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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-alanine
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Accession:CHEBI:16977 term browser browse the term
Definition:The L-enantiomer of alanine.
Synonyms:related_synonym: (2S)-2-aminopropanoic acid;   (S)-2-aminopropanoic acid;   (S)-alanine;   A;   ALANINE;   Ala;   Formula=C3H7NO2;   InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1;   InChIKey=QNAYBMKLOCPYGJ-REOHCLBHSA-N;   L-2-Aminopropionic acid;   L-Alanin;   L-alpha-alanine;   SMILES=C[C@H](N)C(O)=O
 alt_id: CHEBI:13069;   CHEBI:21216;   CHEBI:40734;   CHEBI:40735;   CHEBI:46308;   CHEBI:6171
 xref: Beilstein:1720248;   CAS:56-41-7;   DrugBank:DB00160;   Drug_Central:4255;   ECMDB:ECMDB00161;   Gmelin:49628;   HMDB:HMDB0000161;   KEGG:C00041;   KEGG:D00012;   KNApSAcK:C00001332
 xref_mesh: MESH:D000409
 xref: MetaCyc:ALPHA-ALANINE;   PDBeChem:ALA_LFOH;   PMID:18235971;   PMID:22735334;   PMID:3275662;   Reaxys:1720248;   Wikipedia:Alanine;   YMDB:YMDB00154
 cyclic_relationship: is_conjugate_acid_of CHEBI:32431;   is_conjugate_base_of CHEBI:32432;   is_enantiomer_of CHEBI:15570;   is_tautomer_of CHEBI:57972

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L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in increased chemical synthesis of and results in increased secretion of Alanine CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases abundance
multiple interactions		 ISO IDH2 protein mutant form results in decreased abundance of Alanine
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
3-(5-fluorouracil-1-yl)-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 affects response to substance ISO GRIA3 protein affects the susceptibility to 5-fluorowillardiine CTD PMID:15264227 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753 		JBrowse link
alliin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsd cathepsin D multiple interactions EXP alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] CTD PMID:29305303 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions		 ISO alliin results in decreased secretion of FGF2 protein
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]		 CTD PMID:16351512 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP
ISO		 alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]		 CTD PMID:16640830 PMID:29305303 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:16640830 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] CTD PMID:29305303 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] CTD PMID:29305303 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO alliin results in decreased secretion of VEGFA protein CTD PMID:16351512 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
L-selenocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity EXP Selenocysteine analog results in decreased activity of ALAD protein CTD PMID:14630126 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Selenocysteine results in increased expression of GSTA2 mRNA CTD PMID:12034368 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Selenocysteine results in increased expression of GSTA3 mRNA CTD PMID:12034368 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Selenocysteine results in increased expression of GSTA5 mRNA CTD PMID:12034368 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Selenocysteine results in increased expression of GSTP1 mRNA CTD PMID:12034368 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] CTD PMID:14572605 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
metalaxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO metalaxyl results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO metalaxyl results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
N-benzoyl-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding		 ISO N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein]
N-benzoylalanine binds to THRB protein		 CTD PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
Se-methyl-L-selenocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1 CTD PMID:15897249 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
decreases expression		 EXP Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA] CTD PMID:19025659 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA CTD PMID:25321483 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Ar androgen receptor decreases expression ISO
EXP		 selenomethylselenocysteine results in decreased expression of AR protein
selenomethylselenocysteine results in decreased expression of AR mRNA		 CTD PMID:16637076 PMID:19025659 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP selenomethylselenocysteine results in decreased expression of ARNTL mRNA CTD PMID:19122877 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA CTD PMID:25321483 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Banp Btg3 associated nuclear protein increases expression ISO selenomethylselenocysteine results in increased expression of BANP mRNA CTD PMID:18514395 NCBI chr19:54,766,441...54,843,795
Ensembl chr19:54,766,589...54,840,569 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 selenomethylselenocysteine results in decreased expression of BCL2 mRNA
selenomethylselenocysteine results in decreased expression of BCL2 protein
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein		 CTD PMID:11396176 PMID:19360359 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA CTD PMID:25321483 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA CTD PMID:25321483 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bmf Bcl2 modifying factor multiple interactions
increases expression		 ISO BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; C646 compound inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]
selenomethylselenocysteine metabolite results in increased expression of BMF protein
selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein		 CTD PMID:25321483 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions		 ISO selenomethylselenocysteine results in increased activity of CASP3 protein
selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]		 CTD PMID:15318939 PMID:25321483 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp6 caspase 6 increases expression
multiple interactions		 ISO selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]		 CTD PMID:25321483 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967 		JBrowse link
G Casp8 caspase 8 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form CTD PMID:25321483 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form] CTD PMID:25321483 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccna2 cyclin A2 decreases expression EXP selenomethylselenocysteine results in decreased expression of CCNA2 protein CTD PMID:11396176 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO
EXP		 selenomethylselenocysteine results in decreased expression of CCND1 protein
selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein		 CTD PMID:11396176 PMID:18855134 PMID:19276161 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein CTD PMID:10656618 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein		 CTD PMID:25321483 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP selenomethylselenocysteine results in increased expression of CDKN1B protein CTD PMID:11396176 PMID:19276161 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO selenomethylselenocysteine results in increased expression of CES1 CTD PMID:15897249 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Chmp1a charged multivesicular body protein 1A increases expression ISO selenomethylselenocysteine results in increased expression of CHMP1A mRNA CTD PMID:18514395 NCBI chr19:56,001,724...56,010,004
Ensembl chr19:56,001,724...56,010,004 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein CTD PMID:18514395 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein CTD PMID:18514395 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151 		JBrowse link
G Col4a5 collagen type IV alpha 5 chain increases expression ISO selenomethylselenocysteine results in increased expression of COL4A5 mRNA CTD PMID:18514395 NCBI chr  X:112,769,595...112,983,720
Ensembl chr  X:112,769,645...112,983,685 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain increases expression ISO selenomethylselenocysteine results in increased expression of COL6A1 mRNA CTD PMID:18514395 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561 		JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases expression ISO selenomethylselenocysteine results in decreased expression of COL7A1 mRNA CTD PMID:18514395 NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 increases expression EXP selenomethylselenocysteine results in increased expression of CRY2 mRNA CTD PMID:19122877 NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5 CTD PMID:15897249 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP selenomethylselenocysteine results in increased expression of DBP mRNA CTD PMID:19122877 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO selenomethylselenocysteine results in increased expression of DDIT3 mRNA CTD PMID:10656618 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression EXP selenomethylselenocysteine results in decreased expression of DHCR24 mRNA CTD PMID:19025659 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206 		JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1 CTD PMID:15897249 NCBI chr14:83,460,540...83,476,568
Ensembl chr14:83,460,540...83,476,568 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions		 ISO selenomethylselenocysteine results in decreased expression of ESR1 protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein		 CTD PMID:18855134 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG CTD PMID:15897249 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO selenomethylselenocysteine results in increased expression of GADD45A mRNA CTD PMID:10656618 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases activity
increases expression		 ISO selenomethylselenocysteine results in increased activity of GPX1 protein
selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein		 CTD PMID:18514395 PMID:19033020 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO selenomethylselenocysteine results in increased expression of GPX4 mRNA CTD PMID:18514395 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 increases expression ISO selenomethylselenocysteine results in increased expression of GRIK1 mRNA CTD PMID:18514395 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 increases expression ISO selenomethylselenocysteine results in increased expression of GRIK3 mRNA CTD PMID:18514395 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546 		JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions ISO HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr  X:72,163,777...72,370,058
Ensembl chr  X:72,163,777...72,370,044 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO selenomethylselenocysteine results in increased expression of IGF1R mRNA CTD PMID:18514395 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP selenomethylselenocysteine results in increased phosphorylation of JUN protein CTD PMID:19276161 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Klk1 kallikrein 1 decreases expression ISO selenomethylselenocysteine results in decreased expression of KLK3 protein CTD PMID:16637076 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression		 ISO [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein
selenomethylselenocysteine results in decreased expression of MKI67 protein		 CTD PMID:18855134 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Msrb1 methionine sulfoxide reductase B1 increases expression ISO selenomethylselenocysteine results in increased expression of MSRB1 mRNA CTD PMID:18514395 NCBI chr10:14,105,750...14,111,463
Ensembl chr10:14,105,750...14,111,463 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] CTD PMID:21213327 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21213327 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 increases expression ISO selenomethylselenocysteine results in increased expression of P4HA1 mRNA CTD PMID:18514395 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression		 ISO [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form] CTD PMID:25321483 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Per2 period circadian regulator 2 increases expression EXP selenomethylselenocysteine results in increased expression of PER2 mRNA CTD PMID:19122877 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359 		JBrowse link
G Per3 period circadian regulator 3 increases expression EXP selenomethylselenocysteine results in increased expression of PER3 mRNA CTD PMID:19122877 NCBI chr 5:168,088,126...168,123,482
Ensembl chr 5:168,086,998...168,123,395 		JBrowse link
G Pgr progesterone receptor decreases expression
multiple interactions		 ISO selenomethylselenocysteine results in decreased expression of PGR protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein		 CTD PMID:18855134 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO selenomethylselenocysteine results in increased expression of PPP1R15A mRNA CTD PMID:10656618 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Prkce protein kinase C, epsilon decreases expression ISO selenomethylselenocysteine results in decreased expression of PRKCE protein CTD PMID:10656618 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Prkcz protein kinase C, zeta decreases expression ISO selenomethylselenocysteine results in decreased expression of PRKCZ protein CTD PMID:10656618 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421 		JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO selenomethylselenocysteine results in increased expression of RAB3B mRNA CTD PMID:18514395 NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188 		JBrowse link
G Rab4a RAB4A, member RAS oncogene family increases expression ISO selenomethylselenocysteine results in increased expression of RAB4A mRNA CTD PMID:18514395 NCBI chr19:56,585,598...56,613,078
Ensembl chr19:56,585,767...56,613,075 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:21213327 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO selenomethylselenocysteine results in increased expression of SCARB1 mRNA CTD PMID:18514395 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Selenof selenoprotein F increases expression ISO selenomethylselenocysteine results in increased expression of SELENOF mRNA CTD PMID:18514395 NCBI chr 2:250,600,823...250,633,903
Ensembl chr 2:250,600,823...250,633,897 		JBrowse link
G Selenop selenoprotein P increases expression ISO selenomethylselenocysteine results in increased expression of SELENOP mRNA CTD PMID:18514395 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858 		JBrowse link
G Selenow selenoprotein W increases expression ISO selenomethylselenocysteine results in increased expression of SELENOW mRNA CTD PMID:18514395 NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681
Ensembl chr 1:77,533,148...77,535,681 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake ISO SLC3A1 protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674 		JBrowse link
G Slc6a19 solute carrier family 6 member 19 increases uptake ISO SLC6A19 protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 1:32,199,869...32,218,628
Ensembl chr 1:32,199,810...32,220,045 		JBrowse link
G Snap23 synaptosome associated protein 23 decreases expression ISO selenomethylselenocysteine results in decreased expression of SNAP23 mRNA CTD PMID:18514395 NCBI chr 3:112,333,972...112,362,960 JBrowse link
G Sort1 sortilin 1 increases expression ISO selenomethylselenocysteine results in increased expression of SORT1 mRNA CTD PMID:18514395 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions ISO selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO selenomethylselenocysteine results in decreased expression of SPP1 protein CTD PMID:15318939 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions EXP [selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein CTD PMID:19025659 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] CTD PMID:25321483 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein CTD PMID:19360359 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Trnau1ap tRNA selenocysteine 1 associated protein 1 increases expression ISO selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA CTD PMID:18514395 NCBI chr 5:150,463,797...150,506,803
Ensembl chr 5:150,492,587...150,506,871 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928 		JBrowse link
sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            fundamental metabolite 12653
              L-alanine 100
                (+)-(S)-alapyridaine 0
                2-L-alanyl-5-tert-butyl-1,3,4-oxadiazole 0
                Ala-Ala-Ala 0
                Ala-Ala-Asp 0
                Ala-Ala-Asp-Asp 0
                Ala-Ala-Gly 0
                Ala-Ala-Pro 0
                Ala-Ala-Pro-Pro 0
                Ala-Ala-Ser 0
                Ala-Arg 0
                Ala-Asn 0
                Ala-Asn-Asn-Pro 0
                Ala-Asn-Asp-Pro 0
                Ala-Asn-Gln-Ser 0
                Ala-Asp-Gly 0
                Ala-Asp-Pro 0
                Ala-Asp-Ser 0
                Ala-Cys-Gly 0
                Ala-Gln-Pro 0
                Ala-Gly-Ala-Gly 0
                Ala-Gly-His 0
                Ala-Gly-Pro 0
                Ala-Gly-Ser 0
                Ala-Gly-Tyr 0
                Ala-Leu-Ala-Pro 0
                Ala-Leu-Asp-Asp 0
                Ala-Leu-Asp-Gly 0
                Ala-Leu-Leu-Asp 0
                Ala-Leu-Leu-His 0
                Ala-Leu-Leu-Ser 0
                Ala-Leu-Leu-Thr 0
                Ala-Leu-Thr-Gln 0
                Ala-Leu-Thr-Pro 0
                Ala-Leu-Val-Ser 0
                Ala-Met-Gln-Gln 0
                Ala-Met-Ser-Arg 0
                Ala-Phe-Thr-Ser 0
                Ala-Phe-Trp-Asn 0
                Ala-Pro 0
                Ala-Ser 0
                Ala-Thr-Ala-Pro 0
                Ala-Trp-Asn-Asp 0
                Ala-Tyr 0
                Ala-Val-Asp-His 0
                Ala-Val-Asp-Pro 0
                Ala-Val-Asp-Ser 0
                Ala-Val-Asp-Tyr 0
                Ala-Val-Pro-Pro 0
                Glu-Ala-Trp 0
                Glu-Leu-Phe-Ala 0
                Glu-Lys-Trp-Ala 0
                Gly-Ala-Ala 0
                L-alanine derivative + 98
                L-alanine residue + 0
                L-alanino group + 0
                L-alanyl group 0
                L-alanyl-L-alanine 0
                Leu-Ala 0
                Leu-Ala-Asp 0
                Leu-Ala-Gly 0
                Leu-Ala-Ser 0
                Leu-Leu-Ala 0
                Leu-Thr-Ala 0
                Met-Ala 0
                Met-Ala-Asp 0
                Met-Ala-Met 0
                Phe-Ala 0
                Phe-Ala-Asp 0
                Phe-Ala-Gly 0
                Phe-Ala-Pro 0
                Phe-Trp-Ala 0
                Thr-Ala-Ala 0
                Thr-Ala-Asp 0
                Thr-Ala-His 0
                Thr-Ala-Ser 0
                Trp-Ala 0
                Trp-Ala-Asp 0
                Trp-Ala-Gly 0
                methyl-L-alanine + 0
                norophthalmic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        monocarboxylic acid 17523
                                          fatty acid 16011
                                            saturated fatty acid 15985
                                              propionic acid 3680
                                                alanine 108
                                                  L-alanine 100
                                                    (+)-(S)-alapyridaine 0
                                                    2-L-alanyl-5-tert-butyl-1,3,4-oxadiazole 0
                                                    Ala-Ala-Ala 0
                                                    Ala-Ala-Asp 0
                                                    Ala-Ala-Asp-Asp 0
                                                    Ala-Ala-Gly 0
                                                    Ala-Ala-Pro 0
                                                    Ala-Ala-Pro-Pro 0
                                                    Ala-Ala-Ser 0
                                                    Ala-Arg 0
                                                    Ala-Asn 0
                                                    Ala-Asn-Asn-Pro 0
                                                    Ala-Asn-Asp-Pro 0
                                                    Ala-Asn-Gln-Ser 0
                                                    Ala-Asp-Gly 0
                                                    Ala-Asp-Pro 0
                                                    Ala-Asp-Ser 0
                                                    Ala-Cys-Gly 0
                                                    Ala-Gln-Pro 0
                                                    Ala-Gly-Ala-Gly 0
                                                    Ala-Gly-His 0
                                                    Ala-Gly-Pro 0
                                                    Ala-Gly-Ser 0
                                                    Ala-Gly-Tyr 0
                                                    Ala-Leu-Ala-Pro 0
                                                    Ala-Leu-Asp-Asp 0
                                                    Ala-Leu-Asp-Gly 0
                                                    Ala-Leu-Leu-Asp 0
                                                    Ala-Leu-Leu-His 0
                                                    Ala-Leu-Leu-Ser 0
                                                    Ala-Leu-Leu-Thr 0
                                                    Ala-Leu-Thr-Gln 0
                                                    Ala-Leu-Thr-Pro 0
                                                    Ala-Leu-Val-Ser 0
                                                    Ala-Met-Gln-Gln 0
                                                    Ala-Met-Ser-Arg 0
                                                    Ala-Phe-Thr-Ser 0
                                                    Ala-Phe-Trp-Asn 0
                                                    Ala-Pro 0
                                                    Ala-Ser 0
                                                    Ala-Thr-Ala-Pro 0
                                                    Ala-Trp-Asn-Asp 0
                                                    Ala-Tyr 0
                                                    Ala-Val-Asp-His 0
                                                    Ala-Val-Asp-Pro 0
                                                    Ala-Val-Asp-Ser 0
                                                    Ala-Val-Asp-Tyr 0
                                                    Ala-Val-Pro-Pro 0
                                                    Glu-Ala-Trp 0
                                                    Glu-Leu-Phe-Ala 0
                                                    Glu-Lys-Trp-Ala 0
                                                    Gly-Ala-Ala 0
                                                    L-alanine derivative + 98
                                                    L-alanine residue + 0
                                                    L-alanino group + 0
                                                    L-alanyl group 0
                                                    L-alanyl-L-alanine 0
                                                    Leu-Ala 0
                                                    Leu-Ala-Asp 0
                                                    Leu-Ala-Gly 0
                                                    Leu-Ala-Ser 0
                                                    Leu-Leu-Ala 0
                                                    Leu-Thr-Ala 0
                                                    Met-Ala 0
                                                    Met-Ala-Asp 0
                                                    Met-Ala-Met 0
                                                    Phe-Ala 0
                                                    Phe-Ala-Asp 0
                                                    Phe-Ala-Gly 0
                                                    Phe-Ala-Pro 0
                                                    Phe-Trp-Ala 0
                                                    Thr-Ala-Ala 0
                                                    Thr-Ala-Asp 0
                                                    Thr-Ala-His 0
                                                    Thr-Ala-Ser 0
                                                    Trp-Ala 0
                                                    Trp-Ala-Asp 0
                                                    Trp-Ala-Gly 0
                                                    methyl-L-alanine + 0
                                                    norophthalmic acid 0
paths to the root