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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:albendazole
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Accession:CHEBI:16664 term browser browse the term
Definition:A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations.
Synonyms:exact_synonym: methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate
 related_synonym: (5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester;   5-(propylthio)-2-carbomethoxyaminobenzimidazole;   Albenza;   Eskazole;   Formula=C12H15N3O2S;   InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16);   InChIKey=HXHWSAZORRCQMX-UHFFFAOYSA-N;   O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate;   Proftril;   SMILES=CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1;   Valbazen;   Zentel
 alt_id: CHEBI:13751;   CHEBI:22286;   CHEBI:2545
 xref: Beilstein:752696;   CAS:54965-21-8;   DrugBank:DB00518;   Drug_Central:103;   HMDB:HMDB0014659;   KEGG:C01779;   KEGG:D00134;   LINCS:LSM-3782
 xref_mesh: MESH:D015766
 xref: MetaCyc:ALBENDAZOLE;   PMID:22152396;   PMID:24403707;   PMID:24411094;   Pesticides:albendazole;   Reaxys:752696;   VSDB:895;   Wikipedia:Albendazole


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albendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA CTD PMID:16861626 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA CTD PMID:16861626 NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA CTD PMID:16861626 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Albendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein CTD PMID:16861626 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA CTD PMID:16861626 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA CTD PMID:16861626 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO [Albendazole co-treated with CYP3A4 protein] results in increased expression of CD86 protein CTD PMID:22785256 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA CTD PMID:16861626 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
ISO Albendazole results in increased activity of CYP1A1 promoter; Albendazole results in increased activity of CYP1A1 protein
Albendazole results in increased expression of CYP1A1 mRNA
CTD PMID:12451431, PMID:16714371, PMID:18502397 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
affects metabolic processing
ISO Albendazole results in increased expression of CYP1A2 mRNA
CYP1A2 protein affects the metabolism of Albendazole
CTD PMID:12451431, PMID:12920490 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Albendazole CTD PMID:19501153 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA CTD PMID:16861626 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA CTD PMID:16861626 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA CTD PMID:16861626 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA CTD PMID:16861626 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA CTD PMID:16861626 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA CTD PMID:16861626 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA CTD PMID:16861626 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA CTD PMID:16861626 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA CTD PMID:16861626 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA CTD PMID:16861626 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA CTD PMID:16861626 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Albendazole co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein CTD PMID:22785256 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein CTD PMID:16861626 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA CTD PMID:16861626 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Albendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA CTD PMID:16861626 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Albendazole results in decreased expression of MAPT mRNA; Albendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Albendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA CTD PMID:16861626 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA CTD PMID:16861626 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ptges3 prostaglandin E synthase 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Albendazole affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA CTD PMID:16861626 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Albendazole CTD PMID:19501153 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G St13 ST13, Hsp70 interacting protein multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA CTD PMID:16861626 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Tcp1 t-complex 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA CTD PMID:16861626 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA CTD PMID:16861626 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO U 0126 inhibits the reaction [Albendazole results in increased secretion of TNF protein] CTD PMID:20848085 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA CTD PMID:16861626 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Albendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
albendazole S-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of albendazole sulfoxide CTD PMID:15703302 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO albendazole sulfoxide inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        pharmacological role 18793
          tubulin modulator 2489
            albendazole 44
              albendazole S-oxide + 2
              hydroxyalbendazole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        carbamate ester 7378
                                          carbamate fungicide 165
                                            benzimidazolylcarbamate fungicide 131
                                              albendazole 44
                                                albendazole S-oxide + 2
                                                hydroxyalbendazole 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.