Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzo[d]isothiazol-3-one
go back to main search page
Accession:CHEBI:167099 term browser browse the term
Definition:An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
Synonyms:related_synonym: 1,2-Benzisothiazol-3(2H)-one;   1,2-Benzisothiazolin-3-one;   1,2-Benzisothiazoline-3-one;   2,3-dihydro-3-oxo-1,2-benzisothiazole;   BIT;   Formula=C7H5NOS;   IPX;   InChI=1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9);   InChIKey=DMSMPAJRVJJAGA-UHFFFAOYSA-N;   SMILES=O=c1[nH]sc2ccccc12;   benzisothiazolone
 xref: Beilstein:119510;   CAS:2634-33-5;   HMDB:HMDB0034413
 xref_mesh: MESH:C015699
 xref: PMID:10201825;   PMID:10604041;   PMID:17988285;   PMID:21903403;   PMID:23429043;   PMID:6446435;   PMID:8833462;   PMID:9046655;   PMID:9231500;   PPDB:1361;   Reaxys:119510;   Wikipedia:Benzisothiazolinone


show annotations for term's descendants           Sort by:
 
benzo[d]isothiazol-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G E2f1 E2F transcription factor 1 multiple interactions ISO 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]; 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 protein] CTD PMID:14702633 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity
ISO 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
1,2-benzisothiazoline-3-one results in decreased activity of ESR1 protein
CTD PMID:14702633 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mt2A metallothionein 2A increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19772
    role 19717
      biological role 19716
        xenobiotic 18377
          benzo[d]isothiazol-3-one 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19772
    subatomic particle 19767
      composite particle 19767
        hadron 19767
          baryon 19767
            nucleon 19767
              atomic nucleus 19767
                atom 19767
                  main group element atom 19654
                    p-block element atom 19654
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19231
                                organic heterocyclic compound 18406
                                  organic heteropolycyclic compound 17818
                                    organic heterobicyclic compound 16742
                                      benzo[d]isothiazol-3-one 6
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.