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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vitexin
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Accession:CHEBI:16954 term browser browse the term
Definition:An apigenin flavone glycoside, which is found in the passion flower, bamboo leaves and pearl millet
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol
 related_synonym: Formula=C21H20O10;   InChI=1S/C21H20O10/c22-7-14-17(27)18(28)19(29)21(31-14)16-11(25)5-10(24)15-12(26)6-13(30-20(15)16)8-1-3-9(23)4-2-8/h1-6,14,17-19,21-25,27-29H,7H2/t14-,17-,18+,19-,21+/m1/s1;   InChIKey=SGEWCQFRYRRZDC-VPRICQMDSA-N;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1;   apigenin 8-C-glucoside
 alt_id: CHEBI:10012;   CHEBI:15315;   CHEBI:27308
 xref: CAS:3681-93-4;   KEGG:C01460;   KNApSAcK:C00001110;   LIPID_MAPS_instance:LMPK12110194
 xref_mesh: MESH:C032731
 xref: MetaCyc:VITEXIN;   PMID:21809948;   PMID:22408451;   PMID:22683902;   PMID:22941432;   PMID:23099258;   Reaxys:67796;   Wikipedia:Vitexin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57963



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vitexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO vitexin results in increased expression of ABCA1 mRNA CTD PMID:29545167 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Apoe apolipoprotein E increases expression ISO vitexin results in increased expression of APOE mRNA CTD PMID:29545167 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases expression
ISO vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]; vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA]
vitexin results in decreased expression of APP mRNA; vitexin results in decreased expression of APP protein
CTD PMID:29545167 PMID:32926499 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:29545167 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] CTD PMID:29545167 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein] CTD PMID:29545167 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA] CTD PMID:29545167 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO vitexin results in increased expression of DHCR24 mRNA CTD PMID:29545167 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] CTD PMID:30365938 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA] CTD PMID:29545167 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA] CTD PMID:29545167 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of LHB protein] CTD PMID:30365938 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA] CTD PMID:29545167 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO vitexin results in increased expression of NR1H3 mRNA CTD PMID:29545167 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] CTD PMID:29545167 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        biochemical role 19380
          metabolite 19358
            apigenin 243
              vitexin 15
                7-O-methylvitexin 2''-O-alpha-L-rhamnoside 0
                7-O-methylvitexin 2''-O-beta-L-rhamnoside 0
                vitexin 2''-O-alpha-L-rhamnoside 0
                vitexin 2''-O-beta-D-glucoside 0
                vitexin 2''-O-beta-L-rhamnoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic molecule 19562
                              organic cyclic compound 19356
                                organic heterocyclic compound 18596
                                  oxacycle 17627
                                    benzopyran 10422
                                      1-benzopyran 10148
                                        flavonoid 6522
                                          flavones 4209
                                            hydroxyflavone 4197
                                              trihydroxyflavone 353
                                                apigenin 243
                                                  vitexin 15
                                                    7-O-methylvitexin 2''-O-alpha-L-rhamnoside 0
                                                    7-O-methylvitexin 2''-O-beta-L-rhamnoside 0
                                                    vitexin 2''-O-alpha-L-rhamnoside 0
                                                    vitexin 2''-O-beta-D-glucoside 0
                                                    vitexin 2''-O-beta-L-rhamnoside 0
paths to the root