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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fostriecin
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Accession:CHEBI:167004 term browser browse the term
Definition:A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines.
Synonyms:exact_synonym: (1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]trideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate
 related_synonym: (6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one;   CI 920;   CL 1565A;   Formula=C19H27O9P;   InChI=1S/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16+,17+,19+/m0/s1;   InChIKey=ZMQRJWIYMXZORG-DSWNLJKISA-N;   PD 110,161;   PD 110161;   SMILES=C[C@@](O)(\\C=C\\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\\C=C/C=C\\C=C\\CO)OP(O)(O)=O;   antibiotic CI 920;   antibiotic CL 1565A;   fostriecina;   fostriecine;   fostriecinum;   phosphotrienin
 xref: CAS:87810-56-8;   Chemspider:4510160;   KNApSAcK:C00018551
 xref_mesh: MESH:C040313
 xref: PMID:11457179;   PMID:12119701;   PMID:12369868;   PMID:12489943;   PMID:12837094;   PMID:16316259;   PMID:19592665;   PMID:19902969;   PMID:20645347;   PMID:20687585;   PMID:23352138;   PMID:23586868;   PMID:23671329;   PMID:28027648;   PMID:28090813;   PMID:31584287;   PMID:33184589;   PMID:9738645;   Wikipedia:Fostriecin


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fostriecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]] CTD PMID:24954032 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]] CTD PMID:24954032 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]] CTD PMID:24954032 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO fostriecin promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]] CTD PMID:24954032 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        inhibitor 19476
          apoptosis inhibitor 9861
            fostriecin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      chalcogen 20491
                        oxygen atom 20457
                          oxygen molecular entity 20457
                            hydroxides 20230
                              oxoacid 19289
                                pnictogen oxoacid 15112
                                  phosphorus oxoacid 14667
                                    phosphoric acids 13987
                                      phosphoric acid 13987
                                        phosphoric acid derivative 13899
                                          phosphate 13898
                                            organic phosphate 13898
                                              phosphate monoester 4
                                                fostriecin 4
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