTD PMID:20849824 NCBI chr11:76,220,395...76,243,699
Ensembl chr11:76,120,987...76,243,725
JBrowse link
G Glrb glycine receptor, beta subunit increases expression ISO Cyclophosphamide results in increased expression of GLRB mRNA CTD PMID:17403535 NCBI chr 3:80,843,598...80,913,660
Ensembl chr 3:80,843,599...80,913,660
JBrowse link
G Gls glutaminase increases expression
affects response to substance
ISO Cyclophosphamide results in increased expression of GLS mRNA
GLS protein affects the susceptibility to Cyclophosphamide
CTD PMID:16217747 PMID:21527772 NCBI chr 1:52,163,449...52,235,009
Ensembl chr 1:52,163,448...52,233,232
JBrowse link
G Gm40318 predicted gene, 40318 affects response to substance
decreases expression
ISO S100P protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in decreased expression of S100P mRNA
CTD PMID:16217747 PMID:17403535 NCBI chr 5:36,762,504...36,767,419
Ensembl chr 5:36,762,617...36,766,695
JBrowse link
G Gng12 guanine nucleotide binding protein (G protein), gamma 12 increases expression ISO Cyclophosphamide results in increased expression of GNG12 mRNA CTD PMID:17403535 NCBI chr 6:66,896,397...67,021,361
Ensembl chr 6:66,896,397...67,021,350
JBrowse link
G Gpatch8 G patch domain containing 8 increases expression ISO Cyclophosphamide results in increased expression of GPATCH8 mRNA CTD PMID:27281708 NCBI chr11:102,475,911...102,556,391
Ensembl chr11:102,475,915...102,556,392
JBrowse link
G Gpr137b G protein-coupled receptor 137B increases expression ISO Cyclophosphamide results in increased expression of GPR137B mRNA CTD PMID:21527772 NCBI chr13:13,357,620...13,393,644
Ensembl chr13:13,357,620...13,394,014
JBrowse link
G Gpr18 G protein-coupled receptor 18 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of GPR18 mRNA CTD PMID:24356939 NCBI chr14:121,911,434...121,915,888
Ensembl chr14:121,911,253...121,915,781
JBrowse link
G Gpr20 G protein-coupled receptor 20 increases expression ISO Cyclophosphamide results in increased expression of GPR20 mRNA CTD PMID:20849824 NCBI chr15:73,688,497...73,707,505
Ensembl chr15:73,694,604...73,707,505
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression
increases activity
multiple interactions
ISO
EXP
Cyclophosphamide results in increased expression of GPT protein
Cyclophosphamide results in increased activity of GPT protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]
Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Cyclophosphamide results in increased expression of GPT protein]
CTD PMID:25753322 PMID:25779342 PMID:29753871 PMID:30506662 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpt2 glutamic pyruvate transaminase (alanine aminotransferase) 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of GPT2 mRNA CTD PMID:24356939 NCBI chr 8:85,492,576...85,528,902
Ensembl chr 8:85,492,576...85,527,560
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions
EXP Cyclophosphamide results in decreased expression of GPX1 mRNA
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of GPX1 mRNA]
CTD PMID:23542512 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression EXP Cyclophosphamide results in increased expression of GPX3 mRNA CTD PMID:21041162 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO Cyclophosphamide results in increased expression of GPX4 protein CTD PMID:17475930 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439
JBrowse link
G Gsr glutathione reductase multiple interactions
decreases activity
EXP
ISO
[[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein; Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]
CTD PMID:12114195 PMID:21772021 PMID:23542512 PMID:25446862 PMID:25753322 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]; GSTM1 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] CTD PMID:16087946 PMID:28744217 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 decreases expression ISO Cyclophosphamide results in decreased expression of GSTM2 mRNA CTD PMID:11906922 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
decreases response to substance
affects response to substance
increases expression
ISO
EXP
GSTP1 gene SNP results in increased susceptibility to [Carmustine co-treated with Doxorubicin co-treated with Cyclophosphamide co-treated with Melphalan]
GSTP1 protein results in decreased susceptibility to Cyclophosphamide
GSTP1 protein affects the susceptibility to Cyclophosphamide
GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]
Cyclophosphamide results in increased expression of GSTP1 mRNA; Cyclophosphamide results in increased expression of GSTP1 protein
CTD PMID:10954901 PMID:12791655 PMID:16141653 PMID:16242832 PMID:19696094 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gstp2 glutathione S-transferase, pi 2 multiple interactions
affects response to substance
EXP GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]
GSTP2 protein affects the susceptibility to Cyclophosphamide
CTD PMID:19696094 NCBI chr19:4,040,288...4,042,221
Ensembl chr19:4,040,285...4,046,023
JBrowse link
G Gtf2b general transcription factor IIB increases expression ISO Cyclophosphamide results in increased expression of GTF2B mRNA CTD PMID:27281708 NCBI chr 3:142,765,247...142,783,606
Ensembl chr 3:142,765,045...142,783,606
JBrowse link
G Gtf3c1 general transcription factor III C 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of GTF3C1 mRNA CTD PMID:16322899 NCBI chr 7:125,640,954...125,707,688
Ensembl chr 7:125,640,954...125,707,780
JBrowse link
G Gusb glucuronidase, beta decreases expression
increases activity
multiple interactions
ISO Cyclophosphamide results in decreased expression of GUSB protein
Cyclophosphamide results in increased activity of GUSB protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]
CTD PMID:17686619 PMID:25451569 NCBI chr 5:129,989,011...130,003,049
Ensembl chr 5:129,989,011...130,003,049
JBrowse link
G Gzma granzyme A decreases expression EXP Cyclophosphamide results in decreased expression of GZMA mRNA CTD PMID:21041162 NCBI chr13:113,093,824...113,100,981
Ensembl chr13:113,093,825...113,100,981
JBrowse link
G Gzmb granzyme B increases expression EXP Cyclophosphamide results in increased expression of GZMB mRNA CTD PMID:15331540 NCBI chr14:56,258,836...56,262,334
Ensembl chr14:56,258,838...56,262,260
JBrowse link
G H13 histocompatibility 13 decreases expression EXP Cyclophosphamide results in decreased expression of H13 mRNA CTD PMID:15331540 NCBI chr 2:152,669,422...152,708,668
Ensembl chr 2:152,669,461...152,708,670
JBrowse link
G H2-K1 histocompatibility 2, K1, K region increases expression EXP Cyclophosphamide results in increased expression of H2-K1 mRNA CTD PMID:21041162 NCBI chr17:33,996,012...34,000,619
Ensembl chr17:33,996,017...34,000,347
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Cyclophosphamide results in increased phosphorylation of H2AX protein CTD PMID:32482060 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G Hcrt hypocretin affects localization
decreases expression
ISO Cyclophosphamide affects the localization of HCRT protein
Cyclophosphamide results in decreased expression of HCRT mRNA
CTD PMID:17881193 PMID:19666069 NCBI chr11:100,761,693...100,762,931
Ensembl chr11:100,761,069...100,762,931
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression EXP Cyclophosphamide results in increased expression of HIF1A mRNA CTD PMID:15331540 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hinfp histone H4 transcription factor decreases expression ISO Cyclophosphamide results in decreased expression of HINFP mRNA CTD PMID:27281708 NCBI chr 9:44,292,438...44,305,716
Ensembl chr 9:44,292,440...44,305,671
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr13:119,690,351...119,708,260
Ensembl chr13:119,690,379...119,708,260
JBrowse link
G Hmox1 heme oxygenase 1 affects expression
decreases expression
multiple interactions
increases expression
ISO Cyclophosphamide affects the expression of HMOX1 mRNA
Cyclophosphamide results in decreased expression of HMOX1 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]
Cyclophosphamide results in increased expression of HMOX1 mRNA; Cyclophosphamide results in increased expression of HMOX1 protein
CTD PMID:11906922 PMID:17979934 PMID:18206168 PMID:18246545 PMID:19952508 PMID:20038455 PMID:20433640 PMID:32197949 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hmox2 heme oxygenase 2 decreases expression ISO Cyclophosphamide results in decreased expression of HMOX2 mRNA CTD PMID:11906922 NCBI chr16:4,726,361...4,766,742
Ensembl chr16:4,726,361...4,766,742
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression ISO Cyclophosphamide results in increased expression of HNRNPK protein
Cyclophosphamide results in increased expression of HNRNPK mRNA
CTD PMID:11599041 PMID:17475930 NCBI chr13:58,391,132...58,403,343
Ensembl chr13:58,391,142...58,403,343
JBrowse link
G Hoxa1 homeobox A1 affects response to substance ISO HOXA1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:52,155,367...52,160,007
Ensembl chr 6:52,155,590...52,158,317
JBrowse link
G Hprt hypoxanthine guanine phosphoribosyl transferase increases mutagenesis EXP
ISO
Cyclophosphamide results in increased mutagenesis of HPRT1 gene CTD PMID:17116724 PMID:23677247 NCBI chr  X:52,988,078...53,021,660
Ensembl chr  X:52,988,137...53,021,659
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 decreases expression ISO Cyclophosphamide results in decreased expression of HSP90AA1 mRNA CTD PMID:11906922 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression ISO Cyclophosphamide results in decreased expression of HSP90AB1 mRNA CTD PMID:11906922 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 decreases expression
increases expression
ISO Cyclophosphamide results in decreased expression of HSP90B1 mRNA
Cyclophosphamide results in increased expression of HSP90B1 mRNA
CTD PMID:11599041 PMID:11906922 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa1a heat shock protein 1A increases expression
affects expression
ISO Cyclophosphamide results in increased expression of HSPA1A mRNA; Cyclophosphamide results in increased expression of HSPA1A protein
Cyclophosphamide affects the expression of HSPA1A mRNA
CTD PMID:8917683 PMID:18246545 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa1b heat shock protein 1B decreases expression
increases expression
affects expression
ISO Cyclophosphamide results in decreased expression of HSPA1B mRNA
Cyclophosphamide metabolite results in increased expression of HSPA1B mRNA
Cyclophosphamide affects the expression of HSPA1B mRNA
CTD PMID:16141653 PMID:18246545 PMID:24356939 NCBI chr17:34,956,429...34,959,238
Ensembl chr17:34,956,436...34,959,238
JBrowse link
G Hspa2 heat shock protein 2 affects response to substance
increases expression
ISO HSPA2 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of HSPA2 mRNA
CTD PMID:11599041 PMID:16217747 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Hspa5 heat shock protein 5 decreases expression
increases expression
ISO Cyclophosphamide results in decreased expression of HSPA5 mRNA
Cyclophosphamide metabolite results in increased expression of HSPA5 mRNA
CTD PMID:11906922 PMID:24356939 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa8 heat shock protein 8 affects response to substance ISO HSPA8 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 9:40,801,276...40,805,202
Ensembl chr 9:40,800,984...40,810,087
JBrowse link
G Hspa9 heat shock protein 9 decreases expression ISO Cyclophosphamide results in decreased expression of HSPA9 mRNA CTD PMID:11906922 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspb1 heat shock protein 1 decreases expression
increases expression
ISO Cyclophosphamide results in decreased expression of HSPB1 mRNA
Cyclophosphamide results in increased expression of HSPB1 mRNA
CTD PMID:11599041 PMID:11906922 PMID:18246545 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) decreases expression ISO Cyclophosphamide results in decreased expression of HSPD1 mRNA CTD PMID:11906922 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) decreases expression ISO Cyclophosphamide results in decreased expression of HSPE1 mRNA CTD PMID:11906922 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of HSPH1 mRNA CTD PMID:24356939 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Hyls1 HYLS1, centriolar and ciliogenesis associated decreases expression ISO Cyclophosphamide metabolite results in decreased expression of HYLS1 mRNA CTD PMID:24356939 NCBI chr 9:35,560,821...35,570,069
Ensembl chr 9:35,560,820...35,570,398
JBrowse link
G Hyou1 hypoxia up-regulated 1 decreases expression ISO Cyclophosphamide results in decreased expression of HYOU1 mRNA CTD PMID:11906922 NCBI chr 9:44,379,490...44,392,369
Ensembl chr 9:44,379,490...44,392,369
JBrowse link
G Ica1 islet cell autoantigen 1 affects response to substance EXP ICA1 protein affects the susceptibility to Cyclophosphamide CTD PMID:11751995 NCBI chr 6:8,630,527...8,778,540
Ensembl chr 6:8,630,527...8,778,488
JBrowse link
G Icam1 intercellular adhesion molecule 1 affects response to substance EXP ICAM1 protein affects the susceptibility to Cyclophosphamide CTD PMID:11591119 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ID2 mRNA CTD PMID:24356939 NCBI chr12:25,093,799...25,096,092
Ensembl chr12:25,093,799...25,097,140
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase increases expression ISO Cyclophosphamide metabolite results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr13:8,885,606...8,892,396
Ensembl chr13:8,885,501...8,892,451
JBrowse link
G Ier3 immediate early response 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of IER3 mRNA CTD PMID:24356939 NCBI chr17:35,821,713...35,822,911
Ensembl chr17:35,821,684...35,822,923
JBrowse link
G Ier5 immediate early response 5 increases expression ISO Cyclophosphamide results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr 1:155,096,367...155,099,636
Ensembl chr 1:155,096,361...155,099,636
JBrowse link
G Ifi202b interferon activated gene 202B increases expression EXP Cyclophosphamide results in increased expression of IFI202B mRNA CTD PMID:15331540 NCBI chr 1:173,962,569...173,982,844
Ensembl chr 1:173,962,568...173,982,744
JBrowse link
G Ifi204 interferon activated gene 204 increases expression EXP Cyclophosphamide results in increased expression of IFI204 mRNA CTD PMID:21041162 NCBI chr 1:173,747,293...173,767,069
Ensembl chr 1:173,747,293...173,766,943
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression EXP Cyclophosphamide results in increased expression of IFIT2 mRNA CTD PMID:15331540 NCBI chr19:34,550,550...34,576,534
Ensembl chr19:34,550,694...34,576,419
JBrowse link
G Ifng interferon gamma affects expression
multiple interactions
decreases secretion
increases expression
decreases expression
EXP
ISO
Cyclophosphamide affects the expression of IFNG mRNA
[Cyclophosphamide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
Cyclophosphamide results in decreased secretion of IFNG protein
Cyclophosphamide results in increased expression of IFNG mRNA
Cyclophosphamide results in decreased expression of IFNG mRNA
Cyclophosphamide results in increased expression of IFNG protein
(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; IFNG protein inhibits the reaction [Cyclophosphamide results in increased abundance of Nitric Oxide]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]
CTD PMID:10607705 PMID:11006010 PMID:11014644 PMID:15331540 PMID:18848347 PMID:18957084 PMID:21068404 PMID:22842586 PMID:23395935 PMID:29594315 PMID:32151603 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Ifngr1 interferon gamma receptor 1 decreases expression EXP Cyclophosphamide results in decreased expression of IFNGR1 mRNA CTD PMID:21041162 NCBI chr10:19,591,949...19,610,229
Ensembl chr10:19,591,949...19,610,229
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of IFRD1 mRNA CTD PMID:24356939 NCBI chr12:40,203,129...40,223,189
Ensembl chr12:40,201,567...40,248,504
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:49,085,218...49,215,469
Ensembl chr 6:49,085,223...49,214,957
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects response to substance
decreases expression
ISO IGFBP3 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in decreased expression of IGFBP3 mRNA
CTD PMID:16141653 PMID:16217747 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr11:99,040,005...99,052,655
Ensembl chr11:99,041,244...99,054,392
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression EXP
ISO
Cyclophosphamide results in decreased expression of IGFBP5 mRNA CTD PMID:15331540 PMID:20849824 NCBI chr 1:72,858,065...72,874,865
Ensembl chr 1:72,857,932...72,874,884
JBrowse link
G Igh-VJ558 immunoglobulin heavy chain (J558 family) decreases expression EXP Cyclophosphamide results in decreased expression of IGH-VJ558 mRNA CTD PMID:15331540
G Ighv7-1 immunoglobulin heavy variable 7-1 decreases expression EXP Cyclophosphamide results in decreased expression of IGH-V mRNA CTD PMID:15331540 NCBI chr12:113,896,408...113,896,946
Ensembl chr12:113,896,408...113,896,946
JBrowse link
G Igkc immunoglobulin kappa constant decreases expression EXP Cyclophosphamide results in decreased expression of IGKC mRNA CTD PMID:15331540 NCBI chr 6:70,726,435...70,726,754
Ensembl chr 6:70,726,435...70,726,966
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
increases expression
EXP
ISO
Cyclophosphamide results in decreased expression of IL10 mRNA
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL10 protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]
Cyclophosphamide results in increased expression of IL10 mRNA
Cyclophosphamide results in increased expression of IL10 protein
CTD PMID:11014644 PMID:11948286 PMID:18848347 PMID:21068404 PMID:25451569 PMID:31651976 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12a interleukin 12a multiple interactions EXP [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:29228376 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547
JBrowse link
G Il12b interleukin 12b affects expression
multiple interactions
increases expression
EXP Cyclophosphamide affects the expression of IL12B mRNA
[Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein]
Cyclophosphamide results in increased expression of IL12B mRNA
CTD PMID:15331540 PMID:18957084 PMID:22842586 PMID:29228376 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il13ra1 interleukin 13 receptor, alpha 1 increases expression EXP Cyclophosphamide results in increased expression of IL13RA1 mRNA CTD PMID:21041162 NCBI chr  X:36,112,108...36,171,262
Ensembl chr  X:36,112,110...36,171,259
JBrowse link
G Il15 interleukin 15 multiple interactions
decreases secretion
EXP (4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr 8:82,331,624...82,403,252
Ensembl chr 8:82,331,632...82,403,222
JBrowse link
G Il15ra interleukin 15 receptor, alpha chain increases expression EXP Cyclophosphamide results in increased expression of IL15RA mRNA CTD PMID:21041162 NCBI chr 2:11,705,172...11,733,985
Ensembl chr 2:11,705,290...11,734,317
JBrowse link
G Il16 interleukin 16 decreases expression EXP Cyclophosphamide results in decreased expression of IL16 mRNA CTD PMID:21041162 NCBI chr 7:83,642,819...83,746,028
Ensembl chr 7:83,642,825...83,745,726
JBrowse link
G Il17a interleukin 17A decreases expression
multiple interactions
EXP Cyclophosphamide results in decreased expression of IL17A protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein]
CTD PMID:21880982 PMID:32151603 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 increases expression ISO Cyclophosphamide results in increased expression of IL18 protein CTD PMID:18848347 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
affects response to substance
EXP
ISO
Cyclophosphamide results in increased expression of IL1A mRNA
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1A protein
Cyclophosphamide results in increased expression of IL1A protein
IL1A promoter polymorphism affects the susceptibility to Cyclophosphamide
CTD PMID:15331540 PMID:16636934 PMID:18848347 PMID:31651976 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
increases response to substance
multiple interactions
EXP
ISO
Cyclophosphamide results in increased expression of IL1B mRNA; Cyclophosphamide results in increased expression of IL1B protein
Cyclophosphamide results in decreased expression of IL1B protein
IL1B protein results in increased susceptibility to Cyclophosphamide
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1B protein; [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of IL1B protein; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein]; VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]
CTD PMID:8634684 PMID:11948286 PMID:15331540 PMID:18206168 PMID:18483878 PMID:18710439 PMID:18848347 PMID:20126887 PMID:23695977 PMID:25451569 PMID:29228376 PMID:29753871 PMID:30506662 PMID:31651976 PMID:32151603 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression EXP Cyclophosphamide results in increased expression of IL1RN mRNA CTD PMID:15331540 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il2 interleukin 2 increases expression
decreases expression
decreases secretion
multiple interactions
EXP
ISO
Cyclophosphamide results in increased expression of IL2 mRNA
Cyclophosphamide results in decreased expression of IL2 mRNA
Cyclophosphamide results in decreased secretion of IL2 protein
(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]
Cyclophosphamide results in decreased expression of IL2 protein
CTD PMID:11006010 PMID:11948286 PMID:18848347 PMID:23395935 PMID:32151603 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il21 interleukin 21 multiple interactions
decreases expression
EXP Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 3:37,222,759...37,232,636
Ensembl chr 3:37,222,759...37,232,636
JBrowse link
G Il23a interleukin 23, alpha subunit p19 decreases secretion
decreases expression
multiple interactions
EXP Cyclophosphamide results in decreased secretion of IL23A protein
Cyclophosphamide results in decreased expression of IL23A protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein]
CTD PMID:23395935 PMID:32151603 NCBI chr10:128,296,140...128,298,084
Ensembl chr10:128,296,139...128,298,752
JBrowse link
G Il3 interleukin 3 multiple interactions EXP [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL3 protein CTD PMID:31651976 NCBI chr11:54,265,085...54,267,279
Ensembl chr11:54,265,303...54,267,277
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Cyclophosphamide results in decreased expression of IL4 mRNA; Cyclophosphamide results in decreased expression of IL4 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Cyclophosphamide results in increased expression of IL4 mRNA; Cyclophosphamide results in increased expression of IL4 protein
CTD PMID:11006010 PMID:11014644 PMID:11948286 PMID:18848347 PMID:22842586 PMID:32151603 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il5 interleukin 5 increases expression EXP
ISO
Cyclophosphamide results in increased expression of IL5 mRNA; Cyclophosphamide results in increased expression of IL5 protein CTD PMID:11006010 PMID:18848347 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases secretion
EXP
ISO
[Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of IL6 protein; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein]; Sizofiran promotes the reaction [Cyclophosphamide results in increased expression of IL6 mRNA]; Sizofiran promotes the reaction [Cyclophosphamide results in increased expression of IL6 protein]
Cyclophosphamide results in increased expression of IL6 mRNA; Cyclophosphamide results in increased expression of IL6 protein
Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]
CTD PMID:10052129 PMID:11948286 PMID:17010015 PMID:18848347 PMID:20126887 PMID:21068404 PMID:22842586 PMID:23395935 PMID:23695977 PMID:25753322 PMID:29228376 PMID:30506662 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of ILF3 mRNA CTD PMID:16322899 NCBI chr 9:21,367,731...21,405,363
Ensembl chr 9:21,367,871...21,405,361
JBrowse link
G Irgm2 immunity-related GTPase family M member 2 increases expression EXP Cyclophosphamide results in increased expression of IRGM2 mRNA CTD PMID:15331540 NCBI chr11:58,214,977...58,222,783
Ensembl chr11:58,199,618...58,222,782
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA CTD PMID:16322899 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO Cyclophosphamide results in increased expression of ISG15 mRNA CTD PMID:21527772 NCBI chr 4:156,199,424...156,200,818
Ensembl chr 4:156,199,455...156,200,796
JBrowse link
G Isl2 insulin related protein 2 (islet 2) decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ISL2 mRNA CTD PMID:24356939 NCBI chr 9:55,538,677...55,547,667
Ensembl chr 9:55,538,672...55,546,180
JBrowse link
G Itk IL2 inducible T cell kinase decreases expression EXP Cyclophosphamide results in decreased expression of ITK mRNA CTD PMID:21041162 NCBI chr11:46,325,148...46,389,515
Ensembl chr11:46,325,150...46,389,515
JBrowse link
G Jchain immunoglobulin joining chain decreases expression EXP Cyclophosphamide results in decreased expression of JCHAIN mRNA CTD PMID:15331540 NCBI chr 5:88,519,809...88,527,897
Ensembl chr 5:88,519,809...88,527,891
JBrowse link
G Kbtbd11 kelch repeat and BTB (POZ) domain containing 11 decreases expression ISO Cyclophosphamide results in decreased expression of KBTBD11 mRNA CTD PMID:17403535 NCBI chr 8:15,011,025...15,033,333
Ensembl chr 8:15,011,025...15,033,333
JBrowse link
G Kcnq4 potassium voltage-gated channel, subfamily Q, member 4 decreases expression ISO Cyclophosphamide results in decreased expression of KCNQ4 mRNA CTD PMID:20849824 NCBI chr 4:120,696,134...120,747,491
Ensembl chr 4:120,696,138...120,748,612
JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A multiple interactions
increases expression
ISO Cyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]
Cyclophosphamide results in increased expression of KDM1A protein
CTD PMID:22007908 NCBI chr 4:136,550,533...136,602,787
Ensembl chr 4:136,550,540...136,602,723
JBrowse link
G Kdm2a lysine (K)-specific demethylase 2A increases expression ISO Cyclophosphamide results in increased expression of KDM2A mRNA CTD PMID:27281708 NCBI chr19:4,316,144...4,398,721
Ensembl chr19:4,314,419...4,398,285
JBrowse link
G Kdm4b lysine (K)-specific demethylase 4B multiple interactions ISO KDM4B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr17:56,325,970...56,403,774
Ensembl chr17:56,326,062...56,402,870
JBrowse link
G Kdr kinase insert domain protein receptor decreases expression
increases expression
ISO Cyclophosphamide results in decreased expression of KDR mRNA; Cyclophosphamide results in decreased expression of KDR protein
Cyclophosphamide results in increased expression of KDR mRNA
CTD PMID:18632792 PMID:19701751 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Kif21b kinesin family member 21B decreases expression ISO Cyclophosphamide metabolite results in decreased expression of KIF21B mRNA CTD PMID:24356939 NCBI chr 1:136,131,390...136,178,001
Ensembl chr 1:136,131,389...136,177,998
JBrowse link
G Kif3a kinesin family member 3A multiple interactions ISO KIF3A mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr11:53,565,701...53,604,248
Ensembl chr11:53,567,379...53,601,967
JBrowse link
G Kitl kit ligand affects expression
increases expression
multiple interactions
EXP Cyclophosphamide affects the expression of KITL mRNA
Cyclophosphamide results in increased expression of KITL mRNA
[Cyclophosphamide co-treated with Sizofiran] results in increased expression of KITL mRNA
CTD PMID:10052129 PMID:12624490 PMID:12662436 NCBI chr10:100,015,615...100,100,416
Ensembl chr10:100,015,630...100,100,416
JBrowse link
G Klf13 Kruppel-like factor 13 decreases expression EXP Cyclophosphamide results in decreased expression of KLF13 mRNA CTD PMID:21041162 NCBI chr 7:63,886,351...63,938,915
Ensembl chr 7:63,886,351...63,938,915
JBrowse link
G Klf2 Kruppel-like factor 2 (lung) increases expression EXP Cyclophosphamide results in increased expression of KLF2 mRNA CTD PMID:21041162 NCBI chr 8:72,319,062...72,321,654
Ensembl chr 8:72,319,033...72,321,656
JBrowse link
G Klf4 Kruppel-like factor 4 (gut) decreases response to substance ISO KLF4 results in decreased susceptibility to Cyclophosphamide CTD PMID:21833590 NCBI chr 4:55,527,137...55,532,475
Ensembl chr 4:55,527,143...55,532,466
JBrowse link
G Klf5 Kruppel-like factor 5 affects response to substance ISO KLF5 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr14:99,298,691...99,313,412
Ensembl chr14:99,298,691...99,315,036
JBrowse link
G Klrb1c killer cell lectin-like receptor subfamily B member 1C multiple interactions EXP [Cyclophosphamide co-treated with Sizofiran] results in increased expression of KLRB1C mRNA CTD PMID:10052129 NCBI chr 6:128,778,485...128,788,641
Ensembl chr 6:128,778,485...128,789,215
JBrowse link
G Krcc1 lysine-rich coiled-coil 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 6:71,271,677...71,286,825
Ensembl chr 6:71,271,677...71,285,319
JBrowse link
G Krt8 keratin 8 decreases expression EXP Cyclophosphamide results in decreased expression of KRT8 mRNA CTD PMID:21621594 NCBI chr15:101,996,711...102,004,342
Ensembl chr15:101,996,698...102,004,482
JBrowse link
G Krt80 keratin 80 increases expression ISO Cyclophosphamide results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr15:101,348,315...101,370,162
Ensembl chr15:101,347,444...101,370,162
JBrowse link
G Lama5 laminin, alpha 5 multiple interactions
increases expression
EXP 5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in increased expression of LAMA5 mRNA] CTD PMID:30760223 NCBI chr 2:180,176,373...180,225,904
Ensembl chr 2:180,176,373...180,225,859
JBrowse link
G Lamc2 laminin, gamma 2 increases expression ISO Cyclophosphamide results in increased expression of LAMC2 mRNA CTD PMID:21527772 NCBI chr 1:153,122,756...153,186,447
Ensembl chr 1:153,122,756...153,186,447
JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression ISO Cyclophosphamide results in decreased expression of LASP1 mRNA CTD PMID:27281708 NCBI chr11:97,799,005...97,838,765
Ensembl chr11:97,799,000...97,838,764
JBrowse link
G Lat linker for activation of T cells decreases expression EXP Cyclophosphamide results in decreased expression of LAT mRNA CTD PMID:21041162 NCBI chr 7:126,363,827...126,369,705
Ensembl chr 7:126,363,824...126,369,570
JBrowse link
G Lck lymphocyte protein tyrosine kinase decreases expression EXP Cyclophosphamide results in decreased expression of LCK mRNA CTD PMID:21041162 NCBI chr 4:129,548,344...129,573,641
Ensembl chr 4:129,548,344...129,573,641
JBrowse link
G Lcn2 lipocalin 2 increases expression
multiple interactions
EXP
ISO
Cyclophosphamide results in increased expression of LCN2 mRNA
[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of LCN2 mRNA
CTD PMID:15331540 PMID:18433785 PMID:20623750 NCBI chr 2:32,384,637...32,387,739
Ensembl chr 2:32,384,633...32,388,252
JBrowse link
G Ldhb lactate dehydrogenase B affects response to substance ISO LDHB protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:142,490,249...142,507,957
Ensembl chr 6:142,490,249...142,507,957
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression EXP Cyclophosphamide results in decreased expression of LEF1 mRNA CTD PMID:21041162 NCBI chr 3:131,110,297...131,224,357
Ensembl chr 3:131,110,471...131,224,356
JBrowse link
G Lgals1 lectin, galactose binding, soluble 1 increases expression ISO Cyclophosphamide results in increased expression of LGALS1 mRNA CTD PMID:17403535 NCBI chr15:78,926,725...78,930,465
Ensembl chr15:78,926,725...78,930,465
JBrowse link
G Lgals7 lectin, galactose binding, soluble 7 increases expression ISO Cyclophosphamide results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr 7:28,863,796...28,866,285
Ensembl chr 7:28,863,853...28,866,284
JBrowse link
G Lhb luteinizing hormone beta decreases secretion
multiple interactions
ISO Cyclophosphamide results in decreased secretion of LHB protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein]
CTD PMID:25446862 PMID:32197949 NCBI chr 7:45,417,608...45,421,855
Ensembl chr 7:45,420,820...45,421,897
Ensembl chr 7:45,420,820...45,421,897
JBrowse link
G Lhx2 LIM homeobox protein 2 decreases expression ISO Cyclophosphamide results in decreased expression of LHX2 mRNA CTD PMID:27281708 NCBI chr 2:38,339,271...38,369,737
Ensembl chr 2:38,339,281...38,369,733
JBrowse link
G Limd1 LIM domains containing 1 increases expression ISO Cyclophosphamide results in increased expression of LIMD1 mRNA CTD PMID:27281708 NCBI chr 9:123,478,661...123,521,552
Ensembl chr 9:123,478,706...123,521,552
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression ISO Cyclophosphamide results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 6:112,273,758...112,330,423
Ensembl chr 6:112,273,758...112,330,425
JBrowse link
G Lmnb1 lamin B1 multiple interactions ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 protein CTD PMID:15582267 NCBI chr18:56,707,813...56,753,424
Ensembl chr18:56,707,813...56,753,424
JBrowse link
G Lonrf2 LON peptidase N-terminal domain and ring finger 2 increases expression ISO Cyclophosphamide results in increased expression of LONRF2 mRNA CTD PMID:27281708 NCBI chr 1:38,793,669...38,836,687
Ensembl chr 1:38,793,645...38,836,711
JBrowse link
G Lrmp lymphoid-restricted membrane protein decreases expression EXP Cyclophosphamide results in decreased expression of LRMP mRNA CTD PMID:21041162 NCBI chr 6:145,111,715...145,174,929
Ensembl chr 6:145,115,653...145,174,934
JBrowse link
G Lsg1 large 60S subunit nuclear export GTPase 1 decreases expression ISO Cyclophosphamide results in decreased expression of LSG1 mRNA CTD PMID:20849824 NCBI chr16:30,561,369...30,587,612
Ensembl chr16:30,560,494...30,587,592
JBrowse link
G Ltbr lymphotoxin B receptor increases expression EXP Cyclophosphamide results in increased expression of LTBR mRNA CTD PMID:21041162 NCBI chr 6:125,306,571...125,313,885
Ensembl chr 6:125,306,571...125,313,885
JBrowse link
G Ltf lactotransferrin decreases expression EXP Cyclophosphamide results in decreased expression of LTF mRNA CTD PMID:21621594 NCBI chr 9:111,019,292...111,042,766
Ensembl chr 9:111,019,271...111,042,767
JBrowse link
G Ly6a lymphocyte antigen 6 complex, locus A increases expression EXP Cyclophosphamide results in increased expression of LY6A mRNA CTD PMID:15331540 PMID:21041162 NCBI chr15:74,994,877...74,998,031
Ensembl chr15:74,994,877...74,998,031
JBrowse link
G Ly6c1 lymphocyte antigen 6 complex, locus C1 increases expression EXP Cyclophosphamide results in increased expression of LY6C1 mRNA CTD PMID:21041162 NCBI chr15:75,044,018...75,048,920
Ensembl chr15:75,044,018...75,048,830
JBrowse link
G Maged1 MAGE family member D1 affects response to substance ISO MAGED1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr  X:94,535,474...94,542,025
Ensembl chr  X:94,535,474...94,542,143
JBrowse link
G Man2b2 mannosidase 2, alpha B2 decreases expression ISO Cyclophosphamide results in decreased expression of MAN2B2 mRNA CTD PMID:27281708 NCBI chr 5:36,806,813...36,830,649
Ensembl chr 5:36,806,921...36,830,653
JBrowse link
G Maoa monoamine oxidase A increases expression ISO Cyclophosphamide results in increased expression of MAOA mRNA CTD PMID:17403535 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Map3k12 mitogen-activated protein kinase kinase kinase 12 affects expression ISO Cyclophosphamide affects the expression of MAP3K12 mRNA CTD PMID:18246545 NCBI chr15:102,497,647...102,517,004
Ensembl chr15:102,497,646...102,517,064
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
increases expression
EXP
ISO
Cyclophosphamide results in increased phosphorylation of MAPK1 protein
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Cyclophosphamide results in increased expression of MAPK1 mRNA; Cyclophosphamide results in increased expression of MAPK1 protein modified form
CTD PMID:11599041 PMID:15733095 PMID:17110531 PMID:17409261 PMID:19638304 PMID:19696094 PMID:19996110 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions
decreases expression
affects expression
ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of MAPK14 mRNA
Cyclophosphamide results in decreased expression of MAPK14 mRNA
Cyclophosphamide affects the expression of MAPK14 mRNA
CTD PMID:16322899 PMID:18246545 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases expression
multiple interactions
increases phosphorylation
ISO
EXP
Cyclophosphamide results in increased expression of MAPK3 protein modified form
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Cyclophosphamide results in increased phosphorylation of MAPK3 protein
CTD PMID:15733095 PMID:17110531 PMID:17409261 PMID:19638304 PMID:19696094 PMID:19996110 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK7 protein CTD PMID:17110531 NCBI chr11:61,488,812...61,494,267
Ensembl chr11:61,488,812...61,494,406
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP
ISO
Cyclophosphamide results in increased phosphorylation of MAPK8 protein
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein]
GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]; Mesna inhibits the reaction [GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]
CTD PMID:19696094 PMID:19996110 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:19996110 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 decreases expression ISO Cyclophosphamide results in decreased expression of MARCHF7 mRNA CTD PMID:27281708 NCBI chr 2:60,209,936...60,248,385
Ensembl chr 2:60,209,887...60,250,676
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression ISO Cyclophosphamide results in increased expression of MARCKS mRNA CTD PMID:17403535 NCBI chr10:37,133,243...37,138,926
Ensembl chr10:37,133,375...37,138,920
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression EXP Cyclophosphamide results in decreased expression of MCM5 mRNA CTD PMID:21041162 NCBI chr 8:75,109,468...75,128,439
Ensembl chr 8:75,109,569...75,128,439
JBrowse link
G Mdfic MyoD family inhibitor domain containing decreases expression ISO Cyclophosphamide results in decreased expression of MDFIC mRNA CTD PMID:17403535 NCBI chr 6:15,720,566...15,802,169
Ensembl chr 6:15,720,661...15,802,169
JBrowse link
G Med13l mediator complex subunit 13-like multiple interactions ISO MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 5:118,560,330...118,765,438
Ensembl chr 5:118,560,679...118,765,438
JBrowse link
G Melk maternal embryonic leucine zipper kinase multiple interactions ISO MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 4:44,300,909...44,364,675
Ensembl chr 4:44,300,876...44,364,675
JBrowse link
G Metrn meteorin, glial cell differentiation regulator multiple interactions ISO METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr17:25,794,571...25,797,045
Ensembl chr17:25,793,221...25,797,136
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing decreases expression EXP Cyclophosphamide results in decreased expression of MFGE8 mRNA CTD PMID:15331540 NCBI chr 7:79,133,768...79,149,060
Ensembl chr 7:79,133,768...79,149,060
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression
decreases response to substance
ISO Cyclophosphamide results in decreased expression of MGMT mRNA
MGMT protein results in decreased susceptibility to Cyclophosphamide
CTD PMID:15741301 PMID:17403535 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Cyclophosphamide results in decreased expression of MGST1 mRNA CTD PMID:11906922 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) multiple interactions ISO Cyclophosphamide affects the localization of and affects the expression of MIF protein; Cyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein] CTD PMID:19066630 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO Cyclophosphamide results in decreased expression of MLH1 mRNA CTD PMID:11906922 NCBI chr 9:111,228,228...111,271,786
Ensembl chr 9:111,228,228...111,271,791
JBrowse link
G Mmel1 membrane metallo-endopeptidase-like 1 increases expression ISO Cyclophosphamide results in increased expression of MMEL1 mRNA CTD PMID:27281708 NCBI chr 4:154,869,585...154,895,530
Ensembl chr 4:154,869,585...154,895,528
JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression ISO Cyclophosphamide results in decreased expression of MMP11 mRNA CTD PMID:27281708 NCBI chr10:75,923,221...75,932,502
Ensembl chr10:75,923,222...75,936,496
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Cyclophosphamide results in increased expression of MMP3 mRNA CTD PMID:15331540 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp8 matrix metallopeptidase 8 increases expression ISO Cyclophosphamide results in increased expression of MMP8 mRNA CTD PMID:27281708 NCBI chr 9:7,558,429...7,568,486
Ensembl chr 9:7,558,456...7,568,485
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 affects response to substance ISO MPC2 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 1:165,461,260...165,481,218
Ensembl chr 1:165,460,637...165,481,214
JBrowse link
G Mpg N-methylpurine-DNA glycosylase affects expression ISO Cyclophosphamide affects the expression of MPG mRNA CTD PMID:11906922 NCBI chr11:32,226,505...32,232,702
Ensembl chr11:32,226,505...32,232,700
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
ISO Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:10749792 PMID:17979934 PMID:18710439 PMID:25451569 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mr1 major histocompatibility complex, class I-related increases expression ISO Cyclophosphamide results in increased expression of MR1 mRNA CTD PMID:21527772 NCBI chr 1:155,127,874...155,146,814
Ensembl chr 1:155,127,277...155,146,814
JBrowse link
G Ms4a3 membrane-spanning 4-domains, subfamily A, member 3 decreases expression ISO Cyclophosphamide results in decreased expression of MS4A3 mRNA CTD PMID:17403535 NCBI chr19:11,629,499...11,640,851
Ensembl chr19:11,629,496...11,640,851
JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Cyclophosphamide results in decreased expression of MSH2 mRNA CTD PMID:11056294 PMID:11906922 NCBI chr17:87,672,532...87,723,713
Ensembl chr17:87,672,330...87,723,713
JBrowse link
G Msh3 mutS homolog 3 decreases expression ISO Cyclophosphamide results in decreased expression of MSH3 mRNA CTD PMID:11906922 NCBI chr13:92,211,878...92,355,004
Ensembl chr13:92,211,872...92,355,003
JBrowse link
G Mss51 MSS51 mitochondrial translational activator increases expression ISO Cyclophosphamide results in increased expression of MSS51 mRNA CTD PMID:27281708 NCBI chr14:20,482,857...20,496,901
Ensembl chr14:20,482,867...20,496,901
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase decreases expression ISO Cyclophosphamide metabolite results in decreased expression of MTHFD2 mRNA CTD PMID:24356939 NCBI chr 6:83,305,704...83,326,011
Ensembl chr 6:83,305,691...83,325,908
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase decreases expression ISO Cyclophosphamide results in decreased expression of MTR mRNA CTD PMID:27281708 NCBI chr13:12,181,331...12,258,199
Ensembl chr13:12,182,712...12,258,113
JBrowse link
G Muc13 mucin 13, epithelial transmembrane increases expression EXP Cyclophosphamide results in increased expression of MUC13 mRNA CTD PMID:15331540 NCBI chr16:33,794,037...33,819,929
Ensembl chr16:33,794,037...33,819,934
JBrowse link
G Mup2 major urinary protein 2 decreases expression EXP Cyclophosphamide results in decreased expression of MUP2 mRNA CTD PMID:21621594 NCBI chr 4:60,135,913...60,139,977
Ensembl chr 4:60,135,932...60,154,289
JBrowse link
G Mup5 major urinary protein 5 decreases expression EXP Cyclophosphamide results in decreased expression of MUP5 mRNA CTD PMID:21621594 NCBI chr 4:61,831,319...61,858,043
Ensembl chr 4:61,831,319...61,835,233
JBrowse link
G Mx2 MX dynamin-like GTPase 2 decreases expression ISO Cyclophosphamide results in decreased expression of MX2 mRNA CTD PMID:17403535 NCBI chr16:97,536,081...97,560,901
Ensembl chr16:97,535,308...97,560,900
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein affects response to substance ISO MXI1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr19:53,310,128...53,373,293
Ensembl chr19:53,310,518...53,375,810
JBrowse link
G Myh10 myosin, heavy polypeptide 10, non-muscle affects response to substance ISO MYH10 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr11:68,691,915...68,816,626
Ensembl chr11:68,691,559...68,816,632
JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of NAIP mRNA CTD PMID:16322899 NCBI chr13:100,144,063...100,202,122
Ensembl chr13:100,144,063...100,202,092
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression EXP Cyclophosphamide results in increased expression of NAMPT mRNA CTD PMID:21041162 NCBI chr12:32,820,335...32,853,369
Ensembl chr12:32,819,545...32,853,349
JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr19:60,755,987...60,759,914
Ensembl chr19:60,755,987...60,759,914
JBrowse link
G Nasp nuclear autoantigenic sperm protein (histone-binding) increases expression ISO Cyclophosphamide results in increased expression of NASP mRNA CTD PMID:16141653 NCBI chr 4:116,601,052...116,628,676
Ensembl chr 4:116,601,052...116,627,941
JBrowse link
G Ncoa7 nuclear receptor coactivator 7 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of NCOA7 mRNA CTD PMID:24356939 NCBI chr10:30,645,582...30,807,700
Ensembl chr10:30,628,999...30,803,326
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression EXP Cyclophosphamide results in decreased expression of NDUFS2 mRNA CTD PMID:15331540 NCBI chr 1:171,234,853...171,251,686
Ensembl chr 1:171,234,853...171,251,388
JBrowse link
G Neto2 neuropilin (NRP) and tolloid (TLL)-like 2 increases expression ISO Cyclophosphamide results in increased expression of NETO2 mRNA CTD PMID:21527772 NCBI chr 8:85,636,718...85,700,952
Ensembl chr 8:85,636,588...85,700,924
JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 decreases expression EXP Cyclophosphamide results in decreased expression of NFATC3 mRNA CTD PMID:21041162 NCBI chr 8:106,058,818...106,130,537
Ensembl chr 8:106,058,840...106,130,537
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases response to substance
increases expression
decreases expression
ISO
EXP
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]
NFE2L2 gene mutant form results in increased susceptibility to Cyclophosphamide
Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Cyclophosphamide results in increased expression of NFE2L2 protein
CTD PMID:20038455 PMID:20433640 PMID:27633142 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfe2l3 nuclear factor, erythroid derived 2, like 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of NFE2L3 mRNA CTD PMID:24356939 NCBI chr 6:51,432,669...51,458,772
Ensembl chr 6:51,432,670...51,458,768
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases phosphorylation
EXP ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased phosphorylation of NFKBIA protein] CTD PMID:30506662 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta increases expression EXP Cyclophosphamide results in increased expression of NFKBIZ mRNA CTD PMID:15331540 NCBI chr16:55,811,375...55,838,954
Ensembl chr16:55,811,375...55,838,899
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
decreases expression
EXP
ISO
3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein]; Cyclophosphamide promotes the reaction [NGF results in increased expression of VEGFA mRNA]; VIP protein affects the reaction [Cyclophosphamide results in increased expression of NGF protein]
NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein]; rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein]
Cyclophosphamide results in increased expression of NGF mRNA; Cyclophosphamide results in increased expression of NGF protein
Cyclophosphamide results in decreased expression of NGF protein
CTD PMID:10683293 PMID:16879691 PMID:18299998 PMID:18632792 PMID:19996110 PMID:20127836 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013
JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) increases expression ISO Cyclophosphamide results in increased expression of NGFR mRNA; Cyclophosphamide results in increased expression of NGFR protein CTD PMID:8817519 PMID:18189308 PMID:18842820 NCBI chr11:95,568,818...95,587,698
Ensembl chr11:95,568,818...95,587,735
JBrowse link
G Nid1 nidogen 1 affects response to substance ISO NID1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr13:13,437,602...13,512,275
Ensembl chr13:13,437,551...13,512,269
JBrowse link
G Nkain1 Na+/K+ transporting ATPase interacting 1 multiple interactions ISO NKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 4:130,530,131...130,574,216
Ensembl chr 4:130,531,602...130,574,173
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO Cyclophosphamide results in increased expression of NME1 mRNA CTD PMID:11599041 NCBI chr11:93,958,925...93,968,272
Ensembl chr11:93,956,979...93,968,521
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression
multiple interactions
increases activity
EXP
ISO
Cyclophosphamide results in increased expression of NOS2 mRNA; Cyclophosphamide results in increased expression of NOS2 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Cyclophosphamide results in increased activity of NOS2 protein
Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; ginkgolide B inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
CTD PMID:9006340 PMID:10607705 PMID:11046124 PMID:15821589 PMID:16879691 PMID:18206168 PMID:18296739 PMID:18710439 PMID:19691848 PMID:21068404 PMID:25753322 PMID:29753871 PMID:32197949 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases activity
increases expression
ISO Cyclophosphamide results in decreased activity of NOS3 protein
Cyclophosphamide results in increased expression of NOS3 protein
CTD PMID:9006340 PMID:16125470 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nppb natriuretic peptide type B increases expression ISO Cyclophosphamide results in increased expression of NPPB protein CTD PMID:17562616 PMID:18548196 PMID:18999883 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Nprl2 NPR2 like, GATOR1 complex subunit decreases expression ISO Cyclophosphamide results in decreased expression of NPRL2 mRNA CTD PMID:20849824 NCBI chr 9:107,542,177...107,545,706
Ensembl chr 9:107,542,226...107,545,706
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 decreases expression
multiple interactions
increases expression
ISO
EXP
Cyclophosphamide results in decreased expression of NQO1 mRNA; Cyclophosphamide results in decreased expression of NQO1 protein
Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Cyclophosphamide results in increased expression of NQO1 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
CTD PMID:11906922 PMID:20038455 PMID:20433640 PMID:21041162 PMID:27633142 PMID:32197949 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Cyclophosphamide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Cyclophosphamide results in increased activity of NR1I2 protein
[Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Cyclophosphamide binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Cyclophosphamide results in increased expression of ABCB1 protein]
CTD PMID:17041008 PMID:18839173 PMID:20041327 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CTD PMID:17041008 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 increases expression ISO Cyclophosphamide results in increased expression of NR2C2 mRNA CTD PMID:27281708 NCBI chr 6:92,091,418...92,173,058
Ensembl chr 6:92,091,390...92,174,294
JBrowse link
G Nrap nebulin-related anchoring protein increases expression ISO Cyclophosphamide results in increased expression of NRAP mRNA CTD PMID:27281708 NCBI chr19:56,320,037...56,390,062
Ensembl chr19:56,320,035...56,390,037
JBrowse link
G Nrd1 nardilysin, N-arginine dibasic convertase, NRD convertase 1 decreases expression ISO Cyclophosphamide results in decreased expression of NRD1 mRNA CTD PMID:27281708 NCBI chr 4:109,000,655...109,061,777
Ensembl chr 4:109,000,655...109,061,777
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Cyclophosphamide results in increased expression of NRG1 mRNA CTD PMID:21527772 NCBI chr 8:31,807,452...32,891,609
Ensembl chr 8:31,814,551...32,884,797
JBrowse link
G Nrp1 neuropilin 1 decreases expression
increases expression
EXP
ISO
Cyclophosphamide results in decreased expression of NRP1 mRNA
Cyclophosphamide results in increased expression of NRP1 mRNA
CTD PMID:15331540 PMID:18632792 NCBI chr 8:128,358,591...128,505,476
Ensembl chr 8:128,358,604...128,503,363
JBrowse link
G Nrp2 neuropilin 2 increases expression ISO Cyclophosphamide results in increased expression of NRP2 mRNA CTD PMID:18632792 NCBI chr 1:62,703,317...62,818,692
Ensembl chr 1:62,703,285...62,818,695
JBrowse link
G Nt5c2 5'-nucleotidase, cytosolic II increases expression ISO Cyclophosphamide results in increased expression of NT5C2 mRNA CTD PMID:20849824 NCBI chr19:46,885,390...47,015,174
Ensembl chr19:46,883,317...47,015,153
JBrowse link
G Ntf3 neurotrophin 3 increases expression ISO Cyclophosphamide results in increased expression of NTF3 mRNA CTD PMID:10683293 NCBI chr 6:126,101,412...126,166,772
Ensembl chr 6:126,101,412...126,166,910
JBrowse link
G Ntf5 neurotrophin 5 increases expression ISO Cyclophosphamide results in increased expression of NTF4 mRNA CTD PMID:10683293 NCBI chr 7:45,413,695...45,417,179
Ensembl chr 7:45,413,695...45,417,179
JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 multiple interactions ISO Cyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK1 protein CTD PMID:12412144 NCBI chr 3:87,778,244...87,795,242
Ensembl chr 3:87,778,244...87,795,162
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions ISO Cyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK2 protein CTD PMID:12412144 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Nupl2 nucleoporin like 2 increases expression ISO Cyclophosphamide results in increased expression of NUPL2 mRNA CTD PMID:27281708 NCBI chr 5:24,164,963...24,184,013
Ensembl chr 5:24,164,963...24,184,013
JBrowse link
G Ocln occludin multiple interactions
decreases expression
EXP Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of OCLN protein] CTD PMID:32151603 NCBI chr13:100,496,504...100,552,718
Ensembl chr13:100,496,507...100,552,718
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 increases expression ISO Cyclophosphamide results in increased expression of ODC1 mRNA CTD PMID:11599041 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases expression EXP Cyclophosphamide results in decreased expression of OGG1 protein CTD PMID:27032448 NCBI chr 6:113,326,972...113,334,877
Ensembl chr 6:113,326,972...113,335,068
JBrowse link
G Opn3 opsin 3 affects response to substance ISO OPN3 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 1:175,662,421...175,692,901
Ensembl chr 1:175,662,421...175,692,776
JBrowse link
G Osm oncostatin M affects expression EXP Cyclophosphamide affects the expression of OSM mRNA CTD PMID:12624490 NCBI chr11:4,236,785...4,241,026
Ensembl chr11:4,236,420...4,241,026
JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 increases expression
multiple interactions
ISO Cyclophosphamide results in increased expression of P2RX3 protein
GR 82334 inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein]; Suramin inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein]
CTD PMID:23666265 NCBI chr 2:84,996,549...85,037,108
Ensembl chr 2:84,998,583...85,037,462
JBrowse link
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 decreases expression ISO Cyclophosphamide results in decreased expression of P2RY2 mRNA CTD PMID:17403535 NCBI chr 7:100,996,568...101,012,053
Ensembl chr 7:100,996,568...101,012,866
JBrowse link
G Paip1 polyadenylate binding protein-interacting protein 1 decreases expression ISO Cyclophosphamide results in decreased expression of PAIP1 mRNA CTD PMID:20849824 NCBI chr13:119,428,331...119,460,323
Ensembl chr13:119,428,601...119,458,218
JBrowse link
G Pakap paralemmin A kinase anchor protein increases expression ISO Cyclophosphamide results in increased expression of PALM2AKAP2 mRNA CTD PMID:17403535 NCBI chr 4:57,434,475...57,896,984
Ensembl chr 4:57,717,657...57,896,984
Ensembl chr 4:57,717,657...57,896,984
Ensembl chr 4:57,717,657...57,896,984
JBrowse link
G Pard3 par-3 family cell polarity regulator decreases expression ISO Cyclophosphamide results in decreased expression of PARD3 mRNA CTD PMID:20849824 NCBI chr 8:127,063,381...127,612,286
Ensembl chr 8:127,063,893...127,612,286
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases expression
increases cleavage
decreases expression
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein
Cyclophosphamide results in increased expression of PARP1 mRNA
Cyclophosphamide results in increased cleavage of PARP1 protein
Cyclophosphamide results in decreased expression of PARP1 mRNA
CTD PMID:11599041 PMID:11723234 PMID:11906922 PMID:15582267 PMID:17898787 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen affects expression
multiple interactions
decreases expression
increases expression
ISO
EXP
Cyclophosphamide affects the expression of PCNA mRNA
coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA]
Cyclophosphamide results in decreased expression of PCNA protein
Cyclophosphamide results in increased expression of PCNA mRNA
CTD PMID:11056294 PMID:18246545 PMID:19701751 PMID:21041162 PMID:31557371 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 decreases expression EXP Cyclophosphamide results in decreased expression of PCSK2 mRNA CTD PMID:15331540 NCBI chr 2:143,546,133...143,816,284
Ensembl chr 2:143,546,156...143,816,285
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Cyclophosphamide results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr19:53,892,231...53,937,592
Ensembl chr19:53,892,231...53,929,860
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 decreases expression ISO Cyclophosphamide results in decreased expression of PDIA3 mRNA CTD PMID:11906922 NCBI chr 2:121,413,902...121,438,687
Ensembl chr 2:121,413,775...121,438,687
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 increases expression ISO Cyclophosphamide results in increased expression of PDIA4 mRNA CTD PMID:11599041 NCBI chr 6:47,796,141...47,813,512
Ensembl chr 6:47,796,141...47,813,430
JBrowse link
G Peli1 pellino 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of PELI1 mRNA CTD PMID:24356939 NCBI chr11:21,091,283...21,150,327
Ensembl chr11:21,091,291...21,150,323
JBrowse link
G Per1 period circadian clock 1 multiple interactions
decreases expression
EXP 5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in decreased expression of PER1 mRNA] CTD PMID:30760223 NCBI chr11:69,095,108...69,109,965
Ensembl chr11:69,095,217...69,109,960
JBrowse link
G Phlda2 pleckstrin homology like domain, family A, member 2 increases expression ISO Cyclophosphamide results in increased expression of PHLDA2 mRNA CTD PMID:17403535 NCBI chr 7:143,501,545...143,503,145
Ensembl chr 7:143,501,545...143,503,150
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis ISO Cyclophosphamide results in increased mutagenesis of PIGA CTD PMID:22923490 NCBI chr  X:164,419,780...164,433,916
Ensembl chr  X:164,419,787...164,433,916
JBrowse link
G Pigr polymeric immunoglobulin receptor increases expression EXP Cyclophosphamide results in increased expression of PIGR mRNA CTD PMID:15331540 NCBI chr 1:130,826,684...130,852,249
Ensembl chr 1:130,826,684...130,852,249
JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) increases expression EXP Cyclophosphamide results in increased expression of PLA2G4A mRNA CTD PMID:21041162 NCBI chr 1:149,829,618...149,961,290
Ensembl chr 1:149,829,618...149,961,290
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Cyclophosphamide results in increased expression of PLAU mRNA CTD PMID:21527772 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of PLOD1 mRNA CTD PMID:16322899 NCBI chr 4:147,909,753...147,936,776
Ensembl chr 4:147,909,753...147,936,767
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of PLOD3 mRNA CTD PMID:16322899 NCBI chr 5:136,987,019...136,996,646
Ensembl chr 5:136,987,019...136,996,648
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component increases expression ISO Cyclophosphamide results in increased expression of PMS1 mRNA CTD PMID:11056294 NCBI chr 1:53,189,187...53,297,031
Ensembl chr 1:53,189,187...53,297,018
JBrowse link
G Pms2 PMS1 homolog2, mismatch repair system component decreases expression ISO Cyclophosphamide results in decreased expression of PMS2 mRNA CTD PMID:11056294 NCBI chr 5:143,909,901...143,972,745
Ensembl chr 5:143,909,964...143,933,968
JBrowse link
G Polm polymerase (DNA directed), mu increases expression ISO Cyclophosphamide results in increased expression of POLM mRNA CTD PMID:20849824 NCBI chr11:5,827,860...5,838,832
Ensembl chr11:5,827,860...5,838,016
JBrowse link
G Pomc pro-opiomelanocortin-alpha increases expression ISO Cyclophosphamide results in increased expression of POMC protein CTD PMID:15276878 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Pon1 paraoxonase 1 increases activity ISO Cyclophosphamide results in increased activity of PON1 protein CTD PMID:17874068 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases expression
ISO POR promotes the reaction [CYP2B6 results in increased susceptibility to Cyclophosphamide]; POR promotes the reaction [CYP2C18 results in increased susceptibility to Cyclophosphamide]; POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to Cyclophosphamide]
Cyclophosphamide results in increased expression of POR mRNA
CTD PMID:9766669 PMID:10919648 PMID:11599041 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Postn periostin, osteoblast specific factor decreases expression EXP Cyclophosphamide results in decreased expression of POSTN mRNA CTD PMID:15331540 NCBI chr 3:54,359,267...54,391,041
Ensembl chr 3:54,361,109...54,391,037
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
EXP Cyclophosphamide results in decreased expression of PPARA protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of PPARA protein]
CTD PMID:29753871 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression
increases expression
multiple interactions
ISO Cyclophosphamide results in decreased expression of PPARG mRNA
Cyclophosphamide results in increased expression of PPARG mRNA
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of PPARG mRNA]
CTD PMID:25446862 PMID:27281708 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Prdm13 PR domain containing 13 affects expression ISO Cyclophosphamide affects the expression of PRDM13 mRNA CTD PMID:27281708 NCBI chr 4:21,675,865...21,685,963
Ensembl chr 4:21,677,480...21,685,963
JBrowse link
G Prkcg protein kinase C, gamma decreases expression ISO Cyclophosphamide results in decreased expression of PRKCG mRNA CTD PMID:27281708 NCBI chr 7:3,303,532...3,331,099
Ensembl chr 7:3,289,179...3,331,099
JBrowse link
G Prlr prolactin receptor decreases expression EXP Cyclophosphamide results in decreased expression of PRLR mRNA CTD PMID:15331540 NCBI chr15:10,177,238...10,349,190
Ensembl chr15:10,177,238...10,349,180
JBrowse link
G Procr protein C receptor, endothelial increases expression ISO Cyclophosphamide results in increased expression of PROCR mRNA CTD PMID:21527772 NCBI chr 2:155,751,125...155,755,478
Ensembl chr 2:155,751,117...155,755,471
JBrowse link
G Prtn3 proteinase 3 decreases expression ISO Cyclophosphamide results in decreased expression of PRTN3 mRNA CTD PMID:17403535 NCBI chr10:79,879,667...79,883,174
Ensembl chr10:79,874,476...79,883,174
JBrowse link
G Psma5 proteasome subunit alpha 5 increases expression ISO Cyclophosphamide results in increased expression of PSMA5 protein CTD PMID:17475930 NCBI chr 3:108,256,926...108,279,952
Ensembl chr 3:108,256,926...108,279,974
JBrowse link
G Ptcra pre T cell antigen receptor alpha decreases expression EXP Cyclophosphamide results in decreased expression of PTCRA mRNA CTD PMID:21041162 NCBI chr17:46,755,663...46,763,712
Ensembl chr17:46,755,663...46,763,712
JBrowse link
G Ptger1 prostaglandin E receptor 1 (subtype EP1) decreases expression ISO Cyclophosphamide results in decreased expression of PTGER1 protein CTD PMID:20346049 NCBI chr 8:83,666,644...83,672,756
Ensembl chr 8:83,666,678...83,672,753
JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) multiple interactions
increases expression
ISO Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGER4 protein] CTD PMID:18514386 PMID:20346049 NCBI chr15:5,233,399...5,244,187
Ensembl chr15:5,206,661...5,244,187
JBrowse link
G Ptges3 prostaglandin E synthase 3 increases expression ISO Cyclophosphamide results in increased expression of PTGES3 mRNA CTD PMID:11599041 NCBI chr10:128,058,982...128,077,254
Ensembl chr10:128,058,954...128,077,272
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression EXP Cyclophosphamide results in increased expression of PTGS1 mRNA CTD PMID:21041162 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects response to substance
multiple interactions
increases expression
ISO
EXP
PTGS2 protein affects the susceptibility to Cyclophosphamide
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
Cyclophosphamide results in increased expression of PTGS2 mRNA; Cyclophosphamide results in increased expression of PTGS2 protein
Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]; parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
CTD PMID:12388444 PMID:15331540 PMID:16217747 PMID:17537839 PMID:18514386 PMID:19303104 PMID:25753322 PMID:29753871 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4a1 increases expression EXP Cyclophosphamide results in increased expression of PTP4A1 mRNA CTD PMID:15331540 NCBI chr 1:30,940,303...30,949,877
Ensembl chr 1:30,940,302...30,949,309
Ensembl chr 1:30,940,302...30,949,309
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C decreases expression EXP Cyclophosphamide results in decreased expression of PTPRC mRNA CTD PMID:21041162 NCBI chr 1:138,062,859...138,175,756
Ensembl chr 1:138,062,861...138,175,708
JBrowse link
G