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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chenodeoxycholic acid
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Accession:CHEBI:16755 term browser browse the term
Definition:A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Synonyms:exact_synonym: 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
 related_synonym: 3alpha,7alpha-Dihydroxy-5beta-cholanic acid;   7alpha-hydroxylithocholic acid;   CDCA;   Chenix;   Chenodiol;   Formula=C24H40O4;   InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1;   InChIKey=RUDATBOHQWOJDD-BSWAIDMHSA-N;   SMILES=[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(O)=O;   anthropodeoxycholic acid;   anthropodesoxycholic acid;   chenic acid;   gallodesoxycholic acid
 alt_id: CHEBI:23094;   CHEBI:3588;   CHEBI:3593
 xref: Beilstein:3219887;   CAS:474-25-9;   DrugBank:DB06777;   Drug_Central:4361;   HMDB:HMDB0000518;   KEGG:C02528;   KEGG:D00163;   LINCS:LSM-5353;   LIPID_MAPS_instance:LMST04010032
 xref_mesh: MESH:D002635
 xref: PDBeChem:JN3;   PMID:11530998;   PMID:16037564;   PMID:24448653;   PMID:24464484;   Reaxys:3219887;   Wikipedia:Chenodiol
 cyclic_relationship: is_conjugate_acid_of CHEBI:36234


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chenodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase increases activity EXP Chenodeoxycholic Acid results in increased activity of ACHE protein CTD PMID:3697337 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
G LRP2 LDL receptor related protein 2 increases expression EXP Chenodeoxycholic Acid results in increased expression of LRP2 protein CTD PMID:15375181 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,301...75,716,694
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 876
    chemical entity 876
      molecular entity 874
        polyatomic entity 839
          heteroatomic molecular entity 797
            hydroxides 682
              organic hydroxy compound 595
                hydroxy-5beta-cholanic acid 4
                  dihydroxy-5beta-cholanic acid 2
                    chenodeoxycholic acid 2
                      3-oxochenodeoxycholoyl-CoA 0
                      chenodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                      chenodeoxycholic acid 3-O-(beta-D-glucuronide) 0
                      chenodeoxycholoyl-CoA 0
                      glycochenodeoxycholic acid + 0
                      obeticholic acid 0
                      taurochenodeoxycholic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 876
    subatomic particle 861
      composite particle 861
        hadron 861
          baryon 861
            nucleon 861
              atomic nucleus 861
                atom 861
                  main group element atom 851
                    p-block element atom 848
                      carbon group element atom 823
                        carbon atom 822
                          organic molecular entity 822
                            organic molecule 735
                              organic cyclic compound 645
                                organic polycyclic compound 129
                                  steroid 96
                                    steroid fundamental parent 75
                                      cholane 4
                                        cholanoid 4
                                          cholanic acids 4
                                            cholanic acid 4
                                              5beta-cholanic acid 4
                                                hydroxy-5beta-cholanic acid 4
                                                  dihydroxy-5beta-cholanic acid 2
                                                    chenodeoxycholic acid 2
                                                      3-oxochenodeoxycholoyl-CoA 0
                                                      chenodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                      chenodeoxycholic acid 3-O-(beta-D-glucuronide) 0
                                                      chenodeoxycholoyl-CoA 0
                                                      glycochenodeoxycholic acid + 0
                                                      obeticholic acid 0
                                                      taurochenodeoxycholic acid 0
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