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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1D-myo-inositol 1,4,5-trisphosphate
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Accession:CHEBI:16595 term browser browse the term
Definition:A myo-inositol trisphosphate that has formula C6H15O15P3.
Synonyms:exact_synonym: 1D-myo-inositol 1,4,5-tris(dihydrogen phosphate)
 related_synonym: 1,4,5-Insp3;   D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE;   D-myo-Inositol 1,4,5-trisphosphate;   Formula=C6H15O15P3;   IP3;   InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/t1-,2+,3+,4-,5-,6-/m1/s1;   InChIKey=MMWCIQZXVOZEGG-XJTPDSDZSA-N;   Inositol 1,4,5-trisphosphate;   Ins(1,4,5)P3;   InsP3;   SMILES=O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
 alt_id: CHEBI:11363;   CHEBI:12892;   CHEBI:12894;   CHEBI:19192;   CHEBI:4276;   CHEBI:43249
 xref: Beilstein:3658346;   CAS:85166-31-0;   DrugBank:DB03401;   KEGG:C01245;   KNApSAcK:C00007460
 xref_mesh: MESH:D015544
 xref: PDBeChem:I3P
 cyclic_relationship: is_conjugate_acid_of CHEBI:203600



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1D-myo-inositol 1,4,5-trisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases abundance
multiple interactions
ISO ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B increases abundance
increases metabolic processing
multiple interactions
ISO ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate
ADRA1B protein results in increased metabolism of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 PMID:11278430 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D increases abundance
multiple interactions
ISO ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7874174 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]] CTD PMID:20691780 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects abundance ISO CHRM1 protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19002953 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
increases abundance
ISO Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]] CTD PMID:19002953 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases chemical synthesis
increases abundance
EXP
ISO
cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]
CTD PMID:1443220 PMID:11911850 PMID:20691780 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of FOS protein CTD PMID:16259952 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases expression
EXP Cyclosporine promotes the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 mRNA]; Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein] CTD PMID:16259952 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B decreases abundance ISO HTR2B protein mutant form results in decreased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:15625277 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A multiple interactions ISO benzene 1,2,4-trisphosphate inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate]; Polyphosphates inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate] CTD PMID:18574825 NCBI chr 1:194,190,086...194,380,429
Ensembl chr 1:194,190,393...194,380,428
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Inositol 1,4,5-Trisphosphate inhibits the reaction [bisphenol A binds to ITPR1 protein] CTD PMID:33408296 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYC protein CTD PMID:16259952 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYH7 mRNA CTD PMID:16259952 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions
increases expression
EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein] CTD PMID:16259952 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Npy1r neuropeptide Y receptor Y1 affects abundance EXP NPY1R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
JBrowse link
G Npy2r neuropeptide Y receptor Y2 affects abundance EXP NPY2R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024
JBrowse link
G Tnfsf4 TNF superfamily member 4 increases abundance ISO TNFSF4 protein results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19416722 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            eukaryotic metabolite 19033
              animal metabolite 18895
                mammalian metabolite 18895
                  mouse metabolite 18570
                    1D-myo-inositol 1,4,5-trisphosphate 19
                      D-myo-Ins(1,4,5)P3 hexakis(butyryloxymethyl) ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              oxoacid 18472
                                pnictogen oxoacid 10733
                                  phosphorus oxoacid 9728
                                    phosphoric acids 8536
                                      phosphoric acid 8536
                                        phosphoric acid derivative 8242
                                          phosphate 8242
                                            organic phosphate 8241
                                              cyclitol phosphate 60
                                                inositol phosphate 60
                                                  myo-inositol phosphate 60
                                                    myo-inositol polyphosphate 59
                                                      myo-inositol trisphosphate 19
                                                        1D-myo-inositol 1,4,5-trisphosphate 19
                                                          D-myo-Ins(1,4,5)P3 hexakis(butyryloxymethyl) ester 0
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