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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzo[d]isothiazol-3-one
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Accession:CHEBI:167099 term browser browse the term
Definition:An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
Synonyms:related_synonym: 1,2-Benzisothiazol-3(2H)-one;   1,2-Benzisothiazolin-3-one;   1,2-Benzisothiazoline-3-one;   2,3-dihydro-3-oxo-1,2-benzisothiazole;   BIT;   Formula=C7H5NOS;   IPX;   InChI=1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9);   InChIKey=DMSMPAJRVJJAGA-UHFFFAOYSA-N;   SMILES=O=c1[nH]sc2ccccc12;   benzisothiazolone
 xref: Beilstein:119510;   CAS:2634-33-5;   HMDB:HMDB0034413
 xref_mesh: MESH:C015699
 xref: PMID:10201825;   PMID:10604041;   PMID:17988285;   PMID:21903403;   PMID:23429043;   PMID:6446435;   PMID:8833462;   PMID:9046655;   PMID:9231500;   PPDB:1361;   Reaxys:119510;   Wikipedia:Benzisothiazolinone



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benzo[d]isothiazol-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G E2f1 E2F transcription factor 1 multiple interactions ISO 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]; 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 protein] CTD PMID:14702633 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity
ISO 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
1,2-benzisothiazoline-3-one results in decreased activity of ESR1 protein
CTD PMID:14702633 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Mt2A metallothionein 2A increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        xenobiotic 18778
          benzo[d]isothiazol-3-one 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  organic heteropolycyclic compound 18334
                                    organic heterobicyclic compound 17279
                                      benzo[d]isothiazol-3-one 6
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