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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dTMP
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Accession:CHEBI:17013 term browser browse the term
Definition:The neutral species of thymidine 5'-monophosphate (2'-deoxythymidine 5'-monophosphate).
Synonyms:exact_synonym: 2'-deoxy-5-methyluridine 5'-(dihydrogen phosphate)
 related_synonym: (dT)1;   5'-TMP;   5'-Thymidylic acid;   5-methyl-dUMP;   Formula=C10H15N2O8P;   InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1;   InChIKey=GYOZYWVXFNDGLU-XLPZGREQSA-N;   SMILES=Cc1cn([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)c(=O)[nH]c1=O;   THYMIDINE-5'-PHOSPHATE;   TMP;   Thymidine monophosphate;   Thymidylate;   Thymidylic acid;   deoxyribosylthymine monophosphate;   ribothymidine 5'-monophosphate;   thymidine 5'-(dihydrogen phosphate);   thymidine 5'-phosphoric acid;   thymidine-5'-monophosphoric acid
 alt_id: CHEBI:10529;   CHEBI:14092;   CHEBI:15246;   CHEBI:45759;   CHEBI:45772;   CHEBI:45926;   CHEBI:46013;   CHEBI:46036;   CHEBI:47711;   CHEBI:63549
 xref: Beilstein:47541;   CAS:365-07-1;   DrugBank:DB01643;   HMDB:HMDB0001227;   KEGG:C00364;   KNApSAcK:C00019637
 xref_mesh: MESH:D013938
 xref: PDBeChem:TMPdF10;   PDBeChem:TdF10;   PMID:22512654;   PMID:22761426;   PMID:23149755;   PMID:23288848;   PMID:23362972;   PMID:23501933;   PMID:23518161;   PMID:2559771;   PMID:7110140;   PMID:8647821;   Reaxys:47541;   Wikipedia:Thymidine_monophosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:46960;   is_enantiomer_of CHEBI:42112


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dTMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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G Tyms thymidylate synthetase multiple interactions ISO [Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate CTD PMID:29258758 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            fundamental metabolite 12653
              dTMP 2
                5,6-dihydrothymidine 5'-monophosphate 0
                dTMP 3'-end residue + 0
                dTMP 5'-end residue + 0
                p-nitrophenyl thymidine 5'-monophosphate 0
                thymidine 5'-monophosphate residue + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      chalcogen 19382
                        oxygen atom 19345
                          oxygen molecular entity 19345
                            hydroxides 19071
                              oxoacid 18269
                                pnictogen oxoacid 10312
                                  phosphorus oxoacid 9233
                                    phosphoric acids 7953
                                      phosphoric acid 7953
                                        phosphoric acid derivative 7632
                                          phosphate 7632
                                            organic phosphate 7631
                                              carbohydrate phosphate 1715
                                                phospho sugar 1640
                                                  aldose phosphate 1638
                                                    aldopentose phosphate 1632
                                                      deoxyaldopentose phosphate 9
                                                        2-deoxyribose phosphate 9
                                                          2'-deoxyribonucleotide 8
                                                            2'-deoxyribonucleoside 5'-phosphate 8
                                                              2'-deoxyribonucleoside 5'-monophosphate 3
                                                                pyrimidine 2'-deoxyribonucleoside 5'-monophosphate 3
                                                                  thymidine 5'-monophosphate 2
                                                                    dTMP 2
                                                                      5,6-dihydrothymidine 5'-monophosphate 0
                                                                      dTMP 3'-end residue + 0
                                                                      dTMP 5'-end residue + 0
                                                                      p-nitrophenyl thymidine 5'-monophosphate 0
                                                                      thymidine 5'-monophosphate residue + 0
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