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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mycophenolic acid
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Accession:CHEBI:168396 term browser browse the term
Definition:A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.
Synonyms:exact_synonym: (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
 related_synonym: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid;   Formula=C17H20O6;   InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+;   InChIKey=HPNSFSBZBAHARI-RUDMXATFSA-N;   Mycophenolate;   Mycophenolsaeure;   SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(O)=O;   acide mycophenolique;   acido micofenolico;   acidum mycophenolicum
 alt_id: CHEBI:43973
 xref: Beilstein:318158;   CAS:24280-93-1;   DrugBank:DB01024;   Drug_Central:1860;   KEGG:D05096
 xref_mesh: MESH:D009173
 xref: PDBeChem:MOA;   PMID:11272311;   PMID:15470161;   PMID:16629948;   PMID:16640327;   PMID:17482154;   PMID:17498396;   PMID:18194117;   PMID:18611107;   PMID:18996104;   PMID:19689217;   Patent:US4753935;   Reaxys:318158;   Wikipedia:Mycophenolic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62932


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mycophenolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCF1 ATP binding cassette subfamily F member 1 increases expression ISO Mycophenolic Acid results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr 6:30,571,442...30,591,522
Ensembl chr 6:30,571,393...30,597,179 		JBrowse link
G ADM adrenomedullin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15063164 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397 		JBrowse link
G AGT angiotensinogen decreases expression ISO Mycophenolic Acid results in decreased expression of AGT protein alternative form CTD PMID:15213268 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AIF1 allograft inflammatory factor 1 decreases expression
multiple interactions		 ISO Mycophenolic Acid results in decreased expression of AIF1 mRNA
[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA		 CTD PMID:10688038 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021 		JBrowse link
G AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 increases expression ISO Mycophenolic Acid results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 4:106,315,544...106,349,456
Ensembl chr 4:106,315,544...106,349,456 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases expression EXP Mycophenolic Acid results in increased expression of AKT1 protein CTD PMID:21396949 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALB albumin affects binding EXP Mycophenolic Acid binds to ALB protein CTD PMID:26892221 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G AR androgen receptor multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ATF1 activating transcription factor 1 multiple interactions EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein] CTD PMID:20302854 NCBI chr12:50,763,459...50,821,162
Ensembl chr12:50,763,710...50,821,162 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP Mycophenolic Acid results in increased expression of BAK1 protein CTD PMID:16505121 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein CTD PMID:21396949 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 EXP [Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone]; schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of BCL2 protein] CTD PMID:16505121 PMID:21396949 PMID:35321622 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP1 caspase 1 increases expression ISO Mycophenolic Acid results in increased expression of CASP1 mRNA CTD PMID:19818335 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 increases activity
increases cleavage
multiple interactions		 EXP Mycophenolic Acid results in increased activity of CASP3 protein
Mycophenolic Acid results in increased cleavage of CASP3 protein
[Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased cleavage of CASP3 protein]		 CTD PMID:16059982 PMID:16505121 PMID:21396949 PMID:35321622 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCL15 C-C motif chemokine ligand 15 decreases expression
increases expression		 ISO Mycophenolic Acid results in decreased expression of CCL6 mRNA
Mycophenolic Acid results in increased expression of CCL6 mRNA		 CTD PMID:19818335 NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 increases expression ISO Mycophenolic Acid results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] CTD PMID:17624267 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 decreases expression
increases expression		 ISO Mycophenolic Acid results in decreased expression of CCL20 mRNA
Mycophenolic Acid results in increased expression of CCL20 mRNA		 CTD PMID:19818335 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 increases expression ISO Mycophenolic Acid results in increased expression of CCL22 mRNA CTD PMID:19818335 NCBI chr16:57,357,909...57,366,189
Ensembl chr16:57,358,783...57,366,189 		JBrowse link
G CCL25 C-C motif chemokine ligand 25 increases expression ISO Mycophenolic Acid results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr19:8,052,341...8,062,650
Ensembl chr19:8,052,318...8,062,660 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions
decreases expression		 ISO [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA
Mycophenolic Acid results in decreased expression of CCL5 mRNA		 CTD PMID:10688038 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCL7 C-C motif chemokine ligand 7 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242 		JBrowse link
G CCR10 C-C motif chemokine receptor 10 increases expression ISO Mycophenolic Acid results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr17:42,678,889...42,681,843
Ensembl chr17:42,678,889...42,683,917 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CCR2 mRNA CTD PMID:19818335 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CCR3 C-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 3:46,210,696...46,266,706
Ensembl chr 3:46,130,890...46,266,706 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 increases expression ISO Mycophenolic Acid results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,141 		JBrowse link
G CCR9 C-C motif chemokine receptor 9 increases expression ISO Mycophenolic Acid results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 3:45,886,064...45,903,174
Ensembl chr 3:45,884,425...45,903,174 		JBrowse link
G CD40LG CD40 ligand increases expression ISO Mycophenolic Acid results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions EXP Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] CTD PMID:12193749 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein] CTD PMID:20302854 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 increases expression ISO Mycophenolic Acid results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
increases expression		 ISO Mycophenolic Acid results in decreased expression of CXCL1 mRNA
Mycophenolic Acid results in increased expression of CXCL1 mRNA		 CTD PMID:19818335 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 increases expression ISO Mycophenolic Acid results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCL2 protein CTD PMID:19818335 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
decreases expression
increases secretion
multiple interactions		 ISO
EXP		 Mycophenolic Acid results in increased expression of CXCL15 mRNA; Mycophenolic Acid results in increased expression of CXCL5 mRNA
Mycophenolic Acid results in decreased expression of CXCL5 mRNA
Mycophenolic Acid results in increased secretion of CXCL8 protein
Mycophenolic Acid results in increased expression of CXCL8 mRNA
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased secretion of CXCL8 protein]		 CTD PMID:19818335 PMID:20302854 PMID:29408666 PMID:29594315 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCR2 mRNA CTD PMID:19818335 NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:71,615,919...71,618,511
Ensembl chr  X:71,615,916...71,618,511 		JBrowse link
G CXCR5 C-X-C motif chemokine receptor 5 increases expression ISO Mycophenolic Acid results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr11:118,883,892...118,897,787
Ensembl chr11:118,883,892...118,897,787 		JBrowse link
G CYCS cytochrome c, somatic increases secretion EXP Mycophenolic Acid results in increased secretion of CYCS protein CTD PMID:16505121 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions		 EXP Mycophenolic Acid results in increased expression of CYP1A1 mRNA
Mycophenolic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]		 CTD PMID:25929522 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CTD PMID:25929522 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases methylation EXP CYP2C8 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases methylation
multiple interactions		 EXP CYP3A4 protein results in increased methylation of Mycophenolic Acid
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:15570183 PMID:25455453 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases methylation EXP CYP3A5 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G DES desmin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,735 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FAM200C family with sequence similarity 200 member C increases expression EXP Mycophenolic Acid results in increased expression of FAM200C mRNA CTD PMID:24356939 NCBI chr 5:160,393,148...160,400,054
Ensembl chr 5:160,393,148...160,400,054 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mycophenolic Acid results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GCNA germ cell nuclear acidic peptidase decreases expression EXP Mycophenolic Acid results in decreased expression of GCNA mRNA CTD PMID:24356939 NCBI chr  X:71,578,437...71,613,583
Ensembl chr  X:71,578,437...71,613,583 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein] CTD PMID:20302854 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Mycophenolic Acid results in decreased expression of HSPA5 mRNA CTD PMID:24356939 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G IFNG interferon gamma decreases expression
multiple interactions		 ISO
EXP		 Mycophenolic Acid results in decreased expression of IFNG mRNA
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA		 CTD PMID:11562063 PMID:29594315 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 decreases expression ISO Mycophenolic Acid results in decreased expression of IL10 mRNA CTD PMID:11562063 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL10RA interleukin 10 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr11:117,986,394...118,003,037
Ensembl chr11:117,986,370...118,003,037 		JBrowse link
G IL10RB interleukin 10 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr21:33,266,367...33,310,182
Ensembl chr21:33,266,367...33,311,420 		JBrowse link
G IL11 interleukin 11 increases expression ISO Mycophenolic Acid results in increased expression of IL11 mRNA CTD PMID:19818335 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463 		JBrowse link
G IL12RB2 interleukin 12 receptor subunit beta 2 decreases expression ISO Mycophenolic Acid results in decreased expression of IL12RB2 mRNA CTD PMID:11562063 NCBI chr 1:67,307,364...67,398,724
Ensembl chr 1:67,307,364...67,398,724 		JBrowse link
G IL13 interleukin 13 increases expression ISO Mycophenolic Acid results in increased expression of IL13 mRNA CTD PMID:19818335 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL15 interleukin 15 increases expression ISO Mycophenolic Acid results in increased expression of IL15 mRNA CTD PMID:19818335 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987 		JBrowse link
G IL16 interleukin 16 increases expression ISO Mycophenolic Acid results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058 		JBrowse link
G IL18 interleukin 18 decreases expression ISO Mycophenolic Acid results in decreased expression of IL18 mRNA CTD PMID:19818335 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 increases expression ISO Mycophenolic Acid results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874 		JBrowse link
G IL1R2 interleukin 1 receptor type 2 increases expression ISO Mycophenolic Acid results in increased expression of IL1R2 mRNA CTD PMID:19818335 NCBI chr 2:101,991,960...102,028,544
Ensembl chr 2:101,991,960...102,028,544 		JBrowse link
G IL2 interleukin 2 multiple interactions
decreases expression		 EXP
ISO		 [Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]
Mycophenolic Acid results in decreased expression of IL2 mRNA		 CTD PMID:11562063 PMID:12193749 PMID:29594315 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL2RB interleukin 2 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,118,666...37,175,118 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma increases expression ISO Mycophenolic Acid results in increased expression of IL2RG mRNA CTD PMID:19818335 NCBI chr  X:71,107,404...71,111,577
Ensembl chr  X:71,107,404...71,112,108 		JBrowse link
G IL3 interleukin 3 increases expression ISO Mycophenolic Acid results in increased expression of IL3 mRNA CTD PMID:19818335 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204 		JBrowse link
G IL4 interleukin 4 decreases expression ISO Mycophenolic Acid results in decreased expression of IL4 mRNA CTD PMID:11562063 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5RA interleukin 5 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL5RA mRNA CTD PMID:19818335 NCBI chr 3:3,066,324...3,110,374
Ensembl chr 3:3,066,324...3,126,613 		JBrowse link
G IL6 interleukin 6 increases expression EXP Mycophenolic Acid results in increased expression of IL6 protein CTD PMID:11981085 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6R interleukin 6 receptor increases expression ISO Mycophenolic Acid results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer increases expression ISO Mycophenolic Acid results in increased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G IMPDH2 inosine monophosphate dehydrogenase 2 increases expression ISO Mycophenolic Acid results in increased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 3:49,024,325...49,029,398
Ensembl chr 3:49,024,325...49,029,447 		JBrowse link
G ITGAM integrin subunit alpha M increases expression ISO Mycophenolic Acid results in increased expression of ITGAM mRNA CTD PMID:19818335 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 decreases expression EXP Mycophenolic Acid results in decreased expression of KLRK1 CTD PMID:20736080 NCBI chr12:10,372,353...10,390,041
Ensembl chr12:10,372,353...10,391,874 		JBrowse link
G KRCC1 lysine rich coiled-coil 1 decreases expression EXP Mycophenolic Acid results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 2:88,027,205...88,055,783
Ensembl chr 2:88,027,205...88,064,252 		JBrowse link
G LRRC37A3 leucine rich repeat containing 37 member A3 decreases expression EXP Mycophenolic Acid results in decreased expression of LRRC37A3 mRNA CTD PMID:24356939 NCBI chr17:64,854,130...64,919,478
Ensembl chr17:64,854,130...64,919,480 		JBrowse link
G LTA lymphotoxin alpha increases expression ISO Mycophenolic Acid results in increased expression of LTA mRNA CTD PMID:19818335 NCBI chr 6:31,560,610...31,574,324
Ensembl chr 6:31,572,054...31,574,324 		JBrowse link
G LTB lymphotoxin beta increases expression ISO Mycophenolic Acid results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein CTD PMID:15604220 NCBI chr 8:55,879,835...56,014,169
Ensembl chr 8:55,879,835...56,014,169 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases expression		 EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK1 protein]
Mycophenolic Acid results in decreased expression of MAPK1 protein modified form		 CTD PMID:20302854 PMID:35321622 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases expression		 EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK3 protein]
Mycophenolic Acid results in decreased expression of MAPK3 protein modified form		 CTD PMID:20302854 PMID:35321622 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
decreases expression		 EXP
ISO		 Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK8 protein]
Mycophenolic Acid results in decreased expression of MAPK8 protein modified form		 CTD PMID:20302854 PMID:35321622 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
decreases expression		 EXP
ISO		 Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]
Mycophenolic Acid results in decreased expression of MAPK9 protein modified form		 CTD PMID:20302854 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MAPT microtubule associated protein tau decreases expression EXP Mycophenolic Acid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G MIF macrophage migration inhibitory factor increases expression ISO Mycophenolic Acid results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227 		JBrowse link
G NANOS1 nanos C2HC-type zinc finger 1 increases expression EXP Mycophenolic Acid results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr10:119,029,714...119,033,730
Ensembl chr10:119,029,714...119,033,730 		JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 decreases expression EXP Mycophenolic Acid results in decreased expression of NCR1 CTD PMID:20736080 NCBI chr19:54,898,198...54,938,208
Ensembl chr19:54,906,148...54,916,140 		JBrowse link
G NCR2 natural cytotoxicity triggering receptor 2 decreases expression EXP Mycophenolic Acid results in decreased expression of NCR2 CTD PMID:20736080 NCBI chr 6:41,335,608...41,350,889
Ensembl chr 6:41,335,608...41,350,889 		JBrowse link
G NCR3 natural cytotoxicity triggering receptor 3 decreases expression EXP Mycophenolic Acid results in decreased expression of NCR3 CTD PMID:20736080 NCBI chr 6:31,588,895...31,593,006
Ensembl chr 6:31,588,895...31,593,006 		JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein] CTD PMID:17624267 NCBI chr19:35,862,915...35,869,357
Ensembl chr19:35,825,964...35,869,287 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions		 EXP Mycophenolic Acid results in increased activity of NR1I2 protein
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G OCLN occludin decreases expression
multiple interactions		 EXP Mycophenolic Acid results in decreased expression of OCLN protein
schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of OCLN protein]		 CTD PMID:35321622 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
G PDCD4 programmed cell death 4 increases expression EXP Mycophenolic Acid results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006 		JBrowse link
G PGR progesterone receptor multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PRKCA protein kinase C alpha increases expression EXP Mycophenolic Acid results in increased expression of PRKCA protein CTD PMID:21396949 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G RAC1 Rac family small GTPase 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:17950325 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions		 ISO
EXP		 Mycophenolic Acid results in decreased expression of RELA protein modified form
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]		 CTD PMID:20302854 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RGS2 regulator of G protein signaling 2 increases expression EXP Mycophenolic Acid results in increased expression of RGS2 mRNA CTD PMID:24356939 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275 		JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein CTD PMID:15604220 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Mycophenolic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 decreases expression EXP Mycophenolic Acid results in decreased expression of SLC7A11 mRNA CTD PMID:24356939 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression ISO Mycophenolic Acid results in increased expression of SPP1 mRNA CTD PMID:19818335 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A multiple interactions EXP [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein CTD PMID:15604220 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression ISO Mycophenolic Acid results in decreased expression of TGFB1 mRNA CTD PMID:11562063 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G TJP1 tight junction protein 1 decreases expression
multiple interactions		 EXP Mycophenolic Acid results in decreased expression of TJP1 protein
schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of TJP1 protein]		 CTD PMID:35321622 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915 		JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions
increases expression		 ISO Mycophenolic Acid results in decreased expression of TNF mRNA
Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased secretion of TNF protein]
Mycophenolic Acid results in increased expression of TNF mRNA; Mycophenolic Acid results in increased expression of TNF protein		 CTD PMID:11562063 PMID:11912253 PMID:19818335 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:19818335 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
G TP53 tumor protein p53 affects activity EXP Mycophenolic Acid affects the activity of TP53 protein CTD PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TSPOAP1 TSPO associated protein 1 decreases expression EXP Mycophenolic Acid results in decreased expression of TSPOAP1 mRNA CTD PMID:24356939 NCBI chr17:58,301,231...58,328,795
Ensembl chr17:58,301,228...58,328,795 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions
affects metabolic processing		 EXP UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid
4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide
UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid		 CTD PMID:18498916 PMID:18816295 PMID:31742356 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr19:35,862,915...35,869,357
Ensembl chr19:35,825,964...35,869,287 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        antimicrobial agent 21890
          mycophenolic acid 115
            mycophenolate mofetil 1
            mycophenolic acid O-acyl-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      monocarboxylic acid 21724
                                        fatty acid 18997
                                          unsaturated fatty acid 1111
                                            monounsaturated fatty acid 603
                                              hexenoic acid 115
                                                hex-4-enoic acid 115
                                                  mycophenolic acid 115
                                                    mycophenolate mofetil 1
                                                    mycophenolic acid O-acyl-glucuronide 0
paths to the root