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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(E)-cinnamaldehyde
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Accession:CHEBI:16731 term browser browse the term
Definition:The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.
Synonyms:exact_synonym: (3E)-3-phenylprop-2-enal
 related_synonym: (E)-3-Phenyl-2-propenal;   (E)-3-Phenyl-propenal;   (E)-3-Phenylpropenal;   (E)-Cinnamic aldehyde;   (E)-phenylvinyl aldehyde;   3-phenylacrylaldehyde;   Cinnamaldehyde;   Formula=C9H8O;   InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+;   InChIKey=KJPRLNWUNMBNBZ-QPJJXVBHSA-N;   SMILES=O=C\\C=C\\c1ccccc1;   trans-Cinnamic aldehyde
 alt_id: CHEBI:13994;   CHEBI:181858;   CHEBI:23244;   CHEBI:3709
 xref: BPDB:1069;   Beilstein:1071571;   CAS:14371-10-9;   HMDB:HMDB0003441;   KEGG:C00903;   KNApSAcK:C00002725;   KNApSAcK:C00035187;   PMID:11975643;   PMID:17140783;   PMID:17662960;   PMID:18218683;   PMID:19845671;   PMID:20431333;   PMID:20955755;   PMID:21266172;   PMID:21388814;   PMID:21394803;   PMID:21466812;   PMID:21469739;   PMID:21517069;   PMID:21603596;   PMID:21708228;   PMID:21767279;   PMID:21788726;   PMID:29079364;   Reaxys:1071571;   Wikipedia:Cinnamaldehyde


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alpha-hexylcinnamaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase affects expression EXP hexyl cinnamic aldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413 		JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression
affects expression		 ISO
EXP		 hexyl cinnamic aldehyde results in increased expression of AKR1C3 mRNA
hexyl cinnamic aldehyde affects the expression of AKR1C18 mRNA		 CTD PMID:20566472 PMID:22302311 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236 		JBrowse link
G Cat catalase increases expression ISO hexyl cinnamic aldehyde results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP hexyl cinnamic aldehyde results in increased secretion of CCL2 protein CTD PMID:22245253 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO hexyl cinnamic aldehyde results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccna2 cyclin A2 affects expression EXP hexyl cinnamic aldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 affects expression EXP hexyl cinnamic aldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccne2 cyclin E2 affects expression EXP hexyl cinnamic aldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression EXP hexyl cinnamic aldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of CCR7 protein CTD PMID:37326882 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903 		JBrowse link
G Cd160 CD160 antigen affects expression EXP hexyl cinnamic aldehyde affects the expression of CD160 mRNA CTD PMID:22302311 NCBI chr 3:96,706,079...96,736,667
Ensembl chr 3:96,706,079...96,736,667 		JBrowse link
G Cd207 CD207 antigen affects expression EXP hexyl cinnamic aldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 6:83,648,189...83,654,839
Ensembl chr 6:83,648,197...83,654,839 		JBrowse link
G Cd5l CD5 antigen-like affects expression EXP hexyl cinnamic aldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 3:87,265,188...87,278,381
Ensembl chr 3:87,265,188...87,278,380 		JBrowse link
G Cd80 CD80 antigen multiple interactions
increases expression		 ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
hexyl cinnamic aldehyde results in increased expression of CD80 protein		 CTD PMID:31958493 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697 		JBrowse link
G Cd83 CD83 antigen affects expression EXP hexyl cinnamic aldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608 		JBrowse link
G Cd86 CD86 antigen multiple interactions
increases expression		 ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein] CTD PMID:31958493 PMID:37326882 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cdc20 cell division cycle 20 affects expression EXP hexyl cinnamic aldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549 		JBrowse link
G Cdc25c cell division cycle 25C affects expression EXP hexyl cinnamic aldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586 		JBrowse link
G Cdk1 cyclin dependent kinase 1 affects expression EXP hexyl cinnamic aldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cphx1 cytoplasmic polyadenylated homeobox 1 affects expression EXP hexyl cinnamic aldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr14:25,941,983...25,956,798
Ensembl chr14:25,938,728...25,956,780 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 affects expression EXP hexyl cinnamic aldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
increases secretion		 ISO hexyl cinnamic aldehyde results in increased expression of CXCL8 mRNA
hexyl cinnamic aldehyde results in increased secretion of CXCL8 protein		 CTD PMID:27965148 PMID:31958493 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression		 EXP hexyl cinnamic aldehyde results in increased expression of CXCL2 mRNA; hexyl cinnamic aldehyde results in increased expression of CXCL2 protein
hexyl cinnamic aldehyde results in decreased expression of CXCL2 protein		 CTD PMID:23178550 PMID:28826779 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression EXP hexyl cinnamic aldehyde results in increased expression of CXCL1 mRNA CTD PMID:28826779 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Dio3 deiodinase, iodothyronine type III decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr12:110,245,664...110,247,531
Ensembl chr12:110,245,502...110,247,531 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression EXP hexyl cinnamic aldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Fabp7 fatty acid binding protein 7, brain affects expression EXP hexyl cinnamic aldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546 		JBrowse link
G Fech ferrochelatase increases expression ISO hexyl cinnamic aldehyde results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322 		JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 affects expression EXP hexyl cinnamic aldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr 6:117,910,519...117,914,668
Ensembl chr 6:117,910,520...117,914,653 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO hexyl cinnamic aldehyde results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gsr glutathione reductase increases expression ISO hexyl cinnamic aldehyde results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gzmb granzyme B affects expression EXP hexyl cinnamic aldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of HMOX1 mRNA CTD PMID:20566472 PMID:26244607 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Ifng interferon gamma increases secretion EXP hexyl cinnamic aldehyde results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il12b interleukin 12b affects expression EXP hexyl cinnamic aldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il17a interleukin 17A increases expression EXP hexyl cinnamic aldehyde results in increased expression of IL17A mRNA; hexyl cinnamic aldehyde results in increased expression of IL17A protein CTD PMID:28826779 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP hexyl cinnamic aldehyde results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il2 interleukin 2 increases secretion
increases expression		 EXP hexyl cinnamic aldehyde results in increased secretion of IL2 protein
hexyl cinnamic aldehyde results in increased expression of IL2 protein		 CTD PMID:22245253 PMID:22381623 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il21 interleukin 21 affects expression EXP hexyl cinnamic aldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain affects expression EXP hexyl cinnamic aldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il4 interleukin 4 affects expression
multiple interactions		 EXP
ISO		 hexyl cinnamic aldehyde affects the expression of IL4 mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein		 CTD PMID:22302311 PMID:31958493 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il4ra interleukin 4 receptor, alpha increases expression EXP hexyl cinnamic aldehyde results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Il6 interleukin 6 increases secretion EXP hexyl cinnamic aldehyde results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itgav integrin alpha V affects expression EXP hexyl cinnamic aldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260 		JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276 		JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426 		JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 5:139,777,291...139,788,409
Ensembl chr 5:139,777,268...139,788,408 		JBrowse link
G Mcpt8 mast cell protease 8 affects expression EXP hexyl cinnamic aldehyde affects the expression of MCPT8 mRNA CTD PMID:22302311 NCBI chr14:56,319,620...56,322,951
Ensembl chr14:56,319,623...56,322,730 		JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO hexyl cinnamic aldehyde results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753 		JBrowse link
G Mir146 microRNA 146 increases expression
multiple interactions		 ISO hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA
PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA]		 CTD PMID:37326882 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir27a microRNA 27a decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of MIR27A mRNA CTD PMID:37326882 NCBI chr 8:84,935,301...84,935,387
Ensembl chr 8:84,935,301...84,935,387 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 affects expression EXP hexyl cinnamic aldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mmp10 matrix metallopeptidase 10 affects expression EXP hexyl cinnamic aldehyde affects the expression of MMP10 mRNA CTD PMID:22302311 NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241 		JBrowse link
G Mt1 metallothionein 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nts neurotensin affects expression EXP hexyl cinnamic aldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO hexyl cinnamic aldehyde results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein]; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA] CTD PMID:37326882 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760 		JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO hexyl cinnamic aldehyde results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296 		JBrowse link
G Thbs1 thrombospondin 1 affects expression EXP hexyl cinnamic aldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Thbs4 thrombospondin 4 affects expression EXP hexyl cinnamic aldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr13:92,888,094...92,931,326
Ensembl chr13:92,888,098...92,931,326 		JBrowse link
G Timd2 T cell immunoglobulin and mucin domain containing 2 affects expression EXP hexyl cinnamic aldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr11:46,559,787...46,597,934
Ensembl chr11:46,559,787...46,597,888 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP
ISO		 hexyl cinnamic aldehyde results in increased expression of TNF mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein		 CTD PMID:28826779 PMID:31958493 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 affects expression EXP hexyl cinnamic aldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr19:18,707,566...18,869,885
Ensembl chr19:18,727,347...18,869,875 		JBrowse link
G Txn2 thioredoxin 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO hexyl cinnamic aldehyde results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO hexyl cinnamic aldehyde results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
coniferyl aldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression ISO coniferaldehyde results in increased expression of ABCC2 mRNA CTD PMID:26275128 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression ISO coniferaldehyde results in increased expression of ABCC3 mRNA CTD PMID:26275128 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 multiple interactions
increases expression		 ISO NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]
coniferaldehyde results in increased expression of AKR1C1 mRNA; coniferaldehyde results in increased expression of AKR1C1 protein		 CTD PMID:26275128 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein CTD PMID:26275128 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO coniferaldehyde results in increased expression of GCLM mRNA CTD PMID:26275128 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gsr glutathione reductase increases expression ISO
EXP		 coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein		 CTD PMID:26275128 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein		 CTD PMID:26275128 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Ifng interferon gamma multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO
EXP		 coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]		 CTD PMID:27378624 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 multiple interactions ISO MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric increases expression
multiple interactions		 ISO coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]		 CTD PMID:31944254 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression		 ISO
EXP		 coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein		 CTD PMID:26275128 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP		 coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]		 CTD PMID:27378624 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP coniferaldehyde results in increased expression of NQO1 protein CTD PMID:26275128 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Pkn3 protein kinase N3 multiple interactions ISO PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 2:29,967,657...29,981,031
Ensembl chr 2:29,967,696...29,981,034 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP		 coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]		 CTD PMID:27378624 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO coniferaldehyde results in increased activity of TRPA1 protein CTD PMID:23541125 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coniferaldehyde results in increased expression of TXNRD1 mRNA CTD PMID:26275128 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        aetiopathogenetic role 21283
          sensitiser 10124
            (E)-cinnamaldehyde 96
              (E)-sinapaldehyde + 0
              3,4-dimethoxy cinnamaldehyde 0
              4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
              4-hydroxycinnamaldehyde 0
              4-methoxymagnaldehyde B 0
              alpha-hexylcinnamaldehyde 84
              coniferyl aldehyde + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      carboacyl group 18299
                                        univalent carboacyl group 18299
                                          formyl group 9126
                                            aldehyde 9126
                                              alpha,beta-unsaturated aldehyde 3082
                                                enal 3082
                                                  cinnamaldehydes 317
                                                    3-phenylprop-2-enal 315
                                                      (E)-cinnamaldehyde 96
                                                        (E)-sinapaldehyde + 0
                                                        3,4-dimethoxy cinnamaldehyde 0
                                                        4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
                                                        4-hydroxycinnamaldehyde 0
                                                        4-methoxymagnaldehyde B 0
                                                        alpha-hexylcinnamaldehyde 84
                                                        coniferyl aldehyde + 22
paths to the root