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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:creatine
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Accession:CHEBI:16919 term browser browse the term
Definition:A glycine derivative having methyl and amidino groups attached to the nitrogen.
Synonyms:exact_synonym: N-[amino(imino)methyl]-N-methylglycine
 related_synonym: ((amino(imino)methyl)(methyl)amino)acetic acid;   (N-methylcarbamimidamido)acetic acid;   (alpha-methylguanido)acetic acid;   Creatin;   Formula=C4H9N3O2;   InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9);   InChIKey=CVSVTCORWBXHQV-UHFFFAOYSA-N;   Kreatin;   Methylglycocyamine;   N-(aminoiminomethyl)-N-methylglycine;   N-[(E)-AMINO(IMINO)METHYL]-N-METHYLGLYCINE;   N-amidinosarcosine;   N-carbamimidoyl-N-methylglycine;   N-methyl-N-guanylglycine;   SMILES=CN(CC(O)=O)C(N)=N;   alpha-Methylguanidino acetic acid
 alt_id: CHEBI:14028;   CHEBI:23404;   CHEBI:3909;   CHEBI:41678
 xref: Beilstein:907175;   CAS:57-00-1;   Chemspider:566;   DrugBank:DB00148;   Drug_Central:4661;   Gmelin:240513;   HMDB:HMDB0000064;   KEGG:C00300
 xref_mesh: MESH:D003401
 xref: MetaCyc:CREATINE;   PDBeChem:CRN;   PMID:11356982;   PMID:11483809;   PMID:11867929;   PMID:12085493;   PMID:12184144;   PMID:12878267;   PMID:16445883;   PMID:17190852;   PMID:17253521;   PMID:17416441;   PMID:18555535;   PMID:19082141;   PMID:19651674;   PMID:19741514;   PMID:19968328;   PMID:21556832;   PMID:21660517;   PMID:21698493;   PMID:22038587;   PMID:22101931;   PMID:22196490;   PMID:22252611;   PMID:22347384;   PMID:22386973;   PMID:22422801;   PMID:22429992;   PMID:22465051;   PMID:22521466;   PMID:7752905;   Reaxys:907175;   Wikipedia:Creatine
 cyclic_relationship: is_conjugate_acid_of CHEBI:66924;   is_tautomer_of CHEBI:57947



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creatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 multiple interactions ISO Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G App amyloid beta precursor protein increases secretion ISO Creatine analog results in increased secretion of APP protein modified form CTD PMID:22906069 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
ISO Sirolimus inhibits the reaction [Creatine results in increased expression of BDNF protein] CTD PMID:33022268 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Creatine co-treated with Ribose] results in decreased activity of CASP3 protein CTD PMID:21220914 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO [CSF3 protein co-treated with Paclitaxel] results in decreased abundance of Creatine CTD PMID:9018096 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Dek DEK proto-oncogene increases chemical synthesis ISO DEK protein results in increased chemical synthesis of Creatine CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Gatm glycine amidinotransferase increases chemical synthesis ISO GATM protein results in increased chemical synthesis of Creatine CTD PMID:16820567 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
ISO Creatine results in increased phosphorylation of MTOR protein
Sirolimus inhibits the reaction [Creatine results in increased phosphorylation of MTOR protein]
CTD PMID:33022268 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Creatine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Snca synuclein alpha multiple interactions ISO [coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein CTD PMID:19476553 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
creatinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases abundance ISO ARNTL gene mutant form results in increased abundance of Creatinine CTD PMID:27056296 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Creatinine] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Lepr leptin receptor affects abundance
multiple interactions
increases abundance
ISO LEPR affects the abundance of Creatinine
Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Creatinine]
CTD PMID:20567778 PMID:29988851 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased abundance of Creatinine CTD PMID:28710020 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [SC 560 results in decreased activity of PTGS1 protein] which results in increased abundance of Creatinine CTD PMID:19629487 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Creatinine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Creatinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Sod2 superoxide dismutase 2 decreases abundance ISO SOD2 protein results in decreased abundance of Creatinine CTD PMID:19917352 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            nutraceutical 12734
              creatine 20
                N-phosphocreatine 0
                creatinine 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        amino acid 14872
                                          alpha-amino acid 12865
                                            L-alpha-amino acid 11583
                                              serine family amino acid 2556
                                                glycine 1599
                                                  glycine derivative 1586
                                                    creatine 20
                                                      N-phosphocreatine 0
                                                      creatinine 9
paths to the root