Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biphenyl-2-ol
go back to main search page
Accession:CHEBI:17043 term browser browse the term
Definition:A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.
Synonyms:related_synonym: 1,1'-Biphenyl-2-ol;   2-Biphenylol;   2-Hydroxybiphenyl;   2-Phenylphenol;   Formula=C12H10O;   InChI=1S/C12H10O/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9,13H;   InChIKey=LLEMOWNGBBNAJR-UHFFFAOYSA-N;   Orthophenyl phenol;   SMILES=Oc1ccccc1-c1ccccc1;   o-diphenylol;   o-hydroxybiphenyl;   o-hydroxydiphenyl;   o-phenylphenol
 alt_id: CHEBI:1146;   CHEBI:11591;   CHEBI:19629
 xref: CAS:90-43-7;   Drug_Central:4768;   HMDB:HMDB0032582;   KEGG:C02499;   KEGG:D08367
 xref_mesh: MESH:C004369
 xref: PMID:14753781;   PMID:23156781;   PMID:23665931;   PMID:24525378;   PPDB:1340;   Reaxys:606907;   UM-BBD_compID:c0269;   Wikipedia:Biphenyl-2-ol


show annotations for term's descendants           Sort by:
 
biphenyl-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions
ISO 2-phenylphenol results in decreased activity of AR protein
2-phenylphenol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [2-phenylphenol results in increased activity of AR protein]
CTD PMID:15064155 PMID:18294747 PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2-phenylphenol results in increased expression of CYP1A1 mRNA CTD PMID:23665931 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO 2-phenylphenol binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
affects binding
increases expression
ISO 2-phenylphenol results in decreased expression of ESR1 mRNA
2-phenylphenol binds to ESR1 protein
2-phenylphenol results in increased expression of ESR1 mRNA
CTD PMID:12598185 PMID:12737316 PMID:12822488 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 2-phenylphenol results in increased expression of ESR2 mRNA CTD PMID:12737316 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 affects binding ISO 2-phenylphenol binds to FLT1 protein CTD PMID:32278787 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene] CTD PMID:10334203 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO 2-phenylphenol binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2-phenylphenol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2-phenylphenol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO 2-phenylphenol results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Pgr progesterone receptor increases expression ISO 2-phenylphenol results in increased expression of PGR mRNA CTD PMID:12822488 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO 2-phenylphenol results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Serpinb5 serpin family B member 5 affects binding ISO 2-phenylphenol binds to SERPINB5 protein CTD PMID:32278787 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2-phenylphenol binds to THRB protein CTD PMID:32278787 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 2-phenylphenol CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
JBrowse link
G Vdr vitamin D receptor affects binding ISO 2-phenylphenol binds to VDR protein CTD PMID:32278787 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 2-phenylphenol results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      chemical role 19309
        environmental contaminant 18641
          environmental food contaminant 3413
            biphenyl-2-ol 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                carbocyclic compound 18273
                                  benzenoid aromatic compound 17320
                                    benzenes 17063
                                      biphenyl 178
                                        biphenyl-2-ol 22
paths to the root