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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ecdysone
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Accession:CHEBI:16688 term browser browse the term
Definition:A 6-oxo steroid that is 5beta-cholest-7-en-6-one substituted by hydroxy groups at positions 2, 3, 14, 22 and 25 respectively (the 2beta, 3beta, 22R stereoisomer). It is a steroid prohormone of the major insect moulting hormone 20-hydroxyecdysone.
Synonyms:exact_synonym: (2beta,3beta,5beta,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one
 related_synonym: (22R)-2beta,3beta,14,22,25-pentahydroxy-5beta-cholest-7-en-6-one;   (22R)-2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one;   Formula=C27H44O6;   InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1;   InChIKey=UPEZCKBFRMILAV-JMZLNJERSA-N;   SMILES=[H][C@@]1(CC[C@@]2(O)C3=CC(=O)[C@]4([H])C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@H](O)CCC(C)(C)O
 alt_id: CHEBI:14205;   CHEBI:23889;   CHEBI:4741
 xref: CAS:3604-87-3;   KEGG:C00477;   KNApSAcK:C00003651;   LIPID_MAPS_instance:LMST01010210;   PMID:19342482;   PMID:22310011;   PMID:22828514;   PMID:23017214;   PMID:23072462;   Reaxys:2422986;   Wikipedia:Ecdysone


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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ecdysterone results in increased expression of BAX protein CTD PMID:33878320 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Ecdysterone affects the expression of BCL2 protein CTD PMID:33878320 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein
CTD PMID:29126784 PMID:33878320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression
ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA
CTD PMID:29126784 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Mtor mechanistic target of rapamycin kinase affects expression ISO Ecdysterone affects the expression of MTOR protein CTD PMID:33878320 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ecdysterone results in increased cleavage of PARP1 protein CTD PMID:33878320 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sqstm1 sequestosome 1 affects expression ISO Ecdysterone affects the expression of SQSTM1 protein CTD PMID:33878320 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        prohormone 11
          ecdysone 11
            (24R)-11alpha,20,24-trihydroxyecdysone 0
            (25R)-11alpha,20,26-trihydroxyecdysone 0
            (25S)-11alpha,20,26-trihydroxyecdysone 0
            2,22,25-trideoxyecdysone 0
            2-dehydroecdysone 0
            2-deoxyecdysone 0
            20,26-dihydroxyecdysone 0
            20-hydroxyecdysone 11
            22-deoxy-20,21-dihydroxyecdysone 0
            25-deoxyecdysone 0
            3-dehydroecdysone 0
            ecdysone 25-O-D-glucopyranoside 0
            ecdysteroid ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic polycyclic compound 16535
                                  steroid 13057
                                    hydroxy steroid 12657
                                      3-hydroxy steroid 10367
                                        sterol 439
                                          3beta-sterol 433
                                            ecdysone 11
                                              (24R)-11alpha,20,24-trihydroxyecdysone 0
                                              (25R)-11alpha,20,26-trihydroxyecdysone 0
                                              (25S)-11alpha,20,26-trihydroxyecdysone 0
                                              2,22,25-trideoxyecdysone 0
                                              2-dehydroecdysone 0
                                              2-deoxyecdysone 0
                                              20,26-dihydroxyecdysone 0
                                              20-hydroxyecdysone 11
                                              22-deoxy-20,21-dihydroxyecdysone 0
                                              25-deoxyecdysone 0
                                              3-dehydroecdysone 0
                                              ecdysone 25-O-D-glucopyranoside 0
                                              ecdysteroid ester + 0
paths to the root