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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:streptomycin
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Accession:CHEBI:17076 term browser browse the term
Definition:A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class
Synonyms:exact_synonym: N,N'''-[(1R,2R,3S,4R,5R,6S)-4-{5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyloxy}-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine
 related_synonym: 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside;   Formula=C21H39N7O12;   InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1;   InChIKey=UCSJYZPVAKXKNQ-HZYVHMACSA-N;   Kantrex;   SM;   SMILES=CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@@H](O[C@@H](C)[C@]1(O)C=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]1NC(N)=N;   [2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine};   streomycin
 alt_id: CHEBI:15119;   CHEBI:26784;   CHEBI:45745;   CHEBI:9284
 xref: Beilstein:74498;   CAS:57-92-1;   DrugBank:DB01082;   Drug_Central:2481;   HMDB:HMDB0015214;   KEGG:C00413;   KEGG:D08531
 xref_mesh: MESH:D013307
 xref: MetaCyc:STREPTOMYCIN;   PDBeChem:SRY;   PMID:11228320;   PMID:11905029;   PMID:12118520;   PMID:13030054;   PMID:13116094;   PMID:13136149;   PMID:13596285;   PMID:13691614;   PMID:13985260;   PMID:13990247;   PMID:14623118;   PMID:14828344;   PMID:14852338;   PMID:14939639;   PMID:15081082;   PMID:15137533;   PMID:15207172;   PMID:15686853;   PMID:15736038;   PMID:16904706;   PMID:17105735;   PMID:17238915;   PMID:17429930;   PMID:18173084;   PMID:18916143;   PMID:19052412;   PMID:19335957;   PMID:21350946;   PMID:21362244;   PMID:21593257;   PMID:21937264;   PMID:22101040;   Pesticides:streptomycin;   Reaxys:74498;   Wikipedia:Streptomycin
 cyclic_relationship: is_conjugate_base_of CHEBI:58007


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streptomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxb9 homeo box B9 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Pax3 paired box 3 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Tcf15 transcription factor 15 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Streptomycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:17699551 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Uncx UNC homeobox multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          streptomycin 5
            3''-adenylylstreptomycin 0
            5'-hydroxystreptomycin 0
            streptomycin sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11947
                                        glycosyl compound 10977
                                          glycoside 9260
                                            aminoglycoside 8435
                                              aminoglycoside antibiotic 2536
                                                streptomycins 5
                                                  streptomycin 5
                                                    3''-adenylylstreptomycin 0
                                                    5'-hydroxystreptomycin 0
                                                    streptomycin sulfate 0
paths to the root