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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyanamide
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Accession:CHEBI:16698 term browser browse the term
Definition:A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an amino group.
Synonyms:related_synonym: Carbodiimide;   Formula=CH2N2;   H2N-C#N;   InChI=1S/CH2N2/c2-1-3/h2H2;   InChIKey=XZMCDFZZKTWFGF-UHFFFAOYSA-N;   NH2CN;   SMILES=NC#N;   amidocyanogen;   carbamonitrile;   cyanoamine
 alt_id: CHEBI:14036;   CHEBI:23418;   CHEBI:3967;   CHEBI:41585
 xref: CAS:420-04-2;   DrugBank:DB02679;   Gmelin:784;   KEGG:C01566;   KEGG:D00123
 xref_mesh: MESH:D003484
 xref: PDBeChem:CNN;   PMID:15991038;   PMID:17989515;   PMID:24429000;   PMID:24709147;   PPDB:184;   Reaxys:1732569;   UM-BBD_compID:c0597;   Wikipedia:Cyanamide
 cyclic_relationship: is_conjugate_acid_of CHEBI:64302


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cyanamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions ISO Cyanamide promotes the reaction [[ADH1 protein co-treated with Ethanol] results in increased abundance of Acetaldehyde]; Cyanamide promotes the reaction [[ADH1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde] CTD PMID:7646056, PMID:11981770 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
decreases activity
ISO
EXP
[Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin
Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]]; Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of ALDH2 protein]; Cyanamide affects the reaction [Ethanol affects the expression of ALDH2 protein]
CTD PMID:14690875, PMID:18272654, PMID:19576883, PMID:31550440 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Avp arginine vasopressin multiple interactions
increases expression
EXP [Ethanol co-treated with Cyanamide] results in increased expression of AVP mRNA
Cyanamide results in increased expression of AVP mRNA
CTD PMID:10718921, PMID:10978654, PMID:11139417 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Cyanamide results in increased expression of BAX mRNA CTD PMID:12003908 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Ethanol co-treated with Cyanamide] results in increased expression of BCL2 mRNA CTD PMID:12003908 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO Cyanamide inhibits the reaction [CGA protein results in increased expression of BMP7 mRNA] CTD PMID:22285649 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO Cyanamide inhibits the reaction [CGA protein results in increased expression of CCND2 mRNA] CTD PMID:22285649 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP [Ethanol co-treated with Cyanamide] results in decreased expression of CDKN1A mRNA CTD PMID:12003908 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions ISO Cyanamide inhibits the reaction [CGA protein results in increased expression of BMP7 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of CCND2 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP17A1 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of FSHR mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA] CTD PMID:22285649 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT mRNA]; Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT protein] CTD PMID:17045751 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
EXP [Cyanamide co-treated with Ethanol] results in increased expression of CRH mRNA; [Ethanol co-treated with Cyanamide] results in increased expression of CRH mRNA
Cyanamide results in increased expression of CRH mRNA
CTD PMID:10718921, PMID:10978654, PMID:11139417, PMID:12217933, PMID:16375214 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Cyanamide analog binds to and results in decreased activity of CTSK protein CTD PMID:15896958 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP17A1 mRNA] CTD PMID:22285649 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA] CTD PMID:22285649 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Cyanamide inhibits the reaction [Ethanol results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:18317950 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein; Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]; candesartan inhibits the reaction [[Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein]; candesartan inhibits the reaction [Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]] CTD PMID:26298003 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO Cyanamide inhibits the reaction [CGA protein results in increased expression of FSHR mRNA] CTD PMID:22285649 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions EXP Cyanamide inhibits the reaction [Ethanol results in increased expression of IGFBP1 mRNA] CTD PMID:12394292 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions ISO Cyanamide inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA] CTD PMID:22285649 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO Cyanamide promotes the reaction [Acetaldehyde results in increased lipidation of MAP1LC3B protein]
Cyanamide results in increased lipidation of MAP1LC3B protein
CTD PMID:24492484 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Cyanamide results in decreased expression of MITF mRNA CTD PMID:23489423 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [Cyanamide co-treated with Ethanol] results in increased expression of MYC mRNA CTD PMID:12876071 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
decreases activity
ISO Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein] CTD PMID:22835378 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP [Ethanol co-treated with Cyanamide] results in increased expression of NPPA mRNA CTD PMID:10905996 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases expression
EXP [Cyanamide co-treated with Ethanol] results in increased expression of POMC mRNA; [Ethanol co-treated with Cyanamide] results in decreased expression of POMC mRNA; [Ethanol co-treated with Cyanamide] results in increased expression of POMC mRNA
Cyanamide results in increased expression of POMC mRNA
CTD PMID:10978654, PMID:11139417, PMID:16375214 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Cyanamide promotes the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Cyanamide inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] CTD PMID:17030193 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ren renin multiple interactions EXP [Acetaldehyde co-treated with Cyanamide] results in increased activity of REN protein CTD PMID:26298003 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [Ethanol co-treated with Cyanamide] results in increased expression of TP53 mRNA CTD PMID:12003908 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tyr tyrosinase decreases expression ISO Cyanamide results in decreased expression of TYR mRNA CTD PMID:23489423 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
melamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP melamine results in increased expression of A2M CTD PMID:23052191 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Alb albumin multiple interactions EXP [melamine co-treated with cyanuric acid] results in increased expression of ALB protein CTD PMID:22610612 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAD protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of BAD protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAD protein] CTD PMID:22915474 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAX protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of BAX protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAX protein] CTD PMID:22915474 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO melamine results in decreased expression of BCL2 protein CTD PMID:22915474 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO melamine results in decreased expression of BCL2L1 protein CTD PMID:22915474 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased cleavage of CASP3 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP3 protein] CTD PMID:22915474 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP9 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased cleavage of CASP9 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP9 protein] CTD PMID:22915474 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of CCL2 mRNA] CTD PMID:22915474 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP melamine results in increased expression of CD44 CTD PMID:23052191 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Clu clusterin multiple interactions
increases expression
EXP [cyanuric acid co-treated with melamine] results in increased expression of CLU mRNA; [melamine co-treated with cyanuric acid] results in increased expression of CLU mRNA; [melamine co-treated with cyanuric acid] results in increased expression of CLU protein
melamine results in increased expression of CLU
CTD PMID:21784140, PMID:22610612, PMID:23022069, PMID:23052191 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO melamine results in increased activity of CYP19A1 protein CTD PMID:32113805 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of FN1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of FN1 protein]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 mRNA]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 protein]
melamine results in increased expression of FN1 mRNA; melamine results in increased expression of FN1 protein
CTD PMID:22915474 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP melamine results in increased expression of GPNMB CTD PMID:23052191 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP melamine results in decreased expression of GRIN1 protein CTD PMID:28206646 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP melamine results in decreased expression of GRIN2B protein CTD PMID:28206646 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions
EXP melamine results in increased expression of HAVCR1
[cyanuric acid co-treated with melamine] results in increased expression of HAVCR1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of HAVCR1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of HAVCR1 protein
CTD PMID:21784140, PMID:22610612, PMID:23022069, PMID:23052191 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of IL6 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of IL6 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of IL6 mRNA] CTD PMID:22915474 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcn2 lipocalin 2 multiple interactions
increases expression
EXP [cyanuric acid co-treated with melamine] results in increased expression of LCN2 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of LCN2 mRNA
melamine results in increased expression of LCN2
CTD PMID:21784140, PMID:23022069, PMID:23052191 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO melamine results in increased phosphorylation of MAPK1 protein CTD PMID:22915474 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO melamine results in increased phosphorylation of MAPK3 protein CTD PMID:22915474 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO melamine results in increased phosphorylation of NFKBIA protein CTD PMID:22915474 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO melamine results in increased phosphorylation of RELA protein CTD PMID:22915474 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP [cyanuric acid co-treated with melamine] results in increased expression of SPP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of SPP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of SPP1 protein CTD PMID:21784140, PMID:22610612, PMID:23022069 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tff3 trefoil factor 3 decreases expression EXP melamine results in decreased expression of TFF3 CTD PMID:23052191 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of TGFB1 protein]; SN50 peptide inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of TGFB1 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP3 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP9 protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAD protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAX protein]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 mRNA]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 protein]
melamine results in increased expression of TGFB1 mRNA; melamine results in increased expression of TGFB1 protein
CTD PMID:22915474 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [cyanuric acid co-treated with melamine] results in increased expression of TIMP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of TIMP1 mRNA CTD PMID:21784140, PMID:23022069 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP melamine results in increased expression of TNFRSF12A CTD PMID:23052191 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of VCAM1 mRNA] CTD PMID:22915474 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
thiacloprid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
thiacloprid results in decreased activity of ACHE protein CTD PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression
multiple interactions
ISO thiacloprid results in increased expression of ALDH1A1 mRNA
[thiacloprid co-treated with enilconazole] results in decreased expression of ALDH1A1 mRNA
CTD PMID:32201337 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression
EXP thiacloprid results in decreased activity of CAT protein
Polysaccharides inhibits the reaction [thiacloprid results in decreased activity of CAT protein]; Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of CAT mRNA]
CTD PMID:28692354 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO [clothianidin co-treated with thiacloprid] results in increased expression of CES2 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CES2 protein CTD PMID:32201337 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP thiacloprid results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]; thiacloprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein] CTD PMID:16981889, PMID:25459289 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO thiacloprid results in increased expression of CYBB mRNA CTD PMID:32201337 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
affects expression
multiple interactions
increases expression
ISO thiacloprid results in increased activity of CYP19A1 protein
thiacloprid affects the expression of CYP19A1 mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]
thiacloprid results in increased expression of CYP19A1 mRNA
CTD PMID:26464060, PMID:28750898, PMID:29701941 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO thiacloprid results in increased expression of CYP1A1 mRNA; thiacloprid results in increased expression of CYP1A1 protein CTD PMID:21784029 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO thiacloprid results in increased expression of CYP1A2 mRNA; thiacloprid results in increased expression of CYP1A2 protein
[enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP1A2 mRNA
CTD PMID:21784029, PMID:32201337 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [clothianidin co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B9 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B6 mRNA
thiacloprid results in increased expression of CYP2B6 mRNA
CTD PMID:32201337 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression ISO thiacloprid results in increased expression of CYP2C19 mRNA CTD PMID:32201337 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
ISO thiacloprid results in decreased expression of CYP2E1 mRNA
[clothianidin co-treated with thiacloprid] results in increased expression of CYP2E1 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA
CTD PMID:32201337 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions
ISO thiacloprid results in increased expression of CYP3A5 mRNA
[enilconazole co-treated with thiacloprid] results in increased expression of CYP3A5 protein; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A5 mRNA
CTD PMID:32201337 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
EXP thiacloprid results in increased expression of GPT protein
Polysaccharides inhibits the reaction [thiacloprid results in increased expression of GPT protein]
CTD PMID:31328355 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of GPX1 mRNA] CTD PMID:28692354 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram] CTD PMID:29950287 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO thiacloprid results in increased expression of POR mRNA CTD PMID:32201337 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases activity ISO thiacloprid metabolite results in increased activity of SLC22A1 protein; thiacloprid results in increased activity of SLC22A1 protein CTD PMID:31364238 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO thiacloprid metabolite results in decreased activity of SLC22A2 protein; thiacloprid results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO thiacloprid metabolite results in decreased activity of SLC22A8 protein; thiacloprid results in decreased activity of SLC22A8 protein CTD PMID:31364238 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of SOD1 mRNA] CTD PMID:28692354 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      group 19698
        pseudohalo group 2884
          cyano group 2884
            nitrile 2884
              cyanamide 76
                (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-ylidenecyanamide 0
                melamine + 29
                thiacloprid + 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            one-carbon compound 17560
                              hydrogen cyanide 2889
                                cyanides 2889
                                  nitrile 2884
                                    cyanamide 76
                                      (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-ylidenecyanamide 0
                                      melamine + 29
                                      thiacloprid + 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.