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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:raffinose
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Accession:CHEBI:16634 term browser browse the term
Definition:A trisaccharide composed of alpha-D-galactopyranose, alpha-D-glucopyranose and beta-D-fructofuranose joined in sequence by 1->6 and 1<->2 glycosidic linkages, respectively.
Synonyms:exact_synonym: beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside
 related_synonym: 6G-alpha-D-galactosylsucrose;   Formula=C18H32O16;   Gossypose;   InChI=1S/C18H32O16/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18/h5-17,19-29H,1-4H2/t5-,6-,7-,8+,9-,10-,11+,12+,13-,14-,15+,16+,17-,18+/m1/s1;   InChIKey=MUPFEKGTMRGPLJ-ZQSKZDJDSA-N;   Melitose;   Melitriose;   SMILES=OC[C@H]1O[C@H](OC[C@H]2O[C@H](O[C@]3(CO)O[C@H](CO)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O;   alpha-D-Galp-(1->6)-alpha-D-Glcp-(1<->2)-beta-D-Fruf;   alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranosyl beta-D-fructofuranoside;   rafinose;   raflinose
 alt_id: CHEBI:15015;   CHEBI:26521;   CHEBI:49843;   CHEBI:8771
 xref: CAS:512-69-6;   HMDB:HMDB0003213;   KEGG:C00492;   KEGG:G00249;   KNApSAcK:C00001145
 xref_mesh: MESH:D011887
 xref: MetaCyc:CPD-1099;   PDBeChem:RAF;   PMID:23317449;   PMID:23879777;   PMID:23882273;   PMID:24001862;   PMID:24354450;   PMID:24360500;   Reaxys:99543;   Wikipedia:Raffinose


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raffinose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Raffinose results in decreased expression of ACACA mRNA CTD PMID:29458019 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Raffinose results in increased expression of ACOX1 mRNA CTD PMID:29458019 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases secretion ISO Raffinose results in increased secretion of ADIPOQ protein CTD PMID:29458019 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO
EXP		 Raffinose results in increased phosphorylation of AKT1 protein CTD PMID:29458019 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO Raffinose results in decreased expression of FASN mRNA CTD PMID:29458019 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO
EXP		 Raffinose results in increased phosphorylation of GSK3B protein CTD PMID:29458019 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP
ISO		 Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Genistein inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Wortmannin inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]		 CTD PMID:29458019 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Insr insulin receptor increases phosphorylation EXP
ISO		 Raffinose results in increased phosphorylation of INSR protein CTD PMID:29458019 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Raffinose results in increased expression of PPARA mRNA CTD PMID:29458019 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP
ISO		 Raffinose results in increased expression of SLC2A4 protein CTD PMID:29458019 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Raffinose results in decreased expression of SREBF1 mRNA CTD PMID:29458019 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
verbascose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO [Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; verbascose promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:33130239 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein] CTD PMID:33130239 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO verbascose promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:33130239 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            eukaryotic metabolite 19319
              plant metabolite 17959
                raffinose 14
                  1(F)-alpha-D-galactosylraffinose 0
                  stachyose + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbohydrates and carbohydrate derivatives 15289
                                    carbohydrate 15289
                                      oligosaccharide 618
                                        trisaccharide 177
                                          raffinose 14
                                            1(F)-alpha-D-galactosylraffinose 0
                                            stachyose + 3
paths to the root