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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:simvastatin hydroxy acid
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Accession:CHEBI:169041 term browser browse the term
Synonyms:exact_synonym: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
 related_synonym: Formula=C25H40O6;   InChI=1S/C25H40O6/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29)/t15-,16-,18+,19+,20-,21-,23-/m0/s1;   InChIKey=XWLXKKNPFMNSFA-HGQWONQESA-N;   SMILES=O([C@@H]1[C@@]2([C@H]([C@H](C=CC2=C[C@@H](C1)C)C)CC[C@@H](O)C[C@@H](O)CC(O)=O)[H])C(=O)C(CC)(C)C
 xref: CAS:121009-77-6;   Chemspider:58263;   DrugBank:DB14714;   HMDB:HMDB0061047;   KEGG:C21581
 xref_mesh: MESH:C063287
 xref: PDBeChem:SIM



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simvastatin hydroxy acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO simvastatin acid inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid] CTD PMID:15901796 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 multiple interactions
decreases expression
increases uptake
ISO Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; estrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; Indican promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; Penicillin G promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]
simvastatin acid results in decreased expression of SLCO3A1 protein
CTD PMID:28887287 NCBI chr 1:128,115,184...128,387,887
Ensembl chr 1:128,106,228...128,387,925
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      group 19744
        inorganic group 19267
          oxo group 18678
            organic oxo compound 18678
              carbonyl compound 18678
                simvastatin hydroxy acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      simvastatin hydroxy acid 2
paths to the root