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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Hydroxymephenytoin
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Accession:CHEBI:166516 term browser browse the term
Synonyms:exact_synonym: 5-ethyl-5-(4-hydroxyphenyl)-3-methylimidazolidine-2,4-dione
 related_synonym: Formula=C12H14N2O3;   InChI=1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17);   InChIKey=OQPLORUDZLXXPD-UHFFFAOYSA-N;   SMILES=O=C1N(C(=O)NC1(CC)C2=CC=C(O)C=C2)C
 xref: CAS:61837-65-8;   Chemspider:106722;   HMDB:HMDB0060968
 xref_mesh: MESH:C025687


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Hydroxymephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases chemical synthesis
multiple interactions
ISO CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin
[CYP2C19 protein results in increased metabolism of Mephenytoin] which results in increased chemical synthesis of 4-hydroxymephenytoin; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]
CTD PMID:12401345 PMID:15155557 PMID:21915887 PMID:23850985 PMID:25084468 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      atom 19771
        nonmetal atom 19654
          nitrogen atom 18583
            nitrogen molecular entity 18583
              organonitrogen compound 18371
                organonitrogen heterocyclic compound 17526
                  diazolidine 589
                    imidazolidines 579
                      imidazolidinone 481
                        imidazolidine-2,4-dione 460
                          Hydroxymephenytoin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteromonocyclic compound 16987
                                    diazolidine 589
                                      imidazolidines 579
                                        imidazolidinone 481
                                          imidazolidine-2,4-dione 460
                                            Hydroxymephenytoin 1
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