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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:guanosine
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Accession:CHEBI:16750 term browser browse the term
Definition:A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms:related_synonym: 2(3H)-imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one;   2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one;   9-beta-D-ribofuranosyl-guanine;   Formula=C10H13N5O5;   G;   Guanine riboside;   Guanine-9-beta-D-ribofuranoside;   Guanosin;   Guo;   InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1;   InChIKey=NYHBQMYGNKIUIF-UUOKFMHZSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
 alt_id: CHEBI:14375;   CHEBI:24444;   CHEBI:42840;   CHEBI:42847;   CHEBI:471737;   CHEBI:5564
 xref: Beilstein:625911;   CAS:118-00-3;   DrugBank:DB02857;   ECMDB:ECMDB00133;   Gmelin:55323;   HMDB:HMDB0000133;   KEGG:C00387;   KNApSAcK:C00019679
 xref_mesh: MESH:D006151
 xref: MetaCyc:GUANOSINE;   PDBeChem:GMP;   PMID:11434576;   PMID:15471343;   PMID:15920424;   PMID:17060520;   PMID:17202332;   PMID:18191898;   PMID:18549801;   PMID:21435378;   PMID:21500353;   PMID:21515778;   PMID:21671255;   PMID:21774919;   PMID:2559771;   Reaxys:625911;   Wikipedia:Guanosine;   YMDB:YMDB00509


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guanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Guanosine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:25174304 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E affects binding
multiple interactions		 ISO Guanosine analog binds to EIF4E protein
Guanosine analog inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; Guanosine analog inhibits the reaction [RNA Caps binds to EIF4E protein]		 CTD PMID:27592390 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression EXP Guanosine results in decreased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:18456249 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:18456249 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC] CTD PMID:9381980 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP		 Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Guanosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171 		JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Guanosine CTD PMID:19164483 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Upp1 uridine phosphorylase 1 increases metabolic processing ISO UPP1 protein results in increased metabolism of Guanosine CTD PMID:15772079 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462 		JBrowse link
2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] CTD PMID:9297556 PMID:9403342 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO Deoxyguanosine analog results in decreased activity of MGMT protein CTD PMID:17880193 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          metabolite 19611
            fundamental metabolite 12804
              guanosine 18
                2'-deoxyguanosine + 6
                4-demethyl-7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                4-demethylwyosine 0
                7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine 5'-phosphate + 0
                N(2)-(ADP-D-ribosyl)-guanosine(2-) 0
                cytidylyl-(3'->5')-guanosine 0
                guanosine residue 0
                wybutosine 0
                wybutoxosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            heteroorganic entity 19555
                              organochalcogen compound 19293
                                organooxygen compound 19239
                                  carbohydrates and carbohydrate derivatives 13914
                                    carbohydrate 13914
                                      carbohydrate derivative 13640
                                        glycosyl compound 12896
                                          N-glycosyl compound 5529
                                            nucleoside 5390
                                              ribonucleoside 690
                                                purine ribonucleoside 581
                                                  purines D-ribonucleoside 365
                                                    guanosine 18
                                                      2'-deoxyguanosine + 6
                                                      4-demethyl-7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      4-demethylwyosine 0
                                                      7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine 5'-phosphate + 0
                                                      N(2)-(ADP-D-ribosyl)-guanosine(2-) 0
                                                      cytidylyl-(3'->5')-guanosine 0
                                                      guanosine residue 0
                                                      wybutosine 0
                                                      wybutoxosine 0
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