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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fostriecin
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Accession:CHEBI:167004 term browser browse the term
Definition:A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines.
Synonyms:exact_synonym: (1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]trideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate
 related_synonym: (6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one;   CI 920;   CL 1565A;   Formula=C19H27O9P;   InChI=1S/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16+,17+,19+/m0/s1;   InChIKey=ZMQRJWIYMXZORG-DSWNLJKISA-N;   PD 110,161;   PD 110161;   SMILES=C[C@@](O)(\\C=C\\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\\C=C/C=C\\C=C\\CO)OP(O)(O)=O;   antibiotic CI 920;   antibiotic CL 1565A;   fostriecina;   fostriecine;   fostriecinum;   phosphotrienin
 xref: CAS:87810-56-8;   Chemspider:4510160;   KNApSAcK:C00018551
 xref_mesh: MESH:C040313
 xref: PMID:11457179;   PMID:12119701;   PMID:12369868;   PMID:12489943;   PMID:12837094;   PMID:16316259;   PMID:19592665;   PMID:19902969;   PMID:20645347;   PMID:20687585;   PMID:23352138;   PMID:23586868;   PMID:23671329;   PMID:28027648;   PMID:28090813;   PMID:31584287;   PMID:33184589;   PMID:9738645;   Wikipedia:Fostriecin



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fostriecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]] CTD PMID:24954032 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Casp3 caspase 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]] CTD PMID:24954032 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]] CTD PMID:24954032 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO fostriecin promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]] CTD PMID:24954032 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      biological role 19830
        inhibitor 18907
          apoptosis inhibitor 7183
            fostriecin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      chalcogen 19555
                        oxygen atom 19528
                          oxygen molecular entity 19528
                            hydroxides 19335
                              oxoacid 18769
                                pnictogen oxoacid 14903
                                  phosphorus oxoacid 14492
                                    phosphoric acids 13930
                                      phosphoric acid 13930
                                        phosphoric acid derivative 13836
                                          phosphate 13835
                                            organic phosphate 13835
                                              phosphate monoester 4
                                                fostriecin 4
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