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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:uridine
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Accession:CHEBI:16704 term browser browse the term
Definition:A ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N(1)-glycosidic bond.
Synonyms:related_synonym: 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione;   1-beta-D-ribofuranosyluracil;   Formula=C9H12N2O6;   InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1;   InChIKey=DRTQHJPVMGBUCF-XVFCMESISA-N;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O;   Urd;   Uridin;   beta-Uridine;   u
 alt_id: CHEBI:15296;   CHEBI:27227;   CHEBI:46386;   CHEBI:46391;   CHEBI:46460;   CHEBI:9893
 xref: Beilstein:754904;   CAS:58-96-8;   DrugBank:DB02745;   ECMDB:ECMDB00296;   Gmelin:397474;   HMDB:HMDB0000296;   KEGG:C00299;   KNApSAcK:C00019674
 xref_mesh: MESH:D014529
 xref: MetaCyc:URIDINE;   PDBeChem:URI;   PMID:12084455;   PMID:15621516;   PMID:16839635;   PMID:17190852;   PMID:22392515;   PMID:22770225;   Reaxys:754904;   Wikipedia:Uridine;   YMDB:YMDB00127


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uridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor increases activity EXP Uridine results in increased activity of ADORA1 protein CTD PMID:18313046 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Uridine inhibits the reaction [celastrol results in increased expression of BAX protein] CTD PMID:27374097 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Uridine inhibits the reaction [celastrol results in increased cleavage of CASP3 protein] CTD PMID:27374097 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Uridine inhibits the reaction [celastrol results in increased cleavage of CASP9 protein] CTD PMID:27374097 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Faslg Fas ligand increases expression ISO Uridine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gypa glycophorin A multiple interactions ISO Uridine inhibits the reaction [teriflunomide results in increased expression of GYPA protein] CTD PMID:12181422 NCBI chr19:27,450,311...27,465,940 JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein]; Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein] CTD PMID:17187420 PMID:18163507 PMID:20032772 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein] CTD PMID:9808420 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions
increases uptake
increases transport
increases export
ISO
EXP
Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Cytarabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]; Cytidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]; Lamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]; Sodium affects the reaction [SLC28A1 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
Cytarabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]; Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]
CTD PMID:8700147 PMID:8713072 PMID:9124315 PMID:10772724 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
JBrowse link
G Slc28a2 solute carrier family 28 member 2 increases transport ISO SLC28A2 protein results in increased transport of Uridine CTD PMID:10087507 NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions
increases uptake
ISO
EXP
4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; [SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine; Dilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]; Lidoflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Adenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Cytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Uridine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
2'-deoxyadenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Cytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
CTD PMID:9353301 PMID:9396714 PMID:10366666 PMID:11085929 PMID:18381442 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions
increases uptake
ISO
EXP
4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]; [SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
SLC29A2 protein results in increased uptake of Uridine
2'-deoxyadenosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Adenine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Cytidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Dipyridamole inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Guanosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Inosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]
CTD PMID:9353301 PMID:9396714 PMID:10366666 PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Uridine inhibits the reaction [celastrol results in increased expression of TP53 protein] CTD PMID:27374097 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Upp1 uridine phosphorylase 1 affects abundance
increases metabolic processing
multiple interactions
ISO UPP1 protein affects the abundance of Uridine
UPP1 protein results in increased metabolism of Uridine
[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Fluorouracil; [UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbital
CTD PMID:15772079 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pro-agent 10095
          prodrug 9899
            uracil 5674
              uridine 16
                3'-(enolpyruvyl)uridine 5'-monophosphate 0
                5'-O-(dihydroxyphosphanyl)-2'-O-\{2-[2-(dimethylamino)ethoxy]ethyl\}-5-methyluridine 0
                5-aminomethyl-2-thiouridine + 0
                nikkomycin Z 0
                uridine residue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11945
                                        glycosyl compound 10978
                                          N-glycosyl compound 5515
                                            nucleoside 5376
                                              ribonucleoside 674
                                                pyrimidine ribonucleosides 149
                                                  uridines 49
                                                    uridine 16
                                                      3'-(enolpyruvyl)uridine 5'-monophosphate 0
                                                      5'-O-(dihydroxyphosphanyl)-2'-O-\{2-[2-(dimethylamino)ethoxy]ethyl\}-5-methyluridine 0
                                                      5-aminomethyl-2-thiouridine + 0
                                                      nikkomycin Z 0
                                                      uridine residue 0
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