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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene C4
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Accession:CHEBI:16978 term browser browse the term
Definition:A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.
Synonyms:exact_synonym: L-gamma-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl]-L-cysteinylglycine
 related_synonym: (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)glycine;   5S,6R-Ltc(sub 4);   5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid;   Formula=C30H47N3O9S;   InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1;   InChIKey=GWNVDXQDILPJIG-NXOLIXFESA-N;   LTC (sub 4);   LTC4;   SMILES=CCCCC\\C=C/C\\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
 alt_id: CHEBI:14504;   CHEBI:25025;   CHEBI:6422
 xref: CAS:72025-60-6 "ChemIDplus";   CAS:72025-60-6 "KEGG COMPOUND";   HMDB:HMDB0001198;   KEGG:C02166;   LIPID_MAPS_instance:LMFA03020003 "LIPID MAPS"
 xref_mesh: MESH:D017997
 xref: MetaCyc:LEUKOTRIENE-C4;   PMID:24244016 "Europe PMC";   PMID:8415814 "Europe PMC";   PMID:9042024 "Europe PMC";   PMID:9384524 "Europe PMC";   Reaxys:4732117 "Reaxys";   Wikipedia:Leukotriene_C4
 cyclic_relationship: is_conjugate_acid_of CHEBI:57973


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leukotriene C4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCA8 ATP binding cassette subfamily A member 8 JBrowse link 17 68,867,285 68,955,426 RGD:6480464
G ABCC1 ATP binding cassette subfamily C member 1 JBrowse link 16 15,949,616 16,143,062 RGD:6480464
G ABCC2 ATP binding cassette subfamily C member 2 JBrowse link 10 99,782,602 99,853,741 RGD:6480464
G ABCC3 ATP binding cassette subfamily C member 3 JBrowse link 17 50,634,881 50,692,253 RGD:6480464
G ABCC6 ATP binding cassette subfamily C member 6 JBrowse link 16 16,149,565 16,223,617 RGD:6480464
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 10 45,374,166 45,446,121 RGD:6480464
G ALOX5AP arachidonate 5-lipoxygenase activating protein JBrowse link 13 30,713,478 30,764,428 RGD:6480464
G AMBP alpha-1-microglobulin/bikunin precursor JBrowse link 9 114,060,127 114,078,300 RGD:6480464
G CCL13 C-C motif chemokine ligand 13 JBrowse link 17 34,356,480 34,358,610 RGD:6480464
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:6480464
G CLEC7A C-type lectin domain containing 7A JBrowse link 12 10,116,777 10,130,264 RGD:6480464
G CXCL1 C-X-C motif chemokine ligand 1 JBrowse link 4 73,869,393 73,871,308 RGD:6480464
G CYSLTR1 cysteinyl leukotriene receptor 1 JBrowse link X 78,271,468 78,327,691 RGD:6480464
G CYSLTR2 cysteinyl leukotriene receptor 2 JBrowse link 13 48,653,929 48,711,226 RGD:6480464
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:6480464
G EGFR epidermal growth factor receptor JBrowse link 7 55,019,017 55,211,628 RGD:6480464
G GGT5 gamma-glutamyltransferase 5 JBrowse link 22 24,219,654 24,245,142 RGD:6480464
G GPR17 G protein-coupled receptor 17 JBrowse link 2 127,645,864 127,652,639 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G IL13 interleukin 13 JBrowse link 5 132,656,522 132,661,110 RGD:6480464
G IL5 interleukin 5 JBrowse link 5 132,539,194 132,556,864 RGD:6480464
G LTC4S leukotriene C4 synthase JBrowse link 5 179,793,986 179,796,647 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MGST1 microsomal glutathione S-transferase 1 JBrowse link 12 16,347,142 16,377,192 RGD:6480464
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:6480464
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming JBrowse link 11 1,157,953 1,201,138 RGD:6480464
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:6480464
G PLA2G5 phospholipase A2 group V JBrowse link 1 20,028,349 20,091,911 RGD:6480464
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 122,369,906 122,395,703 RGD:6480464
G RALBP1 ralA binding protein 1 JBrowse link 18 9,475,513 9,538,114 RGD:6480464
G SELP selectin P JBrowse link 1 169,588,849 169,630,125 RGD:6480464
G SYK spleen associated tyrosine kinase JBrowse link 9 90,801,600 90,898,549 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23699
    role 23588
      application 22987
        pharmaceutical 22524
          drug 22524
            bronchoconstrictor agent 64
              leukotriene C4 33
                11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                11,12-dihydro-12-oxoleukotriene C4 0
                leukotriene C4 methyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23699
    subatomic particle 23646
      composite particle 23646
        hadron 23646
          baryon 23646
            nucleon 23646
              atomic nucleus 23646
                atom 23646
                  main group element atom 23465
                    p-block element atom 23465
                      carbon group element atom 23166
                        carbon atom 23143
                          organic molecular entity 23143
                            organic group 21827
                              organic divalent group 21797
                                organodiyl group 21797
                                  carbonyl group 21768
                                    carbonyl compound 21768
                                      carboxylic acid 20796
                                        monocarboxylic acid 19765
                                          fatty acid 18118
                                            unsaturated fatty acid 916
                                              polyunsaturated fatty acid 668
                                                fatty acid 20:4 317
                                                  icosatetraenoic acid 317
                                                    icosa-7,9,11,14-tetraenoic acid 45
                                                      leukotriene C4 33
                                                        11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                                                        11,12-dihydro-12-oxoleukotriene C4 0
                                                        leukotriene C4 methyl ester 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.