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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6-aminohexanoic acid
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Accession:CHEBI:16586 term browser browse the term
Definition:An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.
Synonyms:related_synonym: 6-Aminocaproic acid;   AMINOCAPROIC;   Ahx;   Amicar;   Amikar;   Capralense;   Capramol;   Caproamin;   Caprocid;   Caprolisin;   EACA;   Epsamon;   Epsicaprom;   Epsicapron;   Epsikapron;   Epsilcapramin;   Epsilcapramine;   Epsilon S;   Formula=C6H13NO2;   InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9);   InChIKey=SLXKOJJOQWFEFD-UHFFFAOYSA-N;   Respramin;   SMILES=NCCCCCC(O)=O;   Z;   acide aminocaproque;   acido aminocaproico;   acidum aminocaproicum;   aminocaproic acid;   aminohexanoic acid;   epsilon-Ahx;   epsilon-amino-n-hexanoic acid;   epsilon-aminocaproic acid;   epsilon-aminohexanoic acid;   epsilon-leucine;   epsilon-norleucine;   omega-aminocaproic acid;   omega-aminohexanoic acid
 alt_id: CHEBI:2171;   CHEBI:227755;   CHEBI:40458
 xref: Beilstein:906872;   CAS:1319-82-0;   CAS:60-32-2;   DrugBank:DB00513;   Drug_Central:163;   Gmelin:101724;   HMDB:HMDB0001901;   KEGG:C02378;   KEGG:D00160;   LINCS:LSM-5733;   LIPID_MAPS_instance:LMFA01100035
 xref_mesh: MESH:D015119
 xref: MetaCyc:CPD-884;   PDBeChem:ACA;   PMID:10930630;   PMID:12141409;   PMID:14050038;   PMID:19086806;   PMID:21904257;   PMID:22339947;   PMID:22770225;   PMID:22847395;   PMID:22995453;   PMID:23187124;   PMID:23213034;   PMID:23353035;   PMID:23434921;   PMID:23921838;   Reaxys:906872;   Wikipedia:Aminocaproic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:32396;   is_tautomer_of CHEBI:57826


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6-aminohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Aminocaproic Acid results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Folh1 folate hydrolase 1 multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein] CTD PMID:24508213 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
JBrowse link
G Grpr gastrin releasing peptide receptor multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein] CTD PMID:24508213 NCBI chr  X:32,746,259...32,786,266
Ensembl chr  X:32,745,873...32,786,359
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17482686 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Plg plasminogen multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]; Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Aminocaproic Acid results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19790
      biological role 19790
        biochemical role 19328
          metabolite 19309
            6-aminohexanoic acid 7
              6-(4-hydroxy-3-nitrobenzamido)hexanoic acid 0
              6-(4-hydroxy-5-iodo-3-nitrobenzamido)hexanoic acid 0
              6-[(3-bromo-4-hydroxy-5-nitrophenyl)acetamido]caproic acid + 0
              6-[(4-hydroxy-3-nitrophenyl)acetamido]caproic acid + 0
              6-\{[5-(p-nitrophenoxy)-5-oxopentanoyl]amino\}hexanoic acid 0
              6-aminohexanoic acid cyclic oligomer 0
              N-(2,4-dinitrophenyl)aminohexanoic acid 0
              N-purin-6-oyl-epsilon-aminocaproic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        monocarboxylic acid 17487
                                          fatty acid 16001
                                            saturated fatty acid 15974
                                              straight-chain saturated fatty acid 15427
                                                hexanoic acid 73
                                                  6-aminohexanoic acid 7
                                                    6-(4-hydroxy-3-nitrobenzamido)hexanoic acid 0
                                                    6-(4-hydroxy-5-iodo-3-nitrobenzamido)hexanoic acid 0
                                                    6-[(3-bromo-4-hydroxy-5-nitrophenyl)acetamido]caproic acid + 0
                                                    6-[(4-hydroxy-3-nitrophenyl)acetamido]caproic acid + 0
                                                    6-\{[5-(p-nitrophenoxy)-5-oxopentanoyl]amino\}hexanoic acid 0
                                                    6-aminohexanoic acid cyclic oligomer 0
                                                    N-(2,4-dinitrophenyl)aminohexanoic acid 0
                                                    N-purin-6-oyl-epsilon-aminocaproic acid 0
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