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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-hydroxyglutaric acid
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Accession:CHEBI:17084 term browser browse the term
Definition:A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Synonyms:exact_synonym: 2-hydroxypentanedioic acid
 related_synonym: Formula=C5H8O5;   InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10);   InChIKey=HWXBTNAVRSUOJR-UHFFFAOYSA-N;   SMILES=OC(CCC(O)=O)C(O)=O;   alpha-hydroxyglutaric acid
 alt_id: CHEBI:1160
 xref: Beilstein:1723805;   CAS:2889-31-8;   KEGG:C02630
 xref_mesh: MESH:C019417
 xref: MetaCyc:2-HYDROXYGLUTARIC_ACID;   PMID:17439666;   Reaxys:1723805;   Wikipedia:Alpha-Hydroxyglutaric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132941;   is_conjugate_acid_of CHEBI:36149


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2-hydroxyglutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH2 protein CTD PMID:28269980 NCBI chr12:48,257,575...48,262,244
Ensembl chr12:48,257,609...48,262,243
JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH3 protein CTD PMID:28269980 NCBI chr 3:82,874,242...82,907,467
Ensembl chr 3:82,874,248...82,906,581
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase increases metabolic processing ISO D2HGDH protein results in increased metabolism of alpha-hydroxyglutarate CTD PMID:15609246 NCBI chr 9:100,956,570...100,974,393
Ensembl chr 9:100,956,477...100,974,551
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO [epigallocatechin gallate results in decreased expression of GLUD1 protein] which results in decreased abundance of alpha-hydroxyglutarate CTD PMID:31857147 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 affects abundance ISO IDH1 gene mutant form affects the abundance of alpha-hydroxyglutarate CTD PMID:22057236 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase increases abundance ISO L2HGDH gene mutant form results in increased abundance of alpha-hydroxyglutarate CTD PMID:25800467 NCBI chr 6:92,016,560...92,057,643
Ensembl chr 6:92,016,622...92,057,816
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            2-hydroxyglutaric acid 7
              (R)-2-hydroxyglutaric acid 0
              (S)-2-hydroxyglutaric acid + 0
              2-hydroxyglutaryl-CoA + 0
              diethyl 2-hydroxypentanedioate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      dicarboxylic acids and O-substituted derivatives 10272
                                        dicarboxylic acid 10265
                                          alpha,omega-dicarboxylic acid 2774
                                            glutaric acid 12
                                              2-hydroxyglutaric acid 7
                                                (R)-2-hydroxyglutaric acid 0
                                                (S)-2-hydroxyglutaric acid + 0
                                                2-hydroxyglutaryl-CoA + 0
                                                diethyl 2-hydroxypentanedioate 0
paths to the root

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