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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dehydroepiandrosterone sulfate
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Accession:CHEBI:16814 term browser browse the term
Definition:A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.
Synonyms:exact_synonym: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate
 related_synonym: (3-beta)-3-(Sulfooxy)androst-5-en-17-one;   17-Ketoandrost-5-en-3beta-yl sulfate;   17-oxoandrost-5-en-3beta-yl hydrogen sulphate;   3-O-Sulfodehydroepiandrosterone;   3beta-Hydroxyandrost-5-en-17-one 3-sulfate;   Androst-5-en-17-on-3beta-yl sulfuric acid;   DHEA sulfate;   DHEA-S;   DHEAS;   Dehydroepiandrosterone 3-sulfate;   Dehydroepiandrosterone monosulfate;   Dehydroepiandrosterone sulphate;   Dehydroisoandrosterone sulfate;   Dehydroisoandrosterone-3-sulfate;   Formula=C19H28O5S;   InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1;   InChIKey=CZWCKYRVOZZJNM-USOAJAOKSA-N;   Prasterone sulfate;   SMILES=C1[C@@]2([C@@]([C@@]3(C(C[C@@H](OS(O)(=O)=O)CC3)=C1)C)(CC[C@]4([C@]2(CCC4=O)[H])C)[H])[H]
 alt_id: CHEBI:11912;   CHEBI:1724;   CHEBI:20247;   CHEBI:61003
 xref: CAS:651-48-9;   Drug_Central:4049;   HMDB:HMDB0001032;   KEGG:C04555;   LIPID_MAPS_instance:LMST05020010
 xref_mesh: MESH:D019314
 xref: MetaCyc:DEHYDRO-EPIANDROSTERONE-SULFATE;   PMID:15374110;   PMID:18307294;   PMID:20797618;   PMID:22770225;   PMID:9661815;   Reaxys:2227078;   Wikipedia:Dehydroepiandrosterone_sulfate
 cyclic_relationship: is_conjugate_acid_of CHEBI:57905


show annotations for term's descendants           Sort by:
dehydroepiandrosterone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions 		ISO Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] 		CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions 		ISO Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA] 		CTD PMID:8700121 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions 		EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein] 		CTD PMID:16407456 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions 		EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein] 		CTD PMID:16407456 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression 		EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein 		CTD PMID:25786523 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein CTD PMID:25786523 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions EXP
ISO 		[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6 protein
CYP2C19 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate] 		CTD PMID:25786523 PMID:33771511 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate] CTD PMID:33771511 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing 		EXP
ISO 		[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein
CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate 		CTD PMID:2271712 PMID:25786523 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions 		EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein 		CTD PMID:8700121 PMID:25786523 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA CTD PMID:8700121 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions 		ISO Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA] 		CTD PMID:8700121 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions 		ISO Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA] 		CTD PMID:8700121 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein CTD PMID:15196791 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance 		ISO Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] CTD PMID:12548226 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein CTD PMID:15196791 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] CTD PMID:11470991 NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Pomc proopiomelanocortin increases abundance ISO POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance 		ISO PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate 		CTD PMID:8700121 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prl prolactin increases abundance ISO PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2943108 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein CTD PMID:25786523 NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:23562556 NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a19 solute carrier family 22, member 19 affects transport EXP SLC22A19 protein affects the transport of Dehydroepiandrosterone Sulfate CTD PMID:16079298 NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 increases uptake
multiple interactions 		EXP
ISO 		SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] 		CTD PMID:17132213 PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport ISO SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
increases uptake 		ISO SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate 		CTD PMID:11306713 PMID:16098483 PMID:17255469 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein CTD PMID:16407456 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Sts steroid sulfatase affects metabolic processing ISO STS protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      chemical role 20382
        catalyst 8402
          sulfuric acid 8352
            sulfuric acid derivative 8352
              organic sulfate 2475
                steroid sulfate 66
                  dehydroepiandrosterone sulfate 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      chalcogen 20477
                        oxygen atom 20443
                          oxygen molecular entity 20443
                            hydroxides 20216
                              oxoacid 19271
                                chalcogen oxoacid 13878
                                  sulfur oxoacid 13670
                                    sulfuric acid 8352
                                      sulfuric acid derivative 8352
                                        sulfates 8347
                                          organic sulfate 2475
                                            steroid sulfate 66
                                              dehydroepiandrosterone sulfate 31
paths to the root