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ONTOLOGY REPORT - ANNOTATIONS


Term:ecdysone
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Accession:CHEBI:16688 term browser browse the term
Definition:A 6-oxo steroid that is 5beta-cholest-7-en-6-one substituted by hydroxy groups at positions 2, 3, 14, 22 and 25 respectively (the 2beta, 3beta, 22R stereoisomer). It is a steroid prohormone of the major insect moulting hormone 20-hydroxyecdysone.
Synonyms:exact_synonym: (2beta,3beta,5beta,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one
 related_synonym: (22R)-2beta,3beta,14,22,25-pentahydroxy-5beta-cholest-7-en-6-one;   (22R)-2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one;   Formula=C27H44O6;   InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1;   InChIKey=UPEZCKBFRMILAV-JMZLNJERSA-N;   SMILES=[H][C@@]1(CC[C@@]2(O)C3=CC(=O)[C@]4([H])C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@H](O)CCC(C)(C)O
 alt_id: CHEBI:14205;   CHEBI:23889;   CHEBI:4741
 xref: CAS:3604-87-3 "KEGG COMPOUND";   KEGG:C00477;   KNApSAcK:C00003651;   LIPID_MAPS_instance:LMST01010210 "LIPID MAPS";   PMID:19342482 "Europe PMC";   PMID:22310011 "Europe PMC";   PMID:22828514 "Europe PMC";   PMID:23017214 "Europe PMC";   PMID:23072462 "Europe PMC";   Reaxys:2422986 "Reaxys";   Wikipedia:Ecdysone


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20-hydroxyecdysone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        prohormone 6
          ecdysone 6
            (24R)-11alpha,20,24-trihydroxyecdysone 0
            (25R)-11alpha,20,26-trihydroxyecdysone 0
            (25S)-11alpha,20,26-trihydroxyecdysone 0
            2,22,25-trideoxyecdysone 0
            2-dehydroecdysone 0
            2-deoxyecdysone 0
            20,26-dihydroxyecdysone 0
            20-hydroxyecdysone 6
            22-deoxy-20,21-dihydroxyecdysone 0
            25-deoxyecdysone 0
            3-dehydroecdysone 0
            ecdysone 25-O-D-glucopyranoside 0
            ecdysteroid ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic molecule 19332
                              organic cyclic compound 19083
                                organic polycyclic compound 16024
                                  steroid 12765
                                    hydroxy steroid 12356
                                      3-hydroxy steroid 9983
                                        sterol 409
                                          3beta-sterol 403
                                            ecdysone 6
                                              (24R)-11alpha,20,24-trihydroxyecdysone 0
                                              (25R)-11alpha,20,26-trihydroxyecdysone 0
                                              (25S)-11alpha,20,26-trihydroxyecdysone 0
                                              2,22,25-trideoxyecdysone 0
                                              2-dehydroecdysone 0
                                              2-deoxyecdysone 0
                                              20,26-dihydroxyecdysone 0
                                              20-hydroxyecdysone 6
                                              22-deoxy-20,21-dihydroxyecdysone 0
                                              25-deoxyecdysone 0
                                              3-dehydroecdysone 0
                                              ecdysone 25-O-D-glucopyranoside 0
                                              ecdysteroid ester + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.