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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxalic acid
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Accession:CHEBI:16995 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.
Synonyms:related_synonym: Ethandisaeure;   Ethanedioic acid;   Formula=C2H2O4;   H2ox;   HOOCCOOH;   InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6);   InChIKey=MUBZPKHOEPUJKR-UHFFFAOYSA-N;   Oxalsaeure;   SMILES=OC(=O)C(O)=O;   ethane-1,2-dioic acid
 alt_id: CHEBI:25730;   CHEBI:44583;   CHEBI:7811
 xref: Beilstein:385686;   CAS:144-62-7;   DrugBank:DB03902;   Gmelin:2208;   HMDB:HMDB0002329;   KEGG:C00209;   KNApSAcK:C00001198;   LIPID_MAPS_instance:LMFA01170031
 xref_mesh: MESH:D019815
 xref: MetaCyc:OXALATE;   PDBeChem:OXD;   PMID:15587083;   PMID:22735334;   Reaxys:385686;   Wikipedia:Oxalic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132952;   is_conjugate_acid_of CHEBI:46904



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oxalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases activity
multiple interactions
EXP Oxalic Acid results in decreased activity of AHR protein
Zinc inhibits the reaction [Oxalic Acid results in decreased activity of AHR protein]
CTD PMID:2160969 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of BAX mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of BAX mRNA] CTD PMID:37414240 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in decreased expression of BCL2 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in decreased expression of BCL2 mRNA] CTD PMID:37414240 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CASP3 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CASP3 mRNA] CTD PMID:37414240 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity ISO Oxalic Acid results in decreased activity of CAT protein CTD PMID:24145091 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Oxalic Acid results in increased expression of CCL2 mRNA
[Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]
CTD PMID:24145091 PMID:37414240 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd44 CD44 molecule multiple interactions
increases expression
ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CD44 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CD44 mRNA] CTD PMID:37414240 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CYBA mRNA] CTD PMID:24145091 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions
increases expression
ISO Butyric Acid inhibits the reaction [Oxalic Acid results in increased expression of HDAC1 mRNA] CTD PMID:37414240 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac2 histone deacetylase 2 increases expression
multiple interactions
ISO Oxalic Acid results in increased expression of HDAC2 mRNA
Butyric Acid inhibits the reaction [Oxalic Acid results in increased expression of HDAC2 mRNA]
CTD PMID:37414240 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions
increases expression
ISO Butyric Acid inhibits the reaction [Oxalic Acid results in increased expression of HDAC3 mRNA] CTD PMID:37414240 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions
increases expression
ISO Butyric Acid inhibits the reaction [Oxalic Acid results in increased expression of HDAC8 mRNA] CTD PMID:37414240 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of NCF1 mRNA] CTD PMID:24145091 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA]; Resveratrol inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:24145091 PMID:37414240 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO Oxalic Acid results in increased expression of TGFB1 protein
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFB1 protein]
CTD PMID:24145091 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression
multiple interactions
ISO Oxalic Acid results in increased expression of TGFBR1 protein
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR1 protein]
CTD PMID:24145091 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR2 protein] CTD PMID:24145091 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        biochemical role 19533
          metabolite 19519
            eukaryotic metabolite 19342
              plant metabolite 17961
                oxalic acid 17
                  11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                  11beta,13-dihydrolactucin 15-oxalate 0
                  11beta,13-dihydrolactucopicrin 15-oxalate 0
                  5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
                  8-deoxylactucin 15-oxalate 0
                  L-alpha-amino-gamma-oxalylaminobutyric acid 0
                  Methyl oxalate 0
                  allyl octadecyl oxalate 0
                  lactucin 15-oxalate 0
                  lactucopicrin 15-oxalate 0
                  oxalo group 0
                  oxalooxy group 0
                  oxalyl group 0
                  oxalyl-CoA 0
                  oxamide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            heteroorganic entity 19495
                              organochalcogen compound 19257
                                organooxygen compound 19175
                                  carbonyl compound 18897
                                    dicarboxylic acids and O-substituted derivatives 11080
                                      dicarboxylic acid 11074
                                        alpha,omega-dicarboxylic acid 3138
                                          oxalic acid 17
                                            11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                                            11beta,13-dihydrolactucin 15-oxalate 0
                                            11beta,13-dihydrolactucopicrin 15-oxalate 0
                                            5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
                                            8-deoxylactucin 15-oxalate 0
                                            L-alpha-amino-gamma-oxalylaminobutyric acid 0
                                            Methyl oxalate 0
                                            allyl octadecyl oxalate 0
                                            lactucin 15-oxalate 0
                                            lactucopicrin 15-oxalate 0
                                            oxalo group 0
                                            oxalooxy group 0
                                            oxalyl group 0
                                            oxalyl-CoA 0
                                            oxamide + 0
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