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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:guanosine
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Accession:CHEBI:16750 term browser browse the term
Definition:A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms:related_synonym: 2(3H)-imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one;   2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one;   9-beta-D-ribofuranosyl-guanine;   Formula=C10H13N5O5;   G;   Guanine riboside;   Guanine-9-beta-D-ribofuranoside;   Guanosin;   Guo;   InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1;   InChIKey=NYHBQMYGNKIUIF-UUOKFMHZSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
 alt_id: CHEBI:14375;   CHEBI:24444;   CHEBI:42840;   CHEBI:42847;   CHEBI:471737;   CHEBI:5564
 xref: Beilstein:625911;   CAS:118-00-3;   DrugBank:DB02857;   ECMDB:ECMDB00133;   Gmelin:55323;   HMDB:HMDB0000133;   KEGG:C00387;   KNApSAcK:C00019679
 xref_mesh: MESH:D006151
 xref: MetaCyc:GUANOSINE;   PDBeChem:GMP;   PMID:11434576;   PMID:15471343;   PMID:15920424;   PMID:17060520;   PMID:17202332;   PMID:18191898;   PMID:18549801;   PMID:21435378;   PMID:21500353;   PMID:21515778;   PMID:21671255;   PMID:21774919;   PMID:2559771;   Reaxys:625911;   Wikipedia:Guanosine;   YMDB:YMDB00509

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guanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Guanosine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:25174304 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E affects binding
multiple interactions		 ISO Guanosine analog binds to EIF4E protein
Guanosine analog inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; Guanosine analog inhibits the reaction [RNA Caps binds to EIF4E protein]		 CTD PMID:27592390 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression EXP Guanosine results in decreased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:18456249 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:18456249 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC] CTD PMID:9381980 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP		 Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Guanosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189 		JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Guanosine CTD PMID:19164483 NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790 		JBrowse link
G Upp1 uridine phosphorylase 1 increases metabolic processing ISO UPP1 protein results in increased metabolism of Guanosine CTD PMID:15772079 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276 		JBrowse link
2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] CTD PMID:9297556 PMID:9403342 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO Deoxyguanosine analog results in decreased activity of MGMT protein CTD PMID:17880193 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            fundamental metabolite 12653
              guanosine 18
                2'-deoxyguanosine + 6
                4-demethyl-7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                4-demethylwyosine 0
                7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine 5'-phosphate + 0
                N(2)-(ADP-D-ribosyl)-guanosine(2-) 0
                guanosine residue 0
                wybutosine 0
                wybutoxosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            heteroorganic entity 19195
                              organochalcogen compound 18941
                                organooxygen compound 18868
                                  carbohydrates and carbohydrate derivatives 12260
                                    carbohydrate 12260
                                      carbohydrate derivative 11888
                                        glycosyl compound 10962
                                          N-glycosyl compound 5484
                                            nucleoside 5345
                                              ribonucleoside 667
                                                purine ribonucleoside 559
                                                  purines D-ribonucleoside 347
                                                    guanosine 18
                                                      2'-deoxyguanosine + 6
                                                      4-demethyl-7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      4-demethylwyosine 0
                                                      7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine 5'-phosphate + 0
                                                      N(2)-(ADP-D-ribosyl)-guanosine(2-) 0
                                                      guanosine residue 0
                                                      wybutosine 0
                                                      wybutoxosine 0
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