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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fostriecin
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Accession:CHEBI:167004 term browser browse the term
Definition:A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines.
Synonyms:exact_synonym: (1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]trideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate
 related_synonym: (6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one;   CI 920;   CL 1565A;   Formula=C19H27O9P;   InChI=1S/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16+,17+,19+/m0/s1;   InChIKey=ZMQRJWIYMXZORG-DSWNLJKISA-N;   PD 110,161;   PD 110161;   SMILES=C[C@@](O)(\\C=C\\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\\C=C/C=C\\C=C\\CO)OP(O)(O)=O;   antibiotic CI 920;   antibiotic CL 1565A;   fostriecina;   fostriecine;   fostriecinum;   phosphotrienin
 xref: CAS:87810-56-8;   Chemspider:4510160;   KNApSAcK:C00018551
 xref_mesh: MESH:C040313
 xref: PMID:11457179;   PMID:12119701;   PMID:12369868;   PMID:12489943;   PMID:12837094;   PMID:16316259;   PMID:19592665;   PMID:19902969;   PMID:20645347;   PMID:20687585;   PMID:23352138;   PMID:23586868;   PMID:23671329;   PMID:28027648;   PMID:28090813;   PMID:31584287;   PMID:33184589;   PMID:9738645;   Wikipedia:Fostriecin

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fostriecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]] CTD PMID:24954032 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Casp3 caspase 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]] CTD PMID:24954032 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]] CTD PMID:24954032 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO fostriecin promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]] CTD PMID:24954032 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        inhibitor 18304
          apoptosis inhibitor 6810
            fostriecin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      chalcogen 19454
                        oxygen atom 19415
                          oxygen molecular entity 19415
                            hydroxides 19139
                              oxoacid 18273
                                pnictogen oxoacid 10308
                                  phosphorus oxoacid 9228
                                    phosphoric acids 7945
                                      phosphoric acid 7945
                                        phosphoric acid derivative 7624
                                          phosphate 7624
                                            organic phosphate 7623
                                              phosphate monoester 4
                                                fostriecin 4
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