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ONTOLOGY REPORT - ANNOTATIONS


Term:atropine
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Accession:CHEBI:16684 term browser browse the term
Definition:A racemate composed of equimolar concentrations of (S)- and (R)-atropine . It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae.
Synonyms:exact_synonym: rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate;   rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate
 related_synonym: (+,-)-tropyl tropate;   (+-)-hyoscyamine;   (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate;   8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate;   8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate;   Atropin;   Formula=C17H23NO3;   InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?;   InChIKey=RKUNBYITZUJHSG-SPUOUPEWSA-N;   SMILES=CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1;   [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate;   atropina;   dl-Hyoscyamine;   dl-tropyltropate;   tropine tropate
 alt_id: CHEBI:13866;   CHEBI:22674;   CHEBI:24754;   CHEBI:2917
 xref: Beilstein:1545928 "Beilstein";   Beilstein:4236545 "Beilstein";   CAS:51-55-8 "ChemIDplus";   CAS:51-55-8 "KEGG COMPOUND";   CAS:51-55-8 "NIST Chemistry WebBook";   DrugBank:DB00572;   HMDB:HMDB0014712;   KEGG:C01479;   KEGG:D00113
 xref_mesh: MESH:D001285
 xref: PMID:15374592 "Europe PMC";   PMID:18369575 "Europe PMC";   Reaxys:1545928 "Reaxys"


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atropine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 JBrowse link 2 69,238,282 69,342,616 RGD:6480464
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase JBrowse link 2 31,688,244 31,807,093 RGD:6480464
G Ache acetylcholinesterase JBrowse link 5 137,288,247 137,294,466 RGD:6480464
G Adcy5 adenylate cyclase 5 JBrowse link 16 35,154,494 35,305,743 RGD:6480464
G Aqp5 aquaporin 5 JBrowse link 15 99,591,028 99,594,829 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcar1 breast cancer anti-estrogen resistance 1 JBrowse link 8 111,710,474 111,743,849 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 3 73,635,805 73,708,436 RGD:6480464
G Bdkrb2 bradykinin receptor, beta 2 JBrowse link 12 105,563,172 105,595,244 RGD:6480464
G Bmp6 bone morphogenetic protein 6 JBrowse link 13 38,345,716 38,500,314 RGD:6480464
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit JBrowse link 1 154,390,806 154,884,785 RGD:6480464
G Calca calcitonin/calcitonin-related polypeptide, alpha JBrowse link 7 114,625,981 114,636,910 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Ccna1 cyclin A1 JBrowse link 3 55,045,469 55,057,634 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 17 47,505,051 47,599,689 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 7 38,097,984 38,107,490 RGD:6480464
G Ccne2 cyclin E2 JBrowse link 4 11,190,433 11,204,779 RGD:6480464
G Cd40 CD40 antigen JBrowse link 2 165,055,614 165,071,654 RGD:6480464
G Cdc20 cell division cycle 20 JBrowse link 4 118,432,901 118,437,343 RGD:6480464
G Cdc6 cell division cycle 6 JBrowse link 11 98,907,709 98,923,942 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 10 69,335,146 69,352,912 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 8 93,166,072 93,197,804 RGD:6480464
G Chrm1 cholinergic receptor, muscarinic 1, CNS JBrowse link 19 8,664,005 8,683,606 RGD:6480464
G Chrm2 cholinergic receptor, muscarinic 2, cardiac JBrowse link 6 36,387,991 36,528,638 RGD:6480464
G Chrm3 cholinergic receptor, muscarinic 3, cardiac JBrowse link 13 9,875,486 10,361,062 RGD:6480464
G Chrm4 cholinergic receptor, muscarinic 4 JBrowse link 2 91,922,189 91,929,835 RGD:6480464
G Chrm5 cholinergic receptor, muscarinic 5 JBrowse link 2 112,478,733 112,536,361 RGD:6480464
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 JBrowse link 2 181,022,311 181,043,579 RGD:6480464
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) JBrowse link 3 89,753,448 89,764,632 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 1 64,532,794 64,604,548 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 3 19,693,401 19,695,396 RGD:6480464
G Ctnnb1 catenin (cadherin associated protein), beta 1 JBrowse link 9 120,933,400 120,960,507 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 5 90,786,101 90,788,093 RGD:6480464
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 11 70,000,592 70,010,109 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:6480464
G Egr2 early growth response 2 JBrowse link 10 67,534,469 67,542,188 RGD:6480464
G Ezr ezrin JBrowse link 17 6,738,131 6,782,780 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Ghrl ghrelin JBrowse link 6 113,716,119 113,719,911 RGD:6480464
G Glra1 glycine receptor, alpha 1 subunit JBrowse link 11 55,514,239 55,608,198 RGD:6480464
G Grm4 glutamate receptor, metabotropic 4 JBrowse link 17 27,422,387 27,513,826 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Junb jun B proto-oncogene JBrowse link 8 84,976,909 84,978,748 RGD:6480464
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 JBrowse link 2 55,411,798 55,598,145 RGD:6480464
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 5 75,574,987 75,656,722 RGD:6480464
G Ltf lactotransferrin JBrowse link 9 111,019,292 111,042,766 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk14 mitogen-activated protein kinase 14 JBrowse link 17 28,691,342 28,748,405 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6480464
G Mcm4 minichromosome maintenance complex component 4 JBrowse link 16 15,623,897 15,637,400 RGD:6480464
G Mcm6 minichromosome maintenance complex component 6 JBrowse link 1 128,331,575 128,359,705 RGD:6480464
G Nefh neurofilament, heavy polypeptide JBrowse link 11 4,938,754 4,948,064 RGD:6480464
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Notch4 notch 4 JBrowse link 17 34,564,286 34,588,543 RGD:6480464
G Nppa natriuretic peptide type A JBrowse link 4 148,000,722 148,002,074 RGD:6480464
G Oprl1 opioid receptor-like 1 JBrowse link 2 181,715,000 181,720,985 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 2 132,249,286 132,253,180 RGD:6480464
G Pnoc prepronociceptin JBrowse link 14 65,400,673 65,425,564 RGD:6480464
G Pomc pro-opiomelanocortin-alpha JBrowse link 12 3,954,945 3,960,643 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 15 85,734,910 85,806,851 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Ptk2 PTK2 protein tyrosine kinase 2 JBrowse link 15 73,205,102 73,423,820 RGD:6480464
G Pxn paxillin JBrowse link 5 115,491,970 115,555,987 RGD:6480464
G Rac3 Rac family small GTPase 3 JBrowse link 11 120,721,468 120,723,969 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 9 108,306,160 108,337,943 RGD:6480464
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 JBrowse link 17 12,648,874 12,675,838 RGD:6480464
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 JBrowse link 17 12,584,189 12,628,489 RGD:6480464
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 JBrowse link 17 12,419,972 12,507,704 RGD:6480464
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 JBrowse link 11 53,983,115 54,030,040 RGD:6480464
G Slc47a1 solute carrier family 47, member 1 JBrowse link 11 61,343,400 61,378,842 RGD:6480464
G Slc47a2 solute carrier family 47, member 2 JBrowse link 11 61,301,627 61,342,860 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 11 117,966,079 117,970,336 RGD:6480464
G Spn sialophorin JBrowse link 7 127,123,637 127,145,552 RGD:6480464
G Tat tyrosine aminotransferase JBrowse link 8 109,986,078 109,999,804 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Trio triple functional domain (PTPRF interacting) JBrowse link 15 27,730,649 28,025,848 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 JBrowse link 1 14,872,644 14,918,862 RGD:6480464
G Tshb thyroid stimulating hormone, beta subunit JBrowse link 3 102,777,398 102,789,082 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 3 116,110,020 116,129,688 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20971
    chemical entity 20969
      chemical substance 11539
        mixture 10826
          racemate 9658
            atropine 90
              (6S)-6-hydroxyhyoscyamine 0
              hyoscyamine sulfate dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20971
    subatomic particle 20965
      composite particle 20965
        hadron 20965
          baryon 20965
            nucleon 20965
              atomic nucleus 20965
                atom 20965
                  main group element atom 20803
                    p-block element atom 20803
                      carbon group element atom 20543
                        carbon atom 20519
                          organic molecular entity 20519
                            organic group 19168
                              organic divalent group 19158
                                organodiyl group 19158
                                  carbonyl group 19130
                                    carbonyl compound 19130
                                      carboxylic acid 18806
                                        monocarboxylic acid 17991
                                          fatty acid 16405
                                            saturated fatty acid 16378
                                              propionic acid 3742
                                                2-arylpropionic acid 192
                                                  hydratropic acid 192
                                                    tropic acid 189
                                                      (S)-tropic acid 189
                                                        (S)-atropine 90
                                                          atropine 90
                                                            (6S)-6-hydroxyhyoscyamine 0
                                                            hyoscyamine sulfate dihydrate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.