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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxalic acid
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Accession:CHEBI:16995 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.
Synonyms:related_synonym: Ethandisaeure;   Ethanedioic acid;   Formula=C2H2O4;   H2ox;   HOOCCOOH;   InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6);   InChIKey=MUBZPKHOEPUJKR-UHFFFAOYSA-N;   Oxalsaeure;   SMILES=OC(=O)C(O)=O;   ethane-1,2-dioic acid
 alt_id: CHEBI:25730;   CHEBI:44583;   CHEBI:7811
 xref: Beilstein:385686;   CAS:144-62-7;   DrugBank:DB03902;   Gmelin:2208;   HMDB:HMDB0002329;   KEGG:C00209;   KNApSAcK:C00001198;   LIPID_MAPS_instance:LMFA01170031
 xref_mesh: MESH:D019815
 xref: MetaCyc:OXALATE;   PDBeChem:OXD;   PMID:15587083;   PMID:22735334;   Reaxys:385686;   Wikipedia:Oxalic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132952;   is_conjugate_acid_of CHEBI:46904


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oxalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases activity
multiple interactions		 EXP Oxalic Acid results in decreased activity of AHR protein
Zinc inhibits the reaction [Oxalic Acid results in decreased activity of AHR protein]		 CTD PMID:2160969 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cat catalase decreases activity ISO Oxalic Acid results in decreased activity of CAT protein CTD PMID:24145091 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Oxalic Acid results in increased expression of CCL2 mRNA
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]		 CTD PMID:24145091 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CYBA mRNA] CTD PMID:24145091 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of NCF1 mRNA] CTD PMID:24145091 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:24145091 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 ISO Oxalic Acid results in increased expression of TGFB1 protein
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFB1 protein]		 CTD PMID:24145091 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression
multiple interactions		 ISO Oxalic Acid results in increased expression of TGFBR1 protein
resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR1 protein]		 CTD PMID:24145091 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR2 protein] CTD PMID:24145091 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        biochemical role 19429
          metabolite 19416
            eukaryotic metabolite 19212
              algal metabolite 14711
                oxalic acid 9
                  11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                  11beta,13-dihydrolactucin 15-oxalate 0
                  11beta,13-dihydrolactucopicrin 15-oxalate 0
                  5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
                  8-deoxylactucin 15-oxalate 0
                  L-alpha-amino-gamma-oxalylaminobutyric acid 0
                  Methyl oxalate 0
                  allyl octadecyl oxalate 0
                  lactucin 15-oxalate 0
                  lactucopicrin 15-oxalate 0
                  oxalo group 0
                  oxalooxy group 0
                  oxalyl group 0
                  oxalyl-CoA 0
                  oxamide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      dicarboxylic acids and O-substituted derivatives 10394
                                        dicarboxylic acid 10387
                                          alpha,omega-dicarboxylic acid 2811
                                            oxalic acid 9
                                              11beta,13-dihydro-8-deoxylactucin 15-oxalate 0
                                              11beta,13-dihydrolactucin 15-oxalate 0
                                              11beta,13-dihydrolactucopicrin 15-oxalate 0
                                              5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
                                              8-deoxylactucin 15-oxalate 0
                                              L-alpha-amino-gamma-oxalylaminobutyric acid 0
                                              Methyl oxalate 0
                                              allyl octadecyl oxalate 0
                                              lactucin 15-oxalate 0
                                              lactucopicrin 15-oxalate 0
                                              oxalo group 0
                                              oxalooxy group 0
                                              oxalyl group 0
                                              oxalyl-CoA 0
                                              oxamide + 0
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