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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:melatonin
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Accession:CHEBI:16796 term browser browse the term
Definition:A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Synonyms:exact_synonym: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
 related_synonym: 5-methoxy-N-acetyltryptamine;   Formula=C13H16N2O2;   InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16);   InChIKey=DRLFMBDRBRZALE-UHFFFAOYSA-N;   N-Acetyl-5-methoxytryptamine;   N-[2-(5-methoxyindol-3-yl)ethyl]acetamide;   SMILES=C=1C=C(C=C2C(=CNC12)CCNC(=O)C)OC;   melatonine
 alt_id: CHEBI:14577;   CHEBI:25180;   CHEBI:6730
 xref: Beilstein:205542;   CAS:73-31-4;   DrugBank:DB01065;   Drug_Central:1672;   HMDB:HMDB0001389;   KEGG:C01598;   KEGG:D08170;   LINCS:LSM-4779
 xref_mesh: MESH:D008550
 xref: MetaCyc:N-ACETYL-5-METHOXY-TRYPTAMINE;   PDBeChem:ML1;   PMID:16678784;   PMID:18212404;   PMID:18485664;   Reaxys:205542;   Wikipedia:Melatonin

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melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions		 EXP Melatonin results in increased expression of BCL2 mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]		 CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G CASP3 caspase 3 decreases expression EXP Melatonin results in decreased expression of CASP3 mRNA CTD PMID:31535366 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773 		JBrowse link
G CAT catalase multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA] CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Melatonin results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886 		JBrowse link
G PLIN2 perilipin 2 multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein] CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,274 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein] CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Melatonin results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723 		JBrowse link
G TP53 tumor protein p53 multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Melatonin results in decreased expression of TP53 mRNA		 CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 880
    role 860
      biological role 860
        molecular messenger 217
          hormone 183
            melatonin 8
              2-hydroxymelatonin 0
              6-hydroxymelatonin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 880
    subatomic particle 865
      composite particle 865
        hadron 865
          baryon 865
            nucleon 865
              atomic nucleus 865
                atom 865
                  main group element atom 855
                    p-block element atom 852
                      carbon group element atom 828
                        carbon atom 827
                          organic molecular entity 827
                            organic group 392
                              organic divalent group 390
                                organodiyl group 390
                                  carbonyl group 389
                                    carbonyl compound 389
                                      carboxylic acid 267
                                        carboacyl group 166
                                          univalent carboacyl group 166
                                            carbamoyl group 163
                                              carboxamide 163
                                                acetamides 29
                                                  melatonin 8
                                                    2-hydroxymelatonin 0
                                                    6-hydroxymelatonin 0
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