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ONTOLOGY REPORT - ANNOTATIONS


Term:cortisone
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Accession:CHEBI:16962 term browser browse the term
Definition:A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.
Synonyms:exact_synonym: 17,21-dihydroxypregn-4-ene-3,11,20-trione
 related_synonym: 11-dehydro-17-hydroxycorticosterone;   17-hydroxy-11-dehydrocorticosterone;   17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione;   4-pregnene-17alpha,21-diol-3,11,20-trione;   Cortison;   Delta(4)-pregnene-17alpha,21-diol-3,11,20-trione;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1;   InChIKey=MFYSYFVPBJMHGN-ZPOLXVRWSA-N;   Kendall's compound E;   Kortison;   Reichstein's substance Fa;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   Wintersteiner's compound F;   pregn-4-en-17alpha,21-diol-3,11,20-trione
 alt_id: CHEBI:14026;   CHEBI:23397;   CHEBI:3896
 xref: Beilstein:1356062 "Beilstein";   CAS:53-06-5 "ChemIDplus";   CAS:53-06-5 "KEGG COMPOUND";   CAS:53-06-5 "NIST Chemistry WebBook";   HMDB:HMDB0002802;   KEGG:C00762;   KEGG:D07749;   LIPID_MAPS_instance:LMST02030090 "LIPID MAPS"
 xref_mesh: MESH:D003348
 xref: MetaCyc:CORTISONE;   PMID:11710540 "Europe PMC";   PMID:14874924 "Europe PMC";   PMID:2268561 "Europe PMC";   PMID:24391193 "Europe PMC";   PMID:8989250 "Europe PMC";   Reaxys:1356062 "Reaxys";   Wikipedia:Cortisone


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cortisone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Dhrs7 dehydrogenase/reductase 7 JBrowse link 6 95,522,577 95,541,393 RGD:6480464
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:6480464
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 19 37,476,083 37,481,326 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
17,21-dihydroxy-5beta-pregnane-3,11,20-trione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    chemical entity 19677
      group 19592
        organic group 18351
          3-oxo-Delta(4)-steroid group 7907
            3-oxo-Delta(4) steroid 7907
              cortisone 25
                4,5-dihydrocortisone + 1
                6beta-hydroxycortisone 0
                hydrocortamate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      ketone 15788
                                        oxyketone 8441
                                          alpha-oxyketone 8441
                                            alpha-hydroxy ketone 8441
                                              primary alpha-hydroxy ketone 7435
                                                cortisone 25
                                                  4,5-dihydrocortisone + 1
                                                  6beta-hydroxycortisone 0
                                                  hydrocortamate + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.