Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1H-indole
go back to main search page
Accession:CHEBI:16881 term browser browse the term
Definition:An indole that has formula C8H7N.
Synonyms:related_synonym: 2,3-Benzopyrrole;   Formula=C8H7N;   InChI=1S/C8H7N/c1-2-4-8-7(3-1)5-6-9-8/h1-6,9H;   InChIKey=SIKJAQJRHWYJAI-UHFFFAOYSA-N;   Indol;   SMILES=c1cc2ccccc2[nH]1;   indole
 alt_id: CHEBI:14444;   CHEBI:24794;   CHEBI:43537;   CHEBI:5900
 xref: Beilstein:107693;   CAS:120-72-9;   DrugBank:DB04532;   Gmelin:3477;   KEGG:C00463;   KNApSAcK:C00001418
 xref_mesh: MESH:C030374
 xref: PDBeChem:IND
 cyclic_relationship: is_tautomer_of CHEBI:35579


show annotations for term's descendants           Sort by:
 
1H-indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO indole binds to and results in increased activity of AHR protein; indole results in increased activity of [AHR protein binds to ARNT protein] CTD PMID:9407059, PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO indole results in increased activity of [AHR protein binds to ARNT protein] CTD PMID:9407059 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Epo erythropoietin multiple interactions EXP indole inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]; indole inhibits the reaction [cobaltous chloride results in increased expression of EPO protein] CTD PMID:21863063 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Mc1r melanocortin 1 receptor affects binding ISO indole analog binds to MC1R protein CTD PMID:11909711 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mc3r melanocortin 3 receptor affects binding ISO indole analog binds to MC3R protein CTD PMID:11909711 NCBI chr 3:170,252,901...170,253,998
Ensembl chr 3:170,252,901...170,253,998
JBrowse link
G Mc4r melanocortin 4 receptor affects binding ISO indole analog binds to MC4R protein CTD PMID:11909711 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Mc5r melanocortin 5 receptor affects binding ISO indole analog binds to MC5R protein CTD PMID:11909711 NCBI chr18:64,113,659...64,118,700
Ensembl chr18:64,114,933...64,116,524
JBrowse link
2-methyl-1H-indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO 2-methylindole results in increased expression of ABCB1 mRNA CTD PMID:32092453 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO 2-methylindole results in increased expression of CYP1A1 protein
2-methylindole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD PMID:31201936 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 2-methylindole results in increased expression of CYP1A2 protein CTD PMID:31201936 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects binding
multiple interactions
increases expression
ISO 2-methylindole binds to NR1I2 protein
NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA]
2-methylindole results in increased expression of NR1I2 mRNA
CTD PMID:32092453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        mancude ring 8120
          organic mancude parent 8120
            mancude organic heterocyclic parent 8120
              mancude organic heterobicyclic parent 5198
                indole 11
                  1H-indole 11
                    (R)-3-(5-benzyloxyindol-3-yl)lactic acid 0
                    (R)-indole-3-lactic acid 0
                    2-methyl-1H-indole 4
                    5-isoprenylindole-3-carboxylate beta-D-glycosyl ester 0
                    N-(beta-D-glucopyranosyl)indole 0
                    xenocyloin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      benzopyrrole 9530
                                        indoles 9198
                                          indole 11
                                            1H-indole 11
                                              (R)-3-(5-benzyloxyindol-3-yl)lactic acid 0
                                              (R)-indole-3-lactic acid 0
                                              2-methyl-1H-indole 4
                                              5-isoprenylindole-3-carboxylate beta-D-glycosyl ester 0
                                              N-(beta-D-glucopyranosyl)indole 0
                                              xenocyloin 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.