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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Urolithin A
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Accession:CHEBI:168442 term browser browse the term
Synonyms:exact_synonym: 3,8-dihydroxybenzo[c]chromen-6-one
 related_synonym: Formula=C13H8O4;   InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H;   InChIKey=RIUPLDUFZCXCHM-UHFFFAOYSA-N;   SMILES=O1C2=C(C3=C(C=C(O)C=C3)C1=O)C=CC(O)=C2
 xref: CAS:1143-70-0;   Chemspider:4589709;   DrugBank:DB15464;   HMDB:HMDB0013695
 xref_mesh: MESH:C026423
 xref: PMID:27400265



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Urolithin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in increased activity of CASP3 protein CTD PMID:23811531 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in increased expression of CDKN1A protein CTD PMID:32179165 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one binds to and affects the activity of ESR1 protein CTD PMID:16506809 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one binds to and affects the activity of ESR2 protein CTD PMID:16506809 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gal galanin and GMAP prepropeptide increases activity ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in increased activity of GAL protein CTD PMID:32179165 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in decreased expression of JUN mRNA; 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in decreased expression of JUN protein modified form CTD PMID:23811531 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in decreased expression of MAP3K1 mRNA; 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in decreased expression of MAP3K1 protein CTD PMID:23811531 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 increases expression ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in increased expression of MAPK11 mRNA CTD PMID:23811531 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in increased expression of PPARG protein CTD PMID:23811531 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tp53 tumor protein p53 increases expression ISO 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in increased expression of TP53 protein CTD PMID:32179165 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 20056
    role 20008
      application 19745
        pharmaceutical 19618
          drug 19618
            protective agent 17999
              geroprotector 16992
                Urolithin A 10
Path 2
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  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  oxacycle 17684
                                    benzopyran 11207
                                      1-benzopyran 10945
                                        chromenes 3025
                                          chromenone 2964
                                            coumarins 2720
                                              Urolithin A 10
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