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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biphenyl
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Accession:CHEBI:17097 term browser browse the term
Definition:A benzenoid aromatic compound that consists of two benzene rings connected by a single covalent bond. Biphenyl occurs naturally in coal tar, crude oil, and natural gas. Formerly used as a fungicide for citrus crops.
Synonyms:related_synonym: 1,1'-Biphenyl;   1,1'-Diphenyl;   E230;   Formula=C12H10;   InChI=1S/C12H10/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;   InChIKey=ZUOUZKKEUPVFJK-UHFFFAOYSA-N;   Phenylbenzene;   SMILES=c1ccc(cc1)-c1ccccc1
 alt_id: CHEBI:13909;   CHEBI:22887;   CHEBI:3113;   CHEBI:41238
 xref: Beilstein:1634058;   CAS:92-52-4;   Gmelin:3808;   HMDB:HMDB0034437;   KEGG:C06588
 xref_mesh: MESH:C010574
 xref: MetaCyc:BIPHENYL;   PDBeChem:BNL;   PMID:21337247;   PMID:21575716;   PPDB:82;   Pesticides:biphenyl;   Reaxys:1634058;   UM-BBD_compID:c0371;   Wikipedia:Biphenyl



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biphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases oxidation ISO CYP1A1 protein results in increased oxidation of diphenyl CTD PMID:27137136 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases oxidation
ISO diphenyl results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased oxidation of diphenyl
CTD PMID:15916432 PMID:27137136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO diphenyl binds to and results in decreased activity of CYP1B1 protein CTD PMID:19563207 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects binding
increases oxidation
ISO diphenyl binds to CYP2A13 protein
CYP2A13 protein results in increased oxidation of diphenyl
CTD PMID:27137136 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO diphenyl results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO diphenyl results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
biphenyl-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions
ISO 2-phenylphenol results in decreased activity of AR protein
2-phenylphenol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [2-phenylphenol results in increased activity of AR protein]
CTD PMID:15064155 PMID:18294747 PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2-phenylphenol results in increased expression of CYP1A1 mRNA CTD PMID:23665931 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO 2-phenylphenol binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
affects binding
increases expression
ISO 2-phenylphenol results in decreased expression of ESR1 mRNA
2-phenylphenol binds to ESR1 protein
2-phenylphenol results in increased expression of ESR1 mRNA
CTD PMID:12598185 PMID:12737316 PMID:12822488 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 2-phenylphenol results in increased expression of ESR2 mRNA CTD PMID:12737316 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 affects binding ISO 2-phenylphenol binds to FLT1 protein CTD PMID:32278787 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene] CTD PMID:10334203 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO 2-phenylphenol binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2-phenylphenol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2-phenylphenol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO 2-phenylphenol results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Pgr progesterone receptor increases expression ISO 2-phenylphenol results in increased expression of PGR mRNA CTD PMID:12822488 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO 2-phenylphenol results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Serpinb5 serpin family B member 5 affects binding ISO 2-phenylphenol binds to SERPINB5 protein CTD PMID:32278787 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2-phenylphenol binds to THRB protein CTD PMID:32278787 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 2-phenylphenol CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
G Vdr vitamin D receptor affects binding ISO 2-phenylphenol binds to VDR protein CTD PMID:32278787 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 2-phenylphenol results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
biphenyl-4,4'-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding ISO 4,4'-dihydroxybiphenyl binds to AR protein CTD PMID:12161000 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 4,4'-dihydroxybiphenyl binds to ESR1 protein CTD PMID:12161000 PMID:12753421 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [4,4'-dihydroxybiphenyl co-treated with Lipopolysaccharides] results in increased expression of PTGS2 CTD PMID:19528508 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
biphenyl-4-amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 4-biphenylamine binds to ALB protein CTD PMID:11697451 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Blm BLM RecQ like helicase multiple interactions
decreases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA] CTD PMID:32905825 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of BRCA1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]
CTD PMID:24857880 PMID:32905825 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 multiple interactions
decreases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA] CTD PMID:32905825 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA] CTD PMID:32905825 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne2 cyclin E2 decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of CCNE2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]
CTD PMID:32905825 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of CDK1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]
CTD PMID:32905825 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of CDK2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]
CTD PMID:32905825 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA] CTD PMID:32905825 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO 4-biphenylamine results in decreased expression of CHEK1 mRNA CTD PMID:24857880 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression ISO 4-biphenylamine results in decreased expression of CIDEA mRNA CTD PMID:24857880 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
ISO 4-biphenylamine results in increased expression of CREB1 protein
Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of CREB1 protein]; CREB1 protein affects the reaction [4-biphenylamine results in increased expression of MIR630 mRNA]
CTD PMID:32433928 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases oxidation EXP CYP1A1 protein results in increased oxidation of 4-biphenylamine CTD PMID:2908851 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases oxidation
multiple interactions
increases metabolic processing
affects metabolic processing
ISO
EXP
CYP1A2 protein results in increased activity of 4-biphenylamine
CYP1A2 protein results in increased oxidation of 4-biphenylamine
[furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 4-biphenylamine; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine
CYP1A2 protein results in increased metabolism of 4-biphenylamine
CYP1A2 protein affects the metabolism of 4-biphenylamine
CTD PMID:2655891 PMID:2908851 PMID:11376689 PMID:15450435 PMID:16988941 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO CYP2A13 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine CTD PMID:16988941 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases oxidation EXP CYP2B1 protein results in increased oxidation of 4-biphenylamine CTD PMID:2908851 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation
increases expression
multiple interactions
decreases response to substance
ISO CYP2E1 protein results in increased hydroxylation of 4-biphenylamine
4-biphenylamine results in increased expression of CYP2E1 protein
[Propolis co-treated with allyl sulfide] inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein]; allyl sulfide inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein]; Propolis inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein]
[CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen Species
CYP2E1 gene mutant form results in decreased susceptibility to 4-biphenylamine
CTD PMID:25601990 PMID:33847444 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 increases reduction ISO CYP2S1 protein results in increased reduction of 4-biphenylamine analog CTD PMID:23682735 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 4-biphenylamine results in increased expression of DDIT3 mRNA CTD PMID:24857880 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Exo1 exonuclease 1 decreases expression ISO 4-biphenylamine results in decreased expression of EXO1 mRNA CTD PMID:24857880 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Fancg FA complementation group G decreases expression ISO 4-biphenylamine results in decreased expression of FANCG mRNA; 4-biphenylamine results in decreased expression of FANCG protein CTD PMID:24857880 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of FEN1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]
CTD PMID:24857880 PMID:32905825 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO 4-biphenylamine results in increased expression of GADD45G mRNA CTD PMID:24857880 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; Propolis inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein] CTD PMID:32433928 PMID:32905825 PMID:33847444 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H3f4 H3.4 histone decreases methylation
multiple interactions
ISO 4-biphenylamine results in decreased methylation of H3-4 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein
CTD PMID:17468514 NCBI chr10:43,740,797...43,741,207 JBrowse link
G Hdac2 histone deacetylase 2 decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of HDAC2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]
CTD PMID:32905825 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene CTD PMID:22114069 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis ISO 4-biphenylamine results in increased mutagenesis of HRAS gene CTD PMID:15761837 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Il6 interleukin 6 increases expression ISO 4-biphenylamine results in increased expression of IL6 protein CTD PMID:27746196 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ip6k3 inositol hexakisphosphate kinase 3 decreases expression ISO 4-biphenylamine results in decreased expression of IP6K3 mRNA CTD PMID:24857880 NCBI chr20:5,223,863...5,245,443
Ensembl chr20:5,224,120...5,245,428
JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein CTD PMID:17468514 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO 4-biphenylamine results in decreased expression of LIG1 mRNA CTD PMID:24857880 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
JBrowse link
G Lig4 DNA ligase 4 increases expression
multiple interactions
ISO 4-biphenylamine results in increased expression of LIG4 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]
CTD PMID:32905825 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of MCM8 protein] CTD PMID:32433928 NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions
ISO 4-biphenylamine results in increased expression of MDM2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]
CTD PMID:32905825 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mir17 microRNA 17 increases expression ISO 4-biphenylamine results in increased expression of MIR17 mRNA CTD PMID:24857880 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
JBrowse link
G Mir18a microRNA 18a increases expression ISO 4-biphenylamine results in increased expression of MIR18A mRNA CTD PMID:24857880 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
JBrowse link
G Mir20b microRNA 20b increases expression ISO 4-biphenylamine results in increased expression of MIR20B mRNA CTD PMID:24857880 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282
JBrowse link
G Mir21 microRNA 21 increases expression ISO 4-biphenylamine results in increased expression of MIR21 mRNA CTD PMID:24857880 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir22 microRNA 22 increases expression ISO 4-biphenylamine results in increased expression of MIR22 mRNA CTD PMID:24857880 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO 4-biphenylamine results in increased expression of MIR372 mRNA CTD PMID:24857880 NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646
JBrowse link
G Mir29a microRNA 29a increases expression ISO 4-biphenylamine results in increased expression of MIR29A mRNA CTD PMID:24857880 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir320a microRNA 320a increases expression ISO 4-biphenylamine results in increased expression of MIR320A mRNA CTD PMID:24857880 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
JBrowse link
G Mir340-1 microRNA mir-340-1 increases expression ISO 4-biphenylamine results in increased expression of MIR340 mRNA CTD PMID:24857880 NCBI chr10:34,393,568...34,393,665
Ensembl chr10:34,393,568...34,393,665
JBrowse link
G Mir425 microRNA 425 increases expression ISO 4-biphenylamine results in increased expression of MIR425 mRNA CTD PMID:24857880 NCBI chr 8:109,264,555...109,264,637
Ensembl chr 8:109,264,555...109,264,637
JBrowse link
G Mir431 microRNA 431 increases expression ISO 4-biphenylamine results in increased expression of MIR431 mRNA CTD PMID:24857880 NCBI chr 6:128,544,210...128,544,323
Ensembl chr 6:128,544,210...128,544,323
JBrowse link
G Mir494 microRNA 494 increases expression ISO 4-biphenylamine results in increased expression of MIR494 mRNA CTD PMID:24857880 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
JBrowse link
G Mir7-1 microRNA 7-1 increases expression ISO 4-biphenylamine results in increased expression of MIR7-1 mRNA CTD PMID:24857880 NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360
JBrowse link
G Mir874 microRNA 874 increases expression ISO 4-biphenylamine results in increased expression of MIR874 mRNA CTD PMID:24857880 NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724
JBrowse link
G Mir93 microRNA 93 increases expression ISO 4-biphenylamine results in increased expression of MIR93 mRNA CTD PMID:24857880 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
JBrowse link
G Mirlet7b microRNA let-7b increases expression ISO 4-biphenylamine results in increased expression of MIRLET7B mRNA CTD PMID:24857880 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of 4-biphenylamine CTD PMID:9288889 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO 4-biphenylamine results in decreased expression of MSH2 mRNA CTD PMID:24857880 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Nat1 N-acetyltransferase 1 increases activity
increases metabolic processing
increases acetylation
multiple interactions
increases response to substance
affects response to substance
ISO NAT1 protein results in increased activity of 4-biphenylamine
NAT1 protein results in increased metabolism of 4-biphenylamine
NAT1 protein polymorphism results in increased acetylation of 4-biphenylamine; NAT1 protein results in increased acetylation of 4-biphenylamine
[NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene
NAT1 polymorphism results in increased susceptibility to 4-biphenylamine; NAT1 protein polymorphism results in increased susceptibility to 4-biphenylamine
NAT1 mRNA alternative form affects the susceptibility to 4-biphenylamine
CTD PMID:12088197 PMID:15450435 PMID:16815960 PMID:21837760 PMID:22010219 More... NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
increases metabolic processing
affects response to substance
decreases activity
multiple interactions
increases activity
ISO
EXP
NAT2 protein results in increased acetylation of 4-biphenylamine
NAT2 protein results in increased metabolism of 4-biphenylamine
NAT2 gene polymorphism affects the susceptibility to 4-biphenylamine
4-biphenylamine results in decreased activity of NAT2 protein
4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-biphenylamine]
NAT2 protein results in increased activity of 4-biphenylamine
CTD PMID:12222688 PMID:15450435 PMID:16815960 PMID:16857729 PMID:18842621 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO 4-biphenylamine results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:25601990 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of OGG1 mRNA; 4-biphenylamine results in decreased expression of OGG1 protein
Propolis inhibits the reaction [4-biphenylamine results in decreased expression of OGG1 protein]
CTD PMID:16112689 PMID:33847444 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO 4-biphenylamine results in decreased expression of PCNA mRNA CTD PMID:24857880 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of POLD3 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]
CTD PMID:32905825 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of PRKDC mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]
CTD PMID:32905825 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 4-biphenylamine CTD PMID:11159734 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of 4-biphenylamine CTD PMID:11159734 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of RAD18 mRNA; 4-biphenylamine results in decreased expression of RAD18 protein
Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of RAD18 protein]
CTD PMID:24857880 PMID:32433928 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
JBrowse link
G Rad51 RAD51 recombinase decreases expression
multiple interactions
ISO 4-biphenylamine results in decreased expression of RAD51 mRNA; 4-biphenylamine results in decreased expression of RAD51 protein
Propolis inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]
CTD PMID:24857880 PMID:32905825 PMID:33847444 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rad54b RAD54 homolog B multiple interactions
decreases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA] CTD PMID:32905825 NCBI chr 5:25,030,885...25,104,616
Ensembl chr 5:25,032,066...25,104,616
JBrowse link
G Rpa1 replication protein A1 decreases expression ISO 4-biphenylamine results in decreased expression of RPA1 mRNA CTD PMID:24857880 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rpa2 replication protein A2 multiple interactions
increases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA] CTD PMID:32905825 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
decreases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA] CTD PMID:32905825 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO 4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO 4-biphenylamine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol] CTD PMID:17433394 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tp53 tumor protein p53 affects response to substance
multiple interactions
decreases expression
affects expression
affects binding
ISO TP53 protein affects the susceptibility to 4-biphenylamine
Acetylcysteine affects the reaction [4-biphenylamine affects the expression of TP53 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA]
4-biphenylamine results in decreased expression of TP53 mRNA
4-biphenylamine binds to TP53 gene
CTD PMID:11804609 PMID:12376482 PMID:32905825 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions
increases expression
ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA] CTD PMID:32905825 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Tp73 tumor protein p73 decreases expression ISO 4-biphenylamine results in decreased expression of TP73 mRNA CTD PMID:24857880 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Trex1 three prime repair exonuclease 1 decreases expression ISO 4-biphenylamine results in decreased expression of TREX1 mRNA CTD PMID:24857880 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
multiple interactions
ISO UGT1A4 protein results in increased glucuronidation of 4-biphenylamine
[Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine; hecogenin inhibits the reaction [UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine]; UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine
CTD PMID:15840509 PMID:17080401 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions
ISO UGT1A9 protein results in increased glucuronidation of 4-biphenylamine
[Alamethicin results in increased activity of UGT1A9 protein] which affects the glucuronidation of 4-biphenylamine
CTD PMID:15840509 PMID:17080401 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO 4-biphenylamine results in decreased expression of UNG mRNA CTD PMID:24857880 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Xrcc2 X-ray repair cross complementing 2 decreases expression ISO 4-biphenylamine results in decreased expression of XRCC2 mRNA CTD PMID:24857880 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 decreases expression ISO 4-biphenylamine results in decreased expression of XRCC3 mRNA CTD PMID:24857880 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 multiple interactions
decreases expression
ISO Propolis inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA]
4-biphenylamine results in decreased expression of XRCC5 mRNA; 4-biphenylamine results in decreased expression of XRCC5 protein
CTD PMID:32905825 PMID:33847444 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions
decreases expression
ISO Propolis inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA]
4-biphenylamine results in decreased expression of XRCC6 mRNA; 4-biphenylamine results in decreased expression of XRCC6 protein
CTD PMID:32905825 PMID:33847444 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
JBrowse link
flurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Flurbiprofen results in decreased expression of ACTA1 mRNA CTD PMID:16949054 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 decreases expression ISO Flurbiprofen results in decreased expression of AKR1B7 mRNA CTD PMID:16949054 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Flurbiprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flurbiprofen results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity
ISO [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol CTD PMID:19010312 PMID:21187079 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:16949054 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin affects binding ISO Flurbiprofen binds to ALB protein CTD PMID:9353694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Flurbiprofen results in decreased expression of ALDH7A1 mRNA CTD PMID:16949054 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression ISO Flurbiprofen results in increased expression of ANP32A mRNA CTD PMID:16949054 Ensembl chr 8:62,827,456...62,865,443 JBrowse link
G Anxa1 annexin A1 increases expression ISO Flurbiprofen results in increased expression of ANXA1 mRNA CTD PMID:16949054 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa3 annexin A3 increases expression ISO Flurbiprofen results in increased expression of ANXA3 mRNA CTD PMID:16949054 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Apod apolipoprotein D increases expression ISO Flurbiprofen results in increased expression of APOD mRNA CTD PMID:16949054 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Apof apolipoprotein F increases expression ISO Flurbiprofen results in increased expression of APOF mRNA CTD PMID:16949054 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
JBrowse link
G App amyloid beta precursor protein affects cleavage
multiple interactions
decreases secretion
ISO
EXP
Flurbiprofen affects the cleavage of APP protein
Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium]
alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein]
CTD PMID:14690522 PMID:17292621 PMID:18648507 PMID:19659691 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arg1 arginase 1 decreases expression ISO Flurbiprofen results in decreased expression of ARG1 mRNA CTD PMID:16949054 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases activity EXP Flurbiprofen results in decreased activity of ASIC1 protein CTD PMID:11588175 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Flurbiprofen results in increased expression of BIRC5 mRNA CTD PMID:16949054 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Flurbiprofen results in increased expression of BNIP3 mRNA CTD PMID:16949054 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein] CTD PMID:8581270 PMID:11166334 PMID:12044622 PMID:12791437 PMID:14991081 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Flurbiprofen results in decreased expression of CCNB1 protein CTD PMID:11687965 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Flurbiprofen results in increased expression of CEACAM1 mRNA CTD PMID:16949054 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Ces3a carboxylesterase 3a decreases expression ISO Flurbiprofen results in decreased expression of CES3 mRNA CTD PMID:16949054 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Flurbiprofen results in increased expression of CITED2 mRNA CTD PMID:16949054 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase increases expression ISO Flurbiprofen results in increased expression of CMAS mRNA CTD PMID:16949054 NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 increases expression ISO Flurbiprofen results in increased expression of CMPK2 mRNA CTD PMID:16949054 NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
JBrowse link
G Crisp1 cysteine-rich secretory protein 1 decreases expression ISO Flurbiprofen results in decreased expression of CRISP1 mRNA CTD PMID:16949054 NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO
EXP
Flurbiprofen results in decreased activity of CYP17A1 protein CTD PMID:31184881 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO Flurbiprofen results in decreased expression of CYP24A1 mRNA CTD PMID:16949054 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases expression ISO Flurbiprofen results in increased expression of CYP2F2 mRNA CTD PMID:16949054 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Defb1 defensin beta 1 decreases expression ISO Flurbiprofen results in decreased expression of DEFB1 mRNA CTD PMID:16949054 NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
JBrowse link
G Egf epidermal growth factor increases expression ISO Flurbiprofen results in increased expression of EGF mRNA CTD PMID:16949054 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions
ISO Flurbiprofen results in increased phosphorylation of EIF4E protein
MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein]
CTD PMID:18056468 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
increases expression
ISO ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]
Flurbiprofen results in increased expression of ELAVL1 protein
CTD PMID:18056468 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Eln elastin decreases expression ISO Flurbiprofen results in decreased expression of ELN mRNA CTD PMID:16949054 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression ISO Flurbiprofen results in decreased expression of ENPP2 mRNA CTD PMID:16949054 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Flurbiprofen results in decreased activity of FAAH protein CTD PMID:12751821 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Folr1 folate receptor alpha decreases expression ISO Flurbiprofen results in decreased expression of FOLR1 mRNA CTD PMID:16949054 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]; Flurbiprofen promotes the reaction [Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]]; Urethane inhibits the reaction [Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]]
Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]
CTD PMID:10864209 PMID:11164833 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO Flurbiprofen results in increased expression of GDF15 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]
CTD PMID:21097678 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Flurbiprofen results in decreased expression of GPX3 mRNA CTD PMID:16949054 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression ISO Flurbiprofen results in increased expression of GSTO1 mRNA CTD PMID:16949054 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein] CTD PMID:6696821 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Flurbiprofen results in increased expression of HELLS mRNA CTD PMID:16949054 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases degradation
increases expression
multiple interactions
increases activity
ISO Flurbiprofen results in decreased degradation of HPGD protein
Flurbiprofen results in increased expression of HPGD mRNA
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein
Flurbiprofen results in increased activity of HPGD protein
CTD PMID:19501039 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO Flurbiprofen results in increased expression of HSD11B2 mRNA CTD PMID:16949054 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Flurbiprofen results in increased expression of ICAM1 protein CTD PMID:16020654 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Flurbiprofen results in increased expression of IFIT2 mRNA CTD PMID:16949054 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
JBrowse link
G Ifng interferon gamma multiple interactions ISO Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] CTD PMID:19659691 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:10903797 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]; Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] CTD PMID:12110441 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]
CTD PMID:11112151 PMID:12517972 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10903797 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO Flurbiprofen results in decreased expression of KCNN4 mRNA CTD PMID:16949054 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]] CTD PMID:11166334 PMID:12791437 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Lgals3 galectin 3 increases expression ISO Flurbiprofen results in increased expression of LGALS3 mRNA CTD PMID:16949054 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lgals9 galectin 9 decreases expression ISO Flurbiprofen results in decreased expression of LGALS9 mRNA CTD PMID:16949054 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Testosterone] CTD PMID:31184881 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP Flurbiprofen results in decreased expression of LHCGR mRNA; Flurbiprofen results in decreased expression of LHCGR protein CTD PMID:31184881 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Flurbiprofen results in increased expression of LMO7 mRNA CTD PMID:16949054 NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lto1 LTO1 maturation factor of ABCE1 decreases expression ISO Flurbiprofen results in decreased expression of LTO1 mRNA CTD PMID:16949054 NCBI chr 1:200,074,247...200,080,951
Ensembl chr 1:200,074,253...200,088,061
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:19501039 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468 PMID:21097678 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:19501039 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO Flurbiprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 multiple interactions ISO MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA
Flurbiprofen results in decreased expression of MMP9 mRNA
CTD PMID:19501039 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msmb microseminoprotein, beta increases expression ISO Flurbiprofen results in increased expression of MSMB mRNA CTD PMID:16949054 NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11099482 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO Flurbiprofen results in increased expression of NFKBIZ mRNA CTD PMID:16949054 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions
increases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Flurbiprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]
Flurbiprofen results in increased expression of NGFR mRNA; Flurbiprofen results in increased expression of NGFR protein
CTD PMID:17409433 PMID:17447067 PMID:18056468 PMID:21097678 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Flurbiprofen results in increased expression of NOS2 mRNA
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD PMID:8528547 PMID:11405284 PMID:16944022 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity ISO Flurbiprofen results in increased activity of NQO1 protein CTD PMID:8572925 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Flurbiprofen results in increased expression of PAPSS2 mRNA CTD PMID:16949054 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression ISO Flurbiprofen results in decreased expression of PCP4 mRNA CTD PMID:16949054 NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Flurbiprofen results in increased expression of PDZK1 mRNA CTD PMID:16949054 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514
JBrowse link
G Penk proenkephalin decreases expression ISO Flurbiprofen results in decreased expression of PENK mRNA CTD PMID:16949054 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Flurbiprofen results in increased expression of PIK3C3 mRNA CTD PMID:16949054 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] CTD PMID:15878913 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Psca prostate stem cell antigen multiple interactions
increases expression
ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO
EXP
Flurbiprofen results in decreased activity of PTGS1 protein CTD PMID:9233713 PMID:9258749 PMID:18848576 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
decreases degradation
increases expression
decreases expression
EXP
ISO
Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 protein]
Flurbiprofen results in decreased activity of PTGS2 protein
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]
Flurbiprofen results in decreased degradation of PTGS2 protein; Flurbiprofen results in decreased degradation of PTGS2 protein mutant form
Flurbiprofen results in decreased activity of PTGS2 protein; Flurbiprofen results in decreased activity of PTGS2 protein mutant form
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen results in increased expression of PTGS2 mRNA; Flurbiprofen results in increased expression of PTGS2 protein
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Flurbiprofen results in increased expression of and results in increased activity of PTGS2 protein
Flurbiprofen results in decreased expression of PTGS2 mRNA
CTD PMID:9099957 PMID:9258749 PMID:9321948 PMID:10594327 PMID:11095985 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Flurbiprofen inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
Flurbiprofen inhibits the reaction [Zymosan results in increased localization of and results in increased activity of RELA protein]
CTD PMID:11099482 PMID:11291649 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhog ras homolog family member G increases expression ISO Flurbiprofen results in increased expression of RHOG mRNA CTD PMID:16949054 NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257
JBrowse link
G Rhou ras homolog family member U increases expression ISO Flurbiprofen results in increased expression of RHOU mRNA CTD PMID:16949054 NCBI chr19:51,641,408...51,651,249
Ensembl chr19:51,641,227...51,650,552
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Flurbiprofen inhibits the reaction [alitretinoin binds to RXRA protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sell selectin L decreases expression ISO Flurbiprofen results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 decreases expression ISO Flurbiprofen results in decreased expression of SMOC2 mRNA CTD PMID:16949054 NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Flurbiprofen results in increased expression of SOX2 mRNA CTD PMID:16949054 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Flurbiprofen results in decreased expression of SRD5A1 mRNA; Flurbiprofen results in decreased expression of SRD5A1 protein CTD PMID:31184881 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Tgoln2 trans-golgi network protein 2 increases expression ISO Flurbiprofen results in increased expression of TGOLN2 mRNA CTD PMID:16949054 NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA] CTD PMID:10357836 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Flurbiprofen results in increased expression of TIMP1 protein
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA
CTD PMID:19501039 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Flurbiprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]
CTD PMID:10903797 PMID:19659691 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
decreases response to substance
increases expression
ISO Flurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 protein
TP53 protein results in increased susceptibility to Flurbiprofen
TP53 protein mutant form results in decreased susceptibility to Flurbiprofen
Flurbiprofen results in increased expression of TP53 protein
CTD PMID:11687965 PMID:15710360 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO Flurbiprofen results in decreased expression of TWIST1 mRNA CTD PMID:16949054 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Tyms thymidylate synthetase increases expression ISO Flurbiprofen results in increased expression of TYMS mRNA CTD PMID:16949054 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15117964 PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
N-hydroxy-4-acetylaminobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nat1 N-acetyltransferase 1 decreases activity ISO N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT1 protein CTD PMID:15720122 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nat2 N-acetyltransferase 2 decreases activity ISO N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein CTD PMID:19842618 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
N-hydroxy-4-aminobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene CTD PMID:11275476 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Nat2 N-acetyltransferase 2 increases metabolic processing ISO NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl CTD PMID:16857729 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases sulfation
ISO N-hydroxy-4-aminobiphenyl inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]
SULT1A1 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl
CTD PMID:17433394 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a increases sulfation ISO SULT1C2 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl CTD PMID:17433394 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of TP53 gene CTD PMID:11275476 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
nitroflurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 decreases expression ISO nitroflurbiprofen results in decreased expression of CASP1 mRNA CTD PMID:15081244 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] CTD PMID:16491094 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:16491094 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:16491094 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
nitroflurbiprofen results in decreased expression of NOS2 mRNA
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:8528547 PMID:15081244 PMID:16491094 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen results in decreased activity of RELA protein
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
CTD PMID:12716482 PMID:16491094 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:12716482 PMID:16491094 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        antimicrobial agent 17788
          antimicrobial food preservative 11946
            biphenyl 198
              N-(\{4'-[(1-benzofuran-2-ylcarbonyl)amino]biphenyl-4-yl\}sulfonyl)-L-valine 0
              bifenazate 0
              biphenyl-2-ol 22
              biphenyl-4,4'-diol + 3
              biphenyl-4-amine + 82
              biphenyl-4-yl group + 0
              diphenic acid 0
              flurbiprofen + 108
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic molecule 19835
                              organic cyclic compound 19589
                                carbocyclic compound 18528
                                  benzenoid aromatic compound 17772
                                    benzenes 17582
                                      biphenyl 198
                                        N-(\{4'-[(1-benzofuran-2-ylcarbonyl)amino]biphenyl-4-yl\}sulfonyl)-L-valine 0
                                        bifenazate 0
                                        biphenyl-2-ol 22
                                        biphenyl-4,4'-diol + 3
                                        biphenyl-4-amine + 82
                                        biphenyl-4-yl group + 0
                                        diphenic acid 0
                                        flurbiprofen + 108
paths to the root