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G |
Dek |
DEK proto-oncogene |
multiple interactions |
ISO |
DEK protein results in increased chemical synthesis of and results in increased secretion of Alanine |
CTD |
PMID:28558019 |
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NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
decreases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in decreased abundance of Alanine Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine] |
CTD |
PMID:27469509 |
|
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
affects response to substance |
ISO |
GRIA3 protein affects the susceptibility to 5-fluorowillardiine |
CTD |
PMID:15264227 |
|
NCBI chr X:127,561,843...127,829,763
Ensembl chr X:127,562,660...127,829,753
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G |
Ctsd |
cathepsin D |
multiple interactions |
EXP |
alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] |
CTD |
PMID:17623887 |
|
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] |
CTD |
PMID:29305303 |
|
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases secretion multiple interactions |
ISO |
alliin results in decreased secretion of FGF2 protein alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:16351512 |
|
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP ISO |
alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein] |
CTD |
PMID:16640830 PMID:29305303 |
|
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions |
EXP |
alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] |
CTD |
PMID:16640830 |
|
NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] |
CTD |
PMID:29305303 |
|
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] |
CTD |
PMID:29305303 |
|
NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:16351512 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Vegfa |
vascular endothelial growth factor A |
decreases secretion |
ISO |
alliin results in decreased secretion of VEGFA protein |
CTD |
PMID:16351512 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Alad |
aminolevulinate dehydratase |
decreases activity |
EXP |
Selenocysteine analog results in decreased activity of ALAD protein |
CTD |
PMID:14630126 |
|
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] |
CTD |
PMID:14572605 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTA2 mRNA |
CTD |
PMID:12034368 |
|
NCBI chr 8:85,640,081...85,645,621
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTA3 mRNA |
CTD |
PMID:12034368 |
|
NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTA5 mRNA |
CTD |
PMID:12034368 |
|
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTP1 mRNA |
CTD |
PMID:12034368 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] |
CTD |
PMID:14572605 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases expression |
ISO |
metalaxyl results in decreased expression of CYP2C19 protein |
CTD |
PMID:32194361 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression |
ISO |
metalaxyl results in decreased expression of CYP7A1 protein |
CTD |
PMID:32194361 |
|
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] |
CTD |
PMID:31566444 |
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NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein] |
CTD |
PMID:31566444 |
|
NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions affects binding |
ISO |
N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] N-benzoylalanine binds to THRB protein |
CTD |
PMID:31566444 |
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NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1 |
CTD |
PMID:15897249 |
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NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions decreases expression |
EXP |
Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA] |
CTD |
PMID:19025659 |
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NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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G |
Ar |
androgen receptor |
decreases expression |
ISO EXP |
selenomethylselenocysteine results in decreased expression of AR protein selenomethylselenocysteine results in decreased expression of AR mRNA |
CTD |
PMID:16637076 PMID:19025659 |
|
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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G |
Arntl |
aryl hydrocarbon receptor nuclear translocator-like |
decreases expression |
EXP |
selenomethylselenocysteine results in decreased expression of ARNTL mRNA |
CTD |
PMID:19122877 |
|
NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
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G |
Banp |
Btg3 associated nuclear protein |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of BANP mRNA |
CTD |
PMID:18514395 |
|
NCBI chr19:54,766,441...54,843,795
Ensembl chr19:54,766,589...54,840,569
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
selenomethylselenocysteine results in decreased expression of BCL2 mRNA selenomethylselenocysteine results in decreased expression of BCL2 protein [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein |
CTD |
PMID:11396176 PMID:19360359 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Bcl2l11 |
BCL2 like 11 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
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G |
Bmf |
Bcl2 modifying factor |
multiple interactions increases expression |
ISO |
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; C646 compound inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] selenomethylselenocysteine metabolite results in increased expression of BMF protein selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein |
CTD |
PMID:25321483 |
|
NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
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G |
Casp3 |
caspase 3 |
increases activity increases expression multiple interactions |
ISO |
selenomethylselenocysteine results in increased activity of CASP3 protein selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form] |
CTD |
PMID:15318939 PMID:25321483 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp6 |
caspase 6 |
increases expression multiple interactions |
ISO |
selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form] |
CTD |
PMID:25321483 |
|
NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967 Ensembl chr 2:235,341,365...235,353,967
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G |
Casp8 |
caspase 8 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form |
CTD |
PMID:25321483 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
ISO |
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form] |
CTD |
PMID:25321483 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Ccna2 |
cyclin A2 |
decreases expression |
EXP |
selenomethylselenocysteine results in decreased expression of CCNA2 protein |
CTD |
PMID:11396176 |
|
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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G |
Ccnd1 |
cyclin D1 |
decreases expression multiple interactions |
ISO EXP |
selenomethylselenocysteine results in decreased expression of CCND1 protein selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein |
CTD |
PMID:11396176 PMID:18855134 PMID:19276161 |
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NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein |
CTD |
PMID:10656618 |
|
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein |
CTD |
PMID:25321483 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of CDKN1B protein |
CTD |
PMID:11396176 PMID:19276161 |
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NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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G |
Ces1d |
carboxylesterase 1D |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of CES1 |
CTD |
PMID:15897249 |
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NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
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G |
Chmp1a |
charged multivesicular body protein 1A |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of CHMP1A mRNA |
CTD |
PMID:18514395 |
|
NCBI chr19:56,001,724...56,010,004
Ensembl chr19:56,001,724...56,010,004
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein |
CTD |
PMID:18514395 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Col1a2 |
collagen type I alpha 2 chain |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein |
CTD |
PMID:18514395 |
|
NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
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G |
Col4a5 |
collagen type IV alpha 5 chain |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of COL4A5 mRNA |
CTD |
PMID:18514395 |
|
NCBI chr X:112,769,595...112,983,720
Ensembl chr X:112,769,645...112,983,685
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G |
Col6a1 |
collagen type VI alpha 1 chain |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of COL6A1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
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G |
Col7a1 |
collagen type VII alpha 1 chain |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of COL7A1 mRNA |
CTD |
PMID:18514395 |
|
NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
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G |
Cry2 |
cryptochrome circadian regulator 2 |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of CRY2 mRNA |
CTD |
PMID:19122877 |
|
NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5 |
CTD |
PMID:15897249 |
|
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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G |
Dbp |
D-box binding PAR bZIP transcription factor |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of DBP mRNA |
CTD |
PMID:19122877 |
|
NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of DDIT3 mRNA |
CTD |
PMID:10656618 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
EXP |
selenomethylselenocysteine results in decreased expression of DHCR24 mRNA |
CTD |
PMID:19025659 |
|
NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
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G |
Drg1 |
developmentally regulated GTP binding protein 1 |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1 |
CTD |
PMID:15897249 |
|
NCBI chr14:83,460,540...83,476,568
Ensembl chr14:83,460,540...83,476,568
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions |
ISO |
selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] |
CTD |
PMID:25321483 |
|
NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
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G |
Esr1 |
estrogen receptor 1 |
decreases expression multiple interactions |
ISO |
selenomethylselenocysteine results in decreased expression of ESR1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein |
CTD |
PMID:18855134 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG |
CTD |
PMID:15897249 |
|
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GADD45A mRNA |
CTD |
PMID:10656618 |
|
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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G |
Gpx1 |
glutathione peroxidase 1 |
increases activity increases expression |
ISO |
selenomethylselenocysteine results in increased activity of GPX1 protein selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein |
CTD |
PMID:18514395 PMID:19033020 |
|
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gpx4 |
glutathione peroxidase 4 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GPX4 mRNA |
CTD |
PMID:18514395 |
|
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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G |
Grik1 |
glutamate ionotropic receptor kainate type subunit 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GRIK1 mRNA |
CTD |
PMID:18514395 |
|
NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
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G |
Grik3 |
glutamate ionotropic receptor kainate type subunit 3 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GRIK3 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
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Hdac8 |
histone deacetylase 8 |
multiple interactions |
ISO |
HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter] |
CTD |
PMID:25321483 |
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NCBI chr X:72,163,777...72,370,058
Ensembl chr X:72,163,777...72,370,044
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Igf1r |
insulin-like growth factor 1 receptor |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of IGF1R mRNA |
CTD |
PMID:18514395 |
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NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
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Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
EXP |
selenomethylselenocysteine results in increased phosphorylation of JUN protein |
CTD |
PMID:19276161 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Klk1 |
kallikrein 1 |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of KLK3 protein |
CTD |
PMID:16637076 |
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NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329
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Mki67 |
marker of proliferation Ki-67 |
multiple interactions decreases expression |
ISO |
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein selenomethylselenocysteine results in decreased expression of MKI67 protein |
CTD |
PMID:18855134 |
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NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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Msrb1 |
methionine sulfoxide reductase B1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of MSRB1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr10:14,105,750...14,111,463
Ensembl chr10:14,105,750...14,111,463
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Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] |
CTD |
PMID:21213327 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:21213327 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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P4ha1 |
prolyl 4-hydroxylase subunit alpha 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of P4HA1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
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Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression |
ISO |
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form] |
CTD |
PMID:25321483 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Per2 |
period circadian regulator 2 |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of PER2 mRNA |
CTD |
PMID:19122877 |
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NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
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Per3 |
period circadian regulator 3 |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of PER3 mRNA |
CTD |
PMID:19122877 |
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NCBI chr 5:168,088,126...168,123,482
Ensembl chr 5:168,086,998...168,123,395
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Pgr |
progesterone receptor |
decreases expression multiple interactions |
ISO |
selenomethylselenocysteine results in decreased expression of PGR protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein |
CTD |
PMID:18855134 |
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NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of PPP1R15A mRNA |
CTD |
PMID:10656618 |
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NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
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Prkce |
protein kinase C, epsilon |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of PRKCE protein |
CTD |
PMID:10656618 |
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NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
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Prkcz |
protein kinase C, zeta |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of PRKCZ protein |
CTD |
PMID:10656618 |
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NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
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Rab3b |
RAB3B, member RAS oncogene family |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of RAB3B mRNA |
CTD |
PMID:18514395 |
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NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
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Rab4a |
RAB4A, member RAS oncogene family |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of RAB4A mRNA |
CTD |
PMID:18514395 |
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NCBI chr19:56,585,598...56,613,078
Ensembl chr19:56,585,767...56,613,075
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] |
CTD |
PMID:21213327 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Scarb1 |
scavenger receptor class B, member 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SCARB1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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Selenof |
selenoprotein F |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SELENOF mRNA |
CTD |
PMID:18514395 |
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NCBI chr 2:250,600,823...250,633,903
Ensembl chr 2:250,600,823...250,633,897
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Selenop |
selenoprotein P |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SELENOP mRNA |
CTD |
PMID:18514395 |
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NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
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Selenow |
selenoprotein W |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SELENOW mRNA |
CTD |
PMID:18514395 |
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NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681 Ensembl chr 1:77,533,148...77,535,681
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Slc3a1 |
solute carrier family 3 member 1 |
increases uptake |
ISO |
SLC3A1 protein results in increased uptake of selenomethylselenocysteine |
CTD |
PMID:18845132 |
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NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
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Slc6a19 |
solute carrier family 6 member 19 |
increases uptake |
ISO |
SLC6A19 protein results in increased uptake of selenomethylselenocysteine |
CTD |
PMID:18845132 |
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NCBI chr 1:32,199,869...32,218,628
Ensembl chr 1:32,199,810...32,220,045
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Snap23 |
synaptosome associated protein 23 |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of SNAP23 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 3:112,333,972...112,362,960
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Sort1 |
sortilin 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SORT1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
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Sp3 |
Sp3 transcription factor |
multiple interactions |
ISO |
selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter] |
CTD |
PMID:25321483 |
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NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
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Spp1 |
secreted phosphoprotein 1 |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of SPP1 protein |
CTD |
PMID:15318939 |
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NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
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Srd5a1 |
steroid 5 alpha-reductase 1 |
multiple interactions |
EXP |
[selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein |
CTD |
PMID:19025659 |
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NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
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Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] |
CTD |
PMID:25321483 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein |
CTD |
PMID:19360359 |
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NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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Trnau1ap |
tRNA selenocysteine 1 associated protein 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA |
CTD |
PMID:18514395 |
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NCBI chr 5:150,463,797...150,506,803
Ensembl chr 5:150,492,587...150,506,871
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Xpa |
XPA, DNA damage recognition and repair factor |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein] |
CTD |
PMID:15265038 |
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NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
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Klrc1 |
killer cell lectin like receptor C1 |
decreases expression |
ISO |
sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells |
RGD |
PMID:31218578 |
RGD:40400920 |
NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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Ncr1 |
natural cytotoxicity triggering receptor 1 |
affects expression |
ISO |
sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells |
RGD |
PMID:31218578 |
RGD:40400920 |
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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