CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: guanosine
Accession: CHEBI:16750
browse the term
Definition: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms: related_synonym: 2(3H)-imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one; 2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one; 9-beta-D-ribofuranosyl-guanine; Formula=C10H13N5O5; G; Guanine riboside; Guanine-9-beta-D-ribofuranoside; Guanosin; Guo; InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1; InChIKey=NYHBQMYGNKIUIF-UUOKFMHZSA-N; SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
alt_id: CHEBI:14375; CHEBI:24444; CHEBI:42840; CHEBI:42847; CHEBI:471737; CHEBI:5564
xref: Beilstein:625911; CAS:118-00-3; DrugBank:DB02857; ECMDB:ECMDB00133; Gmelin:55323; HMDB:HMDB0000133; KEGG:C00387; KNApSAcK:C00019679
xref_mesh: MESH:D006151
xref: MetaCyc:GUANOSINE; PDBeChem:GMP; PMID:11434576; PMID:15471343; PMID:15920424; PMID:17060520; PMID:17202332; PMID:18191898; PMID:18549801; PMID:21435378; PMID:21500353; PMID:21515778; PMID:21671255; PMID:21774919; PMID:2559771; Reaxys:625911; Wikipedia:Guanosine; YMDB:YMDB00509
G
Casp3
caspase 3
multiple interactions
EXP
Guanosine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
CTD
PMID:25174304
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Eif4e
eukaryotic translation initiation factor 4E
affects binding multiple interactions
ISO
Guanosine analog binds to EIF4E protein Guanosine analog inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; Guanosine analog inhibits the reaction [RNA Caps binds to EIF4E protein]
CTD
PMID:27592390
NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
G
H2ax
H2A.X variant histone
multiple interactions
ISO
Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]
CTD
PMID:32941855
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
G
Impdh2
inosine monophosphate dehydrogenase 2
decreases expression
EXP
Guanosine results in decreased expression of IMPDH2 mRNA
CTD
PMID:11145582
NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
G
Kras
KRAS proto-oncogene, GTPase
multiple interactions
ISO
Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS]
CTD
PMID:9381980
NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Guanosine results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD
PMID:18456249
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Guanosine results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD
PMID:18456249
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
ISO
Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC]
CTD
PMID:9381980
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
G
Slc29a1
solute carrier family 29 member 1
multiple interactions
ISO EXP
Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
CTD
PMID:9353301 PMID:11085929
NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
G
Slc29a2
solute carrier family 29 member 2
multiple interactions
ISO
Guanosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]
CTD
PMID:11085929
NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189 Ensembl chr 1:220,400,855...220,407,189
G
Slc29a3
solute carrier family 29 member 3
affects transport
ISO
SLC29A3 protein affects the transport of Guanosine
CTD
PMID:19164483
NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
G
Tp53bp1
tumor protein p53 binding protein 1
multiple interactions
ISO
Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]
CTD
PMID:32941855
NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
G
Upp1
uridine phosphorylase 1
increases metabolic processing
ISO
UPP1 protein results in increased metabolism of Guanosine
CTD
PMID:15772079
NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
G
Casp3
caspase 3
multiple interactions
ISO
[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein]
CTD
PMID:9297556 PMID:9403342
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]
CTD
PMID:21907773
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine]
CTD
PMID:21907773
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]
CTD
PMID:21907773
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
G
Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
multiple interactions
ISO
CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine]
CTD
PMID:21907773
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
G
Mgmt
O-6-methylguanine-DNA methyltransferase
decreases activity
ISO
Deoxyguanosine analog results in decreased activity of MGMT protein
CTD
PMID:17880193
NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
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