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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glutathione
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Accession:CHEBI:16856 term browser browse the term
Definition:A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Synonyms:exact_synonym: L-gamma-glutamyl-L-cysteinylglycine
 related_synonym: 5-L-Glutamyl-L-cysteinylglycine;   Formula=C10H17N3O6S;   GSH;   Glutathione-SH;   InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1;   InChIKey=RWSXRVCMGQZWBV-WDSKDSINSA-N;   N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine;   Reduced glutathione;   SMILES=N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O;   gamma-L-Glutamyl-L-cysteinyl-glycine
 alt_id: CHEBI:12402;   CHEBI:14327;   CHEBI:24334;   CHEBI:42873;   CHEBI:43049;   CHEBI:5437
 xref: CAS:70-18-8;   DrugBank:DB00143;   Drug_Central:1312;   HMDB:HMDB0000125;   KEGG:C00051;   KEGG:D00014;   KNApSAcK:C00001518
 xref_mesh: MESH:D005978
 xref: MetaCyc:GLUTATHIONE;   PDBeChem:GSH;   PMID:17439666;   PMID:4200890;   PMID:4745654;   Reaxys:1729812;   Wikipedia:Glutathione
 cyclic_relationship: is_conjugate_acid_of CHEBI:57925


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glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G LOC100739163 glutathione S-transferase P-like multiple interactions EXP GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione] CTD PMID:14573868 NCBI chr 2:4,978,761...4,982,233 JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 902
    role 861
      chemical role 645
        antioxidant 306
          glutathione 5
            DON-10-glutathione 0
            N-(4-oxoglutaryl)-L-cysteinylglycine 0
            S-(2,4-dinitrophenyl)glutathione 0
            S-(2-hydroxyethyl)glutathione 0
            S-acylglutathione + 0
            S-sulfanylglutathione 0
            eoxin C4 0
            glutathione derivative + 3
            phytochelatin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 902
    subatomic particle 887
      composite particle 887
        hadron 887
          baryon 887
            nucleon 887
              atomic nucleus 887
                atom 887
                  main group element atom 856
                    p-block element atom 853
                      carbon group element atom 829
                        carbon atom 828
                          organic molecular entity 828
                            organic group 392
                              organic divalent group 390
                                organodiyl group 390
                                  carbonyl group 389
                                    carbonyl compound 389
                                      carboxylic acid 267
                                        carboacyl group 166
                                          univalent carboacyl group 166
                                            carbamoyl group 163
                                              carboxamide 163
                                                peptide 36
                                                  oligopeptide 12
                                                    tripeptide 8
                                                      glutathione 5
                                                        DON-10-glutathione 0
                                                        N-(4-oxoglutaryl)-L-cysteinylglycine 0
                                                        S-(2,4-dinitrophenyl)glutathione 0
                                                        S-(2-hydroxyethyl)glutathione 0
                                                        S-acylglutathione + 0
                                                        S-sulfanylglutathione 0
                                                        eoxin C4 0
                                                        glutathione derivative + 3
                                                        phytochelatin + 0
paths to the root