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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzo[d]isothiazol-3-one
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Accession:CHEBI:167099 term browser browse the term
Definition:An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
Synonyms:related_synonym: 1,2-Benzisothiazol-3(2H)-one;   1,2-Benzisothiazolin-3-one;   1,2-Benzisothiazoline-3-one;   2,3-dihydro-3-oxo-1,2-benzisothiazole;   BIT;   Formula=C7H5NOS;   IPX;   InChI=1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9);   InChIKey=DMSMPAJRVJJAGA-UHFFFAOYSA-N;   SMILES=O=c1[nH]sc2ccccc12;   benzisothiazolone
 xref: Beilstein:119510;   CAS:2634-33-5;   HMDB:HMDB0034413
 xref_mesh: MESH:C015699
 xref: PMID:10201825;   PMID:10604041;   PMID:17988285;   PMID:21903403;   PMID:23429043;   PMID:6446435;   PMID:8833462;   PMID:9046655;   PMID:9231500;   PPDB:1361;   Reaxys:119510;   Wikipedia:Benzisothiazolinone


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benzo[d]isothiazol-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G E2f1 E2F transcription factor 1 multiple interactions ISO 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]; 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 protein] CTD PMID:14702633 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity
ISO 1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
1,2-benzisothiazoline-3-one results in decreased activity of ESR1 protein
CTD PMID:14702633 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Mt2A metallothionein 2A increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO 1,2-benzisothiazoline-3-one results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        xenobiotic 18452
          benzo[d]isothiazol-3-one 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      benzo[d]isothiazol-3-one 6
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