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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ADP-D-ribose
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Accession:CHEBI:16960 term browser browse the term
Definition:A nucleotide-sugar having ADP as the nucleotide fragment and D-ribofuranos-5-yl as the sugar component.
Synonyms:exact_synonym: adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]
 related_synonym: (Rib5)ppA;   5-(adenosine 5'-pyrophosphoryl)-D-ribose;   A5'pp5Rib;   ADP ribose;   ADP-Rib;   ADP-riboses;   ADPribose;   Adenosine diphosphate ribose;   AdoPPRib;   D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate);   Formula=C15H23N5O14P2;   InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1;   InChIKey=SRNWOUGRCWSEMX-TYASJMOZSA-N;   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O;   adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose;   adenosine 5'-diphosphoribose;   adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose;   ribose adenosinediphosphate
 alt_id: CHEBI:13231;   CHEBI:20850;   CHEBI:2351;   CHEBI:32889;   CHEBI:40752
 xref: Beilstein:1236193;   Beilstein:6081768;   CAS:20762-30-5;   KEGG:C00301
 xref_mesh: MESH:D000246
 cyclic_relationship: is_conjugate_acid_of CHEBI:57967


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ADP-D-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprh ADP-ribosylarginine hydrolase increases hydrolysis ISO ADPRH protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite CTD PMID:21498885 NCBI chr11:64,861,772...64,868,112
Ensembl chr11:64,861,768...64,868,108
JBrowse link
G Adprs ADP-ribosylserine hydrolase increases hydrolysis
multiple interactions
ISO ADPRS protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite
Adenosine Diphosphate Ribose inhibits the reaction [ADPRS protein results in increased hydrolysis of O-Acetyl-ADP-Ribose]
CTD PMID:21498885 NCBI chr 5:144,336,312...144,341,586
Ensembl chr 5:144,336,312...144,341,586
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased ribosylation of Adenosine Diphosphate Ribose] CTD PMID:10318960 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions
increases activity
EXP
ISO
Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]; Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]
CTD PMID:18204483, PMID:20878536, PMID:21900507, PMID:22750002 NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051
JBrowse link
cyclic ADP-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd38 CD38 molecule decreases abundance ISO CD38 gene mutant form results in decreased abundance of Cyclic ADP-Ribose CTD PMID:23343681 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            fundamental metabolite 12621
              ADP 83
                ADP-D-ribose 7
                  2''-O-glutaryl-ADP-D-ribose 0
                  2''-O-malonyl-ADP-D-ribose 0
                  2''-O-succinyl-ADP-D-ribose 0
                  ADP-D-ribose 1'',2''-cyclic phosphate 0
                  ADP-D-ribose 1''-phosphate 0
                  L-glutamyl-5-poly(ADP-ribose) 0
                  N(4)-(ADP-ribosyl)-L-asparagine 0
                  N(omega)-(ADP-D-ribosyl)-L-arginine 0
                  O-(ADP-ribosyl)-L-serine 0
                  S-(ADP-ribosyl)-L-cysteine + 0
                  cyclic ADP-ribose + 3
                  poly-ADP-D-ribose 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      chalcogen 19399
                        oxygen atom 19361
                          oxygen molecular entity 19361
                            hydroxides 19107
                              oxoacid 18241
                                pnictogen oxoacid 10179
                                  phosphorus oxoacid 9071
                                    phosphoric acids 7830
                                      phosphoric acid 7830
                                        phosphoric acid derivative 7511
                                          phosphate 7511
                                            organic phosphate 7510
                                              carbohydrate phosphate 1536
                                                phospho sugar 1462
                                                  aldose phosphate 1460
                                                    aldopentose phosphate 1454
                                                      ribose phosphate 1448
                                                        ribonucleotide 1409
                                                          purine ribonucleotide 1381
                                                            adenyl ribonucleotide 1250
                                                              adenosine phosphate 256
                                                                adenosine 5'-phosphate 255
                                                                  ADP 83
                                                                    ADP-sugar 7
                                                                      ADP-D-ribose 7
                                                                        2''-O-glutaryl-ADP-D-ribose 0
                                                                        2''-O-malonyl-ADP-D-ribose 0
                                                                        2''-O-succinyl-ADP-D-ribose 0
                                                                        ADP-D-ribose 1'',2''-cyclic phosphate 0
                                                                        ADP-D-ribose 1''-phosphate 0
                                                                        L-glutamyl-5-poly(ADP-ribose) 0
                                                                        N(4)-(ADP-ribosyl)-L-asparagine 0
                                                                        N(omega)-(ADP-D-ribosyl)-L-arginine 0
                                                                        O-(ADP-ribosyl)-L-serine 0
                                                                        S-(ADP-ribosyl)-L-cysteine + 0
                                                                        cyclic ADP-ribose + 3
                                                                        poly-ADP-D-ribose 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.