paralytic shellfish toxin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	paralytic shellfish toxin	go back to main search page
Accession:	CHEBI:167564	browse the term
Definition:	An alkaloid compound that is 2,6-diamino-4-methyl-pyrollo[1,2-c]-purin-10-diol produced by several cyanobacteria and dinoflagellates, which can result in paralytic shellfish poisoning when ingested.
Synonyms:	related_synonym:	Formula=C9H12N6O2R4; PSP toxin; SMILES=[C@@H]1([C@]2([C@@]3(N(C(N1)=N)CC(C3(O)O)())NC(N2)=N)[H])C; saxitoxins
	xref:	PMID:11319121; PMID:20692275; PMID:25871287; PMID:30605564; PMID:30983320; PMID:32456077

show annotations for term's descendants Sort by:
Rat (9) Mouse (9) Human (9) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (9)

neosaxitoxin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

multiple interactions

neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

saxitoxin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
affects activity

[Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein
Saxitoxin affects the activity of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

albumin

decreases expression

Saxitoxin results in decreased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

actin related protein 2/3 complex, subunit 5-like

decreases expression

Saxitoxin results in decreased expression of ARPC5L protein

NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538

G

cofilin 2

affects expression

Saxitoxin affects the expression of CFL2 protein

NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674

G

enolase 1

affects expression

Saxitoxin affects the expression of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

heterogeneous nuclear ribonucleoprotein L

decreases expression

Saxitoxin results in decreased expression of HNRNPL protein

NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553

G

voltage-dependent anion channel 1

decreases expression

Saxitoxin results in decreased expression of VDAC1 protein

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

increases expression

Saxitoxin results in increased expression of YWHAB protein

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19921
role	19896
biological role	19894
poison	18643
toxin	15978
paralytic shellfish toxin	9
Decarbamoylgonyautoxin 1	0
Decarbamoylgonyautoxin III	0
Gonyautoxin 1	0
Gonyautoxin 2	0
Gonyautoxin 5	0
decarbamoylsaxitoxin	0
neosaxitoxin	1
saxitoxin +	9
Path 2
Term	Annotations
CHEBI ontology	19921
subatomic particle	19919
composite particle	19919
hadron	19919
baryon	19919
nucleon	19919
atomic nucleus	19919
atom	19919
main group element atom	19867
p-block element atom	19867
carbon group element atom	19812
carbon atom	19807
organic molecular entity	19807
organic molecule	19764
organic cyclic compound	19572
organic heterocyclic compound	18905
organic heteropolycyclic compound	18317
organic heterotricyclic compound	15650
pyrrolopurine	9
paralytic shellfish toxin	9
Decarbamoylgonyautoxin 1	0
Decarbamoylgonyautoxin III	0
Gonyautoxin 1	0
Gonyautoxin 2	0
Gonyautoxin 5	0
decarbamoylsaxitoxin	0
neosaxitoxin	1
saxitoxin +	9

paths to the root