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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:biphenyl-2-ol
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Accession:CHEBI:17043 term browser browse the term
Definition:A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.
Synonyms:exact_synonym: [1,1'-biphenyl]-2-ol
 related_synonym: 2-Biphenylol;   2-Hydroxybiphenyl;   2-Phenylphenol;   Formula=C12H10O;   InChI=1S/C12H10O/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9,13H;   InChIKey=LLEMOWNGBBNAJR-UHFFFAOYSA-N;   Orthophenyl phenol;   SMILES=Oc1ccccc1-c1ccccc1;   o-diphenylol;   o-hydroxybiphenyl;   o-hydroxydiphenyl;   o-phenylphenol
 alt_id: CHEBI:1146;   CHEBI:11591;   CHEBI:19629
 xref: CAS:90-43-7;   Drug_Central:4768;   HMDB:HMDB0032582;   KEGG:C02499;   KEGG:D08367
 xref_mesh: MESH:C004369
 xref: PMID:14753781;   PMID:23156781;   PMID:23665931;   PMID:24525378;   PPDB:1340;   Reaxys:606907;   UM-BBD_compID:c0269;   Wikipedia:Biphenyl-2-ol


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biphenyl-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions		 ISO 2-phenylphenol results in decreased activity of AR protein
2-phenylphenol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [2-phenylphenol results in increased activity of AR protein]		 CTD PMID:15064155 PMID:18294747 PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2-phenylphenol results in increased expression of CYP1A1 mRNA CTD PMID:23665931 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO 2-phenylphenol binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
increases expression
affects binding		 ISO 2-phenylphenol results in decreased expression of ESR1 mRNA
2-phenylphenol results in increased expression of ESR1 mRNA
2-phenylphenol binds to ESR1 protein		 CTD PMID:12598185 PMID:12737316 PMID:12822488 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 2-phenylphenol results in increased expression of ESR2 mRNA CTD PMID:12737316 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 affects binding ISO 2-phenylphenol binds to FLT1 protein CTD PMID:32278787 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene] CTD PMID:10334203 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO 2-phenylphenol binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2-phenylphenol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2-phenylphenol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO 2-phenylphenol results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pgr progesterone receptor increases expression ISO 2-phenylphenol results in increased expression of PGR mRNA CTD PMID:12822488 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO 2-phenylphenol results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Serpinb5 serpin family B member 5 affects binding ISO 2-phenylphenol binds to SERPINB5 protein CTD PMID:32278787 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2-phenylphenol binds to THRB protein CTD PMID:32278787 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 2-phenylphenol CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Vdr vitamin D receptor affects binding ISO 2-phenylphenol binds to VDR protein CTD PMID:32278787 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 2-phenylphenol results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      chemical role 19529
        environmental contaminant 18891
          environmental food contaminant 5888
            biphenyl-2-ol 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                carbocyclic compound 18615
                                  benzenoid aromatic compound 18047
                                    benzenes 17914
                                      biphenyl 199
                                        biphenyl-2-ol 22
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