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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:progesterone
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Accession:CHEBI:17026 term browser browse the term
Definition:A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Synonyms:exact_synonym: pregn-4-ene-3,20-dione
 related_synonym: (S)-4-Pregnene-3,20-dione;   (S)-Pregn-4-en-3,20-dione;   (S)-Progesterone;   17alpha-progesterone;   4-Pregnene-3,20-dione;   Agolutin;   Akrolutin;   Crinone;   Delta(4)-pregnene-3,20-dione;   Formula=C21H30O2;   Gelbkoerperhormon;   InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1;   InChIKey=RJKFOVLPORLFTN-LEKSSAKUSA-N;   Progesteron;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])C(C)=O;   corpus luteum hormone;   luteohormone
 alt_id: CHEBI:14896;   CHEBI:18798;   CHEBI:26269;   CHEBI:439;   CHEBI:45786;   CHEBI:8453
 xref: Beilstein:1915950;   CAS:57-83-0;   DrugBank:DB00396;   Drug_Central:2279;   Gmelin:708590;   HMDB:HMDB0001830;   KEGG:C00410;   KEGG:D00066
 xref_mesh: MESH:D011374
 xref: MetaCyc:PROGESTERONE;   PDBeChem:STR;   PMID:10438974;   PMID:9506942;   Reaxys:1915950;   Wikipedia:Progesterone


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progesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 affects expression EXP Progesterone affects the expression of ESR1 protein CTD PMID:16483645 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544 		JBrowse link
G PGR progesterone receptor affects binding EXP Progesterone binds to PGR protein CTD PMID:16054490 NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 503
    chemical entity 503
      group 497
        organic group 405
          3-oxo-Delta(4)-steroid group 20
            3-oxo-Delta(4) steroid 20
              progesterone 2
                11,21-dioxoprogesterone 0
                11-deoxycorticosterone + 0
                11alpha-hydroxyprogesterone + 0
                11beta-hydroxyprogesterone 0
                12alpha-hydroxyprogesterone 0
                15beta-hydroxyprogesterone 0
                16,17-didehydroprogesterone 0
                16alpha-hydroxyprogesterone 0
                16beta-methylpregn-4-ene-3,20-dione 0
                17alpha-hydroxyprogesterone 0
                2,5-dioxo-1-pyrrolidinyl 6-(6-\{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl\}amino)hexanoate 0
                21-dehydrocortisol 0
                21-dehydrocortisone 0
                3-(progesterone-4-yl)thiopropionic acid 0
                3-(progesterone-7alpha-yl)thiopropionic acid 0
                4-pregnen-3beta,20alpha-diol 0
                4-pregnen-3beta-ol-20-one 0
                5alpha-pregnane-3,20-dione 0
                6-(6-\{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl\}amino)hexanoic acid 0
                6-\{3-[(progesterone-4-yl)thiopropionyl]amino\}hexanoic acid 0
                6beta,16alpha,17alpha-trihydroxyprogesterone 0
                9-fluoro-2alpha-methylpregn-4-ene-3,11,20-trione 0
                Delta(1)-progesterone + 0
                progesterone 3-O-(carboxymethyl)oxime + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 503
    subatomic particle 503
      composite particle 503
        hadron 503
          baryon 503
            nucleon 503
              atomic nucleus 503
                atom 503
                  main group element atom 496
                    p-block element atom 496
                      carbon group element atom 485
                        carbon atom 484
                          organic molecular entity 484
                            heteroorganic entity 478
                              organochalcogen compound 430
                                organooxygen compound 428
                                  carbonyl compound 404
                                    ketone 48
                                      oxo steroid 23
                                        3-oxo steroid 21
                                          3-oxo-Delta(4) steroid 20
                                            progesterone 2
                                              11,21-dioxoprogesterone 0
                                              11-deoxycorticosterone + 0
                                              11alpha-hydroxyprogesterone + 0
                                              11beta-hydroxyprogesterone 0
                                              12alpha-hydroxyprogesterone 0
                                              15beta-hydroxyprogesterone 0
                                              16,17-didehydroprogesterone 0
                                              16alpha-hydroxyprogesterone 0
                                              16beta-methylpregn-4-ene-3,20-dione 0
                                              17alpha-hydroxyprogesterone 0
                                              2,5-dioxo-1-pyrrolidinyl 6-(6-\{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl\}amino)hexanoate 0
                                              21-dehydrocortisol 0
                                              21-dehydrocortisone 0
                                              3-(progesterone-4-yl)thiopropionic acid 0
                                              3-(progesterone-7alpha-yl)thiopropionic acid 0
                                              4-pregnen-3beta,20alpha-diol 0
                                              4-pregnen-3beta-ol-20-one 0
                                              5alpha-pregnane-3,20-dione 0
                                              6-(6-\{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl\}amino)hexanoic acid 0
                                              6-\{3-[(progesterone-4-yl)thiopropionyl]amino\}hexanoic acid 0
                                              6beta,16alpha,17alpha-trihydroxyprogesterone 0
                                              9-fluoro-2alpha-methylpregn-4-ene-3,11,20-trione 0
                                              Delta(1)-progesterone + 0
                                              progesterone 3-O-(carboxymethyl)oxime + 0
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