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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:salicylic acid
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Accession:CHEBI:16914 term browser browse the term
Definition:A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves.
Synonyms:related_synonym: 2-HYDROXYBENZOIC ACID;   2-carboxyphenol;   Formula=C7H6O3;   InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10);   InChIKey=YGSDEFSMJLZEOE-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccccc1O;   o-carboxyphenol;   o-hydroxybenzoic acid
 alt_id: CHEBI:26597;   CHEBI:45521;   CHEBI:9006
 xref: Beilstein:774890;   CAS:69-72-7;   DrugBank:DB00936;   Drug_Central:2416;   Gmelin:3418;   HMDB:HMDB0001895;   KEGG:C00805;   KEGG:D00097;   KNApSAcK:C00000206;   LINCS:LSM-4763
 xref_mesh: MESH:D020156
 xref: MetaCyc:CPD-110;   PDBeChem:SAL;   PMID:11016405;   PMID:12865403;   PMID:1650428;   PMID:19400653;   PMID:19816125;   PMID:22770225;   PMID:29079364;   PMID:32807953;   PMID:3425858;   Reaxys:774890;   Wikipedia:Salicylic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30762


show annotations for term's descendants           Sort by:
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5066
    role 5030
      biological role 5030
        antimicrobial agent 257
          antifungal agent 112
            salicylic acid 3
              1-salicylate glucuronide 0
              2,6-dihydroxy-4-[(2R)-2-hydroxyheptyl]benzoic acid 0
              2-(D-glucosyloxy)benzoic acid + 0
              2-Hydroxy-4-trifluoromethyl benzoic acid 0
              2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid 0
              2-Hydroxy-6-(8-tridecenyl)benzoic acid 0
              2-Hydroxy-6-pentadeca-8,11,14-trienyl benzoic acid 0
              2-Hydroxy-6-tridecylbenzoic acid 0
              2-[[2-[(2-hydroxyphenyl)-oxomethoxy]-1-oxoethyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid methyl ester 0
              2-hydroxy-3-methylbenzoic acid (3-cyano-4-imino-2-oxopentyl) ester 0
              2-hydroxy-4-methylbenzoic acid [2-(2-chloroanilino)-2-oxoethyl] ester 0
              2-hydroxy-5-[(4-methoxyphenyl)sulfamoyl]benzoic acid [2-[1-(3-bicyclo[2.2.1]heptanyl)ethylamino]-2-oxoethyl] ester 0
              2-hydroxy-6-(12-oxoheptadecyl)benzoic acid 0
              2-hydroxy-6-(12-oxopentadecyl)benzoic acid 0
              2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid 0
              2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester 0
              2-hydroxybenzoic acid [2-(2-ethoxyanilino)-2-oxo-1-phenylethyl] ester 0
              2-hydroxybenzoic acid [2-[[(1-methyl-2-pyrrolyl)-oxomethyl]amino]-2-oxoethyl] ester 0
              2-hydroxybenzoyl group 0
              2-hydroxybenzoyl-AMP 0
              2-hydroxybenzoyl-CoA 0
              2-hydroxyethyl salicylate 0
              3,5-dinitrosalicylic acid + 0
              3,6-dimethylsalicylic acid + 0
              3-Hydroxyphthalic acid 0
              3-allyl-2-hydroxybenzoic acid 0
              3-formylsalicylic acid 0
              3-methylsalicylic acid 0
              4-[amino(carboxy)methyl]-2-hydroxybenzoic acid 0
              4-acetamidosalicylic acid + 0
              4-aminosalicylic acid 0
              4-formylsalicylic acid 0
              4-hydroxymethylsalicylic acid 0
              4-methylsalicylic acid 0
              4R,5R,6S-Trihydroxy-2-hydroxymethyl-2-cyclohexen-1-one 6-(2-hydroxy-6-methylbenzoate) 0
              5-(diethylsulfamoyl)-2-hydroxybenzoic acid [2-oxo-2-[4-(trifluoromethoxy)anilino]ethyl] ester 0
              5-[amino(carboxy)methyl]-2-hydroxybenzoic acid 0
              5-formylsalicylic acid 0
              5-nitrososalicylic acid 0
              6-((8Z,11Z,14Z)-heptadeca-8,11,14-trien-1-yl)salicylic acid 0
              6-((Z)-pentadec-10-en-1-yl)salicylic acid 0
              6-((Z)-pentadec-8-en-1-yl)salicylic acid 0
              6-formylsalicylic acid 0
              6-hydroxy platensimycin A1 methyl ester 0
              6-methylsalicylic acid 0
              Ampelomin G 0
              Antibiotic SB 202742 0
              Benzyl salicylate 0
              Butyl salicylate 0
              Chloropupukeananin 0
              Chloropupukeanone A 0
              Choline salicylate 0
              D-glucosyl salicylate + 0
              Ethyl 4-ethoxy-2-hydroxy-3,6-dimethylbenzoate 0
              Ethylhexyl salicylate 0
              Gentisic acid sodium 0
              Gibbestatin B 0
              Ginkgoic acid 0
              Ginkgolic Acid C17-1 0
              Glycerol 1-hydroxy-2,5-dimethyl benzoate 0
              Isoamyl salicylate 0
              Isobutyl salicylate 0
              Methyl 2,6-dihydroxybenzoate 0
              Methyl 2-(10-heptadecenyl)-6-hydroxybenzoate 0
              Methyl 4-(4,6-dihydroxy-5-methoxy-2,5-dimethyl-3-oxocyclohexen-1-yl)oxy-2-hydroxy-3,6-dimethylbenzoate 0
              Methyl 5-chloro-2-hydroxybenzoate 0
              Nabscebetain A 0
              Nabscebetain B 0
              O-(S-2-hydroxybenzoylpantetheine-4'-phosphoryl)-L-serine residue 0
              Phenethyl salicylate 0
              Phomone A 0
              Pleoniol C 0
              Roccellatol 0
              Salaceyin A 0
              Salaceyin B 0
              acetylsalicylic acid + 3
              anacardic acid 0
              diflunisal 0
              hydroxytetracaine 0
              isopropyl salicylate + 0
              menthyl salicylate 0
              mesalamine 0
              methyl salicylate 0
              olsalazine 0
              phenyl salicylate 0
              promysalin 0
              salicylamides + 0
              salicylic acid-d4 0
              salsalate 0
              valerylsalicylic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5066
    subatomic particle 5057
      composite particle 5057
        hadron 5057
          baryon 5057
            nucleon 5057
              atomic nucleus 5057
                atom 5057
                  main group element atom 5026
                    p-block element atom 5023
                      carbon group element atom 4940
                        carbon atom 4939
                          organic molecular entity 4939
                            heteroorganic entity 4779
                              organochalcogen compound 4741
                                organooxygen compound 4703
                                  carbon oxoacid 370
                                    carboxylic acid 366
                                      aromatic carboxylic acid 138
                                        benzoic acids 136
                                          benzoic acid 14
                                            hydroxybenzoic acid 14
                                              monohydroxybenzoic acid 4
                                                salicylic acid 3
                                                  1-salicylate glucuronide 0
                                                  2,6-dihydroxy-4-[(2R)-2-hydroxyheptyl]benzoic acid 0
                                                  2-(D-glucosyloxy)benzoic acid + 0
                                                  2-Hydroxy-4-trifluoromethyl benzoic acid 0
                                                  2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid 0
                                                  2-Hydroxy-6-(8-tridecenyl)benzoic acid 0
                                                  2-Hydroxy-6-pentadeca-8,11,14-trienyl benzoic acid 0
                                                  2-Hydroxy-6-tridecylbenzoic acid 0
                                                  2-[[2-[(2-hydroxyphenyl)-oxomethoxy]-1-oxoethyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid methyl ester 0
                                                  2-hydroxy-3-methylbenzoic acid (3-cyano-4-imino-2-oxopentyl) ester 0
                                                  2-hydroxy-4-methylbenzoic acid [2-(2-chloroanilino)-2-oxoethyl] ester 0
                                                  2-hydroxy-5-[(4-methoxyphenyl)sulfamoyl]benzoic acid [2-[1-(3-bicyclo[2.2.1]heptanyl)ethylamino]-2-oxoethyl] ester 0
                                                  2-hydroxy-6-(12-oxoheptadecyl)benzoic acid 0
                                                  2-hydroxy-6-(12-oxopentadecyl)benzoic acid 0
                                                  2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid 0
                                                  2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester 0
                                                  2-hydroxybenzoic acid [2-(2-ethoxyanilino)-2-oxo-1-phenylethyl] ester 0
                                                  2-hydroxybenzoic acid [2-[[(1-methyl-2-pyrrolyl)-oxomethyl]amino]-2-oxoethyl] ester 0
                                                  2-hydroxybenzoyl group 0
                                                  2-hydroxybenzoyl-AMP 0
                                                  2-hydroxybenzoyl-CoA 0
                                                  2-hydroxyethyl salicylate 0
                                                  3,5-dinitrosalicylic acid + 0
                                                  3,6-dimethylsalicylic acid + 0
                                                  3-Hydroxyphthalic acid 0
                                                  3-allyl-2-hydroxybenzoic acid 0
                                                  3-formylsalicylic acid 0
                                                  3-methylsalicylic acid 0
                                                  4-[amino(carboxy)methyl]-2-hydroxybenzoic acid 0
                                                  4-acetamidosalicylic acid + 0
                                                  4-aminosalicylic acid 0
                                                  4-formylsalicylic acid 0
                                                  4-hydroxymethylsalicylic acid 0
                                                  4-methylsalicylic acid 0
                                                  4R,5R,6S-Trihydroxy-2-hydroxymethyl-2-cyclohexen-1-one 6-(2-hydroxy-6-methylbenzoate) 0
                                                  5-(diethylsulfamoyl)-2-hydroxybenzoic acid [2-oxo-2-[4-(trifluoromethoxy)anilino]ethyl] ester 0
                                                  5-[amino(carboxy)methyl]-2-hydroxybenzoic acid 0
                                                  5-formylsalicylic acid 0
                                                  5-nitrososalicylic acid 0
                                                  6-((8Z,11Z,14Z)-heptadeca-8,11,14-trien-1-yl)salicylic acid 0
                                                  6-((Z)-pentadec-10-en-1-yl)salicylic acid 0
                                                  6-((Z)-pentadec-8-en-1-yl)salicylic acid 0
                                                  6-formylsalicylic acid 0
                                                  6-hydroxy platensimycin A1 methyl ester 0
                                                  6-methylsalicylic acid 0
                                                  Ampelomin G 0
                                                  Antibiotic SB 202742 0
                                                  Benzyl salicylate 0
                                                  Butyl salicylate 0
                                                  Chloropupukeananin 0
                                                  Chloropupukeanone A 0
                                                  Choline salicylate 0
                                                  D-glucosyl salicylate + 0
                                                  Ethyl 4-ethoxy-2-hydroxy-3,6-dimethylbenzoate 0
                                                  Ethylhexyl salicylate 0
                                                  Gentisic acid sodium 0
                                                  Gibbestatin B 0
                                                  Ginkgoic acid 0
                                                  Ginkgolic Acid C17-1 0
                                                  Glycerol 1-hydroxy-2,5-dimethyl benzoate 0
                                                  Isoamyl salicylate 0
                                                  Isobutyl salicylate 0
                                                  Methyl 2,6-dihydroxybenzoate 0
                                                  Methyl 2-(10-heptadecenyl)-6-hydroxybenzoate 0
                                                  Methyl 4-(4,6-dihydroxy-5-methoxy-2,5-dimethyl-3-oxocyclohexen-1-yl)oxy-2-hydroxy-3,6-dimethylbenzoate 0
                                                  Methyl 5-chloro-2-hydroxybenzoate 0
                                                  Nabscebetain A 0
                                                  Nabscebetain B 0
                                                  O-(S-2-hydroxybenzoylpantetheine-4'-phosphoryl)-L-serine residue 0
                                                  Phenethyl salicylate 0
                                                  Phomone A 0
                                                  Pleoniol C 0
                                                  Roccellatol 0
                                                  Salaceyin A 0
                                                  Salaceyin B 0
                                                  acetylsalicylic acid + 3
                                                  anacardic acid 0
                                                  diflunisal 0
                                                  hydroxytetracaine 0
                                                  isopropyl salicylate + 0
                                                  menthyl salicylate 0
                                                  mesalamine 0
                                                  methyl salicylate 0
                                                  olsalazine 0
                                                  phenyl salicylate 0
                                                  promysalin 0
                                                  salicylamides + 0
                                                  salicylic acid-d4 0
                                                  salsalate 0
                                                  valerylsalicylic acid 0
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