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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:raffinose
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Accession:CHEBI:16634 term browser browse the term
Definition:A trisaccharide composed of alpha-D-galactopyranose, alpha-D-glucopyranose and beta-D-fructofuranose joined in sequence by 1->6 and 1<->2 glycosidic linkages, respectively.
Synonyms:exact_synonym: beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside
 related_synonym: 6G-alpha-D-galactosylsucrose;   Formula=C18H32O16;   Gossypose;   InChI=1S/C18H32O16/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18/h5-17,19-29H,1-4H2/t5-,6-,7-,8+,9-,10-,11+,12+,13-,14-,15+,16+,17-,18+/m1/s1;   InChIKey=MUPFEKGTMRGPLJ-ZQSKZDJDSA-N;   Melitose;   Melitriose;   SMILES=OC[C@H]1O[C@H](OC[C@H]2O[C@H](O[C@]3(CO)O[C@H](CO)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O;   alpha-D-Galp-(1->6)-alpha-D-Glcp-(1<->2)-beta-D-Fruf;   alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranosyl beta-D-fructofuranoside;   rafinose;   raflinose
 alt_id: CHEBI:15015;   CHEBI:26521;   CHEBI:49843;   CHEBI:8771
 xref: CAS:512-69-6;   HMDB:HMDB0003213;   KEGG:C00492;   KEGG:G00249;   KNApSAcK:C00001145
 xref_mesh: MESH:D011887
 xref: MetaCyc:CPD-1099;   PDBeChem:RAF;   PMID:23317449;   PMID:23879777;   PMID:23882273;   PMID:24001862;   PMID:24354450;   PMID:24360500;   Reaxys:99543;   Wikipedia:Raffinose


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raffinose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression EXP
ISO		 Raffinose results in decreased expression of ACACA mRNA CTD PMID:29458019 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases expression ISO
EXP		 Raffinose results in increased expression of ACOX1 mRNA CTD PMID:29458019 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases secretion EXP Raffinose results in increased secretion of ADIPOQ protein CTD PMID:29458019 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO
EXP		 Raffinose results in increased phosphorylation of AKT1 protein CTD PMID:29458019 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO
EXP		 Raffinose results in decreased expression of FASN mRNA CTD PMID:29458019 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP
ISO		 Raffinose results in increased phosphorylation of GSK3B protein CTD PMID:29458019 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Ins1 insulin I multiple interactions EXP
ISO		 Genistein inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; wortmannin inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]] CTD PMID:29458019 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Insr insulin receptor increases phosphorylation ISO
EXP		 Raffinose results in increased phosphorylation of INSR protein CTD PMID:29458019 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP
ISO		 Raffinose results in increased expression of PPARA mRNA CTD PMID:29458019 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 increases expression ISO
EXP		 Raffinose results in increased expression of SLC2A4 protein CTD PMID:29458019 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO
EXP		 Raffinose results in decreased expression of SREBF1 mRNA CTD PMID:29458019 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
verbascose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO verbascose inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:33130239 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; verbascose promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:33130239 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein] CTD PMID:33130239 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO verbascose promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:33130239 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          metabolite 21379
            eukaryotic metabolite 21238
              plant metabolite 19119
                raffinose 15
                  1(F)-alpha-D-galactosylraffinose 0
                  stachyose + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbohydrates and carbohydrate derivatives 16021
                                    carbohydrate 16041
                                      oligosaccharide 617
                                        trisaccharide 179
                                          raffinose 15
                                            1(F)-alpha-D-galactosylraffinose 0
                                            stachyose + 4
paths to the root