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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-hydroxyglutaric acid
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Accession:CHEBI:17084 term browser browse the term
Definition:A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Synonyms:exact_synonym: 2-hydroxypentanedioic acid
 related_synonym: Formula=C5H8O5;   InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10);   InChIKey=HWXBTNAVRSUOJR-UHFFFAOYSA-N;   SMILES=OC(CCC(O)=O)C(O)=O;   alpha-hydroxyglutaric acid
 alt_id: CHEBI:1160
 xref: Beilstein:1723805;   CAS:2889-31-8;   HMDB:HMDB0059655;   KEGG:C02630
 xref_mesh: MESH:C019417
 xref: MetaCyc:2-HYDROXYGLUTARIC_ACID;   PMID:17439666;   Reaxys:1723805;   Wikipedia:Alpha-Hydroxyglutaric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132941;   is_conjugate_acid_of CHEBI:36149



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2-hydroxyglutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH2 protein CTD PMID:28269980 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914
JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH3 protein CTD PMID:28269980 NCBI chr 3:79,939,515...79,972,820
Ensembl chr 3:79,939,600...79,972,000
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase increases metabolic processing ISO D2HGDH protein results in increased metabolism of alpha-hydroxyglutarate CTD PMID:15609246 NCBI chr 9:94,350,555...94,368,384
Ensembl chr 9:94,350,576...94,368,382
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO [epigallocatechin gallate results in decreased expression of GLUD1 protein] which results in decreased abundance of alpha-hydroxyglutarate CTD PMID:31857147 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 affects abundance ISO IDH1 gene mutant form affects the abundance of alpha-hydroxyglutarate CTD PMID:22057236 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase increases abundance ISO L2HGDH gene mutant form results in increased abundance of alpha-hydroxyglutarate CTD PMID:25800467 NCBI chr 6:88,164,429...88,205,585
Ensembl chr 6:88,164,440...88,205,578
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        biochemical role 19533
          metabolite 19519
            2-hydroxyglutaric acid 7
              (R)-2-hydroxyglutaric acid 0
              (S)-2-hydroxyglutaric acid + 0
              2-hydroxyglutaryl-CoA + 0
              diethyl 2-hydroxypentanedioate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            heteroorganic entity 19495
                              organochalcogen compound 19257
                                organooxygen compound 19175
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18006
                                        fatty acid 16810
                                          fatty acid derivative 8970
                                            dicarboxylic fatty acid 2650
                                              glutaric acid 21
                                                2-hydroxyglutaric acid 7
                                                  (R)-2-hydroxyglutaric acid 0
                                                  (S)-2-hydroxyglutaric acid + 0
                                                  2-hydroxyglutaryl-CoA + 0
                                                  diethyl 2-hydroxypentanedioate 0
paths to the root