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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propane-1,2-diol
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Accession:CHEBI:16997 term browser browse the term
Definition:The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.
Synonyms:related_synonym: 1,2-Propanediol;   1,2-Propylenglykol;   1,2-dihydroxypropane;   2-hydroxypropanol;   CH3CH(OH)CH2OH;   Formula=C3H8O2;   HOCH2CH(OH)CH3;   HOCH2CH(OH)Me;   InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3;   InChIKey=DNIAPMSPPWPWGF-UHFFFAOYSA-N;   MeCH(OH)CH2OH;   PPD;   Propylene glycol;   SMILES=CC(O)CO;   alpha-propyleneglycol;   isopropylene glycol;   methyl glycol;   methylethyl glycol;   methylethylene glycol;   monopropylene glycol
 alt_id: CHEBI:14899;   CHEBI:8469
 xref: CAS:57-55-6;   DrugBank:DB01839;   Drug_Central:4024;   HMDB:HMDB0001881;   KEGG:C00583;   KEGG:D00078;   KNApSAcK:C00007410;   LINCS:LSM-36856
 xref_mesh: MESH:D019946
 xref: PMID:15665701;   PMID:16078503;   PMID:18346395;   PMID:18845115;   PMID:21616561;   PPDB:1304;   Reaxys:1340498;   VSDB:1304;   Wikipedia:Propylene_glycol


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propane-1,2-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Acetaminophen co-treated with Propylene Glycol] results in increased expression of ABCC2 mRNA CTD PMID:17934960 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Acetaminophen co-treated with Propylene Glycol] results in increased expression of ABCC3 mRNA CTD PMID:17934960 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [Acetaminophen co-treated with Propylene Glycol] results in increased expression of ABCC4 mRNA CTD PMID:17934960 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARHGEF26 mRNA CTD PMID:28065790 NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819
JBrowse link
G Arl15 ADP-ribosylation factor like GTPase 15 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA CTD PMID:28065790 NCBI chr 2:45,438,221...45,822,562 JBrowse link
G Cers6 ceramide synthase 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNA CTD PMID:28065790 NCBI chr 3:53,630,636...53,879,692
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Ddhd2 DDHD domain containing 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of DDHD2 mRNA CTD PMID:28065790 NCBI chr16:66,319,469...66,349,025
Ensembl chr16:66,319,466...66,349,023
JBrowse link
G Gh1 growth hormone 1 affects folding ISO Propylene Glycol affects the folding of GH1 protein CTD PMID:11064379 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of GOSR2 mRNA CTD PMID:28065790 NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased secretion of IL6 protein; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased secretion of IL6 protein CTD PMID:28065790 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of LTN1 mRNA CTD PMID:28065790 NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK1 protein; Quercetin promotes the reaction [[Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:21216973 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK3 protein; Quercetin promotes the reaction [[Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:21216973 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Olr325 olfactory receptor 325 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of OR4D6 mRNA CTD PMID:28065790 NCBI chr 1:209,039,073...209,040,017
Ensembl chr 1:209,037,992...209,045,985
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of PKLR mRNA CTD PMID:28065790 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA CTD PMID:28065790 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK1 protein; [Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK3 protein; Quercetin promotes the reaction [[Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK1 protein]; Quercetin promotes the reaction [[Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:21216973 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        aetiopathogenetic role 19035
          allergen 17264
            propane-1,2-diol 17
              (R)-propane-1,2-diol 0
              (S)-propane-1,2-diol + 0
              2-hydroxypropyl dihydrogen phosphate 0
              2-hydroxypropyl methacrylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              organic hydroxy compound 18668
                                polyol 8079
                                  diol 3344
                                    glycol 3112
                                      propanediol 1161
                                        propane-1,2-diols 1161
                                          propane-1,2-diol 17
                                            (R)-propane-1,2-diol 0
                                            (S)-propane-1,2-diol + 0
                                            2-hydroxypropyl dihydrogen phosphate 0
                                            2-hydroxypropyl methacrylate 0
paths to the root