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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vitexin
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Accession:CHEBI:16954 term browser browse the term
Definition:An apigenin flavone glycoside, which is found in the passion flower, bamboo leaves and pearl millet
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol
 related_synonym: Apigenin 8-C-glucoside;   Formula=C21H20O10;   InChI=1S/C21H20O10/c22-7-14-17(27)18(28)19(29)21(31-14)16-11(25)5-10(24)15-12(26)6-13(30-20(15)16)8-1-3-9(23)4-2-8/h1-6,14,17-19,21-25,27-29H,7H2/t14-,17-,18+,19-,21+/m1/s1;   InChIKey=SGEWCQFRYRRZDC-VPRICQMDSA-N;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1
 alt_id: CHEBI:10012;   CHEBI:15315;   CHEBI:27308
 xref: CAS:3681-93-4;   KEGG:C01460;   KNApSAcK:C00001110;   LIPID_MAPS_instance:LMPK12110194
 xref_mesh: MESH:C032731
 xref: MetaCyc:VITEXIN;   PMID:21809948;   PMID:22408451;   PMID:22683902;   PMID:22941432;   PMID:23099258;   Reaxys:67796;   Wikipedia:Vitexin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57963


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vitexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO vitexin results in increased expression of ABCA1 mRNA CTD PMID:29545167 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Apoe apolipoprotein E increases expression ISO vitexin results in increased expression of APOE mRNA CTD PMID:29545167 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]; vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] CTD PMID:29545167 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:29545167 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] CTD PMID:29545167 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein] CTD PMID:29545167 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA] CTD PMID:29545167 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO vitexin results in increased expression of DHCR24 mRNA CTD PMID:29545167 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] CTD PMID:30365938 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA] CTD PMID:29545167 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA] CTD PMID:29545167 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of LHB protein] CTD PMID:30365938 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA] CTD PMID:29545167 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO vitexin results in increased expression of NR1H3 mRNA CTD PMID:29545167 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] CTD PMID:29545167 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            apigenin 228
              vitexin 15
                7-O-methylvitexin 2''-O-alpha-L-rhamnoside 0
                7-O-methylvitexin 2''-O-beta-L-rhamnoside 0
                vitexin 2''-O-alpha-L-rhamnoside 0
                vitexin 2''-O-beta-D-glucoside 0
                vitexin 2''-O-beta-L-rhamnoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  oxacycle 17181
                                    benzopyran 10132
                                      1-benzopyran 9848
                                        flavonoid 6372
                                          flavones 4166
                                            hydroxyflavone 4154
                                              trihydroxyflavone 338
                                                apigenin 228
                                                  vitexin 15
                                                    7-O-methylvitexin 2''-O-alpha-L-rhamnoside 0
                                                    7-O-methylvitexin 2''-O-beta-L-rhamnoside 0
                                                    vitexin 2''-O-alpha-L-rhamnoside 0
                                                    vitexin 2''-O-beta-D-glucoside 0
                                                    vitexin 2''-O-beta-L-rhamnoside 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.