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ONTOLOGY REPORT - ANNOTATIONS


Term:orotic acid
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Accession:CHEBI:16742 term browser browse the term
Definition:A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Synonyms:related_synonym: 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid;   Formula=C5H4N2O4;   InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11);   InChIKey=PXQPEWDEAKTCGB-UHFFFAOYSA-N;   Orotsaeure;   SMILES=OC(=O)c1cc(=O)[nH]c(=O)[nH]1;   Uracil-6-carboxylic acid
 alt_id: CHEBI:25720;   CHEBI:44781;   CHEBI:7787
 xref: Beilstein:383901 "Beilstein";   CAS:65-86-1 "ChemIDplus";   CAS:65-86-1 "KEGG COMPOUND";   CAS:65-86-1 "NIST Chemistry WebBook";   DrugBank:DB02262;   Drug_Central:3402 "DrugCentral";   Gmelin:101990 "Gmelin";   HMDB:HMDB0000226;   KEGG:C00295;   KEGG:D00055;   KNApSAcK:C00019689
 xref_mesh: MESH:D009963
 xref: MetaCyc:OROTATE;   PDBeChem:ORO;   PMID:11059538 "Europe PMC";   PMID:22019295 "Europe PMC";   PMID:22285839 "Europe PMC";   PMID:22307261 "Europe PMC";   PMID:22371390 "Europe PMC";   PMID:22634191 "Europe PMC";   PMID:22707164 "Europe PMC";   PMID:22770225 "Europe PMC";   PMID:22863860 "Europe PMC";   PMID:7264771 "Europe PMC";   Reaxys:383901 "Reaxys";   Wikipedia:Orotic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30839


show annotations for term's descendants       view all columns           Sort by:
 
orotic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 JBrowse link 5 134,196,910 134,207,888 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464
dihydroorotic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dhodh dihydroorotate dehydrogenase (quinone) JBrowse link 19 42,066,103 42,087,906 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        biochemical role 19130
          metabolite 19098
            orotic acid 17
              dihydroorotic acid + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic molecule 19332
                              organic cyclic compound 19083
                                organic heterocyclic compound 18154
                                  organic heteromonocyclic compound 16248
                                    diazines 12105
                                      pyrimidines 11920
                                        pyrimidine nucleobase 6063
                                          uracil 5625
                                            orotic acid 17
                                              dihydroorotic acid + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.