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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ADP-D-ribose
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Accession:CHEBI:16960 term browser browse the term
Definition:A nucleotide-sugar having ADP as the nucleotide fragment and D-ribofuranos-5-yl as the sugar component.
Synonyms:exact_synonym: adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]
 related_synonym: (Rib5)ppA;   5-(adenosine 5'-pyrophosphoryl)-D-ribose;   A5'pp5Rib;   ADP ribose;   ADP-Rib;   ADP-riboses;   ADPribose;   Adenosine diphosphate ribose;   AdoPPRib;   D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate);   Formula=C15H23N5O14P2;   InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1;   InChIKey=SRNWOUGRCWSEMX-TYASJMOZSA-N;   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O;   adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose;   adenosine 5'-diphosphoribose;   adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose;   ribose adenosinediphosphate
 alt_id: CHEBI:13231;   CHEBI:20850;   CHEBI:2351;   CHEBI:32889;   CHEBI:40752
 xref: Beilstein:1236193;   Beilstein:6081768;   CAS:20762-30-5;   KEGG:C00301
 xref_mesh: MESH:D000246
 cyclic_relationship: is_conjugate_acid_of CHEBI:57967


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ADP-D-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprh ADP-ribosylarginine hydrolase increases hydrolysis ISO ADPRH protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite CTD PMID:21498885 NCBI chr11:62,299,831...62,306,170
Ensembl chr11:62,299,793...62,306,931
JBrowse link
G Adprs ADP-ribosylserine hydrolase increases hydrolysis
multiple interactions
ISO ADPRS protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite
Adenosine Diphosphate Ribose inhibits the reaction [ADPRS protein results in increased hydrolysis of O-Acetyl-ADP-Ribose]
CTD PMID:21498885 NCBI chr 5:138,614,022...138,619,296
Ensembl chr 5:138,614,022...138,619,296
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased ribosylation of Adenosine Diphosphate Ribose] CTD PMID:10318960 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions
increases activity
EXP
ISO
Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]; Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; [Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein; Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; Glutathione inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]
CTD PMID:18204483 PMID:20878536 PMID:21900507 PMID:22750002 PMID:33309544 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
cyclic ADP-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd38 CD38 molecule decreases abundance ISO CD38 gene mutant form results in decreased abundance of Cyclic ADP-Ribose CTD PMID:23343681 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            fundamental metabolite 12766
              ADP 87
                ADP-D-ribose 7
                  2''-O-glutaryl-ADP-D-ribose 0
                  2''-O-malonyl-ADP-D-ribose 0
                  2''-O-succinyl-ADP-D-ribose 0
                  ADP-D-ribose 1'',2''-cyclic phosphate 0
                  ADP-D-ribose 1''-phosphate 0
                  L-glutamyl-5-poly(ADP-ribose) 0
                  N(4)-(ADP-ribosyl)-L-asparagine 0
                  N(omega)-(ADP-D-ribosyl)-L-arginine 0
                  O-(ADP-ribosyl)-L-serine 0
                  S-(ADP-ribosyl)-L-cysteine + 0
                  cyclic ADP-ribose + 3
                  poly-ADP-D-ribose 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              oxoacid 18488
                                pnictogen oxoacid 10688
                                  phosphorus oxoacid 9669
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8171
                                          phosphate 8170
                                            organic phosphate 8169
                                              carbohydrate phosphate 1734
                                                phospho sugar 1659
                                                  aldose phosphate 1657
                                                    aldopentose phosphate 1651
                                                      ribose phosphate 1646
                                                        ribonucleotide 1607
                                                          purine ribonucleotide 1580
                                                            adenyl ribonucleotide 1283
                                                              adenosine phosphate 274
                                                                adenosine 5'-phosphate 273
                                                                  ADP 87
                                                                    ADP-sugar 7
                                                                      ADP-D-ribose 7
                                                                        2''-O-glutaryl-ADP-D-ribose 0
                                                                        2''-O-malonyl-ADP-D-ribose 0
                                                                        2''-O-succinyl-ADP-D-ribose 0
                                                                        ADP-D-ribose 1'',2''-cyclic phosphate 0
                                                                        ADP-D-ribose 1''-phosphate 0
                                                                        L-glutamyl-5-poly(ADP-ribose) 0
                                                                        N(4)-(ADP-ribosyl)-L-asparagine 0
                                                                        N(omega)-(ADP-D-ribosyl)-L-arginine 0
                                                                        O-(ADP-ribosyl)-L-serine 0
                                                                        S-(ADP-ribosyl)-L-cysteine + 0
                                                                        cyclic ADP-ribose + 3
                                                                        poly-ADP-D-ribose 0
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