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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1D-myo-inositol 1,4,5-trisphosphate
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Accession:CHEBI:16595 term browser browse the term
Definition:A myo-inositol trisphosphate that has formula C6H15O15P3.
Synonyms:exact_synonym: 1D-myo-inositol 1,4,5-tris(dihydrogen phosphate)
 related_synonym: 1,4,5-Insp3;   D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE;   D-myo-Inositol 1,4,5-trisphosphate;   Formula=C6H15O15P3;   IP3;   InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/t1-,2+,3+,4-,5-,6-/m1/s1;   InChIKey=MMWCIQZXVOZEGG-XJTPDSDZSA-N;   Inositol 1,4,5-trisphosphate;   Ins(1,4,5)P3;   InsP3;   SMILES=O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
 alt_id: CHEBI:11363;   CHEBI:12892;   CHEBI:12894;   CHEBI:19192;   CHEBI:4276;   CHEBI:43249
 xref: Beilstein:3658346;   CAS:85166-31-0;   DrugBank:DB03401;   KEGG:C01245;   KNApSAcK:C00007460
 xref_mesh: MESH:D015544
 xref: PDBeChem:I3P
 cyclic_relationship: is_conjugate_acid_of CHEBI:203600


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1D-myo-inositol 1,4,5-trisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases abundance
multiple interactions
ISO ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B increases abundance
increases metabolic processing
multiple interactions
ISO ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate
ADRA1B protein results in increased metabolism of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 PMID:11278430 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D increases abundance
multiple interactions
ISO ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7874174 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]] CTD PMID:20691780 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects abundance ISO CHRM1 protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19002953 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
increases abundance
ISO Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]] CTD PMID:19002953 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases chemical synthesis
increases abundance
EXP
ISO
cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]
CTD PMID:1443220 PMID:11911850 PMID:20691780 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of FOS protein CTD PMID:16259952 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases expression
EXP Cyclosporine promotes the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 mRNA]; Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein] CTD PMID:16259952 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B decreases abundance ISO HTR2B protein mutant form results in decreased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:15625277 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A multiple interactions ISO benzene 1,2,4-trisphosphate inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate]; Polyphosphates inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate] CTD PMID:18574825 NCBI chr 1:211,732,163...211,920,844
Ensembl chr 1:211,732,713...211,921,099
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYC protein CTD PMID:16259952 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYH7 mRNA CTD PMID:16259952 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions
increases expression
EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein] CTD PMID:16259952 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Npy1r neuropeptide Y receptor Y1 affects abundance EXP NPY1R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Npy2r neuropeptide Y receptor Y2 affects abundance EXP NPY2R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr 2:181,528,949...181,538,145
Ensembl chr 2:181,530,832...181,531,978
JBrowse link
G Tnfsf4 TNF superfamily member 4 increases abundance ISO TNFSF4 protein results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19416722 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        biochemical role 19360
          metabolite 19341
            eukaryotic metabolite 18998
              animal metabolite 18801
                mammalian metabolite 18800
                  mouse metabolite 18465
                    1D-myo-inositol 1,4,5-trisphosphate 18
                      D-myo-Ins(1,4,5)P3 hexakis(butyryloxymethyl) ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      chalcogen 19454
                        oxygen atom 19415
                          oxygen molecular entity 19415
                            hydroxides 19139
                              oxoacid 18273
                                pnictogen oxoacid 10308
                                  phosphorus oxoacid 9228
                                    phosphoric acids 7945
                                      phosphoric acid 7945
                                        phosphoric acid derivative 7624
                                          phosphate 7624
                                            organic phosphate 7623
                                              cyclitol phosphate 58
                                                inositol phosphate 58
                                                  myo-inositol phosphate 58
                                                    myo-inositol polyphosphate 58
                                                      myo-inositol trisphosphate 18
                                                        1D-myo-inositol 1,4,5-trisphosphate 18
                                                          D-myo-Ins(1,4,5)P3 hexakis(butyryloxymethyl) ester 0
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