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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:streptomycin
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Accession:CHEBI:17076 term browser browse the term
Definition:A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class
Synonyms:exact_synonym: N,N'''-[(1R,2R,3S,4R,5R,6S)-4-{5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyloxy}-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine
 related_synonym: 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside;   Formula=C21H39N7O12;   InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1;   InChIKey=UCSJYZPVAKXKNQ-HZYVHMACSA-N;   Kantrex;   SM;   SMILES=CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@@H](O[C@@H](C)[C@]1(O)C=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]1NC(N)=N;   [2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine};   streomycin
 alt_id: CHEBI:15119;   CHEBI:26784;   CHEBI:45745;   CHEBI:9284
 xref: Beilstein:74498;   CAS:57-92-1;   DrugBank:DB01082;   Drug_Central:2481;   HMDB:HMDB0015214;   KEGG:C00413;   KEGG:D08531
 xref_mesh: MESH:D013307
 xref: MetaCyc:STREPTOMYCIN;   PDBeChem:SRY;   PMID:11228320;   PMID:11905029;   PMID:12118520;   PMID:13030054;   PMID:13116094;   PMID:13136149;   PMID:13596285;   PMID:13691614;   PMID:13985260;   PMID:13990247;   PMID:14623118;   PMID:14828344;   PMID:14852338;   PMID:14939639;   PMID:15081082;   PMID:15137533;   PMID:15207172;   PMID:15686853;   PMID:15736038;   PMID:16904706;   PMID:17105735;   PMID:17238915;   PMID:17429930;   PMID:18173084;   PMID:18916143;   PMID:19052412;   PMID:19335957;   PMID:21350946;   PMID:21362244;   PMID:21593257;   PMID:21937264;   PMID:22101040;   Pesticides:streptomycin;   Reaxys:74498;   Wikipedia:Streptomycin
 cyclic_relationship: is_conjugate_base_of CHEBI:58007


show annotations for term's descendants           Sort by:
 
streptomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxb9 homeo box B9 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
JBrowse link
G Pax3 paired box 3 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Tcf15 transcription factor 15 multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Streptomycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:17699551 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Uncx UNC homeobox multiple interactions ISO [Penicillins co-treated with Streptomycin] results in increased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          streptomycin 5
            3''-adenylylstreptomycin 0
            5'-hydroxystreptomycin 0
            streptomycin sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  carbohydrates and carbohydrate derivatives 12180
                                    carbohydrate 12180
                                      carbohydrate derivative 11804
                                        glycosyl compound 10848
                                          glycoside 9204
                                            aminoglycoside 8416
                                              aminoglycoside antibiotic 2529
                                                streptomycins 5
                                                  streptomycin 5
                                                    3''-adenylylstreptomycin 0
                                                    5'-hydroxystreptomycin 0
                                                    streptomycin sulfate 0
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