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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzo[d]isothiazol-3-one
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Accession:CHEBI:167099 term browser browse the term
Definition:An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
Synonyms:related_synonym: 1,2-Benzisothiazol-3(2H)-one;   1,2-Benzisothiazolin-3-one;   1,2-Benzisothiazoline-3-one;   2,3-dihydro-3-oxo-1,2-benzisothiazole;   BIT;   Formula=C7H5NOS;   IPX;   InChI=1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9);   InChIKey=DMSMPAJRVJJAGA-UHFFFAOYSA-N;   SMILES=O=c1[nH]sc2ccccc12;   benzisothiazolone
 xref: Beilstein:119510;   CAS:2634-33-5;   HMDB:HMDB0034413
 xref_mesh: MESH:C015699
 xref: PMID:10201825;   PMID:10604041;   PMID:17988285;   PMID:21903403;   PMID:23429043;   PMID:6446435;   PMID:8833462;   PMID:9046655;   PMID:9231500;   PPDB:1361;   Reaxys:119510;   Wikipedia:Benzisothiazolinone


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benzo[d]isothiazol-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G E2F1 E2F transcription factor 1 multiple interactions EXP 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]; 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 protein] CTD PMID:14702633 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases activity		 EXP 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
1,2-benzisothiazoline-3-one results in decreased activity of ESR1 protein		 CTD PMID:14702633 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP 1,2-benzisothiazoline-3-one results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507 		JBrowse link
G MT2A metallothionein 2A increases expression EXP 1,2-benzisothiazoline-3-one results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 1,2-benzisothiazoline-3-one results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G TXN thioredoxin increases expression EXP 1,2-benzisothiazoline-3-one results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        xenobiotic 20368
          benzo[d]isothiazol-3-one 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organic heteropolycyclic compound 21329
                                    organic heterobicyclic compound 18570
                                      benzo[d]isothiazol-3-one 6
paths to the root