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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:D-mannitol
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Accession:CHEBI:16899 term browser browse the term
Definition:The D-enantiomer of mannitol.
Synonyms:related_synonym: (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexaol;   (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol;   E 421;   E421;   Formula=C6H14O6;   InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1;   InChIKey=FBPFZTCFMRRESA-KVTDHHQDSA-N;   Mannitol;   Osmitrol;   SMILES=OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO;   dulcite;   manna sugar;   mannite
 alt_id: CHEBI:12996;   CHEBI:130180;   CHEBI:21050;   CHEBI:44192;   CHEBI:6686
 xref: Beilstein:1721898;   CAS:69-65-8;   DrugBank:DB00742;   Drug_Central:935;   Gmelin:83161;   HMDB:HMDB0000765;   KEGG:C00392;   KEGG:D00062;   KNApSAcK:C00001165
 xref_mesh: MESH:D008353
 xref: MetaCyc:MANNITOL;   PDBeChem:MTL;   PMID:11784135;   PMID:12646037;   PMID:15658873;   PMID:15863337;   PMID:16854081;   PMID:16901854;   PMID:17336832;   PMID:17420133;   PMID:17827020;   PMID:17973471;   PMID:17979222;   PMID:17983214;   PMID:18207412;   PMID:18220330;   PMID:22770225;   PMID:24643482;   PMID:25108762;   Reaxys:1721898;   Wikipedia:Mannitol


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D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA] CTD PMID:15327746 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acacb acetyl-CoA carboxylase beta decreases expression ISO Mannitol results in decreased expression of ACACB mRNA CTD PMID:25270620 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acly ATP citrate lyase increases expression ISO Mannitol results in increased expression of ACLY mRNA CTD PMID:25270620 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 increases expression ISO Mannitol results in increased expression of ADAMTS18 mRNA CTD PMID:25270620 NCBI chr19:46,005,055...46,167,912
Ensembl chr19:46,005,277...46,101,250
JBrowse link
G Aida axin interactor, dorsalization associated decreases expression ISO Mannitol results in decreased expression of AIDA mRNA CTD PMID:25270620 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Aire autoimmune regulator decreases expression ISO Mannitol results in decreased expression of AIRE mRNA CTD PMID:25270620 NCBI chr20:11,365,630...11,380,636
Ensembl chr20:11,365,697...11,380,631
JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Mannitol CTD PMID:9733774 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO Mannitol results in increased expression of ARHGAP1 mRNA CTD PMID:25270620 NCBI chr 3:80,555,196...80,576,881
Ensembl chr 3:80,555,196...80,576,856
JBrowse link
G Arr3 arrestin 3 increases expression ISO Mannitol results in increased expression of ARR3 mRNA CTD PMID:25270620 NCBI chr  X:70,438,590...70,452,140
Ensembl chr  X:70,438,617...70,452,067
JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation
multiple interactions
EXP Mannitol results in increased phosphorylation of BAD protein
wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]
CTD PMID:15786717 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO Mannitol results in decreased expression of BBOX1 mRNA CTD PMID:25270620 NCBI chr 3:101,425,684...101,474,848
Ensembl chr 3:101,427,055...101,474,890
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Mannitol results in increased expression of BCL2 protein CTD PMID:15786717 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cables2 Cdk5 and Abl enzyme substrate 2 decreases expression ISO Mannitol results in decreased expression of CABLES2 mRNA CTD PMID:25270620 NCBI chr 3:175,630,266...175,644,994
Ensembl chr 3:175,631,881...175,644,988
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein] CTD PMID:10567913, PMID:12011046, PMID:29803612 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO Mannitol results in increased activity of CASP9 protein CTD PMID:12011046 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbx1 chromobox 1 increases expression ISO Mannitol results in increased expression of CBX1 mRNA CTD PMID:25270620 NCBI chr10:84,656,698...84,677,112
Ensembl chr10:84,669,914...84,675,741
JBrowse link
G Ccdc127 coiled-coil domain containing 127 decreases expression ISO Mannitol results in decreased expression of CCDC127 mRNA CTD PMID:25270620 NCBI chr 1:31,538,088...31,545,573
Ensembl chr 1:31,539,215...31,545,559
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO Mannitol results in decreased expression of CCN3 mRNA CTD PMID:25270620 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ckap5 cytoskeleton associated protein 5 increases expression ISO Mannitol results in increased expression of CKAP5 mRNA CTD PMID:25270620 NCBI chr 3:80,424,320...80,526,583
Ensembl chr 3:80,468,154...80,526,593
JBrowse link
G Clcn3 chloride voltage-gated channel 3 affects response to substance ISO CLCN3 protein affects the susceptibility to Mannitol deficiency CTD PMID:22108225 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Ctnna2 catenin alpha 2 decreases expression ISO Mannitol results in decreased expression of CTNNA2 mRNA CTD PMID:25270620 NCBI chr 4:107,880,611...109,042,724
Ensembl chr 4:107,881,826...108,008,484
JBrowse link
G Dbh dopamine beta-hydroxylase increases expression ISO Mannitol results in increased expression of DBH mRNA CTD PMID:25270620 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Dctn2 dynactin subunit 2 increases expression ISO Mannitol results in increased expression of DCTN2 mRNA CTD PMID:25270620 NCBI chr 7:70,555,953...70,571,433
Ensembl chr 7:70,556,019...70,572,614
JBrowse link
G Defb3 beta-defensin 3 decreases expression ISO Mannitol results in decreased expression of DEFB7 mRNA CTD PMID:25270620 Ensembl chr16:75,589,530...75,599,534 JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO Mannitol results in increased expression of DGKA mRNA CTD PMID:25270620 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Elf2 E74 like ETS transcription factor 2 increases expression ISO Mannitol results in increased expression of ELF2 mRNA CTD PMID:25270620 NCBI chr 2:140,310,374...140,399,312
Ensembl chr 2:140,310,375...140,387,505
JBrowse link
G Fam185a family with sequence similarity 185, member A increases expression ISO Mannitol results in increased expression of FAM185A mRNA CTD PMID:25270620 NCBI chr 4:10,213,679...10,269,999 JBrowse link
G Fam222a family with sequence similarity 222, member A decreases expression ISO Mannitol results in decreased expression of FAM222A mRNA CTD PMID:25270620 NCBI chr12:47,742,449...47,793,534
Ensembl chr12:47,748,165...47,793,534
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mannitol results in increased expression of FOS mRNA CTD PMID:11557636 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gal3st2 galactose-3-O-sulfotransferase 2 decreases expression ISO Mannitol results in decreased expression of GAL3ST2 mRNA CTD PMID:25270620 NCBI chr 9:100,982,996...100,994,226
Ensembl chr 9:100,990,523...100,993,206
JBrowse link
G Gas2l2 growth arrest-specific 2 like 2 decreases expression ISO Mannitol results in decreased expression of GAS2L2 mRNA CTD PMID:25270620 NCBI chr10:70,639,429...70,646,402
Ensembl chr10:70,639,862...70,646,495
JBrowse link
G Gpc6 glypican 6 increases expression ISO Mannitol results in increased expression of GPC6 mRNA CTD PMID:25270620 NCBI chr15:102,164,091...103,174,721
Ensembl chr15:102,164,751...103,170,847
JBrowse link
G Gpr19 G protein-coupled receptor 19 decreases expression ISO Mannitol results in decreased expression of GPR19 mRNA CTD PMID:25270620 NCBI chr 4:168,639,930...168,668,345
Ensembl chr 4:168,639,940...168,656,673
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Mannitol results in increased expression of HMOX1 mRNA CTD PMID:11592956 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO Mannitol results in increased expression of HPRT mRNA CTD PMID:25270620 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hrh2 histamine receptor H 2 increases expression ISO Mannitol results in increased expression of HRH2 mRNA CTD PMID:25270620 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:16285992 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein] CTD PMID:10567913 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Rotenone inhibits the reaction [Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] CTD PMID:23867654 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mannitol results in increased expression of JUN mRNA CTD PMID:11557636 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member increases expression ISO Mannitol results in increased expression of KHDC3 mRNA CTD PMID:25270620 NCBI chr 8:79,781,941...79,783,845
Ensembl chr 8:79,781,983...79,783,592
JBrowse link
G Krtap11-1 keratin associated protein 11-1 increases expression ISO Mannitol results in increased expression of KRTAP11-1 mRNA CTD PMID:25270620 NCBI chr11:29,709,809...29,711,328
Ensembl chr11:29,710,298...29,710,849
JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Mannitol results in decreased expression of LSM6 mRNA CTD PMID:25270620 NCBI chr19:32,770,640...32,785,215
Ensembl chr19:32,770,655...32,785,215
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein] CTD PMID:16510265 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK1 protein] CTD PMID:10910949 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK8 protein] CTD PMID:10910949 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mta2 metastasis associated 1 family, member 2 increases expression ISO Mannitol results in increased expression of MTA2 mRNA CTD PMID:25270620 NCBI chr 1:225,140,863...225,149,584
Ensembl chr 1:225,140,863...225,149,583
JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP Mannitol results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Mylk3 myosin light chain kinase 3 increases expression ISO Mannitol results in increased expression of MYLK3 mRNA CTD PMID:25270620 NCBI chr19:27,388,163...27,442,451
Ensembl chr19:27,404,712...27,441,536
JBrowse link
G Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 increases expression ISO Mannitol results in increased expression of NAALAD2 mRNA CTD PMID:25270620 NCBI chr 8:17,453,198...17,525,906
Ensembl chr 8:17,454,122...17,525,906
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 decreases expression ISO Mannitol results in decreased expression of NDUFA13 mRNA CTD PMID:25270620 NCBI chr16:21,275,311...21,282,246
Ensembl chr16:21,275,311...21,282,246
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO Mannitol results in increased expression of NFAT5 mRNA CTD PMID:23867654 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nkg7 natural killer cell granule protein 7 increases expression ISO Mannitol results in increased expression of NKG7 mRNA CTD PMID:25270620 NCBI chr 1:98,492,873...98,493,940
Ensembl chr 1:98,492,828...98,493,978
JBrowse link
G Nppa natriuretic peptide A increases expression ISO Mannitol results in increased expression of NPPA protein CTD PMID:2177369 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nts neurotensin increases transport EXP NTS protein results in increased transport of Mannitol CTD PMID:11208724 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Mannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Pcp2 Purkinje cell protein 2 increases expression ISO Mannitol results in increased expression of PCP2 mRNA CTD PMID:25270620 NCBI chr12:2,172,378...2,174,674
Ensembl chr12:2,172,378...2,174,131
JBrowse link
G Pdcd4 programmed cell death 4 increases expression
decreases expression
ISO Mannitol results in increased expression of PDCD4 mRNA
Mannitol results in decreased expression of PDCD4 mRNA
CTD PMID:21873647 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Plcl2 phospholipase C-like 2 decreases expression ISO Mannitol results in decreased expression of PLCL2 mRNA CTD PMID:25270620 NCBI chr 9:1,782,536...1,984,654
Ensembl chr 9:1,782,536...1,984,654
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Mannitol results in increased expression of PLEKHO1 mRNA CTD PMID:25270620 NCBI chr 2:198,112,104...198,120,202
Ensembl chr 2:198,112,076...198,120,120
JBrowse link
G Pou1f1 POU class 1 homeobox 1 increases expression ISO Mannitol results in increased expression of POU1F1 mRNA CTD PMID:25270620 NCBI chr11:2,645,659...2,662,581
Ensembl chr11:2,645,865...2,662,579
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO Mannitol results in decreased expression of PPP1R10 mRNA CTD PMID:25270620 NCBI chr20:3,329,677...3,344,286
Ensembl chr20:3,329,677...3,344,286
JBrowse link
G Ppp4c protein phosphatase 4, catalytic subunit increases expression ISO Mannitol results in increased expression of PPP4C mRNA CTD PMID:25270620 NCBI chr 1:198,219,012...198,225,775
Ensembl chr 1:198,219,054...198,225,580
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]; Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein] CTD PMID:16285992 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of PRKCD protein] CTD PMID:16285992 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptger1 prostaglandin E receptor 1 increases expression EXP Mannitol results in increased expression of PTGER1 mRNA CTD PMID:12888618 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression EXP Mannitol results in decreased expression of PTGER4 mRNA CTD PMID:12888618 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein]; Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein CTD PMID:12011046 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Mannitol results in decreased expression of RBL1 mRNA CTD PMID:25270620 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rbp2 retinol binding protein 2 decreases expression ISO Mannitol results in decreased expression of RBP2 mRNA CTD PMID:25270620 NCBI chr 8:106,479,253...106,527,726
Ensembl chr 8:106,503,504...106,527,711
JBrowse link
G Rgl3 ral guanine nucleotide dissociation stimulator-like 3 increases expression ISO Mannitol results in increased expression of RGL3 mRNA CTD PMID:25270620 NCBI chr 8:22,980,727...23,000,881
Ensembl chr 8:22,979,181...23,000,485
JBrowse link
G Samd10 sterile alpha motif domain containing 10 decreases expression ISO Mannitol results in decreased expression of SAMD10 mRNA CTD PMID:25270620 NCBI chr 3:177,091,467...177,095,599
Ensembl chr 3:177,091,457...177,095,597
JBrowse link
G Sbsn suprabasin decreases expression ISO Mannitol results in decreased expression of SBSN mRNA CTD PMID:25270620 NCBI chr 1:89,202,527...89,206,994
Ensembl chr 1:89,202,527...89,206,994
JBrowse link
G Sele selectin E multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of SELE mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of SELE protein] CTD PMID:16285992 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sgsm3 small G protein signaling modulator 3 decreases expression ISO Mannitol results in decreased expression of SGSM3 mRNA CTD PMID:25270620 NCBI chr 7:122,203,498...122,232,993
Ensembl chr 7:122,203,532...122,232,991
JBrowse link
G Slc12a1 solute carrier family 12 member 1 increases activity
multiple interactions
EXP Mannitol results in increased activity of SLC12A1 protein
[Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water
CTD PMID:12433675 NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367
JBrowse link
G Slc2a8 solute carrier family 2 member 8 decreases expression ISO Mannitol results in decreased expression of SLC2A8 mRNA CTD PMID:25270620 NCBI chr 3:12,020,227...12,029,920
Ensembl chr 3:12,020,229...12,029,877
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein] CTD PMID:16510265 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stx8 syntaxin 8 decreases expression ISO Mannitol results in decreased expression of STX8 mRNA CTD PMID:25270620 NCBI chr10:54,512,922...54,753,302
Ensembl chr10:54,512,983...54,753,302
JBrowse link
G Timd4 T-cell immunoglobulin and mucin domain containing 4 decreases expression ISO Mannitol results in decreased expression of TIMD4 mRNA CTD PMID:25270620 NCBI chr10:31,880,822...31,917,215 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Mannitol inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Mannitol inhibits the reaction [Quartz results in increased secretion of TNF protein] CTD PMID:19298665 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Mannitol results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpd52 tumor protein D52 decreases expression
increases expression
ISO Mannitol results in decreased expression of TPD52 mRNA
Mannitol results in increased expression of TPD52 mRNA
CTD PMID:21873647 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
G Triml1 tripartite motif family-like 1 increases expression ISO Mannitol results in increased expression of TRIML1 mRNA CTD PMID:25270620 NCBI chr16:52,169,426...52,177,548
Ensembl chr16:52,169,450...52,177,586
JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression ISO Mannitol results in increased expression of ULBP1 mRNA CTD PMID:25270620 NCBI chr 1:1,181,301...1,200,526
Ensembl chr 1:1,180,932...1,220,916
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 protein] CTD PMID:16285992 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wdr20 WD repeat domain 20 decreases expression ISO Mannitol results in decreased expression of WDR20 mRNA CTD PMID:25270620 NCBI chr 6:135,156,984...135,226,425
Ensembl chr 6:135,156,984...135,226,425
JBrowse link
G Zfp13 zinc finger protein 13 decreases expression ISO Mannitol results in decreased expression of ZFP13 mRNA CTD PMID:25270620 NCBI chr10:12,908,643...12,916,784
Ensembl chr10:12,908,643...12,916,784
JBrowse link
G Zg16 zymogen granule protein 16 decreases expression ISO Mannitol results in decreased expression of ZG16 mRNA CTD PMID:25270620 NCBI chr 1:198,483,800...198,486,157
Ensembl chr 1:198,483,805...198,486,157
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        hapten 3006
          D-mannitol 92
            1,5-anhydro-D-mannitol 0
            2-O-(alpha-D-Manp)-D-Man-OH 0
            D-mannitol 1,6-bis(methanesulfonate) 0
            D-mannitol 1-phosphate 0
            alpha-D-Galp-(1->2)-D-mannitol 0
            alpha-D-Manp-(1->1)-D-Man-OH 0
            alpha-D-Manp-(1->3)-Man-OH 0
            alpha-L-Fucp-(1->2)-D-Man-OH 0
            alpha-L-Fucp-(1->3)-D-mannitol 0
            beta-D-Galf-(1->3)-D-Man-OH 0
            beta-D-Galp-(1->3)-Man-OH 0
            isomalt 0
            mannopine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon group molecular entity 19572
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      alditol 1871
                                        hexitol 112
                                          mannitol 92
                                            D-mannitol 92
                                              1,5-anhydro-D-mannitol 0
                                              2-O-(alpha-D-Manp)-D-Man-OH 0
                                              D-mannitol 1,6-bis(methanesulfonate) 0
                                              D-mannitol 1-phosphate 0
                                              alpha-D-Galp-(1->2)-D-mannitol 0
                                              alpha-D-Manp-(1->1)-D-Man-OH 0
                                              alpha-D-Manp-(1->3)-Man-OH 0
                                              alpha-L-Fucp-(1->2)-D-Man-OH 0
                                              alpha-L-Fucp-(1->3)-D-mannitol 0
                                              beta-D-Galf-(1->3)-D-Man-OH 0
                                              beta-D-Galp-(1->3)-Man-OH 0
                                              isomalt 0
                                              mannopine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.