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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:scopolamine
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Accession:CHEBI:16794 term browser browse the term
Definition:A tropane alkaloid that is the (S)-tropic acid ester of 6beta,7beta-epoxy-1alphaH,5alphaH-tropan-3alpha-ol.
Synonyms:exact_synonym: (1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate
 related_synonym: (1S,3S,5R,6R,7S)-6,7-epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoate;   6,7-Epoxytropine tropate;   6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate;   Formula=C17H21NO4;   Hyoscine;   InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1;   InChIKey=STECJAGHUSJQJN-FWXGHANASA-N;   SMILES=CN1[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1;   Transderm-Scop;   alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester;   scopine (-)-tropate
 alt_id: CHEBI:15066;   CHEBI:26610;   CHEBI:9056
 xref: CAS:51-34-3;   DrugBank:DB00747;   HMDB:HMDB0003573;   KEGG:C01851;   KEGG:D00138;   KNApSAcK:C00002292
 xref_mesh: MESH:D012601
 xref: MetaCyc:SCOPOLAMINE;   PMID:11718188;   PMID:23334071;   Reaxys:91904;   Wikipedia:Scopolamine
 cyclic_relationship: is_conjugate_base_of CHEBI:61269



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scopolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression EXP Scopolamine results in decreased expression of ABCB1 mRNA CTD PMID:12818353 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression EXP Scopolamine results in increased expression of ABCG1 mRNA CTD PMID:12818353 NCBI chr20:9,128,056...9,184,312 JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
increases response to substance
affects response to substance
decreases expression
decreases activity
affects activity
increases expression
ISO
EXP
kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
ACHE protein results in increased susceptibility to Scopolamine
ACHE affects the susceptibility to Scopolamine
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; polygalacic acid inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]
Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein
CTD PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 More... NCBI chr12:25,042,882...25,050,608 JBrowse link
G Adora3 adenosine A3 receptor multiple interactions ISO [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12672554 NCBI chr 2:193,352,759...193,392,946 JBrowse link
G Agt angiotensinogen multiple interactions ISO [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Scopolamine results in decreased phosphorylation of AKT1 protein CTD PMID:27346436 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Apba1 amyloid beta precursor protein binding family A member 1 increases expression EXP Scopolamine results in increased expression of APBA1 mRNA CTD PMID:12818353 NCBI chr 1:221,363,769...221,569,496 JBrowse link
G Aplp2 amyloid beta precursor like protein 2 increases expression EXP Scopolamine results in increased expression of APLP2 mRNA CTD PMID:12818353 NCBI chr 8:29,599,230...29,662,311 JBrowse link
G App amyloid beta precursor protein decreases cleavage ISO Scopolamine results in decreased cleavage of APP protein CTD PMID:16423497 NCBI chr11:37,506,207...37,724,351 JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression
decreases expression
EXP
ISO
Scopolamine results in decreased expression of ARC mRNA
scopolamine decreases expression of Arc mRNA and protein in cerebral cortex and hippocampus
CTD
RGD
PMID:17540011 PMID:24012642 RGD:401938610 NCBI chr 7:108,444,959...108,448,413 JBrowse link
G Arg2 arginase 2 decreases expression EXP Scopolamine results in decreased expression of ARG2 mRNA CTD PMID:12818353 NCBI chr 6:103,669,001...103,694,375 JBrowse link
G Arl4d ARF like GTPase 4D decreases expression EXP Scopolamine results in decreased expression of ARL4D mRNA CTD PMID:17540011 NCBI chr10:86,592,054...86,602,843 JBrowse link
G Avp arginine vasopressin multiple interactions EXP [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr 3:138,246,544...138,248,522 JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP [[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:11553362 NCBI chr 7:59,999,743...60,003,667 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Donepezil inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]
Galantamine inhibits the reaction [Scopolamine results in increased expression of BAX protein]; intybin inhibits the reaction [Scopolamine results in increased expression of BAX protein]
CTD PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Scopolamine results in increased expression of BCAT1 mRNA CTD PMID:17540011 NCBI chr 4:179,695,662...179,777,973 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]
Galantamine inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]
CTD PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP
ISO
Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein
CTD PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 More... NCBI chr 3:116,619,633...116,670,212 JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression EXP Scopolamine results in increased expression of CACNA1D mRNA CTD PMID:12818353 NCBI chr16:5,227,157...5,521,163 JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Scopolamine results in decreased expression of CAMKK2 mRNA CTD PMID:17540011 NCBI chr12:39,451,828...39,505,719 JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Scopolamine results in decreased expression of CARTPT mRNA CTD PMID:17540011 NCBI chr 2:32,989,215...32,991,794 JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
increases cleavage
ISO
EXP
Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]
Galantamine inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]; intybin inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]
CTD PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
ISO
EXP
acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]
Galantamine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; intybin inhibits the reaction [Scopolamine results in decreased activity of CAT protein]
CTD PMID:20673844 PMID:27346436 PMID:27717698 PMID:31077737 PMID:34371027 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex decreases expression EXP Scopolamine results in decreased expression of CD3E mRNA CTD PMID:17540011 NCBI chr 8:54,200,617...54,211,770 JBrowse link
G Cdkl4 cyclin-dependent kinase-like 4 increases expression EXP Scopolamine results in increased expression of CDKL4 mRNA CTD PMID:17540011 NCBI chr 6:20,202,047...20,244,821 JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions
ISO Scopolamine results in decreased activity of CHAT protein
kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
CTD PMID:20694781 PMID:26408985 PMID:29133030 NCBI chr16:7,657,362...7,717,093 JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
increases expression
decreases expression
EXP
ISO
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]
CTD PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261 NCBI chr 1:205,567,226...205,583,001 JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases response to substance ISO CHRM4 protein results in increased susceptibility to Scopolamine CTD PMID:12729838 NCBI chr 3:98,349,080...98,356,821 JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 decreases response to substance ISO CHRM5 protein results in decreased susceptibility to Scopolamine CTD PMID:13679217 NCBI chr 3:99,284,846...99,337,252 JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
ISO Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 3:168,136,246...168,157,839 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 2:175,181,402...175,189,619 JBrowse link
G Coch cochlin decreases expression EXP Scopolamine results in decreased expression of COCH mRNA CTD PMID:12818353 NCBI chr 6:69,031,139...69,045,124 JBrowse link
G Coro1b coronin 1B increases expression EXP Scopolamine results in increased expression of CORO1B mRNA CTD PMID:12818353 NCBI chr 1:201,442,977...201,448,416 JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression EXP Scopolamine results in increased expression of COX5B mRNA CTD PMID:12818353 NCBI chr 9:38,921,980...38,923,806 JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
ISO Scopolamine results in decreased phosphorylation of CREB1 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]
CTD PMID:26408985 PMID:31077737 NCBI chr 9:73,397,333...73,466,339 JBrowse link
G Cryab crystallin, alpha B increases expression EXP Scopolamine results in increased expression of CRYAB mRNA CTD PMID:17540011 NCBI chr 8:59,989,885...59,995,532 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases response to substance
ISO IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr10:38,887,692...38,889,673 JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 decreases expression EXP Scopolamine results in decreased expression of CXCR5 mRNA CTD PMID:12818353 NCBI chr 8:53,738,878...53,756,813 JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Scopolamine results in decreased expression of DDC mRNA CTD PMID:17540011 NCBI chr14:86,378,685...86,469,189 JBrowse link
G Dguok deoxyguanosine kinase increases expression EXP Scopolamine results in increased expression of DGUOK mRNA CTD PMID:17540011 NCBI chr 4:117,544,784...117,572,414 JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression EXP Scopolamine results in increased expression of DIO2 mRNA CTD PMID:12818353 NCBI chr 6:115,396,308...115,410,594 JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression EXP Scopolamine results in decreased expression of DUSP5 mRNA CTD PMID:17540011 NCBI chr 1:262,543,774...262,557,201 JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression EXP Scopolamine results in decreased expression of DUSP6 mRNA CTD PMID:17540011 NCBI chr 7:35,979,502...35,983,834 JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP Scopolamine results in decreased expression of EGFR mRNA CTD PMID:12818353 NCBI chr14:95,378,626...95,551,358 JBrowse link
G Egr1 early growth response 1 multiple interactions
decreases expression
EXP
ISO
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA]
Scopolamine results in decreased expression of EGR1 mRNA
Scopolamine results in decreased expression of EGR1 protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
CTD PMID:8861055 PMID:17540011 PMID:29133030 NCBI chr18:26,737,078...26,740,877 JBrowse link
G Egr2 early growth response 2 decreases expression EXP Scopolamine results in decreased expression of EGR2 mRNA CTD PMID:17540011 NCBI chr20:21,051,270...21,056,322 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression EXP Scopolamine results in increased expression of EIF2S1 mRNA CTD PMID:12818353 NCBI chr 6:103,405,880...103,430,549 JBrowse link
G Eml1 EMAP like 1 decreases expression EXP Scopolamine results in decreased expression of EML1 mRNA CTD PMID:17540011 NCBI chr 6:127,283,968...127,457,246 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
increases expression
EXP
ISO
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]
Scopolamine results in decreased expression of FOS mRNA
Scopolamine results in decreased expression of FOS protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]
CTD PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 More... NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases expression EXP Scopolamine results in increased expression of GABBR1 mRNA CTD PMID:17540011 NCBI chr20:1,469,779...1,499,352 JBrowse link
G Gap43 growth associated protein 43 decreases expression
multiple interactions
ISO Scopolamine results in decreased expression of GAP43 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]
CTD PMID:22096544 NCBI chr11:71,882,131...71,975,799 JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression
ISO Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]
Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein
CTD PMID:22096544 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP Scopolamine results in increased expression of GJB2 mRNA CTD PMID:17540011 NCBI chr15:31,260,390...31,278,222 JBrowse link
G Gpc3 glypican 3 decreases expression EXP Scopolamine results in decreased expression of GPC3 mRNA CTD PMID:12818353 NCBI chr  X:136,789,770...137,157,598 JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:5,484,172...5,572,821 JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
ISO Scopolamine results in decreased activity of GSR protein
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]
CTD PMID:26408985 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gypc glycophorin C decreases expression EXP Scopolamine results in decreased expression of GYPC mRNA CTD PMID:17540011 NCBI chr18:24,434,921...24,467,592 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein] CTD PMID:32001261 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Homer1 homer scaffold protein 1 decreases expression EXP Scopolamine results in decreased expression of HOMER1 mRNA CTD PMID:17540011 NCBI chr 2:26,279,012...26,388,279 JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:19215234 NCBI chr 4:149,120,511...149,204,267 JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions EXP [[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine] CTD PMID:11640976 PMID:19215234 NCBI chr17:10,366,004...10,407,791 JBrowse link
G Hrh3 histamine receptor H3 multiple interactions EXP [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine CTD PMID:16488453 NCBI chr 3:167,191,551...167,196,642 JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression EXP Scopolamine results in increased expression of HSPA2 mRNA CTD PMID:12818353 NCBI chr 6:100,864,172...100,866,946 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases expression
EXP [4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine]
Scopolamine increases expression of Htr1a mRNA in amygdala, hippocampal formation; Scopolamine increases expression of Htr1a protein in amygdala, hippocampal formation
CTD
RGD
PMID:10578133 PMID:27760517 RGD:405850209 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression EXP Scopolamine results in increased expression of HTR2C mRNA CTD PMID:17540011 NCBI chr  X:115,453,190...115,682,325 JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 decreases expression EXP Scopolamine results in decreased expression of HTR6 mRNA CTD PMID:19733250 NCBI chr 5:156,579,901...156,595,147 JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
EXP Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA] CTD PMID:21161262 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
ISO Scopolamine results in decreased expression of IL10 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; polygalacic acid inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]
CTD PMID:26926176 PMID:31077737 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il1a interleukin 1 alpha decreases response to substance ISO IL1A protein results in decreased susceptibility to Scopolamine CTD PMID:8003924 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; polygalacic acid inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA]
CTD PMID:18357464 PMID:19426756 PMID:21161262 PMID:26926176 PMID:31077737 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] CTD PMID:8877002 NCBI chr 3:27,509,836...27,525,738 JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA]
Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein]
CTD PMID:18357464 PMID:21161262 PMID:31077737 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Scopolamine results in increased expression of ITPR1 mRNA CTD PMID:12818353 NCBI chr 4:142,743,401...143,066,505 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
EXP
ISO
Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]
CTD PMID:11337201 PMID:29133030 NCBI chr 5:115,009,900...115,012,993 JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Scopolamine results in decreased expression of JUNB mRNA CTD PMID:17540011 NCBI chr19:23,176,265...23,178,049 JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 increases expression EXP Scopolamine results in increased expression of KCNA4 mRNA CTD PMID:12579815 NCBI chr 3:93,756,399...93,778,004 JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 increases expression EXP Scopolamine results in increased expression of KCNB1 mRNA CTD PMID:12579815 PMID:15567561 NCBI chr 3:176,239,285...176,332,408 JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 decreases expression EXP Scopolamine results in decreased expression of KCND2 mRNA CTD PMID:12579815 NCBI chr 4:49,775,812...50,277,746 JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 3:39,944,896...40,106,646 JBrowse link
G Klf2 KLF transcription factor 2 decreases expression EXP Scopolamine results in decreased expression of KLF2 mRNA CTD PMID:17540011 NCBI chr16:17,521,107...17,523,739 JBrowse link
G Klf4 KLF transcription factor 4 decreases expression EXP Scopolamine results in decreased expression of KLF4 mRNA CTD PMID:17540011 NCBI chr 5:75,074,107...75,079,182 JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase multiple interactions ISO [AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine CTD PMID:11707427 NCBI chr 1:66,931,712...67,027,610 JBrowse link
G Madd MAP-kinase activating death domain increases expression EXP Scopolamine results in increased expression of MADD mRNA CTD PMID:12818353 NCBI chr 3:77,114,330...77,157,865 JBrowse link
G Map2 microtubule-associated protein 2 decreases expression
multiple interactions
ISO Scopolamine results in decreased expression of MAP2 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]
CTD PMID:22096544 NCBI chr 9:75,173,038...75,431,606 JBrowse link
G Mapt microtubule-associated protein tau decreases expression EXP Scopolamine results in decreased expression of MAPT mRNA CTD PMID:12818353 NCBI chr10:89,638,618...89,736,108 JBrowse link
G Mbp myelin basic protein decreases expression
multiple interactions
ISO Scopolamine results in decreased expression of MBP protein
Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein]
CTD PMID:29476728 NCBI chr18:75,855,878...75,966,404 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases expression ISO
EXP
Scopolamine results in decreased expression of MUC5AC protein CTD PMID:18357464 PMID:21161262 NCBI chr 1:206,293,717...206,326,006 JBrowse link
G Nefh neurofilament heavy chain multiple interactions
decreases expression
ISO Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein] CTD PMID:22096544 NCBI chr14:84,044,428...84,054,413 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
ISO
EXP
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]
Galantamine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]
CTD PMID:27346436 PMID:32001261 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Ngf nerve growth factor decreases response to substance
increases response to substance
multiple interactions
decreases secretion
EXP
ISO
NGF protein results in decreased susceptibility to Scopolamine
NGF protein results in increased susceptibility to Scopolamine
Galantamine promotes the reaction [Scopolamine results in decreased secretion of NGF protein]; intybin inhibits the reaction [Scopolamine results in decreased secretion of NGF protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
CTD PMID:1661212 PMID:8635431 PMID:16405025 PMID:27346436 NCBI chr 2:192,589,580...192,642,971 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:26408985 PMID:31077737 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nova1 NOVA alternative splicing regulator 1 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA] CTD PMID:20470870 NCBI chr 6:69,506,983...69,632,437 JBrowse link
G Nova2 NOVA alternative splicing regulator 2 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA] CTD PMID:20470870 NCBI chr 1:87,700,328...87,741,755 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases expression
ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] CTD PMID:26408985 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 increases expression EXP Scopolamine results in increased expression of NQO2 mRNA CTD PMID:20861374 NCBI chr17:30,909,482...30,938,725 JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression EXP Scopolamine results in decreased expression of NR1D1 mRNA CTD PMID:17540011 NCBI chr10:84,224,599...84,231,812 JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression EXP Scopolamine results in decreased expression of NR4A1 mRNA CTD PMID:17540011 NCBI chr 7:132,368,399...132,389,300 JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA] CTD PMID:8635431 NCBI chr 4:158,914,984...158,984,453 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases expression
EXP
ISO
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]
CTD PMID:8635431 PMID:29476728 PMID:31077737 NCBI chr17:5,560,558...5,875,899 JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 multiple interactions EXP Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA] CTD PMID:8635431 NCBI chr 1:141,526,192...141,913,575 JBrowse link
G Pdcd4 programmed cell death 4 increases expression EXP Scopolamine results in increased expression of PDCD4 mRNA CTD PMID:12818353 NCBI chr 1:252,921,342...252,944,278 JBrowse link
G Pdyn prodynorphin decreases response to substance
increases expression
multiple interactions
ISO
EXP
PDYN protein modified form results in decreased susceptibility to Scopolamine
Scopolamine results in increased expression of PDYN mRNA
MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine]
CTD PMID:7768285 PMID:17540011 NCBI chr 3:137,354,161...137,366,503 JBrowse link
G Penk proenkephalin multiple interactions EXP Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] CTD PMID:7637876 NCBI chr 5:21,981,381...21,987,074 JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression EXP Scopolamine results in decreased expression of PGAM1 mRNA CTD PMID:12818353 NCBI chr 1:250,673,152...250,680,762 JBrowse link
G Prep prolyl endopeptidase increases response to substance
multiple interactions
increases expression
EXP PREP protein results in increased susceptibility to Scopolamine
Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]
CTD PMID:17244263 PMID:18318186 NCBI chr20:48,556,211...48,653,165 JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 decreases expression EXP Scopolamine results in decreased expression of PRKRA mRNA CTD PMID:12818353 NCBI chr 3:61,575,447...61,594,393 JBrowse link
G Psen2 presenilin 2 decreases expression EXP Scopolamine results in decreased expression of PSEN2 mRNA CTD PMID:12818353 NCBI chr13:94,499,451...94,528,419 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Scopolamine results in increased expression of PTGS2 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
CTD PMID:26408985 PMID:31077737 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression EXP Scopolamine results in increased expression of RAB14 mRNA CTD PMID:17540011 NCBI chr 3:38,899,430...38,920,572 JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 decreases expression EXP Scopolamine results in decreased expression of RAPGEF3 mRNA CTD PMID:12818353 NCBI chr 7:128,875,772...128,898,203 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein] CTD PMID:19182383 PMID:19426756 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rem2 RRAD and GEM like GTPase 2 decreases expression EXP Scopolamine results in decreased expression of REM2 mRNA CTD PMID:17540011 NCBI chr15:27,933,950...27,938,429 JBrowse link
G Rgs7bp regulator of G-protein signaling 7 binding protein decreases expression EXP Scopolamine results in decreased expression of RGS7BP mRNA CTD PMID:17540011 NCBI chr 2:37,867,698...37,965,587 JBrowse link
G Robo3 roundabout guidance receptor 3 decreases expression EXP Scopolamine results in decreased expression of ROBO3 mRNA CTD PMID:17540011 NCBI chr 8:37,133,542...37,151,674 JBrowse link
G Rraga Ras-related GTP binding A increases expression EXP Scopolamine results in increased expression of RRAGA mRNA CTD PMID:12818353 NCBI chr 5:106,159,335...106,160,930 JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression EXP Scopolamine results in decreased expression of S100A4 mRNA CTD PMID:17540011 NCBI chr 2:178,388,529...178,390,838 JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases expression EXP Scopolamine results in increased expression of S1PR1 mRNA CTD PMID:12818353 NCBI chr 2:206,309,715...206,314,070 JBrowse link
G Scamp2 secretory carrier membrane protein 2 increases expression EXP Scopolamine results in increased expression of SCAMP2 mRNA CTD PMID:12818353 NCBI chr 8:66,861,504...66,888,151 JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions ISO [2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine CTD PMID:12028363 NCBI chr 5:56,904,155...56,907,012 JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128 JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Scopolamine results in increased expression of SULT1A1 mRNA CTD PMID:17540011 NCBI chr 1:190,702,592...190,706,112 JBrowse link
G Syp synaptophysin multiple interactions
increases expression
decreases expression
EXP
ISO
cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein]
Scopolamine results in decreased expression of SYP mRNA
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]
CTD PMID:20188767 PMID:34371027 NCBI chr  X:17,521,348...17,536,449 JBrowse link
G Tac1 tachykinin, precursor 1 decreases response to substance EXP TAC1 protein modified form results in decreased susceptibility to Scopolamine CTD PMID:20600432 NCBI chr 4:36,645,344...36,653,548 JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]
Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein
CTD PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnrc6a trinucleotide repeat containing adaptor 6A decreases expression EXP Scopolamine results in decreased expression of TNRC6A mRNA CTD PMID:17540011 NCBI chr 1:186,992,457...187,146,764 JBrowse link
G Tpd52l1 TPD52 like 1 increases expression EXP Scopolamine results in increased expression of TPD52L1 mRNA CTD PMID:17540011 NCBI chr 1:27,991,114...28,109,767 JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression EXP Scopolamine results in decreased expression of VGF mRNA CTD PMID:17540011 NCBI chr12:19,637,313...19,645,123 JBrowse link
G Vip vasoactive intestinal peptide decreases response to substance EXP VIP protein results in decreased susceptibility to Scopolamine CTD PMID:8208360 NCBI chr 1:44,470,232...44,478,561 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        biochemical role 19577
          metabolite 19563
            scopolamine 129
              scopolamine methobromide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      monocarboxylic acid 18028
                                        fatty acid 16855
                                          saturated fatty acid 16572
                                            propionic acid 3878
                                              2-arylpropionic acid 200
                                                hydratropic acid 200
                                                  tropic acid 198
                                                    (S)-tropic acid 198
                                                      scopolamine 129
                                                        scopolamine methobromide 0
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