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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-nitroquinoline N-oxide
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Accession:CHEBI:16907 term browser browse the term
Definition:A quinoline N-oxide carrying a nitro substituent at position 4.
Synonyms:related_synonym: 4-Nitroquinoline-1-oxide;   Formula=C9H6N2O3;   InChI=1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H;   InChIKey=YHQDZJICGQWFHK-UHFFFAOYSA-N;   Nitrochin;   SMILES=[O-][N+](=O)c1cc[n+]([O-])c2ccccc12
 alt_id: CHEBI:12037;   CHEBI:1917;   CHEBI:20460;   CHEBI:57944
 xref: CAS:56-57-5;   KEGG:C03474
 xref_mesh: MESH:D015112
 xref: PMID:16448841;   PMID:24105297;   Reaxys:165756;   Wikipedia:4-Nitroquinoline_1-oxide


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4-nitroquinoline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) affects export
multiple interactions		 EXP ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog
Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]		 CTD PMID:15766272 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression
decreases expression		 ISO 4-Nitroquinoline-1-oxide results in increased expression of ABL1 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of ABL1 mRNA		 CTD PMID:22561872 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675 		JBrowse link
G ACSL1 acyl-CoA synthetase long chain family member 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL1 mRNA CTD PMID:22561872 NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL6 mRNA CTD PMID:22561872 NCBI chr 5:131,949,973...132,012,213
Ensembl chr 5:131,949,973...132,012,243 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO [Ethanol co-treated with 4-Nitroquinoline-1-oxide] results in increased phosphorylation of AKT1 protein CTD PMID:37406968 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BCL2A1 BCL2 related protein A1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BCL2A1B mRNA CTD PMID:22561872 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BSCL2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr11:62,690,262...62,709,537
Ensembl chr11:62,689,289...62,709,845 		JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BUB1 mRNA CTD PMID:22561872 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL2 mRNA CTD PMID:22561872 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL3 mRNA CTD PMID:22561872 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL4 mRNA CTD PMID:22561872 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 increases expression
decreases expression		 ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL5 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of CCL5 mRNA		 CTD PMID:22561872 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCL7 C-C motif chemokine ligand 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL7 mRNA CTD PMID:22561872 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242 		JBrowse link
G CCNA2 cyclin A2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNA2 mRNA CTD PMID:22561872 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNB1 mRNA CTD PMID:22561872 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression		 EXP
ISO		 [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]
4-Nitroquinoline-1-oxide results in increased expression of CCND1 mRNA		 CTD PMID:20043093 PMID:27148699 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE2 cyclin E2 decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNE2 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CCNE2 mRNA		 CTD PMID:22561872 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CD59 CD59 molecule (CD59 blood group) multiple interactions ISO [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 PMID:20202993 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479 		JBrowse link
G CDC25C cell division cycle 25C decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDC25C mRNA
4-Nitroquinoline-1-oxide results in increased expression of CDC25C mRNA		 CTD PMID:22561872 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355 		JBrowse link
G CDC7 cell division cycle 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CDC7 mRNA CTD PMID:22561872 NCBI chr 1:91,500,851...91,525,764
Ensembl chr 1:91,500,851...91,525,764 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDKN1B mRNA CTD PMID:22561872 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CPT1B carnitine palmitoyltransferase 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CPT1B mRNA CTD PMID:22561872 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465 		JBrowse link
G CRYAB crystallin alpha B multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein CTD PMID:19840781 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722 		JBrowse link
G CRYZ crystallin zeta increases activity
multiple interactions		 ISO 4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein
ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein]		 CTD PMID:12566915 NCBI chr 1:74,705,486...74,733,050
Ensembl chr 1:74,705,482...74,733,408 		JBrowse link
G CSF2 colony stimulating factor 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CSF2 mRNA CTD PMID:22561872 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CTSD cathepsin D multiple interactions
increases activity		 ISO geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CTSD protein] CTD PMID:23499697 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573 		JBrowse link
G CTTN cortactin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CTTN mRNA; 4-Nitroquinoline-1-oxide results in increased expression of CTTN protein CTD PMID:27148699 NCBI chr11:70,398,529...70,436,575
Ensembl chr11:70,398,404...70,436,584 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL1 mRNA CTD PMID:22561872 PMID:27148699 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of CXCL10 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CXCL10 mRNA		 CTD PMID:22561872 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL11 mRNA CTD PMID:22561872 NCBI chr 4:76,033,682...76,036,070
Ensembl chr 4:76,033,682...76,041,415 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL2 mRNA CTD PMID:22561872 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL5 mRNA CTD PMID:27148699 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL9 mRNA CTD PMID:22561872 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCR3 mRNA CTD PMID:22561872 NCBI chr  X:71,615,919...71,618,511
Ensembl chr  X:71,615,916...71,618,511 		JBrowse link
G CYB5A cytochrome b5 type A multiple interactions
increases activity		 ISO geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein] CTD PMID:23499697 NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973 		JBrowse link
G E2F3 E2F transcription factor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of E2F3 mRNA CTD PMID:22561872 NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714 		JBrowse link
G EPCAM epithelial cell adhesion molecule increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of EPCAM mRNA CTD PMID:27148699 NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601 		JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions EXP Glucose inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of GPX2 protein] CTD PMID:32942007 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746 		JBrowse link
G GPX4 glutathione peroxidase 4 increases expression
multiple interactions		 EXP 4-Nitroquinoline-1-oxide results in increased expression of GPX4 protein
4-Nitroquinoline-1-oxide promotes the reaction [Glucose results in increased expression of GPX4 protein]		 CTD PMID:32942007 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G H2AX H2A.X variant histone increases expression
increases phosphorylation		 EXP 4-Nitroquinoline-1-oxide results in increased expression of H2AX protein
4-Nitroquinoline-1-oxide results in increased phosphorylation of H2AX protein		 CTD PMID:32087850 PMID:34510228 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HMOX1 heme oxygenase 1 affects expression
multiple interactions		 EXP 4-Nitroquinoline-1-oxide affects the expression of HMOX1 protein
4-Nitroquinoline-1-oxide inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; [4-Nitroquinoline-1-oxide results in increased susceptibility to Glucose] which results in increased expression of HMOX1 protein; Glucose inhibits the reaction [4-Nitroquinoline-1-oxide affects the expression of HMOX1 protein]		 CTD PMID:32942007 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP 4-Nitroquinoline-1-oxide results in increased mutagenesis of HPRT1 gene CTD PMID:26362870 PMID:28454271 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513 		JBrowse link
G HRAS HRas proto-oncogene, GTPase multiple interactions EXP [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA] CTD PMID:20043093 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein CTD PMID:19840781 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295 		JBrowse link
G IFNB1 interferon beta 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IFNB1 mRNA CTD PMID:22561872 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IFNG interferon gamma decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of IFNG mRNA
4-Nitroquinoline-1-oxide results in increased expression of IFNG mRNA		 CTD PMID:22561872 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL10 mRNA CTD PMID:22561872 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL12A mRNA CTD PMID:22561872 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL12B mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL12B mRNA		 CTD PMID:22561872 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL19 interleukin 19 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL19 mRNA CTD PMID:22561872 NCBI chr 1:206,770,773...206,842,981
Ensembl chr 1:206,770,764...206,842,981 		JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions		 ISO 4-Nitroquinoline-1-oxide results in increased expression of IL1B mRNA
[Ethanol co-treated with 4-Nitroquinoline-1-oxide] results in increased expression of IL1B mRNA
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of IL1B protein]		 CTD PMID:22561872 PMID:28397014 PMID:37406968 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL23A interleukin 23 subunit alpha decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL23A mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL23A mRNA		 CTD PMID:22561872 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL24 interleukin 24 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL24 mRNA CTD PMID:22561872 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139 		JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions		 ISO 4-Nitroquinoline-1-oxide results in increased expression of IL6 mRNA
[Ethanol co-treated with 4-Nitroquinoline-1-oxide] results in increased expression of IL6 mRNA		 CTD PMID:22561872 PMID:37406968 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ethanol co-treated with 4-Nitroquinoline-1-oxide] results in increased expression of JUN mRNA CTD PMID:37406968 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G MAPK6 mitogen-activated protein kinase 6 multiple interactions
increases expression		 ISO 4-Nitroquinoline-1-oxide results in increased expression of and results in increased phosphorylation of MAPK6 protein
4-Nitroquinoline-1-oxide results in increased expression of MAPK6 mRNA		 CTD PMID:22561872 NCBI chr15:51,971,825...52,067,375
Ensembl chr15:51,952,106...52,067,375 		JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions
increases expression		 ISO Ethanol promotes the reaction [4-Nitroquinoline-1-oxide results in increased expression of MKI67 protein] CTD PMID:37406968 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MMP10 matrix metallopeptidase 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP10 mRNA CTD PMID:22561872 NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628 		JBrowse link
G MMP12 matrix metallopeptidase 12 decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP12 mRNA
4-Nitroquinoline-1-oxide results in increased expression of MMP12 mRNA		 CTD PMID:22561872 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982 		JBrowse link
G MMP13 matrix metallopeptidase 13 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP13 mRNA CTD PMID:22561872 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP3 matrix metallopeptidase 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP3 mRNA CTD PMID:22561872 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP9 mRNA CTD PMID:22561872 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein]; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein] CTD PMID:12566915 PMID:28397014 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases reduction
multiple interactions
decreases activity
decreases response to substance		 EXP
ISO		 NQO1 protein results in increased reduction of 4-Nitroquinoline-1-oxide
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein]
NQO1 protein results in decreased susceptibility to 4-Nitroquinoline-1-oxide		 CTD PMID:9310146 PMID:23499697 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G OSM oncostatin M increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSM mRNA CTD PMID:22561872 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851 		JBrowse link
G OSMR oncostatin M receptor increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSMR mRNA CTD PMID:22561872 NCBI chr 5:38,846,012...38,945,579
Ensembl chr 5:38,845,858...38,945,596 		JBrowse link
G PIGA phosphatidylinositol glycan anchor biosynthesis class A multiple interactions
increases mutagenesis		 ISO 4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA; 4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene		 CTD PMID:19965957 PMID:20202993 PMID:22923490 PMID:29362862 NCBI chr  X:15,319,451...15,335,554
Ensembl chr  X:15,319,452...15,335,554 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO [Ethanol co-treated with 4-Nitroquinoline-1-oxide] results in increased phosphorylation of PIK3R1 protein CTD PMID:37406968 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions
increases activity		 ISO geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of POR protein] CTD PMID:23499697 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PPBP pro-platelet basic protein decreases expression
increases expression		 ISO 4-Nitroquinoline-1-oxide results in decreased expression of PPBP mRNA
4-Nitroquinoline-1-oxide results in increased expression of PPBP mRNA		 CTD PMID:22561872 NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases response to substance		 EXP
ISO		 [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]
4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein]
PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide
Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide]
4-Nitroquinoline-1-oxide results in increased expression of PTGS2 mRNA; 4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein		 CTD PMID:20043093 PMID:20857495 PMID:22561872 PMID:28397014 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTHLH parathyroid hormone like hormone increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of PTHLH mRNA CTD PMID:27148699 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions		 ISO 4-Nitroquinoline-1-oxide affects the localization of RELA protein
4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein]		 CTD PMID:22561872 PMID:28397014 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of RRM2 mRNA CTD PMID:22561872 NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725 		JBrowse link
G SRXN1 sulfiredoxin 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200 		JBrowse link
G TK1 thymidine kinase 1 increases mutagenesis EXP 4-Nitroquinoline-1-oxide results in increased mutagenesis of TK1 gene CTD PMID:28454271 PMID:32087850 NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 ISO geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of TNF protein] CTD PMID:28397014 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TNFAIP3 mRNA CTD PMID:22561872 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TNFSF11 TNF superfamily member 11 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of TNFSF11 mRNA CTD PMID:22561872 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TP53 tumor protein p53 affects response to substance
increases expression
decreases expression		 ISO
EXP		 TRP53 protein affects the susceptibility to 4-Nitroquinoline-1-oxide
4-Nitroquinoline-1-oxide results in increased expression of TP53 protein
4-Nitroquinoline-1-oxide results in decreased expression of TP53 protein		 CTD PMID:16543248 PMID:20599846 PMID:32087850 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TRAF1 TNF receptor associated factor 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TRAF1 mRNA CTD PMID:22561872 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173 		JBrowse link
G WEE1 WEE1 G2 checkpoint kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of WEE1 mRNA CTD PMID:22561872 NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457 		JBrowse link
G XCL1 X-C motif chemokine ligand 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of XCL1 mRNA CTD PMID:22561872 NCBI chr 1:168,576,605...168,582,069
Ensembl chr 1:168,576,605...168,582,069 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        aetiopathogenetic role 24592
          carcinogenic agent 22899
            4-nitroquinoline N-oxide 82
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organonitrogen heterocyclic compound 20349
                                    quinolines 2680
                                      quinoline N-oxide 83
                                        4-nitroquinoline N-oxide 82
paths to the root