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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-alanine
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Accession:CHEBI:16977 term browser browse the term
Definition:The L-enantiomer of alanine.
Synonyms:related_synonym: (2S)-2-aminopropanoic acid;   (S)-2-aminopropanoic acid;   (S)-alanine;   A;   ALANINE;   Ala;   Formula=C3H7NO2;   InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1;   InChIKey=QNAYBMKLOCPYGJ-REOHCLBHSA-N;   L-2-Aminopropionic acid;   L-Alanin;   L-alpha-alanine;   SMILES=C[C@H](N)C(O)=O
 alt_id: CHEBI:13069;   CHEBI:21216;   CHEBI:40734;   CHEBI:40735;   CHEBI:46308;   CHEBI:6171
 xref: CAS:56-41-7;   DrugBank:DB00160;   Drug_Central:4255;   ECMDB:ECMDB00161;   Gmelin:49628;   HMDB:HMDB0000161;   KEGG:C00041;   KEGG:D00012;   KNApSAcK:C00001332
 xref_mesh: MESH:D000409
 xref: MetaCyc:ALPHA-ALANINE;   PDBeChem:ALA_LFOH;   PMID:18235971;   PMID:22735334;   PMID:3275662;   Reaxys:1720248;   Wikipedia:Alanine;   YMDB:YMDB00154
 cyclic_relationship: is_conjugate_acid_of CHEBI:32431;   is_conjugate_base_of CHEBI:32432;   is_enantiomer_of CHEBI:15570;   is_tautomer_of CHEBI:57972


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L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in increased chemical synthesis of and results in increased secretion of Alanine CTD PMID:28558019 NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases abundance
multiple interactions 		ISO IDH2 protein mutant form results in decreased abundance of Alanine
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine] 		CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
3-(5-fluorouracil-1-yl)-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 affects response to substance ISO GRIA3 protein affects the susceptibility to 5-fluorowillardiine CTD PMID:15264227 NCBI chr  X:125,103,975...125,369,690
Ensembl chr  X:125,103,782...125,369,679 		JBrowse link
alliin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsd cathepsin D multiple interactions EXP alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] CTD PMID:29305303 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions 		ISO alliin results in decreased secretion of FGF2 protein
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] 		CTD PMID:16351512 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP
ISO 		alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein] 		CTD PMID:16640830 PMID:29305303 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:16640830 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] CTD PMID:29305303 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] CTD PMID:29305303 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO alliin results in decreased secretion of VEGFA protein CTD PMID:16351512 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
L-selenocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity EXP Selenocysteine analog results in decreased activity of ALAD protein CTD PMID:14630126 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Selenocysteine results in increased expression of GSTA2 mRNA CTD PMID:12034368 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Selenocysteine results in increased expression of GSTA3 mRNA CTD PMID:12034368 NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Selenocysteine results in increased expression of GSTA5 mRNA CTD PMID:12034368 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Selenocysteine results in increased expression of GSTP1 mRNA CTD PMID:12034368 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] CTD PMID:14572605 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
LCL161 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO LCL161 binds to and affects the activity of ABCB1 protein; LCL161 inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; LCL161 inhibits the reaction [ABCB1 protein results in increased export of mitotracker green FM] CTD PMID:32497533 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
decreases expression 		ISO LCL161 results in decreased expression of BIRC2 protein
LCL161 decreases expression of BIRC2 protein in hepatocellular carcinoma cells 		CTD
RGD		 PMID:32497533 PMID:24976294 RGD:153305953 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO LCL161 decreases expression of BIRC3 protein in hepatocellular carcinoma cells RGD PMID:24976294 RGD:153305953 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO LCL161 results in decreased expression of BIRC5 protein CTD PMID:32497533 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO LCL161 decreases expression of XIAP protein in hepatocellular carcinoma cells RGD PMID:24976294 RGD:153305953 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
metalaxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression ISO metalaxyl results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO metalaxyl results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
N-benzoyl-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding 		ISO N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein]
N-benzoylalanine binds to THRB protein 		CTD PMID:31566444 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
Se-methyl-L-selenocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1 CTD PMID:15897249 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
decreases expression 		EXP Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA] CTD PMID:19025659 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA CTD PMID:25321483 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Ar androgen receptor decreases expression ISO
EXP 		selenomethylselenocysteine results in decreased expression of AR protein
selenomethylselenocysteine results in decreased expression of AR mRNA 		CTD PMID:16637076 PMID:19025659 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA CTD PMID:25321483 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Banp Btg3 associated nuclear protein increases expression ISO selenomethylselenocysteine results in increased expression of BANP mRNA CTD PMID:18514395 NCBI chr19:66,916,417...66,994,286
Ensembl chr19:66,916,267...66,991,317 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO
EXP 		selenomethylselenocysteine results in decreased expression of BCL2 mRNA
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein
selenomethylselenocysteine results in decreased expression of BCL2 protein 		CTD PMID:11396176 PMID:19360359 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA CTD PMID:25321483 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA CTD PMID:25321483 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 decreases expression EXP selenomethylselenocysteine results in decreased expression of BMAL1 mRNA CTD PMID:19122877 NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739 		JBrowse link
G Bmf Bcl2 modifying factor multiple interactions
increases expression 		ISO 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]
selenomethylselenocysteine metabolite results in increased expression of BMF protein
selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein 		CTD PMID:25321483 NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression 		ISO selenomethylselenocysteine results in increased activity of CASP3 protein
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form] 		CTD PMID:15318939 PMID:25321483 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp6 caspase 6 increases expression
multiple interactions 		ISO selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form] 		CTD PMID:25321483 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp8 caspase 8 increases expression ISO selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form CTD PMID:25321483 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression 		ISO BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form] CTD PMID:25321483 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccna2 cyclin A2 decreases expression EXP selenomethylselenocysteine results in decreased expression of CCNA2 protein CTD PMID:11396176 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions 		ISO
EXP 		selenomethylselenocysteine results in decreased expression of CCND1 protein
selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein 		CTD PMID:11396176 PMID:18855134 PMID:19276161 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein CTD PMID:10656618 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions 		ISO selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein 		CTD PMID:25321483 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP selenomethylselenocysteine results in increased expression of CDKN1B protein CTD PMID:11396176 PMID:19276161 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO selenomethylselenocysteine results in increased expression of CES1 CTD PMID:15897249 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Chmp1a charged multivesicular body protein 1A increases expression ISO selenomethylselenocysteine results in increased expression of CHMP1A mRNA CTD PMID:18514395 NCBI chr19:68,146,672...68,154,952
Ensembl chr19:68,146,672...68,154,952 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein CTD PMID:18514395 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein CTD PMID:18514395 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Col4a5 collagen type IV alpha 5 chain increases expression ISO selenomethylselenocysteine results in increased expression of COL4A5 mRNA CTD PMID:18514395 NCBI chr  X:109,907,251...110,111,214
Ensembl chr  X:109,907,346...110,111,214 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain increases expression ISO selenomethylselenocysteine results in increased expression of COL6A1 mRNA CTD PMID:18514395 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107 		JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases expression ISO selenomethylselenocysteine results in decreased expression of COL7A1 mRNA CTD PMID:18514395 NCBI chr 8:118,483,364...118,515,736
Ensembl chr 8:118,483,364...118,517,439 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 increases expression EXP selenomethylselenocysteine results in increased expression of CRY2 mRNA CTD PMID:19122877 NCBI chr 3:98,830,479...98,860,437
Ensembl chr 3:98,830,483...98,860,447 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5 CTD PMID:15897249 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP selenomethylselenocysteine results in increased expression of DBP mRNA CTD PMID:19122877 NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO selenomethylselenocysteine results in increased expression of DDIT3 mRNA CTD PMID:10656618 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression EXP selenomethylselenocysteine results in decreased expression of DHCR24 mRNA CTD PMID:19025659 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1 CTD PMID:15897249 NCBI chr14:82,328,320...82,344,416
Ensembl chr14:82,328,320...82,344,348 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions 		ISO selenomethylselenocysteine results in decreased expression of ESR1 protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein 		CTD PMID:18855134 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG CTD PMID:15897249 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO selenomethylselenocysteine results in increased expression of GADD45A mRNA CTD PMID:10656618 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases activity
increases expression 		ISO selenomethylselenocysteine results in increased activity of GPX1 protein
selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein 		CTD PMID:18514395 PMID:19033020 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO selenomethylselenocysteine results in increased expression of GPX4 mRNA CTD PMID:18514395 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 increases expression ISO selenomethylselenocysteine results in increased expression of GRIK1 mRNA CTD PMID:18514395 NCBI chr11:40,655,974...41,056,966
Ensembl chr11:40,655,975...41,056,517 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 increases expression ISO selenomethylselenocysteine results in increased expression of GRIK3 mRNA CTD PMID:18514395 NCBI chr 5:143,052,442...143,268,873
Ensembl chr 5:143,052,442...143,268,873 		JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions ISO HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr  X:71,425,240...71,632,865
Ensembl chr  X:71,394,928...71,632,865 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO selenomethylselenocysteine results in increased expression of IGF1R mRNA CTD PMID:18514395 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP selenomethylselenocysteine results in increased phosphorylation of JUN protein CTD PMID:19276161 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Klk1 kallikrein 1 decreases expression ISO selenomethylselenocysteine results in decreased expression of KLK3 protein CTD PMID:16637076 NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:103,779,164...103,783,270 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression 		ISO [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein
selenomethylselenocysteine results in decreased expression of MKI67 protein 		CTD PMID:18855134 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Msrb1 methionine sulfoxide reductase B1 increases expression ISO selenomethylselenocysteine results in increased expression of MSRB1 mRNA CTD PMID:18514395 NCBI chr10:14,269,414...14,275,140
Ensembl chr10:14,269,414...14,274,184 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] CTD PMID:21213327 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21213327 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 increases expression ISO selenomethylselenocysteine results in increased expression of P4HA1 mRNA CTD PMID:18514395 NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression 		ISO [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form] CTD PMID:25321483 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Per2 period circadian regulator 2 increases expression EXP selenomethylselenocysteine results in increased expression of PER2 mRNA CTD PMID:19122877 NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993 		JBrowse link
G Per3 period circadian regulator 3 increases expression EXP selenomethylselenocysteine results in increased expression of PER3 mRNA CTD PMID:19122877 NCBI chr 5:166,740,914...166,778,243
Ensembl chr 5:166,743,050...166,777,999 		JBrowse link
G Pgr progesterone receptor decreases expression
multiple interactions 		ISO selenomethylselenocysteine results in decreased expression of PGR protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein 		CTD PMID:18855134 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO selenomethylselenocysteine results in increased expression of PPP1R15A mRNA CTD PMID:10656618 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Prkce protein kinase C, epsilon decreases expression ISO selenomethylselenocysteine results in decreased expression of PRKCE protein CTD PMID:10656618 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288 		JBrowse link
G Prkcz protein kinase C, zeta decreases expression ISO selenomethylselenocysteine results in decreased expression of PRKCZ protein CTD PMID:10656618 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO selenomethylselenocysteine results in increased expression of RAB3B mRNA CTD PMID:18514395 NCBI chr 5:128,859,034...128,926,087
Ensembl chr 5:128,841,716...128,926,086 		JBrowse link
G Rab4a RAB4A, member RAS oncogene family increases expression ISO selenomethylselenocysteine results in increased expression of RAB4A mRNA CTD PMID:18514395 NCBI chr19:68,692,228...68,720,169
Ensembl chr19:68,692,890...68,720,166 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:21213327 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO selenomethylselenocysteine results in increased expression of SCARB1 mRNA CTD PMID:18514395 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980 		JBrowse link
G Selenof selenoprotein F increases expression ISO selenomethylselenocysteine results in increased expression of SELENOF mRNA CTD PMID:18514395 NCBI chr 2:236,302,439...236,335,216
Ensembl chr 2:236,302,683...236,335,210 		JBrowse link
G Selenop selenoprotein P increases expression ISO selenomethylselenocysteine results in increased expression of SELENOP mRNA CTD PMID:18514395 NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:54,225,152...54,236,019 		JBrowse link
G Selenow selenoprotein W increases expression ISO selenomethylselenocysteine results in increased expression of SELENOW mRNA CTD PMID:18514395 NCBI chr 1:85,727,631...85,732,703
Ensembl chr 1:85,727,632...85,732,703 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake ISO SLC3A1 protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 6:15,361,037...15,396,695
Ensembl chr 6:15,361,046...15,394,775 		JBrowse link
G Slc6a19 solute carrier family 6 member 19 increases uptake ISO SLC6A19 protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 1:31,414,744...31,434,932
Ensembl chr 1:31,414,744...31,433,517 		JBrowse link
G Slc6a20a solute carrier family 6 member 20a increases uptake ISO SLC6A20B protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 8:132,159,768...132,200,016
Ensembl chr 8:132,158,915...132,200,008 		JBrowse link
G Snap23 synaptosome associated protein 23 decreases expression ISO selenomethylselenocysteine results in decreased expression of SNAP23 mRNA CTD PMID:18514395 NCBI chr 3:127,966,184...127,999,929
Ensembl chr 3:127,967,886...127,998,067 		JBrowse link
G Sort1 sortilin 1 increases expression ISO selenomethylselenocysteine results in increased expression of SORT1 mRNA CTD PMID:18514395 NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions ISO selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:78,219,426...78,264,517 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO selenomethylselenocysteine results in decreased expression of SPP1 protein CTD PMID:15318939 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions EXP [selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein CTD PMID:19025659 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] CTD PMID:25321483 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stx3 syntaxin 3 increases expression ISO selenomethylselenocysteine results in increased expression of STX3 mRNA CTD PMID:18514395 NCBI chr 1:217,940,697...218,114,865
Ensembl chr 1:217,909,169...218,110,466 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein CTD PMID:19360359 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Trnau1ap tRNA selenocysteine 1 associated protein 1 increases expression ISO selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA CTD PMID:18514395 NCBI chr 5:149,791,631...149,808,149
Ensembl chr 5:149,791,631...149,808,680 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425 		JBrowse link
sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:164,828,163...164,838,464 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:78,657,409...78,665,255
Ensembl chr 1:78,659,262...78,703,273 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      biological role 20799
        biochemical role 20250
          metabolite 20231
            fundamental metabolite 14714
              L-alanine 106
                (+)-(S)-alapyridaine 0
                2-L-alanyl-5-tert-butyl-1,3,4-oxadiazole 0
                Ac-Tyr-Val-Ala-Asp-chloromethylketone 0
                Ala-Ala-Ala 0
                Ala-Ala-Asp 0
                Ala-Ala-Asp-Asp 0
                Ala-Ala-Gly 0
                Ala-Ala-Pro 0
                Ala-Ala-Pro-Pro 0
                Ala-Ala-Ser 0
                Ala-Arg 0
                Ala-Asn 0
                Ala-Asn-Asn-Pro 0
                Ala-Asn-Asp-Pro 0
                Ala-Asn-Gln-Ser 0
                Ala-Asp-Gly 0
                Ala-Asp-Pro 0
                Ala-Asp-Ser 0
                Ala-Cys 0
                Ala-Cys-Gly 0
                Ala-Gln-Pro 0
                Ala-Gly-Ala-Gly 0
                Ala-Gly-His 0
                Ala-Gly-Pro 0
                Ala-Gly-Ser 0
                Ala-Gly-Tyr 0
                Ala-Leu-Ala 0
                Ala-Leu-Ala-Pro 0
                Ala-Leu-Asp-Asp 0
                Ala-Leu-Asp-Gly 0
                Ala-Leu-Leu-Asp 0
                Ala-Leu-Leu-His 0
                Ala-Leu-Leu-Ser 0
                Ala-Leu-Leu-Thr 0
                Ala-Leu-Thr-Gln 0
                Ala-Leu-Thr-Pro 0
                Ala-Leu-Val-Ser 0
                Ala-Met-Asp-Tyr 0
                Ala-Met-Gln-Gln 0
                Ala-Met-Ser-Arg 0
                Ala-Phe-Thr-Ser 0
                Ala-Phe-Trp-Asn 0
                Ala-Pro 0
                Ala-Ser 0
                Ala-Thr-Ala-Pro 0
                Ala-Trp-Asn-Asp 0
                Ala-Tyr 0
                Ala-Val-Asp-His 0
                Ala-Val-Asp-Pro 0
                Ala-Val-Asp-Ser 0
                Ala-Val-Asp-Tyr 0
                Ala-Val-Pro-Pro 0
                Glu-Ala-Trp 0
                Glu-Leu-Phe-Ala 0
                Glu-Lys-Trp-Ala 0
                Gly-Ala-Ala 0
                L-Alanine-d3 0
                L-alanine derivative + 104
                L-alanine residue + 0
                L-alanino group + 0
                L-alanyl group 0
                L-alanyl-L-alanine 0
                Leu-Ala 0
                Leu-Ala-Asp 0
                Leu-Ala-Gly 0
                Leu-Ala-Ser 0
                Leu-Leu-Ala 0
                Leu-Thr-Ala 0
                Lys-Ala + 0
                Met-Ala 0
                Met-Ala-Asp 0
                Met-Ala-Met 0
                Phe-Ala 0
                Phe-Ala-Asp 0
                Phe-Ala-Gly 0
                Phe-Ala-Pro 0
                Phe-Trp-Ala 0
                Thr-Ala-Ala 0
                Thr-Ala-Asp 0
                Thr-Ala-His 0
                Thr-Ala-Ser 0
                Trp-Ala 0
                Trp-Ala-Asp 0
                Trp-Ala-Gly 0
                methyl-L-alanine + 0
                norophthalmic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbon oxoacid 19142
                                    carboxylic acid 19139
                                      monocarboxylic acid 18291
                                        fatty acid 16980
                                          saturated fatty acid 16678
                                            propionic acid 3889
                                              alanine 116
                                                L-alanine 106
                                                  (+)-(S)-alapyridaine 0
                                                  2-L-alanyl-5-tert-butyl-1,3,4-oxadiazole 0
                                                  Ac-Tyr-Val-Ala-Asp-chloromethylketone 0
                                                  Ala-Ala-Ala 0
                                                  Ala-Ala-Asp 0
                                                  Ala-Ala-Asp-Asp 0
                                                  Ala-Ala-Gly 0
                                                  Ala-Ala-Pro 0
                                                  Ala-Ala-Pro-Pro 0
                                                  Ala-Ala-Ser 0
                                                  Ala-Arg 0
                                                  Ala-Asn 0
                                                  Ala-Asn-Asn-Pro 0
                                                  Ala-Asn-Asp-Pro 0
                                                  Ala-Asn-Gln-Ser 0
                                                  Ala-Asp-Gly 0
                                                  Ala-Asp-Pro 0
                                                  Ala-Asp-Ser 0
                                                  Ala-Cys 0
                                                  Ala-Cys-Gly 0
                                                  Ala-Gln-Pro 0
                                                  Ala-Gly-Ala-Gly 0
                                                  Ala-Gly-His 0
                                                  Ala-Gly-Pro 0
                                                  Ala-Gly-Ser 0
                                                  Ala-Gly-Tyr 0
                                                  Ala-Leu-Ala 0
                                                  Ala-Leu-Ala-Pro 0
                                                  Ala-Leu-Asp-Asp 0
                                                  Ala-Leu-Asp-Gly 0
                                                  Ala-Leu-Leu-Asp 0
                                                  Ala-Leu-Leu-His 0
                                                  Ala-Leu-Leu-Ser 0
                                                  Ala-Leu-Leu-Thr 0
                                                  Ala-Leu-Thr-Gln 0
                                                  Ala-Leu-Thr-Pro 0
                                                  Ala-Leu-Val-Ser 0
                                                  Ala-Met-Asp-Tyr 0
                                                  Ala-Met-Gln-Gln 0
                                                  Ala-Met-Ser-Arg 0
                                                  Ala-Phe-Thr-Ser 0
                                                  Ala-Phe-Trp-Asn 0
                                                  Ala-Pro 0
                                                  Ala-Ser 0
                                                  Ala-Thr-Ala-Pro 0
                                                  Ala-Trp-Asn-Asp 0
                                                  Ala-Tyr 0
                                                  Ala-Val-Asp-His 0
                                                  Ala-Val-Asp-Pro 0
                                                  Ala-Val-Asp-Ser 0
                                                  Ala-Val-Asp-Tyr 0
                                                  Ala-Val-Pro-Pro 0
                                                  Glu-Ala-Trp 0
                                                  Glu-Leu-Phe-Ala 0
                                                  Glu-Lys-Trp-Ala 0
                                                  Gly-Ala-Ala 0
                                                  L-Alanine-d3 0
                                                  L-alanine derivative + 104
                                                  L-alanine residue + 0
                                                  L-alanino group + 0
                                                  L-alanyl group 0
                                                  L-alanyl-L-alanine 0
                                                  Leu-Ala 0
                                                  Leu-Ala-Asp 0
                                                  Leu-Ala-Gly 0
                                                  Leu-Ala-Ser 0
                                                  Leu-Leu-Ala 0
                                                  Leu-Thr-Ala 0
                                                  Lys-Ala + 0
                                                  Met-Ala 0
                                                  Met-Ala-Asp 0
                                                  Met-Ala-Met 0
                                                  Phe-Ala 0
                                                  Phe-Ala-Asp 0
                                                  Phe-Ala-Gly 0
                                                  Phe-Ala-Pro 0
                                                  Phe-Trp-Ala 0
                                                  Thr-Ala-Ala 0
                                                  Thr-Ala-Asp 0
                                                  Thr-Ala-His 0
                                                  Thr-Ala-Ser 0
                                                  Trp-Ala 0
                                                  Trp-Ala-Asp 0
                                                  Trp-Ala-Gly 0
                                                  methyl-L-alanine + 0
                                                  norophthalmic acid 0
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