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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:paralytic shellfish toxin
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Accession:CHEBI:167564 term browser browse the term
Definition:An alkaloid compound that is 2,6-diamino-4-methyl-pyrollo[1,2-c]-purin-10-diol produced by several cyanobacteria and dinoflagellates, which can result in paralytic shellfish poisoning when ingested.
Synonyms:related_synonym: Formula=C9H12N6O2R4;   PSP toxin;   SMILES=[C@@H]1([C@]2([C@@]3(N(C(N1*)=N)CC(C3(O)O)(*)*)NC(N2)=N)[H])C*;   saxitoxins
 xref: PMID:11319121;   PMID:20692275;   PMID:25871287;   PMID:30605564;   PMID:30983320;   PMID:32456077


show annotations for term's descendants           Sort by:
neosaxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor multiple interactions ISO neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:32471037 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
saxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity 		ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein
Saxitoxin affects the activity of ABCB1 protein 		CTD PMID:29128272 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Alb albumin decreases expression ISO Saxitoxin results in decreased expression of ALB protein CTD PMID:29228856 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like decreases expression ISO Saxitoxin results in decreased expression of ARPC5L protein CTD PMID:29228856 NCBI chr 3:43,169,518...43,177,224
Ensembl chr 3:43,169,462...43,177,240
Ensembl chr 9:43,169,462...43,177,240 		JBrowse link
G Cfl2 cofilin 2 affects expression ISO Saxitoxin affects the expression of CFL2 protein CTD PMID:29228856 NCBI chr 6:78,090,843...78,094,888
Ensembl chr 6:78,090,843...78,094,888 		JBrowse link
G Eno1 enolase 1 affects expression ISO Saxitoxin affects the expression of ENO1 protein CTD PMID:29228856 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Saxitoxin results in decreased expression of HNRNPL protein CTD PMID:29228856 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:93,235,729...93,239,061 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Saxitoxin results in decreased expression of VDAC1 protein CTD PMID:29228856 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression ISO Saxitoxin results in increased expression of YWHAB protein CTD PMID:29228856 NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        poison 19097
          toxin 16209
            paralytic shellfish toxin 9
              Decarbamoylgonyautoxin 1 0
              Decarbamoylgonyautoxin III 0
              Gonyautoxin 1 0
              Gonyautoxin 2 0
              Gonyautoxin 5 0
              decarbamoylsaxitoxin 0
              neosaxitoxin 1
              saxitoxin + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20403
                                organic heterocyclic compound 19386
                                  organic heteropolycyclic compound 18633
                                    organic heterotricyclic compound 16027
                                      pyrrolopurine 9
                                        paralytic shellfish toxin 9
                                          Decarbamoylgonyautoxin 1 0
                                          Decarbamoylgonyautoxin III 0
                                          Gonyautoxin 1 0
                                          Gonyautoxin 2 0
                                          Gonyautoxin 5 0
                                          decarbamoylsaxitoxin 0
                                          neosaxitoxin 1
                                          saxitoxin + 9
paths to the root