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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-nitroquinoline N-oxide
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Accession:CHEBI:16907 term browser browse the term
Definition:A quinoline N-oxide carrying a nitro substituent at position 4.
Synonyms:related_synonym: 4-Nitroquinoline-1-oxide;   Formula=C9H6N2O3;   InChI=1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H;   InChIKey=YHQDZJICGQWFHK-UHFFFAOYSA-N;   Nitrochin;   SMILES=[O-][N+](=O)c1cc[n+]([O-])c2ccccc12
 alt_id: CHEBI:12037;   CHEBI:1917;   CHEBI:20460;   CHEBI:57944
 xref: CAS:56-57-5;   KEGG:C03474
 xref_mesh: MESH:D015112
 xref: PMID:16448841;   PMID:24105297;   Reaxys:165756;   Wikipedia:4-Nitroquinoline_1-oxide



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4-nitroquinoline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
multiple interactions
ISO ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog
Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]
CTD PMID:15766272 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of ABL1 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of ABL1 mRNA
CTD PMID:22561872 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL1 mRNA CTD PMID:22561872 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL6 mRNA CTD PMID:22561872 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BCL2A1B mRNA CTD PMID:22561872 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:205,731,814...205,743,430
Ensembl chr 1:205,733,872...205,743,421
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BUB1 mRNA CTD PMID:22561872 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL2 mRNA CTD PMID:22561872 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL3 mRNA CTD PMID:22561872 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL4 mRNA CTD PMID:22561872 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL5 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of CCL5 mRNA
CTD PMID:22561872 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL7 mRNA CTD PMID:22561872 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNA2 mRNA CTD PMID:22561872 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNB1 mRNA CTD PMID:22561872 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]
4-Nitroquinoline-1-oxide results in increased expression of CCND1 mRNA
CTD PMID:20043093 PMID:27148699 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne2 cyclin E2 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNE2 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CCNE2 mRNA
CTD PMID:22561872 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cd59 CD59 molecule multiple interactions EXP [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 PMID:20202993 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cdc25c cell division cycle 25C decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDC25C mRNA
4-Nitroquinoline-1-oxide results in increased expression of CDC25C mRNA
CTD PMID:22561872 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdc7 cell division cycle 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CDC7 mRNA CTD PMID:22561872 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDKN1B mRNA CTD PMID:22561872 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CPT1B mRNA CTD PMID:22561872 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein CTD PMID:19840781 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cryz crystallin zeta increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein
ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein]
CTD PMID:12566915 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CSF2 mRNA CTD PMID:22561872 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctsd cathepsin D increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CTSD protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CTSD protein]
CTD PMID:23499697 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cttn cortactin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CTTN mRNA; 4-Nitroquinoline-1-oxide results in increased expression of CTTN protein CTD PMID:27148699 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CXCL10 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CXCL10 mRNA
CTD PMID:22561872 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL11 mRNA CTD PMID:22561872 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL2 mRNA CTD PMID:22561872 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL1 mRNA CTD PMID:22561872 PMID:27148699 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL5 mRNA CTD PMID:27148699 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL9 mRNA CTD PMID:22561872 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCR3 mRNA CTD PMID:22561872 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cyb5a cytochrome b5 type A increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein]
CTD PMID:23499697 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of E2F3 mRNA CTD PMID:22561872 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of EPCAM mRNA CTD PMID:27148699 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Glucose inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of GPX2 protein] CTD PMID:32942007 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
increases expression
ISO 4-Nitroquinoline-1-oxide promotes the reaction [Glucose results in increased expression of GPX4 protein]
4-Nitroquinoline-1-oxide results in increased expression of GPX4 protein
CTD PMID:32942007 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of H2AX protein CTD PMID:32087850 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 affects expression
multiple interactions
ISO 4-Nitroquinoline-1-oxide affects the expression of HMOX1 protein
4-Nitroquinoline-1-oxide inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; [4-Nitroquinoline-1-oxide results in increased susceptibility to Glucose] which results in increased expression of HMOX1 protein; Glucose inhibits the reaction [4-Nitroquinoline-1-oxide affects the expression of HMOX1 protein]
CTD PMID:32942007 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 4-Nitroquinoline-1-oxide results in increased mutagenesis of HPRT1 gene CTD PMID:26362870 PMID:28454271 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA] CTD PMID:20043093 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein CTD PMID:19840781 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IFNB1 mRNA CTD PMID:22561872 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IFNG mRNA
4-Nitroquinoline-1-oxide results in increased expression of IFNG mRNA
CTD PMID:22561872 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL10 mRNA CTD PMID:22561872 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL12A mRNA CTD PMID:22561872 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL12B mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL12B mRNA
CTD PMID:22561872 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il19 interleukin 19 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL19 mRNA CTD PMID:22561872 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
4-Nitroquinoline-1-oxide results in increased expression of IL1B mRNA
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of IL1B protein]
CTD PMID:22561872 PMID:28397014 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL23A mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL23A mRNA
CTD PMID:22561872 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il24 interleukin 24 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL24 mRNA CTD PMID:22561872 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL6 mRNA CTD PMID:22561872 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 multiple interactions
increases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of and results in increased phosphorylation of MAPK6 protein
4-Nitroquinoline-1-oxide results in increased expression of MAPK6 mRNA
CTD PMID:22561872 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP10 mRNA CTD PMID:22561872 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP12 mRNA
4-Nitroquinoline-1-oxide results in increased expression of MMP12 mRNA
CTD PMID:22561872 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP13 mRNA CTD PMID:22561872 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP3 mRNA CTD PMID:22561872 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP9 mRNA CTD PMID:22561872 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein]; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein] CTD PMID:12566915 PMID:28397014 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction
decreases activity
multiple interactions
decreases response to substance
ISO
EXP
NQO1 protein results in increased reduction of 4-Nitroquinoline-1-oxide
4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein]
NQO1 protein results in decreased susceptibility to 4-Nitroquinoline-1-oxide
CTD PMID:9310146 PMID:23499697 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Osm oncostatin M increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSM mRNA CTD PMID:22561872 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G Osmr oncostatin M receptor increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSMR mRNA CTD PMID:22561872 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis
EXP
ISO
4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA; 4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene
CTD PMID:19965957 PMID:20202993 PMID:22923490 PMID:29362862 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases activity
EXP geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of POR protein] CTD PMID:23499697 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppbp pro-platelet basic protein increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of PPBP mRNA
4-Nitroquinoline-1-oxide results in decreased expression of PPBP mRNA
CTD PMID:22561872 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases response to substance
ISO
EXP
[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein]
PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide
Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide]
4-Nitroquinoline-1-oxide results in increased expression of PTGS2 mRNA; 4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein
CTD PMID:20043093 PMID:20857495 PMID:22561872 PMID:28397014 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of PTHLH mRNA CTD PMID:27148699 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO
EXP
4-Nitroquinoline-1-oxide affects the localization of RELA protein
4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein]
CTD PMID:22561872 PMID:28397014 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of RRM2 mRNA CTD PMID:22561872 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO 4-Nitroquinoline-1-oxide results in increased mutagenesis of TK1 gene CTD PMID:28454271 PMID:32087850 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of TNF protein] CTD PMID:28397014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TNFAIP3 mRNA CTD PMID:22561872 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of TNFSF11 mRNA CTD PMID:22561872 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 affects response to substance
increases expression
decreases expression
ISO
EXP
TRP53 protein affects the susceptibility to 4-Nitroquinoline-1-oxide
4-Nitroquinoline-1-oxide results in increased expression of TP53 protein
4-Nitroquinoline-1-oxide results in decreased expression of TP53 protein
CTD PMID:16543248 PMID:20599846 PMID:32087850 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TRAF1 mRNA CTD PMID:22561872 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of WEE1 mRNA CTD PMID:22561872 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of XCL1 mRNA CTD PMID:22561872 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        aetiopathogenetic role 19027
          carcinogenic agent 18362
            4-nitroquinoline N-oxide 79
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organonitrogen heterocyclic compound 17661
                                    quinolines 2598
                                      quinoline N-oxide 79
                                        4-nitroquinoline N-oxide 79
paths to the root