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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxalic acid
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Accession:CHEBI:16995 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.
Synonyms:related_synonym: Ethandisaeure;   Ethanedioic acid;   Formula=C2H2O4;   H2ox;   HOOCCOOH;   InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6);   InChIKey=MUBZPKHOEPUJKR-UHFFFAOYSA-N;   Oxalsaeure;   SMILES=OC(=O)C(O)=O;   ethane-1,2-dioic acid
 alt_id: CHEBI:25730;   CHEBI:44583;   CHEBI:7811
 xref: Beilstein:385686;   CAS:144-62-7;   DrugBank:DB03902;   Gmelin:2208;   HMDB:HMDB0002329;   KEGG:C00209;   KNApSAcK:C00001198;   LIPID_MAPS_instance:LMFA01170031
 xref_mesh: MESH:D019815
 xref: MetaCyc:OXALATE;   PDBeChem:OXD;   PMID:15587083;   PMID:22735334;   Reaxys:385686;   Wikipedia:Oxalic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132952;   is_conjugate_acid_of CHEBI:46904

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oxalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases activity
multiple interactions		 EXP Oxalic Acid results in decreased activity of AHR protein
Zinc inhibits the reaction [Oxalic Acid results in decreased activity of AHR protein]		 CTD PMID:2160969 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cat catalase decreases activity ISO Oxalic Acid results in decreased activity of CAT protein CTD PMID:24145091 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Oxalic Acid results in increased expression of CCL2 mRNA
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]		 CTD PMID:24145091 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CYBA mRNA] CTD PMID:24145091 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of NCF1 mRNA] CTD PMID:24145091 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:24145091 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 ISO Oxalic Acid results in increased expression of TGFB1 protein
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFB1 protein]		 CTD PMID:24145091 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression
multiple interactions		 ISO Oxalic Acid results in increased expression of TGFBR1 protein
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR1 protein]		 CTD PMID:24145091 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR2 protein] CTD PMID:24145091 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              algal metabolite 13939
                oxalic acid 9
                  11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                  11beta,13-dihydrolactucin 15-oxalate 0
                  11beta,13-dihydrolactucopicrin 15-oxalate 0
                  5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
                  8-deoxylactucin 15-oxalate 0
                  L-alpha-amino-gamma-oxalylaminobutyric acid 0
                  Methyl oxalate 0
                  allyl octadecyl oxalate 0
                  lactucin 15-oxalate 0
                  lactucopicrin 15-oxalate 0
                  oxalo group 0
                  oxalooxy group 0
                  oxalyl group 0
                  oxalyl-CoA 0
                  oxamide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      dicarboxylic acids and O-substituted derivatives 10366
                                        dicarboxylic acid 10358
                                          alpha,omega-dicarboxylic acid 2796
                                            oxalic acid 9
                                              11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                                              11beta,13-dihydrolactucin 15-oxalate 0
                                              11beta,13-dihydrolactucopicrin 15-oxalate 0
                                              5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
                                              8-deoxylactucin 15-oxalate 0
                                              L-alpha-amino-gamma-oxalylaminobutyric acid 0
                                              Methyl oxalate 0
                                              allyl octadecyl oxalate 0
                                              lactucin 15-oxalate 0
                                              lactucopicrin 15-oxalate 0
                                              oxalo group 0
                                              oxalooxy group 0
                                              oxalyl group 0
                                              oxalyl-CoA 0
                                              oxamide + 0
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