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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tryptamine
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Accession:CHEBI:16765 term browser browse the term
Definition:An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.
Synonyms:related_synonym: 1H-indole-3-ethanamine;   2-(1H-INDOL-3-YL)ETHANAMINE;   2-(3-indolyl)ethylamine;   3-(2-Aminoethyl)indole;   Formula=C10H12N2;   InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2;   InChIKey=APJYDQYYACXCRM-UHFFFAOYSA-N;   SMILES=NCCc1c[nH]c2ccccc12
 alt_id: CHEBI:15274;   CHEBI:27161;   CHEBI:46157;   CHEBI:9767
 xref: Beilstein:125513;   CAS:61-54-1;   DrugBank:DB08653;   Gmelin:603448;   HMDB:HMDB0000303;   KEGG:C00398;   KNApSAcK:C00001434
 xref_mesh: MESH:C030820
 xref: MetaCyc:TRYPTAMINE;   PDBeChem:TSS;   PMID:16126914;   PMID:22770225;   PMID:24345948;   PMID:24558969;   Reaxys:125513;   Wikipedia:Tryptamine
 cyclic_relationship: is_conjugate_base_of CHEBI:57887



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tryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gast gastrin decreases cleavage EXP tryptamine results in decreased cleavage of GAST protein CTD PMID:10332097 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases response to substance
affects response to substance
multiple interactions
ISO HTR2A gene SNP results in decreased susceptibility to tryptamine
HTR2A protein affects the susceptibility to tryptamine
tryptamine binds to and results in increased activity of HTR2A protein
CTD PMID:16314884 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Maoa monoamine oxidase A decreases amination
multiple interactions
ISO MAOA protein results in decreased amination of tryptamine
[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole; [MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde
CTD PMID:26686552 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases amination
ISO [[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole; [MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indole-3-acetaldehyde CTD PMID:26686552 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tryptamine results in increased activity of NR1I2 protein CTD PMID:33002526 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity
ISO [tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
2-methylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO 2-methyl-5-HT binds to and results in increased activity of HTR3A protein CTD PMID:15802305 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15802305 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:15802305 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
5-methoxy-N,N-diisopropyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO 5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion
CTD PMID:26599973 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole CTD PMID:26599973 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 increases metabolic processing EXP CYP2D1 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine CTD PMID:18191824 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases metabolic processing EXP CYP2D2 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine CTD PMID:18191824 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone CTD PMID:26599973 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
5-methoxytryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine CTD PMID:12777961 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP CTD PMID:14578406 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Kmo kynurenine 3-monooxygenase increases expression EXP 5-Methoxytryptamine results in increased expression of KMO mRNA CTD PMID:32243540 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B decreases phosphorylation
increases phosphorylation
ISO 5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B protein
5-Methoxytryptamine results in increased phosphorylation of PPP1R1B protein
CTD PMID:11880652 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP 5-Methoxytryptamine results in decreased expression of SOD2 mRNA CTD PMID:32243540 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO 5-Methoxytryptamine results in increased activity of TAAR1 protein
[5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
G Tph1 tryptophan hydroxylase 1 decreases expression EXP 5-Methoxytryptamine results in decreased expression of TPH1 mRNA CTD PMID:32243540 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
6-hydroxymelatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO
EXP
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin] CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
luzindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein] CTD PMID:23554006 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gast gastrin multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein] CTD PMID:23554006 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G H19 H19 imprinted maternally expressed transcript multiple interactions ISO luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide decreases expression of H19 RNA in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Kras protein in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mir675 microRNA 675 multiple interactions ISO luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide decreases expression of Mir675 RNA in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358
JBrowse link
G Mtnr1a melatonin receptor 1A multiple interactions EXP luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein] CTD PMID:28238930 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions ISO
EXP
[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin; luzindole binds to and results in decreased activity of MTNR1B protein
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
CTD PMID:11270484 PMID:21473625 PMID:28238930 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]] CTD PMID:26283214 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PPARG protein] CTD PMID:29734669 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]] CTD PMID:25159133 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prnp prion protein multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] CTD PMID:29734669 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]] CTD PMID:26283214 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] CTD PMID:25159133 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein] CTD PMID:23554006 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein] CTD PMID:23554006 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]] CTD PMID:26283214 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Trp53 protein in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Usp10 ubiquitin specific peptidase 10 multiple interactions ISO luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide increases expression of Usp10 protein in C-kit+ cardiac progenitor cells]] RGD PMID:27062045 RGD:158013773 NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897
JBrowse link
melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in decreased expression of ABCB1 protein] CTD PMID:28223141 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions
decreases metabolic processing
ISO [ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
ABCB6 gene mutant form results in decreased metabolism of Melatonin
CTD PMID:25623066 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACADM mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Acan aggrecan increases expression ISO Melatonin results in increased expression of ACAN mRNA CTD PMID:20738756 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACAT1 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of ACE2 protein] CTD PMID:35844137 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of ACHE]; Melatonin inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Melatonin inhibits the reaction [Dexamethasone results in increased activity of ACHE protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of ACHE protein]] CTD PMID:19705549 PMID:21986892 PMID:22013727 PMID:30372842 PMID:35526705 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]] CTD PMID:35093381 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACSM2 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 multiple interactions ISO Melatonin inhibits the reaction [Cisplatin results in decreased expression of ACSM3 mRNA] CTD PMID:35367536 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:26882442 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Melatonin results in decreased expression of ADIPOQ mRNA CTD PMID:20738756 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adora2b adenosine A2B receptor multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA]
Melatonin results in decreased expression of ADORA2B mRNA
CTD PMID:21461237 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of AGER protein] CTD PMID:29763682 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
EXP
ISO
Melatonin results in decreased expression of AGT protein
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein]
CTD PMID:19018803 PMID:35844137 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IBA1 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of AIF1 protein] CTD PMID:34673010 PMID:36566971 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aim2 absent in melanoma 2 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of AIM2 mRNA
Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]; Melatonin inhibits the reaction [Nickel results in increased expression of AIM2 mRNA]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Nickel inhibits the reaction [Melatonin results in decreased expression of AIM2 mRNA]
CTD PMID:36504304 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA] CTD PMID:20033131 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Melatonin results in increased phosphorylation of AKT1 protein
Melatonin inhibits the reaction [cyfluthrin results in increased expression of AKT1 mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]
CTD PMID:18078454 PMID:21138475 PMID:22225513 PMID:23374533 PMID:23963992 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions ISO Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein] CTD PMID:24523661 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alb albumin multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in decreased expression of ALB protein] CTD PMID:16652224 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA] CTD PMID:23963992 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression
multiple interactions
ISO
EXP
Melatonin results in increased expression of ALPL mRNA
Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of ALPL protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of ALPL mRNA]
CTD PMID:20738756 PMID:31809235 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Amh anti-Mullerian hormone increases expression
multiple interactions
EXP Melatonin results in increased expression of AMH mRNA
bisphenol A inhibits the reaction [Melatonin results in increased expression of AMH mRNA]
CTD PMID:33967032 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of AOX1 mRNA] CTD PMID:31330490 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA] CTD PMID:33962019 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases expression
ISO
EXP
Melatonin affects the reaction [APP protein binds to APP protein]; Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form]
Melatonin inhibits the reaction [[Aluminum Chloride results in increased expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]]
Melatonin analog results in decreased expression of APP protein; Melatonin results in decreased expression of APP protein
CTD PMID:10617124 PMID:18231852 PMID:18537544 PMID:33130240 PMID:35526705 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
EXP [Melatonin co-treated with Ethanol] results in increased expression of AR protein; Ethanol inhibits the reaction [Melatonin results in increased expression of AR protein] CTD PMID:23591044 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 multiple interactions EXP Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of ARG1 mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased secretion of ARG1 protein] CTD PMID:36566971 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of ARNT mRNA] CTD PMID:33962019 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Astl astacin like metalloendopeptidase multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in decreased expression of and affects the localization of ASTL protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of and affects the localization of ASTL protein] CTD PMID:28178360 PMID:31931096 NCBI chr 3:114,563,135...114,580,295
Ensembl chr 3:114,563,135...114,578,868
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein] CTD PMID:23591579 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP
ISO
Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]
Melatonin inhibits the reaction [Atrazine results in increased expression of ATF4 protein]
CTD PMID:17645694 PMID:25259610 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of ATF6 protein]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of ATF6 protein]
CTD PMID:18715270 PMID:25259610 PMID:28070110 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA] CTD PMID:35568058 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]] CTD PMID:35568058 PMID:36421005 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of ATM protein] CTD PMID:35643323 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278
JBrowse link
G Bace1 beta-secretase 1 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of BACE1 protein] CTD PMID:33130240 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases phosphorylation
ISO Melatonin promotes the reaction [YWHAB protein binds to BAD protein]
Melatonin results in increased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased phosphorylation of BAD protein]
CTD PMID:18078454 PMID:21138475 PMID:29763682 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO
EXP
[Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAK1 mRNA]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
Melatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]
CTD PMID:10965999 PMID:19220725 PMID:23963992 PMID:33962019 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of BAX protein
Melatonin results in increased expression of BAX mRNA
Melatonin inhibits the reaction [Cisplatin results in increased cleavage of BAX protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Galactose results in increased expression of BAX protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Indomethacin affects the localization of BAX protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Methionine results in increased expression of BAX protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
Melatonin results in increased expression of BAX protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]]
[Doxorubicin co-treated with Melatonin] results in increased expression of BAX protein; [Melatonin co-treated with Tretinoin] results in increased expression of BAX protein; [Tretinoin co-treated with Melatonin] results in increased expression of BAX protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX protein]; Melatonin inhibits the reaction [BAX protein binds to BAX protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BAX protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BAX mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]; Melatonin results in increased activity of and results in increased expression of BAX protein
Melatonin results in increased expression of BAX mRNA; Melatonin results in increased expression of BAX protein
CTD PMID:9649124 PMID:10965999 PMID:14690559 PMID:15683462 PMID:15964511 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BBC3 mRNA]
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BBC3 mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of BBC3 protein]
CTD PMID:25259610 PMID:33962019 PMID:35643323 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
affects localization
ISO
EXP
[Doxorubicin co-treated with Melatonin] results in decreased expression of BCL2 protein; [Melatonin co-treated with Tretinoin] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Melatonin] results in decreased expression of BCL2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BCL2 protein]; Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]
Melatonin results in decreased expression of BCL2 mRNA; Melatonin results in decreased expression of BCL2 protein
[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein; Melatonin inhibits the reaction [decamethrin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Methionine results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of BCL2 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]
Melatonin results in increased expression of BCL2 protein
Melatonin affects the localization of BCL2 protein
CTD PMID:9649124 PMID:10965999 PMID:12220328 PMID:14690559 PMID:14993511 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2L1 mRNA]
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein]
CTD PMID:19220725 PMID:21244482 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BCL2L11 mRNA] CTD PMID:35643323 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l15 Bcl2-like 15 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BCL2L15 mRNA] CTD PMID:33962019 NCBI chr 2:191,338,959...191,344,078
Ensembl chr 2:191,338,959...191,344,078
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cisplatin results in decreased expression of BDH2 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP
Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]; Melatonin inhibits the reaction [Dietary Fats results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Ethanol results in decreased expression of BDNF mRNA]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein]]
CTD PMID:29476728 PMID:30372842 PMID:35526705 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Cisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased expression of BECN1 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]]
CTD PMID:24799992 PMID:35568058 PMID:36421005 PMID:37277016 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO
EXP
Melatonin results in increased expression of BGLAP mRNA
Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of BGLAP mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased secretion of BGLAP protein]
CTD PMID:20738756 PMID:31809235 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BID mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]
Melatonin results in increased expression of BID protein
CTD PMID:19552762 PMID:33962019 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of BIRC5 mRNA
[Doxorubicin co-treated with Melatonin] results in decreased expression of BIRC5 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BIRC5 mRNA]
CTD PMID:33507000 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 multiple interactions EXP Melatonin affects the reaction [Rotenone affects the expression of BMAL1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of BMAL1] CTD PMID:23085516 PMID:25430725 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger multiple interactions
increases expression
ISO Melatonin affects the reaction [Rotenone affects the phosphorylation of BMI1 protein]
Melatonin results in increased expression of BMI1 mRNA
CTD PMID:33157086 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions
increases expression
ISO [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of BNIP3 protein]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of PINK1 protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BNIP3 mRNA]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BNIP3 mRNA]; Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]
CTD PMID:31330490 PMID:33962019 PMID:37028639 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BNIP3L mRNA] CTD PMID:33962019 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of BTG2 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of BTG2 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]
CTD PMID:28095641 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CALCA protein]] CTD PMID:34146326 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Capn1 calpain 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CAPN1 mRNA]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of CAPN1 protein]
CTD PMID:25259610 PMID:30372842 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CASP1 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Melatonin inhibits the reaction [Nickel results in increased expression of CASP1 mRNA]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP1 protein
CTD PMID:23963992 PMID:25903262 PMID:36504304 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions EXP
ISO
[Melatonin co-treated with Aluminum Chloride] results in decreased expression of CASP12 protein; Melatonin inhibits the reaction [Galactose results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased expression of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP12 protein]
Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP12 protein]
CTD PMID:17645694 PMID:18715270 PMID:28070110 PMID:30910607 PMID:33130240 More... NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
decreases expression
ISO
EXP
[Doxorubicin co-treated with Melatonin] results in increased expression of CASP3 protein; [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP3 protein; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin promotes the reaction [flavone results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein]
Melatonin results in increased expression of CASP3 protein
Melatonin results in decreased activity of CASP3 protein
Melatonin results in increased activity of CASP3 protein
Melatonin results in decreased expression of CASP3 protein
[Melatonin co-treated with Thioacetamide] results in increased expression of CASP3 protein; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Galactose results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Methotrexate results in increased expression of and results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]]
Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]; Melatonin inhibits the reaction [Radon results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]]
CTD PMID:12220328 PMID:12880480 PMID:15683462 PMID:15800915 PMID:15964511 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO
EXP
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CASP8 mRNA]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of CASP8 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein]
Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]
Melatonin results in increased activity of CASP8 protein
CTD PMID:19012662 PMID:21431366 PMID:25259610 PMID:25454643 PMID:33962019 More... NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO
EXP
Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of CASP9 protein modified form]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]]
Melatonin results in increased activity of CASP9 protein
Melatonin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]
CTD PMID:19012662 PMID:19220725 PMID:19552762 PMID:20130848 PMID:20964710 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
decreases activity
ISO
EXP
[aluminum lactate co-treated with Melatonin] results in increased expression of CAT mRNA; [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CAT mRNA]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Urethane results in increased expression of CAT protein]
Melatonin results in increased expression of CAT mRNA
[Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
Melatonin results in decreased activity of CAT protein
[aluminum lactate co-treated with Melatonin] results in increased activity of CAT mRNA; [aluminum lactate co-treated with Melatonin] results in increased activity of CAT protein; [Melatonin co-treated with aluminum lactate] results in increased expression of CAT mRNA; [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of CAT]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein]; Melatonin inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:9194422 PMID:12500499 PMID:12823611 PMID:15589378 PMID:16098089 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin increases secretion EXP Melatonin results in increased secretion of CCK protein CTD PMID:15009505 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22225513 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of CCL5 mRNA]
CTD PMID:22225513 PMID:31330490 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of CCNB1 mRNA; Melatonin results in decreased expression of CCNB1 protein
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of CCNB1 protein]
CTD PMID:21108658 PMID:35643323 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Melatonin results in decreased expression of CCND1 mRNA; Melatonin results in decreased expression of CCND1 protein CTD PMID:21108658 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of CCR7 mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of CCR7 protein] CTD PMID:36265525 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd14 CD14 molecule multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of CD14 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd200 Cd200 molecule decreases expression ISO Melatonin results in decreased expression of CD200 protein CTD PMID:27503577 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CD36 mRNA] CTD PMID:21689150 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of CDK1 mRNA; Melatonin results in decreased expression of CDK1 protein
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK1 protein]
CTD PMID:21108658 PMID:35643323 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK2 protein] CTD PMID:23963992 PMID:35643323 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Melatonin results in decreased expression of CDK4 mRNA; Melatonin results in decreased expression of CDK4 protein CTD PMID:21108658 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Melatonin results in increased expression of CDKN1A protein
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CDKN1A mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Melatonin inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]
CTD PMID:12071473 PMID:18384530 PMID:29330934 PMID:29734669 PMID:33962019 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CDKN1B mRNA] CTD PMID:33962019 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein] CTD PMID:34673010 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO CEBPB protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]
Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CEBPB protein]
CTD PMID:34973135 PMID:38008054 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA]
Melatonin results in decreased expression of CISH mRNA
CTD PMID:21461237 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Melatonin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CKB protein] CTD PMID:19389042 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Clec4a C-type lectin domain family 4, member A multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC4N mRNA]
Melatonin results in decreased expression of CLEC4N mRNA
CTD PMID:21461237 NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 increases expression
multiple interactions
ISO Melatonin results in increased expression of CLEC4A3 mRNA
Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC4A3 mRNA]
CTD PMID:21461237 NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817
JBrowse link
G Clock clock circadian regulator multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Melatonin inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA] CTD PMID:38000455 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Colec12 collectin sub-family member 12 multiple interactions ISO [Lipopolysaccharides co-treated with Melatonin] results in increased expression of COLEC12 mRNA CTD PMID:21461237 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of COX4I1 protein] CTD PMID:30910607 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA] CTD PMID:23963992 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cry1 cryptochrome circadian regulator 1 multiple interactions EXP Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY1]; Melatonin affects the reaction [Rotenone affects the expression of CRY1 mRNA] CTD PMID:23085516 PMID:25430725 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
JBrowse link
G Cry2 cryptochrome circadian regulator 2 affects expression
multiple interactions
EXP Melatonin affects the expression of CRY2 mRNA
Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY2]; Melatonin affects the reaction [Rotenone affects the expression of CRY2 mRNA]
CTD PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]
Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of CTNNB1 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CTNNB1 protein]
CTD PMID:26990689 PMID:31809235 PMID:35526705 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions ISO Melatonin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CTSB protein] CTD PMID:21392095 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CXCL10 mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
Melatonin results in decreased expression of CXCL10 mRNA
CTD PMID:21461237 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [cyfluthrin results in increased expression of CYBB mRNA]
[SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CYBB mRNA; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CYBB mRNA]
Melatonin results in decreased expression of CYBB mRNA
Melatonin inhibits the reaction [Galactose results in increased expression of CYBB protein]
CTD PMID:31330490 PMID:34673010 PMID:36504304 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CYCS mRNA]
Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]]
CTD PMID:33962019 PMID:36421005 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
decreases activity
ISO
EXP
Melatonin results in decreased expression of CYP19A1
Melatonin results in decreased activity of CYP19A1 protein
CTD PMID:16080194 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation
EXP
ISO
Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA]
Melatonin results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of Melatonin
CTD PMID:15616152 PMID:19919601 PMID:20033131 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation
multiple interactions
increases metabolic processing
increases hydroxylation
affects metabolic processing
decreases activity
ISO
EXP
CYP1A2 protein results in decreased methylation of Melatonin
[ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
CYP1A2 protein results in increased hydroxylation of Melatonin
CYP1A2 protein affects the metabolism of Melatonin
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA
Melatonin results in decreased activity of CYP1A2 protein
Melatonin inhibits the reaction [CYP1A2 protein results in increased hydrolysis of Benzo(a)pyrene]
CTD PMID:15616152 PMID:15626586 PMID:15824912 PMID:17565714 PMID:19919601 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation
ISO 2,4,3',5'-tetramethoxystilbene inhibits the reaction [CYP1B1 protein results in increased hydroxylation of Melatonin]
Melatonin results in decreased activity of CYP1B1 protein
CTD PMID:15616152 PMID:19919601 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO Melatonin inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA] CTD PMID:28095641 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation
decreases methylation
ISO CYP2C19 protein results in increased hydroxylation of Melatonin
CYP2C19 protein results in decreased methylation of Melatonin
CTD PMID:15616152 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein]
Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
CTD PMID:20338863 PMID:20964710 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of CYP7A1 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]
CTD PMID:28095641 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO Melatonin inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA] CTD PMID:28095641 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dap3 death associated protein 3 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions EXP Melatonin inhibits the reaction [Methotrexate results in decreased expression of DDAH1 protein] CTD PMID:36890697 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions EXP Melatonin inhibits the reaction [Methotrexate results in decreased expression of DDAH2 protein] CTD PMID:36890697 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of DDIT3 protein]
Melatonin inhibits the reaction [Atrazine results in increased expression of DDIT3 protein]
CTD PMID:18715270 PMID:25259610 PMID:28070110 PMID:33130240 PMID:34673010 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression
multiple interactions
ISO Melatonin results in increased expression of DIABLO mRNA; Melatonin results in increased expression of DIABLO protein
[Doxorubicin co-treated with Melatonin] results in increased expression of DIABLO protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of DIABLO mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of DIABLO mRNA]
CTD PMID:33507000 PMID:33962019 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of DNM1L protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein]
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of DNM1L mRNA]; Melatonin inhibits the reaction [Rotenone results in increased expression of DNM1L protein]
CTD PMID:26882442 PMID:29183837 PMID:29966675 PMID:33962019 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein] CTD PMID:24969583 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]
Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]
CTD PMID:18289173 PMID:24969583 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of E2F1 protein] CTD PMID:23963992 PMID:25259610 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cisplatin results in decreased expression of ECHS1 mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form] CTD PMID:28070110 PMID:34673010 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein] CTD PMID:28070110 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:19054297 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eno2 enolase 2 multiple interactions ISO Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein] CTD PMID:24969583 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression ISO Melatonin results in increased expression of ERCC1 protein CTD PMID:24799992 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]; Melatonin promotes the reaction [Cyclosporine results in increased expression of ERN1 protein] CTD PMID:20136702 PMID:28070110 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]
Melatonin results in decreased expression of ESR1 mRNA
Melatonin results in decreased expression of ESR1 mRNA; Melatonin results in decreased expression of ESR1 protein
[Ethanol co-treated with Melatonin] results in decreased expression of ESR1 protein; [Ethanol co-treated with Melatonin] results in increased expression of ESR1 protein; Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA]
CTD PMID:15813899 PMID:16030176 PMID:16051031 PMID:16635015 PMID:23591044 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
EXP [Melatonin co-treated with Ethanol] results in increased expression of ESR2 protein; Ethanol inhibits the reaction [Melatonin results in decreased expression of ESR2 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of ESR2 protein] CTD PMID:23591044 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Melatonin results in decreased expression of FABP4 mRNA CTD PMID:20738756 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [bisphenol A results in increased expression of FAS protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein]
Melatonin results in decreased expression of FAS mRNA; Melatonin results in decreased expression of FAS protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Melatonin inhibits the reaction [Atrazine results in increased expression of FAS protein]
CTD PMID:14993511 PMID:20181888 PMID:23963992 PMID:25259610 PMID:25454643 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP
ISO
Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein]
Melatonin inhibits the reaction [Atrazine results in increased expression of FASL protein]
CTD PMID:14993511 PMID:25259610 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FASN mRNA] CTD PMID:21689150 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fcgr2b Fc gamma receptor 2B multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FCGR2B mRNA]
Melatonin results in decreased expression of FCGR2B mRNA
CTD PMID:21461237 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions EXP Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA]; Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein] CTD PMID:19476551 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Doxorubicin results in increased expression of FIS1 protein]
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of FIS1 mRNA]
CTD PMID:29966675 PMID:33962019 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] CTD PMID:19524604 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Melatonin inhibits the reaction [Capsaicin results in increased expression of FOS protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of FOS protein] CTD PMID:19172228 PMID:28238930 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Melatonin inhibits the reaction [Ethanol results in decreased expression of FSHB protein] CTD PMID:23591044 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fundc1 FUN14 domain containing 1 multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]] CTD PMID:35093381 NCBI chr  X:5,083,635...5,100,293
Ensembl chr  X:5,083,617...5,100,284
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP
ISO
Melatonin results in increased activity of G6PD protein
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of G6PD protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein
CTD PMID:16224550 PMID:25903262 PMID:29763682 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in decreased expression of GAP43 protein] CTD PMID:19409439 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gast gastrin multiple interactions
increases expression
EXP luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 PMID:16207293 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]] CTD PMID:25550330 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP
ISO
Melatonin inhibits the reaction [Carmustine results in decreased expression of GFAP protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GFAP protein]
Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein]
CTD PMID:17572393 PMID:25288107 PMID:34673010 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] CTD PMID:15700767 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Melatonin inhibits the reaction [Glucose results in increased expression of GLB1 protein] CTD PMID:38000455 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP Melatonin promotes the reaction [bisphenol A results in increased expression of GNRH1 mRNA] CTD PMID:33967032 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression
multiple interactions
EXP Melatonin results in increased expression of GNRHR mRNA
[bisphenol A co-treated with Melatonin] results in increased expression of GNRHR mRNA
CTD PMID:33967032 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Melatonin co-treated with Thioacetamide] results in increased expression of GPT protein; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Melatonin inhibits the reaction [Methotrexate results in increased expression of GPT protein] CTD PMID:15700767 PMID:26882442 PMID:31967703 PMID:36890697 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
EXP
ISO
[aluminum lactate co-treated with Melatonin] results in increased expression of GPX1 mRNA
Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein]
Melatonin results in increased expression of GPX1 mRNA
CTD PMID:15589378 PMID:25288107 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA CTD PMID:20033131 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]] CTD PMID:35093381 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Melatonin inhibits the reaction [Galactose results in increased expression of GRIN1 protein] CTD PMID:34673010 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Melatonin inhibits the reaction [Galactose results in increased expression of GRIN2B protein] CTD PMID:34673010 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO
EXP
Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of GSK3B protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of GSK3B protein modified form]]
CTD PMID:15842767 PMID:31809235 PMID:35526705 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
decreases expression
EXP
ISO
[Cadmium Chloride co-treated with Melatonin] results in decreased expression of GSR mRNA; aluminum lactate affects the reaction [Melatonin results in increased activity of GSR protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased activity of GSR protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of GSR protein
Melatonin results in decreased expression of GSR protein
[aluminum lactate co-treated with Melatonin] results in increased expression of GSR mRNA; aluminum lactate promotes the reaction [Melatonin results in decreased expression of GSR protein]; luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased expression of GSR protein]
Melatonin results in decreased expression of GSR mRNA
CTD PMID:12823611 PMID:16098089 PMID:16224550 PMID:16931443 PMID:19405147 More... NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:20033131 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA CTD PMID:20033131 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]
Melatonin affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA]
CTD PMID:21986892 PMID:23963992 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H19 H19 imprinted maternally expressed transcript increases expression EXP monocrotaline increases expression of H19 RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein] CTD PMID:35643323 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of HAVCR1 protein] CTD PMID:29763682 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions
decreases activity
ISO CEBPB protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]; RELA protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein] CTD PMID:34973135 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of HIF1A mRNA] CTD PMID:33962019 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [decabromobiphenyl ether affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein]]; Melatonin inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of HMGB1 protein]
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMGB1 mRNA]
CTD PMID:27413111 PMID:35844137 PMID:36566971 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
EXP
ISO
Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of HMOX1 mRNA]]
Melatonin results in increased expression of HMOX1 protein
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
Melatonin results in decreased expression of HMOX1 mRNA
CTD PMID:10942521 PMID:12420312 PMID:16948784 PMID:17645694 PMID:18715270 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
decreases expression
EXP [Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNA; Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]
Melatonin results in decreased expression of HMOX2 mRNA
CTD PMID:21442002 PMID:21986892 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA] CTD PMID:23963992 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of HSPA1A mRNA] CTD PMID:31330490 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of HSPA5 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 protein] CTD PMID:20136702 PMID:28070110 PMID:33130240 PMID:34673010 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP Melatonin affects the reaction [Mercuric Chloride results in increased expression of HSPA9 protein] CTD PMID:16801527 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IFNG protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG mRNA]
CTD PMID:16373423 PMID:23374533 PMID:23963992 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA] CTD PMID:23963992 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression EXP melatonin decreases expression of Igf1r RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL10 protein]; IL17A protein affects the reaction [[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 protein]
Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of IL10 mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased secretion of IL10 protein]
CTD PMID:16373423 PMID:36566971 PMID:37269891 PMID:37598416 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Melatonin inhibits the reaction [Dextran Sulfate results in decreased expression of IL11 protein] CTD PMID:36265525 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]] CTD PMID:34146326 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il17a interleukin 17A multiple interactions ISO IL17A protein affects the reaction [[Melatonin co-treated with Fluorides] results in increased expression of IL10 mRNA]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A protein]] CTD PMID:34146326 PMID:37269891 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL18 mRNA]; Melatonin inhibits the reaction [Nickel results in increased expression of IL18 mRNA] CTD PMID:36504304 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1A protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]
Melatonin results in decreased expression of IL1A mRNA
CTD PMID:21461237 PMID:36265525 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression
ISO
EXP
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL1B protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL1B mRNA]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Nickel results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Nickel inhibits the reaction [Melatonin results in decreased expression of IL1B mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of IL1B protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]]
Melatonin results in decreased secretion of IL1B protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]]
Melatonin results in decreased expression of IL1B mRNA; Melatonin results in decreased expression of IL1B protein
CTD PMID:15714805 PMID:16373423 PMID:19028472 PMID:20374443 PMID:21461237 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases activity
multiple interactions
ISO Melatonin results in increased activity of IL2 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL2 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]]
CTD PMID:9730580 PMID:16373423 PMID:36421005 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein] CTD PMID:36265525 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL4 protein]] CTD PMID:27871981 PMID:34146326 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL5 protein]] CTD PMID:34146326 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion
EXP
ISO
Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 protein]
Melatonin results in decreased secretion of IL6 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL6 protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]]
CTD PMID:16373423 PMID:20374443 PMID:21158907 PMID:27413111 PMID:28238930 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il7 interleukin 7 multiple interactions ISO Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]] CTD PMID:36421005 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Ins1 insulin 1 multiple interactions EXP Melatonin affects the reaction [Streptozocin results in decreased expression of INS1 protein]; Melatonin inhibits the reaction [Colforsin results in increased secretion of INS1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse inhibits the reaction [INS1 protein results in increased uptake of Glucose]] CTD PMID:12153439 PMID:17198541 PMID:32554039 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Insr insulin receptor multiple interactions EXP Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein] CTD PMID:19705549 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:29763682 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA] CTD PMID:23963992 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 multiple interactions EXP Melatonin inhibits the reaction [Galactose results in increased expression of ITPR3 protein] CTD PMID:34673010 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
JBrowse link
G Izumo1r IZUMO1 receptor, JUNO multiple interactions ISO Melatonin inhibits the reaction [bisphenol A affects the expression of and affects the localization of IZUMO1R protein]; Melatonin inhibits the reaction [Ethinyl Estradiol affects the localization of IZUMO1R protein] CTD PMID:28178360 PMID:31931096 NCBI chr 8:11,744,384...11,748,131
Ensembl chr 8:11,725,863...11,748,465
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of JUN protein] CTD PMID:28238930 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of KDR mRNA] CTD PMID:33962019 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of KEAP1 protein
Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]
CTD PMID:25288107 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kl Klotho multiple interactions ISO 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]] CTD PMID:25550330 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of LAMP2 protein] CTD PMID:26882442 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lep leptin decreases expression ISO
EXP
Melatonin results in decreased expression of LEP mRNA
Melatonin results in decreased expression of LEP protein
CTD PMID:19028472 PMID:20738756 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Melatonin co-treated with LHB protein] results in increased chemical synthesis of Testosterone; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of LHB] CTD PMID:16054318 PMID:23085516 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO Melatonin results in decreased expression of LPL mRNA CTD PMID:20738756 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of LRP1 protein] CTD PMID:33130240 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of LY96 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of LY96 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:27413111 PMID:28238930 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 multiple interactions ISO Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD1L1 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD1L1 protein] CTD PMID:35643323 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 multiple interactions ISO Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD2L1 mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of MAD2L1 protein] CTD PMID:35643323 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of MAOA protein] CTD PMID:37348669 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA] CTD PMID:35568058 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Melatonin inhibits the reaction [Atrazine results in increased expression of MAP1LC3B protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]; Melatonin inhibits the reaction [Radon results in increased expression of MAP1LC3B protein]; Melatonin promotes the reaction [Paraquat results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Melatonin results in increased expression of and results in increased lipidation of MAP1LC3B protein; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]] CTD PMID:25259610 PMID:33107683 PMID:36421005 PMID:37028639 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA] CTD PMID:23963992 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA] CTD PMID:23963992 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK1 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]
CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 PMID:35643323 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Melatonin results in increased expression of MAPK10 protein CTD PMID:19012662 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK3 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]
CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 PMID:35643323 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Melatonin results in increased expression of MAPK8 protein CTD PMID:19012662 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Melatonin results in increased expression of MAPK9 protein CTD PMID:19012662 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Melatonin inhibits the reaction [Wortmannin results in increased phosphorylation of MAPT protein]
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]; Melatonin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin metabolite inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of MAPT protein modified form]]
Melatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]
CTD PMID:10617124 PMID:15842767 PMID:23963992 PMID:31833155 PMID:35526705 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mbp myelin basic protein multiple interactions ISO Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein] CTD PMID:29476728 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO Melatonin inhibits the reaction [oxaliplatin results in decreased expression of MCL1 protein] CTD PMID:20626587 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:20033131 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mff mitochondrial fission factor multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of MFF mRNA] CTD PMID:33962019 NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039
JBrowse link
G Mfn1 mitofusin 1 multiple interactions
increases expression
EXP
ISO
[Doxorubicin results in increased susceptibility to Melatonin] which results in increased expression of MFN1 protein; [Melatonin results in increased susceptibility to Doxorubicin] which results in increased expression of MFN1 protein
Melatonin results in increased expression of MFN1 mRNA
CTD PMID:29966675 PMID:33962019 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfn2 mitofusin 2 multiple interactions
increases expression
EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of MFN2 protein]
Melatonin affects the reaction [[Glucose co-treated with Deferoxamine] results in decreased expression of MFN2 mRNA]
Melatonin results in increased expression of MFN2 mRNA
CTD PMID:26882442 PMID:29966675 PMID:33962019 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mief2 mitochondrial elongation factor 2 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of MIEF2 mRNA] CTD PMID:33962019 NCBI chr10:45,408,055...45,414,144
Ensembl chr10:45,408,082...45,414,144
JBrowse link
G Mir200a microRNA 200a decreases expression EXP melatonin decreases expression of Mir200a RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir21 microRNA 21 multiple interactions EXP Melatonin inhibits the reaction [Cisplatin results in increased expression of MIR21 mRNA] CTD PMID:36006825 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir497 microRNA 497 multiple interactions
increases expression
ISO MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA]
Melatonin results in increased expression of MIR497 mRNA
CTD PMID:28095641 NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584
JBrowse link
G Mir675 microRNA 675 increases expression EXP melatonin increases expression of Mir675 RNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MKI67 protein]
Melatonin results in decreased expression of MKI67 mRNA; Melatonin results in decreased expression of MKI67 protein
CTD PMID:19028472 PMID:21062352 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein] CTD PMID:35844137 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of MME protein] CTD PMID:33130240 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions EXP Melatonin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of MMP2 protein]
Melatonin results in decreased expression of MMP2 mRNA; Melatonin results in decreased expression of MMP2 protein
[Doxorubicin co-treated with Melatonin] results in decreased expression of MMP2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP2 mRNA]
Melatonin inhibits the reaction [sodium arsenite results in increased expression of MMP2 protein]
CTD PMID:16150113 PMID:16934674 PMID:29763682 PMID:33507000 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [Galactose results in decreased expression of MMP9 protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of and results in increased secretion of MMP9 protein]
Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 mRNA]; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 protein]
Melatonin results in decreased expression of MMP9 mRNA; Melatonin results in decreased expression of MMP9 protein
CTD PMID:16150113 PMID:33507000 PMID:34673010 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; Melatonin inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein] CTD PMID:26519479 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO Melatonin inhibits the reaction [Paraquat results in increased expression of COX2 protein] CTD PMID:37028639 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Melatonin promotes the reaction [lead acetate results in increased expression of MT1A mRNA] CTD PMID:25601058 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
JBrowse link
G Mt2A metallothionein 2A multiple interactions EXP Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA] CTD PMID:25601058 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
increases expression
multiple interactions
ISO
EXP
Melatonin analog binds to MTNR1A protein; Melatonin binds to MTNR1A protein
Melatonin results in increased expression of MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein]
[Ethanol co-treated with Melatonin] results in increased expression of MTNR1A protein; luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]
CTD PMID:11063602 PMID:17645693 PMID:20399199 PMID:23591044 PMID:28027439 More... NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions
increases expression
affects binding
ISO
EXP
[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
Melatonin analog binds to MTNR1B protein; Melatonin binds to MTNR1B protein
CTD PMID:11063602 PMID:11270484 PMID:16030176 PMID:17645693 PMID:20399199 More... NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
increases activity
ISO
EXP
Cisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]; Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Melatonin inhibits the reaction [Methotrexate results in increased phosphorylation of MTOR protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]]
Melatonin results in increased activity of MTOR protein
CTD PMID:19054297 PMID:24799992 PMID:35568058 PMID:36421005 PMID:36890697 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 PMID:36566971 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression EXP melatonin increases expression of NCAM1 protein isoform 180 in hippocampus of ethanol treated rats RGD PMID:16207289 RGD:401959613 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA1 protein] CTD PMID:29330934 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA3 protein] CTD PMID:29330934 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase affects response to substance
multiple interactions
decreases expression
ISO [NEDD4 protein affects the susceptibility to Oxygen deficiency] which affects the susceptibility to Melatonin
Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of NEDD4 protein]; Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein]; Melatonin promotes the reaction [Cycloheximide results in decreased expression of NEDD4 protein]; Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein]
Melatonin results in decreased expression of NEDD4 protein
CTD PMID:31325559 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
JBrowse link
G Nefh neurofilament heavy chain decreases phosphorylation ISO Melatonin analog results in decreased phosphorylation of NEFH protein; Melatonin results in decreased phosphorylation of NEFH protein CTD PMID:18231852 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nes nestin decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of NES protein
Melatonin inhibits the reaction [Carmustine results in increased expression of NES protein]
CTD PMID:16369854 PMID:17572393 PMID:21269327 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
EXP
ISO
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]
Melatonin results in increased expression of NFE2L2 mRNA
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NFE2L2 mRNA]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of NFE2L2 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of NFE2L2 mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]
Melatonin results in increased expression of NFE2L2 protein
CTD PMID:20433640 PMID:25288107 PMID:25550330 PMID:27871981 PMID:30372842 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NFKB1 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NFKB1 mRNA]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]
CTD PMID:19028472 PMID:21158907 PMID:23963992 PMID:30372842 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]]; Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]
Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of and results in increased localization of NFKBIA protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of NFKBIA mRNA]]
CTD PMID:26283214 PMID:35526705 PMID:36566971 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
decreases expression
ISO [Nickel co-treated with Melatonin] results in decreased expression of NLRP3 protein; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of NLRP3 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 protein]; Nickel inhibits the reaction [Melatonin results in decreased expression of NLRP3 mRNA] CTD PMID:36504304 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
EXP Melatonin affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of NOS1 mRNA]
Melatonin results in decreased expression of NOS1 mRNA
CTD PMID:16948784 PMID:21442002 PMID:21986892 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
decreases expression
ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NOS2 mRNA]
Melatonin results in increased expression of NOS2 mRNA
Melatonin results in decreased expression of NOS2 mRNA
Melatonin affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA]; Melatonin affects the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Amphetamine results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]
CTD PMID:12074098 PMID:16801527 PMID:16948784 PMID:18524487 PMID:21442002 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]] CTD PMID:21585521 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch2 notch receptor 2 multiple interactions ISO Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of NOTCH2 protein alternative form] CTD PMID:37277016 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Melatonin inhibits the reaction [Galactose results in increased expression of NOX4 protein] CTD PMID:34673010 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]] CTD PMID:17198541 PMID:35093381 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP
ISO
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Melatonin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NQO1 mRNA]
Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]]; Melatonin affects the reaction [manganese chloride affects the expression of NQO1 protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of NQO1 mRNA]]
Melatonin results in increased expression of NQO1 protein
CTD PMID:20033131 PMID:20433640 PMID:24969583 PMID:25288107 PMID:27871981 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions
affects activity
ISO Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]
Melatonin affects the activity of NQO2 protein
CTD PMID:20399199 PMID:22289031 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1H3 protein] CTD PMID:21689150 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1I2 mRNA] CTD PMID:15617534 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects localization
ISO
EXP
Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Melatonin promotes the reaction [Dexamethasone results in decreased expression of NR3C1 mRNA]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]]
Melatonin inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Melatonin affects the localization of NR3C1 protein
CTD PMID:10463946 PMID:15813899 PMID:18395440 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NRF1 protein] CTD PMID:26882442 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein] CTD PMID:23963992 PMID:29476728 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ocln occludin multiple interactions ISO Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN protein] CTD PMID:37598416 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of OPA1 mRNA]
Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]
CTD PMID:33962019 PMID:35093381 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] CTD PMID:23963992 NCBI chr  X:65,681,680...65,717,404
Ensembl chr  X:65,683,232...65,721,748
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Doxorubicin results in increased expression of PARP1 protein modified form]
Melatonin inhibits the reaction [Atrazine results in increased cleavage of PARP1 protein]
CTD PMID:25259610 PMID:29966675 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression EXP Melatonin results in decreased expression of PAWR protein CTD PMID:15964511 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PCNA protein]
Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of PCNA protein]
Melatonin results in decreased expression of PCNA mRNA
CTD PMID:19028472 PMID:21062352 PMID:35643323 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdcd4 programmed cell death 4 increases expression EXP melatonin increases expression of Pdcd4 mRNA in pulmonary artery smooth muscle cells RGD PMID:30240970 RGD:156430315 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pde1b phosphodiesterase 1B multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA] CTD PMID:23963992 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA] CTD PMID:23963992 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PECR mRNA] CTD PMID:35367536 PMID:36006825 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
G Per1 period circadian regulator 1 multiple interactions EXP Melatonin affects the reaction [Cadmium Chloride affects the expression of PER1]; Melatonin affects the reaction [Rotenone affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER1 mRNA] CTD PMID:17590544 PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per2 period circadian regulator 2 multiple interactions
affects expression
EXP Melatonin affects the reaction [Rotenone affects the expression of PER2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER2 mRNA]
Melatonin affects the expression of PER2 mRNA
CTD PMID:17590544 PMID:21442002 PMID:25430725 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pf4 platelet factor 4 multiple interactions ISO [Lipopolysaccharides co-treated with Melatonin] results in increased expression of PF4 mRNA CTD PMID:21461237 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of PGR]
Melatonin results in decreased expression of PGR protein alternative form
[Ethanol co-treated with Melatonin] results in decreased expression of PGR protein alternative form; [Ethanol co-treated with Melatonin] results in increased expression of PGR protein alternative form; Ethanol inhibits the reaction [Melatonin results in decreased expression of PGR protein alternative form]; Melatonin inhibits the reaction [Ethanol results in decreased expression of PGR protein alternative form]
CTD PMID:22041583 PMID:23591044 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA]]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA] CTD PMID:35568058 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
increases expression
EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein]
Melatonin results in increased expression of PINK1 protein
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of IL1B protein]]; [BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]
[PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of BNIP3 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of BNIP3 protein]; [PINK1 protein co-treated with BNIP3 protein] affects the reaction [Melatonin results in increased expression of PINK1 protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of PINK1 mRNA]; Melatonin promotes the reaction [Paraquat results in increased expression of PINK1 protein]
CTD PMID:26882442 PMID:29966675 PMID:33962019 PMID:37028639 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of PMAIP1 mRNA] CTD PMID:33962019 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases response to substance
EXP
ISO
[Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein
Melatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]; Melatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone]
Melatonin results in decreased susceptibility to POMC protein
CTD PMID:11478929 PMID:19301769 PMID:21332028 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 protein]
Melatonin results in decreased expression of POU5F1 mRNA; Melatonin results in decreased expression of POU5F1 protein
CTD PMID:27551335 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA mRNA]; Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA protein]
Melatonin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of PPARA protein]; Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARA mRNA]
CTD PMID:35367536 PMID:36006825 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
increases expression
multiple interactions
ISO Melatonin results in decreased expression of PPARG mRNA
Melatonin results in increased expression of PPARG mRNA; Melatonin results in increased expression of PPARG protein
GW 1929 inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PPARG protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PPARG protein]
CTD PMID:20738756 PMID:29734669 PMID:33962019 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO
EXP
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]; Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA]
Melatonin results in increased expression of PPARGC1A mRNA
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]
CTD PMID:25159133 PMID:26882442 PMID:29966675 PMID:33962019 PMID:35367536 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRKN protein] CTD PMID:26882442 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prl prolactin multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL protein]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL] CTD PMID:23085516 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prmt1 protein arginine methyltransferase 1 multiple interactions EXP Melatonin inhibits the reaction [Methotrexate results in decreased expression of PRMT1 protein] CTD PMID:36890697 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prnp prion protein increases expression
multiple interactions
ISO Melatonin results in increased expression of PRNP protein
GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PRNP protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PRNP protein]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]
CTD PMID:29734669 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of PROM1 mRNA; Melatonin results in decreased expression of PROM1 protein
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; N-caproylsphingosine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; N-caproylsphingosine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein]
CTD PMID:30421542 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA] CTD PMID:23963992 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA] CTD PMID:23963992 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
JBrowse link
G Psmd3 proteasome 26S subunit, non-ATPase 3 multiple interactions ISO [Oxygen deficiency co-treated with Melatonin] results in decreased expression of PSMD3 protein CTD PMID:31325559 NCBI chr10:83,643,473...83,655,620
Ensembl chr10:83,643,647...83,655,618
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]
Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [Radon results in decreased expression of PTGS2 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]]
CTD PMID:18588940 PMID:23376440 PMID:33107683 PMID:36421005 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
decreases expression
ISO Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD protein]; Melatonin inhibits the reaction [Nickel results in increased expression of PYCARD mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of PYCARD protein]
Melatonin results in decreased expression of PYCARD mRNA; Melatonin results in decreased expression of PYCARD protein
CTD PMID:36504304 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of RAB7A protein] CTD PMID:26882442 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA] CTD PMID:23963992 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Melatonin co-treated with Tretinoin] results in increased activity of RARA protein; Melatonin promotes the reaction [Tretinoin results in increased activity of RARA protein] CTD PMID:10965999 PMID:15813899 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RELA protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA protein]; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [[Formaldehyde co-treated with diisononyl phthalate] promotes the reaction [OVAL protein results in increased phosphorylation of RELA protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]]; Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]; Melatonin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]; RELA protein inhibits the reaction [Melatonin results in decreased activity of HDAC3 protein]
Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]
CTD PMID:20433640 PMID:22225513 PMID:22526374 PMID:26283214 PMID:27871981 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Renbp renin binding protein multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of RENBP protein] CTD PMID:29763682 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516
JBrowse link
G Rgn regucalcin multiple interactions ISO Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]] CTD PMID:29734669 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of RIPK1 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK1 protein] CTD PMID:29763682 PMID:35844137 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO
EXP
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK3 protein]
[Melatonin co-treated with Thioacetamide] results in increased expression of RIPK3 protein
CTD PMID:29763682 PMID:31967703 PMID:35844137 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO Melatonin binds to RORA protein CTD PMID:16030176 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Rpl19 ribosomal protein L19 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA] CTD PMID:23963992 NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
JBrowse link
G Rpl23 ribosomal protein L23 multiple interactions ISO Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870
JBrowse link
G Rpl3 ribosomal protein L3 multiple interactions ISO Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of RPL3 protein] CTD PMID:31325559 NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468
JBrowse link
G Rps19 ribosomal protein S19 multiple interactions ISO Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
JBrowse link
G Rps7 ribosomal protein S7 multiple interactions ISO Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
ISO
EXP
Melatonin results in increased expression of RUNX2 mRNA
Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]
Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of RUNX2 mRNA]
CTD PMID:20738756 PMID:31809235 PMID:38000455 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G S100g S100 calcium binding protein G increases expression
multiple interactions
EXP Melatonin results in increased expression of S100G mRNA; Melatonin results in increased expression of S100G protein
Hydrogen Peroxide promotes the reaction [Melatonin results in increased expression of S100G protein]
CTD PMID:20041988 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433
JBrowse link
G Selenom selenoprotein M multiple interactions
affects response to substance
ISO [SELENOM protein affects the susceptibility to Melatonin] which affects the abundance of Malondialdehyde; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CASP1 protein; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of CYBB mRNA; [SELENOM protein affects the susceptibility to Melatonin] which affects the expression of NLRP3 protein; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CASP1 protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of CYBB mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL18 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of IL1B mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of NLRP3 protein]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD mRNA]; Melatonin affects the reaction [[SELENOM protein affects the susceptibility to Nickel] which affects the expression of PYCARD protein]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of IL1B protein]]; Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]; Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]; Melatonin affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]; Melatonin inhibits the reaction [SELENOM protein affects the susceptibility to Nickel]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of AIM2 mRNA]]; Nickel affects the reaction [Melatonin affects the reaction [SELENOM protein affects the expression of IL1B protein]] CTD PMID:36504304 NCBI chr14:78,395,826...78,398,429
Ensembl chr14:78,395,826...78,398,429
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 multiple interactions ISO Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of SETDB1 protein] CTD PMID:35643323 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of SIRT1 protein
Melatonin inhibits the reaction [decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein]]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in decreased expression of and results in decreased localization of SIRT1 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]
CTD PMID:21062352 PMID:25159133 PMID:29966675 PMID:36566971 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA] CTD PMID:20964710 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA]
Melatonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:21599003 PMID:23963992 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]
CTD PMID:17198541 PMID:29763682 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]
Melatonin inhibits the reaction [manganese chloride results in decreased expression of SLC6A3 protein]
CTD PMID:18289173 PMID:24969583 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Snca synuclein alpha multiple interactions EXP
ISO
Melatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Melatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]]
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]
CTD PMID:17645694 PMID:18289173 PMID:34808223 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases activity
increases expression
EXP
ISO
[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; [Cadmium Chloride co-treated with Melatonin] results in increased expression of SOD1 mRNA; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD1 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]
Melatonin results in increased activity of SOD1 protein
Melatonin results in increased expression of SOD1 mRNA
[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of SOD1 protein]
CTD PMID:11523592 PMID:15589378 PMID:17198541 PMID:19405147 PMID:19680607 More... NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
increases expression
EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD2 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD2 protein]
luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of SOD2 protein]
Melatonin results in increased expression of SOD2 mRNA
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
CTD PMID:10942521 PMID:11523592 PMID:15589378 PMID:16098089 PMID:20210856 More... NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 protein] CTD PMID:38000455 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of SQSTM1 protein]
Melatonin results in increased expression of SQSTM1 protein
Melatonin inhibits the reaction [Atrazine results in increased expression of SQSTM1 protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 protein]; Melatonin inhibits the reaction [Radon results in increased expression of SQSTM1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of SQSTM1 mRNA]
CTD PMID:25259610 PMID:26882442 PMID:31330490 PMID:33107683 PMID:36421005 More... NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein] CTD PMID:21689150 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:21158907 PMID:22225513 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases response to substance
increases phosphorylation
ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
STAT3 protein results in increased susceptibility to Melatonin
Melatonin results in increased phosphorylation of STAT3 protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of STAT3 protein]
CTD PMID:19028472 PMID:21342247 PMID:22225513 PMID:23963992 PMID:27871981 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat4 signal transducer and activator of transcription 4 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA] CTD PMID:23963992 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] CTD PMID:27871981 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] CTD PMID:27871981 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Syp synaptophysin multiple interactions EXP Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]; Melatonin inhibits the reaction [Methamphetamine results in decreased expression of SYP protein] CTD PMID:17572393 PMID:19409439 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Syt5 synaptotagmin 5 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA] CTD PMID:23963992 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin CTD PMID:16952380 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tf transferrin increases expression
multiple interactions
EXP Melatonin results in increased expression of TF protein
[Melatonin results in increased expression of TF protein] which affects the abundance of Iron
CTD PMID:18571630 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
increases expression
ISO
EXP
Melatonin inhibits the reaction [nickel chloride results in decreased expression of TFAM protein]
Melatonin results in increased expression of TFAM mRNA
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFAM protein]
CTD PMID:21797922 PMID:26882442 PMID:33962019 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]] CTD PMID:27551335 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tfrc transferrin receptor decreases expression EXP Melatonin results in decreased expression of TFRC mRNA; Melatonin results in decreased expression of TFRC protein CTD PMID:17091493 PMID:18571630 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
[Tretinoin co-treated with Melatonin] results in increased expression of TGFB1 mRNA
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Melatonin inhibits the reaction [Carmustine results in decreased expression of TGFB1 protein]
CTD PMID:9649124 PMID:17572393 PMID:23963992 PMID:26882442 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP
ISO
Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein]
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of TH protein]
CTD PMID:18289173 PMID:19409439 PMID:20964710 PMID:24969583 PMID:34808223 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein] CTD PMID:16934674 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein] CTD PMID:37598416 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of TLR4 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]]
Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TLR4 protein]
CTD PMID:27413111 PMID:28238930 PMID:34808223 PMID:36566971 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions ISO Melatonin inhibits the reaction [Paraquat results in increased expression of TLR9 protein] CTD PMID:37028639 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO
EXP
[BNIP3 protein co-treated with PINK1 protein] affects the reaction [Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]]; Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of TNF protein]; Melatonin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Paraquat results in increased secretion of TNF protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]]
melatonin inhibits the reaction [liver reperfusion increases secretion of Tnf protein in plasma]
Melatonin results in decreased secretion of TNF protein
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]; Melatonin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF protein]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Melatonin inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]]
CTD
RGD
PMID:15714805 PMID:16373423 PMID:17602819 PMID:19028472 PMID:19080501 More... RGD:2325259 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA] CTD PMID:23963992 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases response to substance ISO TNFRSF1B protein results in increased susceptibility to Melatonin CTD PMID:21342247 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO
EXP
Melatonin results in increased expression of TP53 protein
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of TP53 mRNA]; Melatonin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Glucose results in increased expression of TP53 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of TRP53 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]]
Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]
CTD PMID:12071473 PMID:14993511 PMID:19012662 PMID:20041988 PMID:20964710 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TRADD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TRADD protein] CTD PMID:29763682 PMID:35844137 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Trappc6a trafficking protein particle complex subunit 6A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in decreased expression of TRAPPC6A mRNA] CTD PMID:31330490 NCBI chr 1:79,158,587...79,165,502
Ensembl chr 1:79,158,529...79,165,493
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Melatonin inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased expression of TRPV1 protein] CTD PMID:34146326 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride affects the expression of TSHB]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB mRNA]; Melatonin inhibits the reaction [Cadmium results in decreased expression of TSHB mRNA] CTD PMID:16948784 PMID:23085516 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]] CTD PMID:27871981 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA] CTD PMID:23963992 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein] CTD PMID:30421542 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Txn1 thioredoxin 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of TXN1 mRNA
Nickel inhibits the reaction [Melatonin results in decreased expression of TXN1 mRNA]
CTD PMID:36504304 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnip thioredoxin interacting protein decreases expression
multiple interactions
ISO Melatonin results in decreased expression of TXNIP mRNA
Melatonin affects the reaction [Nickel affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]]; Melatonin affects the reaction [SELENOM protein affects the expression of TXNIP mRNA]; Nickel inhibits the reaction [Melatonin results in decreased expression of TXNIP mRNA]
CTD PMID:36504304 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Txnrd3 thioredoxin reductase 3 multiple interactions
decreases response to substance
ISO TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of SQSTM1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of PTGS2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TNF mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin results in decreased susceptibility to nickel chloride]
TXNRD3 gene mutant form results in decreased susceptibility to Melatonin
CTD PMID:36421005 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491
JBrowse link
G Ubb ubiquitin B multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA] CTD PMID:23963992 NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP Melatonin inhibits the reaction [ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA]; Melatonin inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA] CTD PMID:22846377 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Vamp5 vesicle-associated membrane protein 5 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA] CTD PMID:23963992 NCBI chr 4:104,423,813...104,435,059
Ensembl chr 4:104,423,820...104,426,212
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP
ISO
Melatonin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of VEGFA mRNA]
CTD PMID:32554039 PMID:33962019 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vps45 vacuolar protein sorting 45 homolog multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA] CTD PMID:23963992 NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:183,555,921...183,616,295
JBrowse link
G Wnt3 Wnt family member 3 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]; Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]]; Zinc Sulfate promotes the reaction [Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of WNT3 protein]] CTD PMID:35526705 NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of WNT3A protein] CTD PMID:31809235 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein]
Melatonin inhibits the reaction [Atrazine affects the splicing of XBP1]
CTD PMID:17645694 PMID:25259610 PMID:28070110 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]] CTD PMID:35093381 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions ISO Melatonin promotes the reaction [YWHAB protein binds to BAD protein] CTD PMID:18078454 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
JBrowse link
G Yy1 YY1 transcription factor decreases expression
multiple interactions
ISO Melatonin results in decreased expression of YY1 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA]
CTD PMID:28095641 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
JBrowse link
G Zp2 zona pellucida glycoprotein 2 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased cleavage of ZP2 protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in increased cleavage of ZP2 protein] CTD PMID:28178360 PMID:31931096 NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288
JBrowse link
N,N-dimethyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of N,N-Dimethyltryptamine CTD PMID:27320963 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of N,N-Dimethyltryptamine CTD PMID:27320963 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of N,N-Dimethyltryptamine CTD PMID:27320963 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases response to substance
multiple interactions
affects response to substance
ISO HTR2A gene SNP results in decreased susceptibility to N,N-Dimethyltryptamine
N,N-Dimethyltryptamine binds to and results in increased activity of HTR2A protein
HTR2A protein affects the susceptibility to N,N-Dimethyltryptamine
CTD PMID:16314884 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
N-acetylserotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO N-acetylserotonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein] CTD PMID:19961921 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases glucuronidation
ISO methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate inhibits the reaction [UGT1A6 protein results in increased glucuronidation of N-acetylserotonin] CTD PMID:34910929 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; AG 1879 inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; guanosine 5'-O-(2-thiodiphosphate) inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; Serotonin results in increased expression of and results in increased activity of ACAT1 protein
Serotonin results in increased expression of ACAT1 mRNA alternative form
CTD PMID:16157345 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:26408985 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases activity
multiple interactions
ISO Serotonin results in increased activity of AKT1 protein
[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]
CTD PMID:22975078 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein increases response to substance
multiple interactions
ISO APP protein modified form results in increased susceptibility to Serotonin
Oils, Volatile inhibits the reaction [[APP protein modified form binds to APP protein modified form] which results in increased susceptibility to Serotonin]; Ursolic Acid inhibits the reaction [APP protein modified form results in increased susceptibility to Serotonin]
CTD PMID:28915354 PMID:34902447 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions
increases expression
ISO
EXP
[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA]
Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]
CTD PMID:25766885 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP
ISO
[Butyrates co-treated with Serotonin] results in increased expression of BDNF mRNA; [trichostatin A co-treated with Serotonin] results in increased expression of BDNF mRNA; [Valproic Acid co-treated with Serotonin] results in increased expression of BDNF mRNA
Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
CTD PMID:19360904 PMID:26408985 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion
EXP [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein] CTD PMID:11166334 PMID:12791437 PMID:14991081 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein] CTD PMID:24650663 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP7 protein] CTD PMID:24650663 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Serotonin] CTD PMID:11435997 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein]
Serotonin results in increased activity of CFTR protein
CTD PMID:15151902 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] CTD PMID:26408985 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of CNR1 protein] CTD PMID:30611738 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] CTD PMID:26408985 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin]; corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein results in increased secretion of Serotonin] CTD PMID:14575894 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions ISO DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin]; DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin] CTD PMID:15148402 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 protein] CTD PMID:20887679 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein] CTD PMID:20887679 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G En2 engrailed homeobox 2 affects abundance ISO EN2 protein affects the abundance of Serotonin; EN2 protein affects the abundance of Serotonin metabolite CTD PMID:16935268 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943
JBrowse link
G Enam enamelin decreases expression ISO Serotonin results in decreased expression of ENAM mRNA CTD PMID:21083617 NCBI chr14:19,556,729...19,581,433
Ensembl chr14:19,556,729...19,581,425
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions ISO [Serotonin co-treated with Dextran Sulfate] results in decreased expression of FAAH protein CTD PMID:30611738 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP Serotonin results in increased expression of FGF1 protein CTD PMID:15264218 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf5 fibroblast growth factor 5 affects uptake EXP FGF5 protein affects the uptake of Serotonin CTD PMID:8167846 NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Serotonin results in increased expression of FOS mRNA CTD PMID:10700011 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [tryptamine-4,5-dione co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein CTD PMID:23009681 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases export EXP GHRL protein results in decreased export of Serotonin CTD PMID:20553917 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Gla galactosidase, alpha affects response to substance ISO GLA protein affects the susceptibility to Serotonin CTD PMID:18565198 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions ISO [Bile Acids and Salts binds to and results in increased activity of GPBAR1 protein] which results in increased secretion of Serotonin CTD PMID:23041323 NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Serotonin results in increased phosphorylation of GSK3B protein CTD PMID:20190034 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein] CTD PMID:26408985 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases activity
affects binding
increases uptake
increases expression
affects response to substance
EXP
ISO
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; Guanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Magnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]; Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]
Serotonin results in increased activity of HTR1A protein
Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1A protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Serotonin results in increased activity of HTR1A protein]; Serotonin binds to and results in increased activity of HTR1A protein
Serotonin results in increased expression of HTR1A mRNA
HTR1A protein affects the susceptibility to Serotonin
CTD PMID:11106871 PMID:16528294 PMID:21083617 PMID:21126535 PMID:30102254 More... NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding
multiple interactions
EXP
ISO
Serotonin binds to HTR1B protein
Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1B protein]; Serotonin binds to and results in increased activity of HTR1B protein
CTD PMID:11888550 PMID:30102254 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D affects abundance ISO HTR1D gene polymorphism affects the abundance of Serotonin CTD PMID:17203304 NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
JBrowse link
G Htr1f 5-hydroxytryptamine receptor 1F multiple interactions ISO Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1F protein]; Serotonin binds to and results in increased activity of HTR1F protein CTD PMID:30102254 NCBI chr11:2,642,751...2,644,150
Ensembl chr11:2,642,751...2,644,150
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases response to substance
affects response to substance
affects binding
increases expression
multiple interactions
ISO
EXP
HTR2A gene SNP results in decreased susceptibility to Serotonin
HTR2A protein affects the susceptibility to Serotonin
Serotonin binds to HTR2A protein
Serotonin results in increased expression of HTR2A mRNA
[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein]
HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]
[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; Serotonin binds to and results in increased activity of HTR2A protein
CTD PMID:8627522 PMID:11076827 PMID:11880652 PMID:16314884 PMID:16528294 More... NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B increases expression
affects binding
multiple interactions
affects response to substance
ISO
EXP
Serotonin results in increased expression of HTR2B mRNA
Serotonin binds to HTR2B protein
1-(5-fluoropentyl)-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [Serotonin binds to HTR2B protein]; 1-pentyl-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; JWH-073 inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; Serotonin binds to and results in increased activity of HTR2B protein
HTR2B protein affects the susceptibility to Serotonin
CTD PMID:8627522 PMID:9857084 PMID:21083617 PMID:27449567 NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects expression
multiple interactions
ISO
EXP
Serotonin affects the expression of HTR2C mRNA
[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]; Serotonin binds to and results in increased activity of HTR2C protein
CTD PMID:9050900 PMID:21083617 PMID:21554931 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
increases activity
affects localization
ISO
EXP
1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]
Cocaine inhibits the reaction [Serotonin results in increased activity of HTR3A protein]
Serotonin affects the localization of HTR3A protein alternative form
1,1,1-trichloroethane promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Toluene promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Trichloroethylene promotes the reaction [Serotonin results in increased activity of HTR3A protein]
CTD PMID:12681521 PMID:17360702 PMID:17436349 PMID:32209479 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B multiple interactions ISO 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] CTD PMID:17360702 NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444
JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions ISO HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions ISO HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP] CTD PMID:11406289 PMID:11880652 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP CTD PMID:14578406 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Il12b interleukin 12B affects secretion ISO Serotonin affects the secretion of IL12B protein CTD PMID:15802305 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 affects response to substance ISO IL13 protein affects the susceptibility to Serotonin CTD PMID:12370375 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta affects secretion
multiple interactions
increases expression
ISO Serotonin affects the secretion of IL1B protein
anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]
Serotonin results in increased expression of IL1B
CTD PMID:15302781 PMID:15802305 PMID:30611738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 affects response to substance ISO IL4 protein affects the susceptibility to Serotonin CTD PMID:12370375 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 affects expression
multiple interactions
increases expression
affects secretion
ISO Serotonin affects the expression of IL6 mRNA
anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]
Serotonin results in increased expression of IL6 mRNA
[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; calphostin C inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Serotonin results in increased expression of and results in increased secretion of IL6 protein
Serotonin affects the secretion of IL6 protein
CTD PMID:11076827 PMID:15302781 PMID:15802305 PMID:30611738 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Serotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] CTD PMID:22975078 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO
EXP
ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]; TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]
ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]
CTD PMID:18234883 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Serotonin increases expression of Itgam protein on neutrophils RGD PMID:30586717 RGD:329853774 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb3 integrin subunit beta 3 affects abundance ISO ITGB3 gene polymorphism affects the abundance of Serotonin CTD PMID:16724005 PMID:17203304 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 multiple interactions EXP Serotonin inhibits the reaction [KCNK3 protein results in increased transport of Potassium] CTD PMID:16020457 NCBI chr 6:25,761,487...25,799,153
Ensembl chr 6:25,763,228...25,799,153
JBrowse link
G Kng1 kininogen 1 multiple interactions EXP [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] CTD PMID:11166334 PMID:12791437 PMID:18234883 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
JBrowse link
G Maoa monoamine oxidase A increases metabolic processing
multiple interactions
increases degradation
decreases amination
increases abundance
ISO
EXP
MAOA protein results in increased metabolism of Serotonin
[MAOA protein results in increased hydroxylation of Serotonin] which results in increased chemical synthesis of Hydroxyindoleacetic Acid
MAOA protein results in increased degradation of Serotonin
[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde; Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]; Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Quercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]
MAOA protein results in decreased amination of Serotonin
1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; 3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Isocarboxazid inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]
MAOA mutant form results in increased abundance of Serotonin
MAOA gene polymorphism results in increased abundance of Serotonin
CTD PMID:3961266 PMID:10647887 PMID:11834493 PMID:18405062 PMID:23009399 More... NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B increases abundance
decreases amination
multiple interactions
ISO MAOB mutant form results in increased abundance of Serotonin
MAOB protein results in decreased amination of Serotonin
3,4-Methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]
CTD PMID:11834493 PMID:26721607 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Serotonin results in increased phosphorylation of MAPK1 protein CTD PMID:30592962 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Serotonin results in increased phosphorylation of MAPK3 protein CTD PMID:30592962 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp20 matrix metallopeptidase 20 decreases expression ISO Serotonin results in decreased expression of MMP20 mRNA CTD PMID:21083617 NCBI chr 8:4,789,415...4,830,035
Ensembl chr 8:4,789,415...4,830,035
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine]
glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]
CTD PMID:23009681 PMID:30611738 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin CTD PMID:18226494 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]; Sirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein] CTD PMID:27133527 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions ISO GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein] CTD PMID:30611738 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:26408985 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] CTD PMID:26408985 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP [dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions EXP [dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Otc ornithine transcarbamylase affects metabolic processing
multiple interactions
ISO OTC gene mutant form affects the metabolism of Serotonin
Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]
CTD PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases secretion ISO OXT protein results in increased secretion of Serotonin CTD PMID:19228979 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects abundance ISO PARP1 affects the abundance of Serotonin CTD PMID:21990073 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Penk proenkephalin multiple interactions EXP Serotonin inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA] CTD PMID:1363325 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases localization
multiple interactions
ISO Serotonin results in increased localization of PPARG protein
[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased localization of PPARG protein]
CTD PMID:25766885 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions
increases phosphorylation
decreases phosphorylation
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
Serotonin results in increased expression of PTGS2 mRNA; Serotonin results in increased expression of PTGS2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; AG 1879 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; bisindolylmaleimide I inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; Calcium deficiency inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
CTD PMID:21262218 PMID:26408985 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity ISO Serotonin results in increased activity of RELA protein CTD PMID:11076827 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO [TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions
increases uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects binding
increases uptake
increases transport
multiple interactions
affects uptake
ISO
EXP
Serotonin binds to SLC18A2 protein
Serotonin binds to Slc8a2 protein
SLC18A2 protein binds to Serotonin
SLC18A2 protein results in increased uptake of Serotonin
SLC18A2 protein results in increased transport of Serotonin
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]; Serotonin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Valinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin]
SLC18A2 gene SNP affects the uptake of Serotonin
CTD
RGD
PMID:1438304 PMID:7912402 PMID:9038139 PMID:15475732 PMID:18287335 More... RGD:5130957 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake
EXP
ISO
Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A3 protein results in increased uptake of Serotonin
CTD PMID:9830022 PMID:16928864 PMID:20858707 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Serotonin CTD PMID:20858707 NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Serotonin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Serotonin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases uptake
ISO SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
SLC6A3 protein results in increased uptake of Serotonin
CTD PMID:17234900 PMID:17250655 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases activity
decreases activity
increases uptake
affects binding
increases expression
affects abundance
ISO
EXP
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine; Cocaine inhibits the reaction [Serotonin results in increased activity of SLC6A4 protein]; Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]
serotonin decreases activity of Slc6a4 protein in epithelial colorectal adenocarcinoma cells
Serotonin binds to SLC6A4 protein
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [Fluoxetine results in decreased expression of SLC6A4 mRNA] which results in decreased abundance of Serotonin; Aminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Dextroamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]
Serotonin results in increased expression of SLC6A4 mRNA
SLC6A4 gene polymorphism affects the abundance of Serotonin
CTD
RGD
PMID:15972295 PMID:16272152 PMID:16476009 PMID:16982082 PMID:17203304 More... RGD:36947380 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Sorl1 sortilin related receptor 1 multiple interactions
increases expression
ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] CTD PMID:24650663 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Stxbp3 syntaxin binding protein 3 affects secretion ISO STXBP3 protein affects the secretion of Serotonin CTD PMID:18556422 NCBI chr 2:196,442,738...196,485,733
Ensembl chr 2:196,442,634...196,485,671
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Serotonin CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] CTD PMID:11166334 PMID:18234883 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin CTD PMID:16952380 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor affects secretion
multiple interactions
increases expression
ISO Serotonin affects the secretion of TNF protein
[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein; anandamide inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]; glyceryl 2-arachidonate inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]
Serotonin results in increased expression of TNF
CTD PMID:15302781 PMID:15802305 PMID:30611738 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tph1 tryptophan hydroxylase 1 affects abundance
multiple interactions
increases chemical synthesis
increases abundance
ISO TPH1 gene polymorphism affects the abundance of Serotonin
Granisetron inhibits the reaction [Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]]; Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]
TPH1 protein results in increased chemical synthesis of Serotonin
TPH1 gene polymorphism results in increased abundance of Serotonin
CTD PMID:17203304 PMID:18405062 PMID:18506000 PMID:30611738 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Tph2 tryptophan hydroxylase 2 affects abundance ISO TPH2 protein affects the abundance of Serotonin CTD PMID:20722968 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased secretion of Serotonin] CTD PMID:19507004 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Serotonin promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased transport of Calcium] CTD PMID:16901936 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions ISO TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] CTD PMID:18234883 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation
affects glucuronidation
multiple interactions
ISO UGT1A6 protein results in increased glucuronidation of Serotonin; UGT1A6 protein results in increased glucuronidation of Serotonin metabolite
UGT1A6 gene polymorphism affects the glucuronidation of Serotonin; UGT1A6 gene polymorphism affects the glucuronidation of Serotonin metabolite
bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin]
CTD PMID:15761113 PMID:15761114 PMID:18214896 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein; sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] CTD PMID:22785018 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] CTD PMID:23009681 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] CTD PMID:22975078 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
JBrowse link
sumatriptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of BDNF protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of BDNF protein] CTD PMID:22150557 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
decreases expression
ISO
EXP
Sumatriptan results in decreased expression of and results in decreased secretion of CALCA protein
Sumatriptan results in decreased expression of CALCA mRNA
3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; GR 127935 inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; isamoltane inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]
CTD PMID:12574409 PMID:14715155 PMID:15689192 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 protein] CTD PMID:29958920 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CCL2 protein] CTD PMID:22150557 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL20 protein] CTD PMID:22150557 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL22 protein] CTD PMID:22150557 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL3 protein] CTD PMID:22150557 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCR4 protein] CTD PMID:22150557 NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP [Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CD80 protein] CTD PMID:22150557 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cilk1 ciliogenesis associated kinase 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CILK1 protein] CTD PMID:22150557 NCBI chr 8:78,984,075...79,042,695
Ensembl chr 8:78,984,258...79,042,691
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTF protein] CTD PMID:22150557 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Cntfr ciliary neurotrophic factor receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTFR protein] CTD PMID:22150557 NCBI chr 5:56,823,448...56,861,049
Ensembl chr 5:56,823,965...56,841,392
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CSF2 protein] CTD PMID:22150557 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein] CTD PMID:22150557 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein] CTD PMID:22150557 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein] CTD PMID:22150557 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein] CTD PMID:22150557 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein] CTD PMID:22150557 NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein] CTD PMID:22150557 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein] CTD PMID:22150557 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FADD protein] CTD PMID:22150557 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FAS protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FAS protein] CTD PMID:22150557 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FASLG protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FASLG protein] CTD PMID:22150557 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein] CTD PMID:22150557 NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496
JBrowse link
G Fgl1 fibrinogen-like 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FGL1 protein] CTD PMID:22150557 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FOS protein] CTD PMID:12110114 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein] CTD PMID:22150557 NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA1 protein] CTD PMID:22150557 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
JBrowse link
G Gfra2 GDNF family receptor alpha 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA2 protein] CTD PMID:22150557 NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GH1 protein] CTD PMID:22150557 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Ghr growth hormone receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GHR protein] CTD PMID:22150557 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of HCRT protein] CTD PMID:22150557 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions
affects binding
EXP Sumatriptan binds to and results in increased activity of HTR1B protein
Sumatriptan binds to HTR1B protein
CTD PMID:11301495 PMID:11888550 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D multiple interactions EXP Sumatriptan binds to and results in increased activity of HTR1D protein CTD PMID:11301495 NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
JBrowse link
G Ide insulin degrading enzyme multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IDE protein] CTD PMID:22150557 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Ifng interferon gamma multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IFNG protein] CTD PMID:22150557 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL10 protein] CTD PMID:22150557 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL13 protein] CTD PMID:22150557 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IL1A protein] CTD PMID:22150557 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of IL1B mRNA] CTD PMID:22150557 PMID:29958920 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL2 protein] CTD PMID:22150557 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL3 protein] CTD PMID:22150557 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL4 protein] CTD PMID:22150557 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL5 protein] CTD PMID:22150557 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL6 protein] CTD PMID:22150557 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhba inhibin subunit beta A multiple interactions EXP Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INHBA protein] CTD PMID:22150557 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Ins1 insulin 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INS1 protein] CTD PMID:22150557 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Lep leptin multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MIF protein] CTD PMID:22150557 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein] CTD PMID:22150557 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP2 protein] CTD PMID:22150557 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Musk muscle associated receptor tyrosine kinase multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MUSK protein] CTD PMID:22150557 NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932
JBrowse link
G Ngf nerve growth factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA] CTD PMID:12574409 PMID:22150557 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGFR protein] CTD PMID:22150557 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein] CTD PMID:14510930 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO Sumatriptan results in decreased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nrp1 neuropilin 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NRP1 protein] CTD PMID:22150557 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PDGFA protein] CTD PMID:22150557 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Plin2 perilipin 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of PLIN2 protein] CTD PMID:22150557 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
ISO
EXP
Sumatriptan results in decreased expression of POMC protein modified form
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein]
CTD PMID:7640145 PMID:22150557 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein] CTD PMID:22150557 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prlr prolactin receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRLR protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of PRLR protein] CTD PMID:22150557 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Prok1 prokineticin 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PROK1 protein] CTD PMID:22150557 NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Sumatriptan inhibits the reaction [Vincristine results in increased phosphorylation of RELA protein] CTD PMID:29958920 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retn resistin multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETN protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETN protein] CTD PMID:22150557 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Retnlb resistin like beta multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETNLB protein] CTD PMID:22150557 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368
JBrowse link
G Sele selectin E multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELE protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELE protein] CTD PMID:22150557 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sell selectin L multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELL protein] CTD PMID:22150557 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]; Sumatriptan promotes the reaction [Capsaicin results in increased expression of SPP1 protein] CTD PMID:22150557 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TAL1 protein] CTD PMID:22150557 NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TEK protein] CTD PMID:22150557 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein] CTD PMID:22150557 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein] CTD PMID:22150557 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein] CTD PMID:22150557 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein] CTD PMID:22150557 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein] CTD PMID:22150557 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein] CTD PMID:22150557 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TLR4 protein] CTD PMID:22150557 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of TNF mRNA] CTD PMID:22150557 PMID:29958920 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein] CTD PMID:22150557 NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein] CTD PMID:22150557 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein] CTD PMID:22150557 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of VEGFA protein] CTD PMID:22150557 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
zolmitriptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD protein] CTD PMID:31129132 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein] CTD PMID:31129132 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] CTD PMID:31129132 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:31129132 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein] CTD PMID:31129132 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 protein] CTD PMID:31129132 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO zolmitriptan results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein] CTD PMID:31129132 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 mRNA] CTD PMID:31129132 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of NOS3 mRNA] CTD PMID:31129132 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            alkaloid 7819
              indole alkaloid 1945
                tryptamine 504
                  N,N-dimethyltryptamine + 96
                  N-acetyltryptamine 0
                  N-methyltryptamine 0
                  baeocystin 0
                  luzindole 19
                  melatonin + 382
                  norbaeocystin 0
                  serotonin + 112
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  organic heteropolycyclic compound 18334
                                    organic heterobicyclic compound 17279
                                      benzopyrrole 9742
                                        indoles 9430
                                          tryptamines 511
                                            tryptamine 504
                                              N,N-dimethyltryptamine + 96
                                              N-acetyltryptamine 0
                                              N-methyltryptamine 0
                                              baeocystin 0
                                              luzindole 19
                                              melatonin + 382
                                              norbaeocystin 0
                                              serotonin + 112
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