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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:AZT-1152
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Accession:CHEBI:167636 term browser browse the term
Definition:A dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma.
Synonyms:exact_synonym: 2-[ethyl(3-{[4-({5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl}amino)quinazolin-7-yl]oxy}propyl)amino]ethyl dihydrogen phosphate
 related_synonym: AZD1152-HQPA dihydrogen phosphate;   AZD2811;   Formula=C26H31FN7O6P;   INH-34;   InChI=1S/C26H31FN7O6P/c1-2-34(10-12-40-41(36,37)38)9-4-11-39-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(35)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17H,2,4,9-12,15H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32,33);   InChIKey=GBJVVSCPOBPEIT-UHFFFAOYSA-N;   SMILES=CCN(CCCOC1=CC2=C(C=C1)C(NC1=NNC(CC(=O)NC3=CC(F)=CC=C3)=C1)=NC=N2)CCOP(O)(O)=O;   barasertib;   barasertibum
 xref: CAS:722543-31-9;   CAS:957881-03-7;   DrugBank:DB11747;   PMCID:PMC4108943;   PMID:21565405;   PMID:21626115;   PMID:21679421;   PMID:21976672;   PMID:22661287;   PMID:22864876;   PMID:23315030;   PMID:23557198;   PMID:23605952;   PMID:23763917;   PMID:24598913;   PMID:26637878;   PMID:26993175;   PMID:27069145;   PMID:27496133;   PMID:28292940;   PMID:29491065;   PMID:30540594;   PMID:30872381;   PMID:32968211



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Path 1
Term Annotations click to browse term
  CHEBI ontology 19863
    role 19835
      application 19677
        pro-agent 11550
          prodrug 11311
            AZT-1152 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    main group molecular entity 19807
                      s-block molecular entity 19639
                        hydrogen molecular entity 19620
                          hydrides 19126
                            inorganic hydride 18134
                              pnictogen hydride 18123
                                nitrogen hydride 18032
                                  azane 17837
                                    ammonia 17836
                                      organic amino compound 17836
                                        primary amino compound 9322
                                          primary amine 6326
                                            primary arylamine 3649
                                              aniline 3487
                                                anilide 1110
                                                  AZD-1152 0
                                                    AZT-1152 0
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