CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: paralytic shellfish toxin
Accession: CHEBI:167564
browse the term
Definition: An alkaloid compound that is 2,6-diamino-4-methyl-pyrollo[1,2-c]-purin-10-diol produced by several cyanobacteria and dinoflagellates, which can result in paralytic shellfish poisoning when ingested.
Synonyms: related_synonym: Formula=C9H12N6O2R4; PSP toxin; SMILES=[C@@H]1([C@]2([C@@]3(N(C(N1*)=N)CC(C3(O)O)(*)*)NC(N2)=N)[H])C*; saxitoxins
xref: PMID:11319121; PMID:20692275; PMID:25871287; PMID:30605564; PMID:30983320; PMID:32456077
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Tnf
tumor necrosis factor
multiple interactions
ISO
neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
CTD
PMID:32471037
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions affects activity
ISO
[Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein Saxitoxin affects the activity of ABCB1 protein
CTD
PMID:29128272
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
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Alb
albumin
decreases expression
ISO
Saxitoxin results in decreased expression of ALB protein
CTD
PMID:29228856
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
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Arpc5l
actin related protein 2/3 complex, subunit 5-like
decreases expression
ISO
Saxitoxin results in decreased expression of ARPC5L protein
CTD
PMID:29228856
NCBI chr 3:43,169,518...43,177,224
Ensembl chr 3:43,169,462...43,177,240 Ensembl chr 9:43,169,462...43,177,240
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Cfl2
cofilin 2
affects expression
ISO
Saxitoxin affects the expression of CFL2 protein
CTD
PMID:29228856
NCBI chr 6:78,090,843...78,094,888
Ensembl chr 6:78,090,843...78,094,888
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Eno1
enolase 1
affects expression
ISO
Saxitoxin affects the expression of ENO1 protein
CTD
PMID:29228856
NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003 Ensembl chr 5:77,946,261...77,986,003
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Hnrnpl
heterogeneous nuclear ribonucleoprotein L
decreases expression
ISO
Saxitoxin results in decreased expression of HNRNPL protein
CTD
PMID:29228856
NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:93,235,729...93,239,061
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Vdac1
voltage-dependent anion channel 1
decreases expression
ISO
Saxitoxin results in decreased expression of VDAC1 protein
CTD
PMID:29228856
NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541
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Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
increases expression
ISO
Saxitoxin results in increased expression of YWHAB protein
CTD
PMID:29228856
NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854
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