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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:codeine
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Accession:CHEBI:16714 term browser browse the term
Definition:A morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.
Synonyms:exact_synonym: 3-methoxy-17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-6alpha-ol
 related_synonym: (1S,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10,15-tetraen-14-ol;   (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol;   7,8-didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol;   Codein;   Codicept;   Coducept;   Formula=C18H21NO3;   InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1;   InChIKey=OROGSEYTTFOCAN-DNJOTXNNSA-N;   O(3)-methylmorphine;   SMILES=[H][C@]12C=C[C@H](O)[C@@H]3Oc4c(OC)ccc5C[C@H]1N(C)CC[C@@]23c45;   codeina;   codeine anhydrous;   l-codeine;   methylmorphine;   morphine monomethyl ether;   morphine-3-methyl ether
 alt_id: CHEBI:14006;   CHEBI:23348;   CHEBI:3803
 xref: Beilstein:5303198;   Beilstein:5768734;   Beilstein:94996;   CAS:76-57-3;   DrugBank:DB00318;   Drug_Central:725;   Gmelin:232454;   KEGG:C06174;   KNApSAcK:C00001837
 xref_mesh: MESH:D003061
 xref: PMID:2215478;   PMID:23507688;   PMID:24069665;   PMID:24176887;   PMID:24324229;   PMID:24396053;   PMID:24458010;   PMID:24491926;   PMID:24517264;   PMID:9776433;   Reaxys:94996;   Wikipedia:Codeine
 cyclic_relationship: is_conjugate_base_of CHEBI:57871


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codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Codeine results in increased secretion of CCL2 protein CTD PMID:17441793 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Codeine affects the secretion of and affects the expression of CCL5 protein CTD PMID:17441793 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Codeine analog CTD PMID:25445008 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation
ISO CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CTD PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 PMID:16595712 PMID:17470523 PMID:17564651 PMID:21241245 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects metabolic processing
multiple interactions
increases metabolic processing
ISO CYP3A4 protein affects the metabolism of Codeine
[CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CTD PMID:15286053 PMID:16595712 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Codeine binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Codeine binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Codeine binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
norcodeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          codeine 9
            dihydrocodeine phosphate 0
            norcodeine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    main group molecular entity 19658
                      s-block molecular entity 19423
                        hydrogen molecular entity 19416
                          hydrides 18755
                            inorganic hydride 17460
                              pnictogen hydride 17435
                                nitrogen hydride 17281
                                  azane 17017
                                    ammonia 17016
                                      organic amino compound 17015
                                        tertiary amino compound 8654
                                          morphine 463
                                            codeine 9
                                              dihydrocodeine phosphate 0
                                              norcodeine 2
paths to the root