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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fostriecin
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Accession:CHEBI:167004 term browser browse the term
Definition:A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines.
Synonyms:exact_synonym: (1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]trideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate
 related_synonym: (6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one;   CI 920;   CL 1565A;   Formula=C19H27O9P;   InChI=1S/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16+,17+,19+/m0/s1;   InChIKey=ZMQRJWIYMXZORG-DSWNLJKISA-N;   PD 110,161;   PD 110161;   SMILES=C[C@@](O)(\\C=C\\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\\C=C/C=C\\C=C\\CO)OP(O)(O)=O;   antibiotic CI 920;   antibiotic CL 1565A;   fostriecina;   fostriecine;   fostriecinum;   phosphotrienin
 xref: CAS:87810-56-8;   Chemspider:4510160;   KNApSAcK:C00018551
 xref_mesh: MESH:C040313
 xref: PMID:11457179;   PMID:12119701;   PMID:12369868;   PMID:12489943;   PMID:12837094;   PMID:16316259;   PMID:19592665;   PMID:19902969;   PMID:20645347;   PMID:20687585;   PMID:23352138;   PMID:23586868;   PMID:23671329;   PMID:28027648;   PMID:28090813;   PMID:31584287;   PMID:33184589;   PMID:9738645;   Wikipedia:Fostriecin


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fostriecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]] CTD PMID:24954032 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]] CTD PMID:24954032 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]] CTD PMID:24954032 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO fostriecin promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]] CTD PMID:24954032 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        inhibitor 18573
          apoptosis inhibitor 6905
            fostriecin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      chalcogen 19445
                        oxygen atom 19418
                          oxygen molecular entity 19418
                            hydroxides 19152
                              oxoacid 18466
                                pnictogen oxoacid 10732
                                  phosphorus oxoacid 9727
                                    phosphoric acids 8535
                                      phosphoric acid 8535
                                        phosphoric acid derivative 8241
                                          phosphate 8241
                                            organic phosphate 8240
                                              phosphate monoester 4
                                                fostriecin 4
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